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EAU 2017: Does nadir testosterone at the end of long term androgen deprivation therapy predict outcomes in high risk … – UroToday

Mar 25th, 2017
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London, England (UroToday.com) Dr. Nabid and colleagues presented their study this morning at the EAU 2017s advanced prostate cancer poster session, assessing the impact of nadir testosterone on clinical outcomes after long-term androgen deprivation therapy (ADT) and radiation therapy (RT) for high risk prostate cancer. With emerging literature highlighting additional risks of ADT, including depression, cognitive decline, etc., this study is timely in assessing duration of ADT with regards to castrate testosterone levels and subsequent clinical outcomes.

This cohort included 630 patients with high risk prostate cancer undergoing RT who were randomized to receive either 18 or 36 months of goserelin. Castrate levels of testosterone were sub-stratified as 0.7 (20 ng/dL surgical castration), 0.7-1.7 (>20-

Dr. Nabid and colleagues study shows that our goal for testosterone nadir after ADT among men with high risk prostate cancer undergoing concomitant RT should be

Presented by: AbdenourNabid, Department of Radio-Oncology, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Canada

Written by: Zachary Klaassen, MD, Urologic Oncology Fellow, University of Toronto Twitter: @zklaassen_md

at the #EAU17 -March 24-28, 2017- London, England

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Association between DTC advertising and testosterone testing and initiation – Pharmacy Today, American Pharmacists Association, pharmacist.com

Mar 25th, 2017
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Epidemiologists questioned whether an increase in direct-to-consumer advertising from 200013 contributed to a concurrent surge in testosterone testing and initiation among U.S. men. Extracting data from commercial insurance claims for roughly 17.2 million patients in the country’s 75 largest designated market areas (DMAs), they did in fact establish a link between the parallel trends. The numbers indicated that more than 1 million men in the target DMAs underwent serum testosterone screening during the study period and about 283,000 started testosterone treatment. For every new household advertisement exposure, an additional 0.14 testosterone tests per 10,000 men were performed. Additionally, 0.05 more new treatment initiations per 10,000 men took place during the time frame, including a mean absolute gain of 0.02 more treatment initiations that occurred without the patient first being screened.

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Does ‘false hope syndrome’ make it hard to lose weight? – The Sydney Morning Herald

Mar 25th, 2017
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For years, whenever Vik Kapoor spoke before a crowd, his stomach swirled with anxiety, his heart raced and he concluded each lecture drenched in sweat.

“My fear of public speaking affected my self-confidence, which is why I made it my New Year’s resolution to tackle this problem,” says Kapoor, a life coach and adjunct professor at Howard University’s law school. “Initially, I tried to lessen my fear by looking for simple solutions. I vowed to wear black whenever I spoke in public to hide the sweat stains, and I scheduled a doctor’s appointment to see if a health issue was causing my anxiety. I also decided to become my own cheerleader by giving myself mini pep talks before each of my lectures.”

After coming up with these solutions, Kapoor felt better. But the next time he spoke in public, his planning failed. “As soon as I began my talk, my stomach churned and I started sweating. My mind went blank.”

Kapoor became so frustrated that he discarded his resolution.

Kapoor didn’t know it at the time, but he now realises he was suffering from “false-hope syndrome,” a tendency to have unrealistic beliefs about what is required to change behaviour.

University of Toronto professors Janet Polivy and C. Peter Herman coined the term in 2000 based on their research showing that people frequently underestimate the work needed to meet self-improvement goals. When hope meets reality, the commitment to change often collapses.

Several other social scientists believe that false-hope syndrome helps explain why people struggle to lose weight, quit smoking and exercise regularly.

About 25 per cent of those who make New Year’s resolutions abandon them within a week, according to the statistics website StatisticsBrain.com, whether it’s to begin the Paleo diet, sign up for a daily yoga challenge or start a meditation practice. By February, most people have given up on their resolutions altogether.

Sasha Albani, a psychotherapist and marriage and family therapist in San Francisco, says the key to sticking with a resolution is to make sure that it aligns with one’s personal values.

“We are more likely to follow through on our goals when we make value-led decisions. For example, if we value the physical and mental health benefits of exercise, we’re more likely to succeed at beginning a new exercise program,” Albani says.

She says that our goals are harder to accomplish when our values clash. For example, let’s say that you want to stop drinking coffee and soda, but you really value how alert caffeine makes you feel. In this case, it’s going to be more difficult to change your behaviour.

A theory of behaviour change known as acceptance and commitment therapy, or ACT, may help some people stick with resolutions.

According to the American Psychological Association, ACT therapy may work particularly well when we want to change a bad habit but we are unclear about the barriers that could get in our way.

This psychological intervention can help increase cognitive flexibility by showing people how to identify their values and the steps that they need to take to change their behaviour.

“ACT therapy breaks down goal-setting into three steps by using the guiding principles of values, commitment and willingness to change,” says Daniela Tempesta, a psychotherapist and life coach in San Francisco.

According to Tempesta, these are the psychological components that are necessary for achieving your new goals.

After several years of failing to keep his resolutions, Kapoor contacted an ACT psychotherapist. He quickly learned that while he valued speaking confidently, he didn’t value himself. When he had tried to give himself mini pep talks, he spoke to himself unkindly.

“I’d tell myself, ‘Anyone can do this, it’s easy, just pull it together.’ I realised that this was negative self-talk and not a pep talk at all,” Kapoor says.

With the help of his therapist, he learned how to apply ACT in a way that set him up for success.

“I realised that my fear of public speaking stemmed from a deep worry about not trusting myself. My anxiety was my body’s way of propelling into the fight-or-flight response. Once I identified this insight, I had to examine why I didn’t feel confident about my abilities,” Kapoor says.

For those who make resolutions, Tempesta suggests looking at the changes to be made and thinking about how they can be achieved. She recommends these ACT principles:

Examine barriers: If you’re vowing yet again to run a marathon or lose weight, ask yourself what stood in your way before. What will you do differently this time that might make success more likely? For example, if you began training for a marathon by running in the morning even though you’re really not a morning person, you might choose to train at a different time of day.

Clarify values: While resolutions often reflect someone’s values, they can compete with other values. For example, if you want to lose weight but eating is one way that you cope with stress, you may want to see whether there are other methods that will help you control stress. You might decide to adopt a pet or begin a weekly yoga class. Tempesta says that if you find a way to align your values (managing stress and eating healthier), you’re more likely to reach your goals.

Accept emotions: Once you have clarified your values, ask yourself what feelings might arise as you work toward your goal. For example, if you give up caffeine because it can make you anxious, will you then feel irritable, tired or depressed? Personal reflection can help you consider mechanisms for coping with these feelings.

Take action: Commit to making behaviour changes based on your values. For example, if you value eating healthier but your colleagues often invite you out to lunch, think about how you will avoid ordering french fries instead of salad. You might take control by suggesting a restaurant with healthy offerings where you won’t be tempted to eat your favourite carbs.

If you stumble along the way, don’t give up, Tempesta says. Simply notice the thoughts and feelings that block your path and begin again. Remember that if you falter on your resolutions, you don’t need to wait until January1 comes around again to harness new hope.

Fraga is a psychologist. She is not an ACT therapist.

The Washington Post

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Overweight student loses 4st in just 12 months you won’t believe what she looks like now – Daily Star

Mar 25th, 2017
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RILEY HEMSON reveals how she lost 4st in just 12 months.

INSTAGRAM/HEALTHYCHICK101

The one thing Riley Hemson stresses about losing weight is that there are no shortcuts.

The 21-year-old New Zealander has lost an astounding 4st from changing her diet and adding more exercise to her everyday life.

Riley has documented her on-going weight loss on her Instagram page @healthychick101, which has amassed an impressive 25,000 followers.

INSTAGRAM/HEALTHYCHICK101

Rileys weight loss journey began last year when she weighed nearly 18st.

I would take pics [sic] of myself and just be so unhappy. But then I would only last a couple of days eating healthy before I went back off track. My main issue was I would eat one bad thing and then go “oh well, may as well eat EVERYTHING BAD EVER and start fresh tomorrow, Riley explained in an Instagram post.

This would happen day after day. As soon as I allowed myself to have a treat and then get back on track, not let one slip up ruin my day, I was away.

INSTAGRAM/HEALTHYCHICK101

Good news dieters! The 23 foods that contain NO calories because you burn more than you consume as you eat

1 / 23

APRICOTS – Calorie content: 12 kcals per apricotEating apricots is said to help reduce the risk of strokes, and heart attacks. They’re also full of vitamin C, potassium and dietary fibre, which all promote good heart health

Now she has lost 4st and hopes to reach her goal weight of 11st in the next few months.

Ive achieved this body transformation (and will continue to) through eating healthy and exercising, Riley said.

There are no short cuts or tips and tricks! It’s all hard work and dedication.

Riley said one of the things that has helped her the most with her weight loss is taking full-length pictures of herself throughout the year.

These pictures show the dramatic change in her body over the time.

INSTAGRAM/HEALTHYCHICK101

When I look between each pic [sic], there’s a difference but it’s not drastic. Then looking between the first and most recent there very clearly is a massive change, the trainee paramedic wrote.

It’s easy to want to give up when you don’t see the results happening as fast as you would like them too. But just keep going, it will happen! It’s all about consistency.

This shows it does take time, hard work and commitment. There really is no quick fix.

Riley added she works out five times a week a mixture of weight lifting, circuit training and hight intensity interval training and has cut junk food from her diet.

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Cost of nutrients and relative value of feedstuffs for Pennsylvania dairy farms – Lancaster Farming

Mar 25th, 2017
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The Class III milk futures continue to trade in $16 per hundredweight range out into the foreseeable months, which is below where many forecast the price to be back at the end of 2016. Luckily, feed prices have remained fairly low and stable with the exception of a few feeds like blood meal, which has skyrocketed up $300 per ton in the past two months. While the lower feed prices are welcome, there are still opportunities to improve income over feed cost (IOFC). To do this, dairy producers need to explore what cost-effective feedstuffs are available in their market place. To compare feedstuffs based on their nutrient value and price can be difficult. However, the SESAME program, developed at The Ohio State University, was designed with this purpose in mind. The software program determines the economic values of dairy feedstuffs by evaluating commonly used feedstuffs based on their content of five basic nutrients: net energy for lactation (NEL), rumen degradable protein (RDP), digestible rumen undegradable protein (d-RUP), non-effective neutral detergent fiber (ne-NDF), and effective neutral detergent fiber (e-NDF). These nutrients are valued on a megacalorie basis for NEL and a per pound basis for RDP, d-RUP, ne-NDF and e-NDF. If you are evaluating your ration ingredients based on other nutrients, please be aware that there are differences and consult with your nutritionist on any potential ration changes.

The SESAME analysis of the Pennsylvania feed market uses 29 commonly fed commodities to determine the intrinsic value for each of the five basic nutrients described above in a feeding program. The intrinsic value is the price that the market is willing to pay for that particular nutrient. As an example, a pound of digestible rumen undegradable protein is currently worth approximately $0.445 in the market (See Table 1), regardless of whether that d-RUP comes from soybean meal, blood meal, or corn, etc. For the past nine years that we have conducted this analysis, d-RUP is consistently the most expensive nutrient in a lactating dairy cows diet. Therefore, based on the intrinsic value for each of the five nutrients within a specific feedstuff, we can determine the potential break-even price based on a book value for each nutrient in that feedstuff, and economically, where the price of a byproduct feed has to fall to be considered as an alternative in ration formulation. The calculated costs for the five basic nutrients are shown in Table 1.

Table 2 provides the actual prices for the feedstuffs that were evaluated in the current SESAME analysis along with their predicted prices based on nutrient content. In addition, the table includes the 75 percent confidence limits of prices for each commodity. A 75 percent confidence limit indicates that we are about 75 percent sure that the true cost of the feedstuff based on nutrient content is between the lower and upper limit prices. In reading the table, one should consider feedstuffs with an actual price below the lower limit as bargains in the present market. The feedstuffs with an actual price above the upper limit would be considered overpriced, and feedstuffs with actual prices falling between the limits would be priced at their approximate nutrient value.

In the protein byproduct feedstuff markets, there are two undervalued protein sources, distillers dried grains with solubles (DDGS) and meat meal. However, farmers should understand the limitations of each of these different protein sources. There two limitations with DDGS: a very low content of lysine, one of the two limiting amino acids for milk production in dairy cows, and a high fat content, which can limit DDGS inclusion level in the diet. Therefore, these bargain feedstuffs need to be evaluated very carefully before incorporating them into the diet. Among animal-based RUP sources, fishmeal and blood meal remain extremely high-priced in the market, being marketed at 283 percent and 180 percent of their expected value, respectively. These protein sources need to be carefully scrutinized in the diet due to their continued high prices in the market. Alternatively, rumen-protected amino acid supplements may be more cost effective for balancing for amino acids within a lactating cow diet, and can be effectively used in lower CP diets. The market dynamics suggest that dairy producers should avoid soybean meal 44 percent as it is over its highest market value, and therefore, has virtually no value when compared to soybean meal 48 percent.

Among energy feedstuffs, the byproduct feedstuffs including bakery byproduct meal, corn gluten feed, hominy, and wheat midds are at or below the lower limit price. If possible, avoid citrus pulp and tallow as they continue to be overpriced in the market. Supplemental fat sources are another over-priced feedstuff that need to be used judiciously if possible given the abundance of more cost-effective energy sources. However, because the prices used in the SESAME analysis are aggregated, approximate feed prices, the local prices for all feeds may be different than those listed in Table 2. There are several warnings about the information presented in Table 2.

Warnings:

1. Actual Prices listed in Table 2 are approximate and represent aggregated prices for the State of Pennsylvania. Check with your local suppliers for actual delivered prices.

2. Prices are on a commodity basis, and represent farm-delivered, full tractor-trailer loads (TTL) prices. No services are included; commodity feeds have little or no nutritional guarantees.

3. Results do not imply that a balanced ration can be made solely with bargain feeds, or that over-priced feeds should be eliminated from the ration. Certainly, there is an economic incentive to maximize the use of bargain feeds and minimize the use of over-priced feeds.

4. The analysis is based on the five most economically important nutrients in dairy rations. For very high production herds, other nutrients such as amino acid content of the undegradable protein should also be considered. This would change the predicted price of some commodities such as blood meal.

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DaVita Shares Online Kidney Diet Resources for National Nutrition Month – Yahoo Finance

Mar 25th, 2017
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DENVER, March 22, 2017 /PRNewswire/ –DaVita Kidney Care, a division of DaVita Inc. (DVA), and a leading provider of kidney care services in the United States, celebrates March as National Nutrition Month by sharing kidney-friendly recipes, diet tips and online resources.

“Diet and nutrition play an integral role in managing the health of dialysis and kidney disease patients,” said Sara Colman, RDN, CDE, and manager for DaVita.com nutrition. “National Nutrition Month is a great time to empower those with kidney disease to make healthy dietary choices using free, online tools such as the DaVita Diet Helper and kidney-friendly cookbooks.”

The “Today’s Kidney Diet: Juices, Smoothies & Drinks” cookbook contains 12 refreshing recipes to help kidney disease patients feel energized and nourished while adhering to a kidney-friendly diet. It also features ways to incorporate protein and how to safely add low-potassium fruits and vegetables to smoothies and drinks. To download DaVita’s cookbook collections for free, visit DaVita.com/FreeCookbook.

The DaVita Diet Helperonline tool allows users to plan and track kidney-friendly meals that adhere to important nutrition levels, such as phosphorus, potassium and sodium. It features more than 1,000 recipes that are kidney-and diabetes-friendly.

DaVita Kidney Care recently hosted a live Facebook video featuring renal dietitian Candace Schopper. Schopper discusses how caregivers and those with kidney disease can best approach cooking for kidney diet restrictions. To watch the full recorded video, visit Facebook.com/DaVitaKidneyCare.

Additional recipes and kidney-friendly diet tips can also be found on the DaVita Kidney Diet Tips blog atBlogs.DaVita.comand on Pinterest atPinterest.com/DaVitaPins.

About DaVita Kidney Care

DaVita Kidney Care is a division of DaVita Inc., a Fortune 500 company that, through its operating divisions, provides a variety of health care services to patient populations throughout the United States and abroad. A leading provider of dialysis services in the United States, DaVita Kidney Care treats patients with chronic kidney failure and end stage renal disease. DaVita Kidney Care strives to improve patients’ quality of life by innovating clinical care, and by offering integrated treatment plans, personalized care teams and convenient health-management services. As of December 31, 2016, DaVita Kidney Care operated or provided administrative services at 2,350 outpatient dialysis centers located in the United States serving approximately 188,000 patients. The company also operated 154 outpatient dialysis centers located in 11 countries outside the United States. DaVita Kidney Care supports numerous programs dedicated to creating positive, sustainable change in communities around the world. The company’s leadership development initiatives and social responsibility efforts have been recognized by Fortune, Modern Healthcare, Newsweek and WorldBlu. For more information, please visit DaVita.com.

Contact Information

Media: Kelsey Fairholm (303) 876-0488 Kelsey.Fairholm@davita.com

To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/davita-shares-online-kidney-diet-resources-for-national-nutrition-month-300427538.html

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Speaking of Your Health: The importance of fruits and vegetables – Logan Daily News

Mar 25th, 2017
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According to the CDC, eating a diet with plenty of fruits and vegetables provides important health benefits when you select and prepare them safely. Fruits and veggies add nutrients to your diet that help protect you from heart disease, stroke, and some cancers. And choosing produce including vegetables, fruits, and nuts instead of high-calorie foods also helps you manage your weight.

However, sometimes harmful germs such as, Salmonella, E. coli, and Listeria can contaminate raw fruits and vegetables. This can make you and your family sick with food poisoning. CDC says that nearly half of foodborne illnesses in the United States are caused by germs on contaminated fresh produce.

Safer choices for produce are washed, fresh fruits/vegetables and cooked vegetables. Unwashed, fresh vegetables are more likely to make people sick with a foodborne illness. The CDC gives these steps to help avoid food poisoning and still enjoy uncooked fruits and vegetables.

Check fruits and vegetables for bruising and damage.

Throw away fruits and vegetables that are spoiled or have been recalled.

Wash your hands, kitchen utensils, and food preparation surfaces, including chopping boards and countertops, before and after preparing fruits and vegetables.

Clean fruits and vegetables before eating, cutting, or cooking, unless the package says that the contents have been pre-washed.

Wash or scrub all fruits and vegetables under running water even if you do not plan to eat the peel so dirt and germs are not transferred from the surface to the inside when you cut the produce.

Dry fruit or vegetables with a clean paper towel.

Keep fruits and vegetables separate from other foods that could contaminate them, such as raw meat and seafood.

Refrigerate fruits and vegetables that you have cut up, peeled, or cooked as soon as possible, or within two hours. Refrigerate within one hour if the temperature outside is above 90 degrees. Chill them at 40 degree or below in a clean container.

Anyone can get a foodborne illness, but some individuals are more likely to get sick and to have a more serious illness. These groups of people are:

Adults aged 65 and older

People with weakened immune systems

If you or someone you care for has a greater chance of food poisoning, it’s especially important to take steps to prevent food poisoning when preparing and eating fresh fruits and vegetables.

Brittney Tschudy, BSH, RN, TTS Hocking County Health Department writes a weekly column published in The Logan Daily News. The views of this column may not necessarily reflect that of the newspaper.

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Raising Arizona V. 2017 Part IV – Lone Star Ball

Mar 25th, 2017
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Every year on this trip theres a handful of moments that seem to make the entire trek worth while. Not that the whole exercise isnt super fun, but like any other vacation, theres really only 2 things youll remember: 1) the overall vibe and 2) 3 or 4 remarkable moments. Leodys walkoff will be in the latter group. As will David Garcias 1.82 pop time. And a late entrant into the memory cache will be most of today bumper car action. My pal and yours, Scott Lucas and I spent the entire afternoon caromming from field to field because finally, on my last day in Surprise, the heat really came out. The names you know and the ones you soon will seemed to all be in action somewhere today. Speas, Ragans, Enright, Taveras, Palumbo, Martin, Morgan, Tiedemann, Cody, and Roberts. All doled out varying levels of look at me today. It was an absolute blast.

Before I go any further, Ive got to once again implore all of you to pencil in this trip next year or sometime soon. Its the best. Id also like to thank all the scouts and front office folks (particularly the Rangers guys) who put up with my bizarre obsession. Truth is, Im not much more than a mouthy fan and they all seem to tolerate it. So thanks. Now go Fly A Flag, dammit.

On to the juice. Ill cut right to the chase. Joe Palumbo was the most impressive Rangers pitcher not named Cole Hamels I saw on this trip. Id heard all about the progress he made in Hickory last year and the weight and strength hed addedall leading to a bump of about 6mph on his FB. Heard it all. Now Ive seen it all. He looked like a future MLB starting pitcher. Not a superstar, but a guy whos gonna get there and compete. The FB sat 93-94 and touched 96 twice in 3ip. He got two swinging Ks with the CH and at least one with his CB. The CB is truly nasty and safely projects as a plus offering. He commanded the FB well and held his velo. Seemed poised and to have a plan. Also, he has a lot of tattoos. Not necessarily a tall kid, but he gets decent plane and good movement on his FB. Get this dude a knife and fork and let him start eating innings. Reps and experience will be key over the next 2 seasons, but if I woke up from a coma in 2020 and 25 year-old lefty Joe Palumbo was Texas number 4 starter, I wouldnt be shocked.

Cole Ragans is straight out of central casting. The reports of his Hamels hankering are accurate and I got a chance to chat with Ragans about that for a little while and I couldnt be happier he has Hollywood to try and emulate. Ragans is as polished as they come for his age and experience level. Affable and polite on non-pitching days, I saw a decidedly different demeanor today. Focused and workmanlike. He threw all FBs in a live BP session and they were 89-92 and it had plenty of shake and wiggle. In warmups, he snapped off some of the patent–pending CHs hes learned by watching Hamels. Its gonna be a plus pitch. An easy 64 with room to add weight to what Id guess is about 200lbs, hes exactly what it looks like. Gonna be a fun few years tracking this kid.

Brett Martin threw 4 frames and was mostly 91-93 with the FB and the damn thing comes off a mountain top. Serious extension from his 65 frame. His velo has a chance to play up because of the angle he creates. Its pretty awesome. He wasnt particularly sharp until his final frame when he became a whiff machine with both his 84/5mph CH and his 79-81mph bender. When he has all 3 going, he can strike out 15 batters in 7 innings of a playoff game. Hes got a couple more years to go, but could be prettayyy prettayyy salty when he gets there.

Alex Speas threw in the same live BP session that Ragans did, and he too was on an all-fastballs diet. But he has juice. Serious juice. He threw easy 93-95 and ran out a handful of 96s. He can pump it into the upper-90s anytime he wants. He throws very hard. As I mentioned previously, hes pretty raw mechanically, but his arm speed is a sight to behold. Or to not see at all. Its moving that quickly.

Pedro Payano threw and hes a guy to keep in the back of your mind because he throws 4 pitches and will most definitely get to the upper levels. Hes fully healed from the broken forearm that ended his season prematurely last year and hes ready to eat innings. Way crazier things have happened in this game than a guy like Pedro Payano collecting a few big league check(s) before its all said and done.

I asked around and it seems likely my favorite 17 year-old switch-hitting catcher David Garcia is likely ticketed for the Dominican Summer League. Former UTA Maverick and Mansfield High alum Chad Comer is a coach down there and he is a highly respected catching instructor, so it appears the powers that be are gonna stash my lil buddy in the DR for 2017. See you next year, kid!

Heres a name not many people are talking about- Kyle Cody. Id heard good stuff about him this spring from a couple of scouts and got a chance to see it in action for a few innings today. Its good. Real good. Really promising. A hulking 67 22 year-old former Kentucky Wildcat, Cody appears to be a near lock for a rotation spot in Hickory. And why the hell not? He sat 93-96 today and broke off a few mega-legit SLs. It could very well be a plus pitch. He threw a fair number of CHs and thatll most definitely be his working on this offering for 2017. But theres plenty to be excited about. He touched 98 and seemed to be able to manipulate the depth on the SL a bit. More reps and more reps can only help and Id love to see this kid make 18-20 starts this season.

Demarcus Evans is interesting because hes a 20 year-old big bodied righty (64 240lbs) who gets massive extension on his arm and seems to spin the holy hell outta the FB. I say that because he misses bats in the 91-93 velo band and misses them by a fair margin. Thats sometimes attributable to spin rate and when you see how high his release point is and how massive his hands are, it all kinda makes sense. Member that name.

Kyle Roberts is another name to sock away. Hes left handed and threw 94-95mph today. Last summers 5th round pick is, unlike Demarcus Evans, not 64. Hes 66. 100% certain Texas would win a prospect pickup basketball tournament.

Tyree Thompson has a bit of helium as well. The 19 year-old righty, and New Orleans native, signed for $100,000 after being taken in the 26th round last year. Hes listed at 64 and 165lbs. Now, as you probably know, the listed weights are often inaccurate and usually on the low side. Occasionally, theyre wildly inaccurateon the low side. In this case, Id say its probably just about right. Regardless of his weight, I know his velocity is accurate because I saw it being measured by several different devices today and it was routinely 91-93.

You know who Im hopeful for this summer? Yey Yey, thats who. Yeyson Yrizarri has tools and will probably play in the big leagues because he can play on the left side of the infield and can throw with jet propulsion. But last year in Hickory, he was far from fearsome with the stick. He hit .269, but drew 9 walks in 479 plate appearances and posted a .681 OPS. I think hes better than that. And he needs to be better than that. He just turned 20 years old, so theres more than ample time, but Ive always said Id like Yey Yey to get on that back leg a bit and try to lift the ball. I know he can do it because Ive seen it. Heres a long F7:

Here he is getting positive encouragment from some other baby sluggers all trying to pump bombos. (He hits first and leeeeeans back)

Miguel Aparicio was held out of game action after picking up a slight shin cut when he met a spike sliding into second base, but I was soundly impressed by what I saw. Basically, hes Leody Taveras-lite. Which still makes him a prospect. Possibly a very good one. Hes not big and only turned 18 a week ago, but the ball leaps off his bat. A centerfielder, he runs very well and is most definitely a name to remember. This time next year, Miguel Aparicio might be a dude of notable order.

Josh Morgan caught again and hes lightning quick back there. Took a foul ball square off the mask, so it probably wouldnt have been a good day to ask if he loved catching. But he did well back there and handled some really good arms in Cody, Palumbo, and Thompson. He posted a 2.09 pop time and nearly caught former Oregon Ducks centerfielder Austin Grebeck at 2B. Josh remains a very intriguing prospect, even without catching. Adding catching to his game makes him a VERY intriguing prospect. Have I mentioned he can hit?

So thats it. Thats all she wrote for another year in Surprise. Im sure youre all tired of hearing me implore you to get out here for a few days in March, but until I meet and shake the hand of each and every one of you on a backfield, my mission will remain incomplete. Ive uploaded a bushel full of videos to my YouTube page, so feel free to check them out and dream a little dream. Until we meet again, Surprise. Farewell, my love.

As Always, Enjoy Baseball!

Love Ya!

-Tepid

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Researchers prove prescription weight-loss pill decreases urge to use opiates – News-Medical.net

Mar 25th, 2017
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Researchers from The University of Texas Medical Branch at Galveston have confirmed that a prescription weight-loss pill decreases the urge to use opiates such as oxycodone.

In a study published in ACS Chemical Neuroscience, the researchers led by UTMB scientist Kathryn Cunningham found that the drug, lorcaserin, reduced the use and craving for the opioid oxycodone in preclinical studies. Cunningham is director of UTMB’s Center for Addiction Research and a professor in the department of Pharmacology and Toxicology.

Opiate abuse is a major public health problem and according to the U.S. Centers for Disease Control and Prevention, the number of deaths from prescription opiate overdose in America has quadrupled since 1999. High relapse rates and too few people remaining in treatment programs long enough for it to really benefit them continues to pose major challenges in treatment for the misuse of prescription opiates such as oxycodone and illegal opiates such as heroin.

Most of the treatments available to reduce opiate misuse work by occupying opioid receptors in the brain. If someone were to take an opiate while on these treatments, they would not feel the signature euphoria as strongly. However, a person’s drug-taking environment is a powerful cue that can condition someone to anticipate the experience of taking of the drug; this is called cue reactivity. People who have tried the currently available medications often relapse when they are around the people, places or paraphernalia that they associate with opiate use.

Lorcaserin, prescribed for weight loss, alters the serotonin system by changing chemical signals that affect satiety, the sensation of fullness. Serotonin regulates the brain circuitry involved in drug reward and cue reactivity, particularly though activating serotonin 2C receptors. Previous work by Cunningham and her team have shown that lorcaserin decreases how many times rats will complete a simple task to earn a dose of cocaine. However, much less is known about the involvement of the serotonin 2C receptors in altering how opiates feel rewarding for the user.

The researchers trained rats to self-administer oxycodone while exposed to specific lights and sounds that create a drug-taking environment. Once the rats were used to regularly consuming oxycodone, they went through a period where no oxycodone was available to them. The researchers then gave lorcaserin to some of the rats while others were given a placebo and placed them in the drug-associated environment. At this point, oxycodone was again made available to the rats. The lorcaserin rats self-administered less oxycodone and reacted less strongly to cues associated with taking the drug. In order to show that this effect was attributed to the lorcaserin, a group of rats was given lorcaserin as well as a drug that blocks the serotonin 2C receptors – thus cancelling out the effect of the lorcaserin – those rats tried very hard to get oxycodone.

“The effectiveness of lorcaserin in reducing oxycodone seeking and craving highlights the therapeutic potential for lorcaserin in the treatment of opioid use disorder,” said Cunningham. “We plan more studies to better understand how drugs like lorcaserin can help us stem the tide of addiction in America.”

Source:

University of Texas Medical Branch at Galveston

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Posted in: Medical Research News | Medical Condition News | Pharmaceutical News

Tags: Addiction, Brain, Drugs, Heroin, Neuroscience, Oxycodone, Pharmacology, Placebo, Preclinical, Public Health, Serotonin, Toxicology, Weight Loss

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Finally, a weight-loss program that’s ‘Ideal for me – Marysville Globe

Mar 25th, 2017
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LAKEWOOD Seems like almost everyone, especially after the holidays, wants to lose weight.

I cant tell you the number of times thats been my New Years Resolution.

I have tried about every diet possible: Atkins, Nutrasystems, Weight Watchers, etc. Thanks to being held accountable by Julie Muhlstein at The Herald, when I worked there a dozen years ago, Weight Watchers worked the best for me.

Until now.

At the Marysville-Tulalip Chamber of Commerce Dinner and Auction in December, I was the high bidder on an item offered by Emily Countryman of Ideal Wellness in Lakewood. I had done a story on that program a few years ago and decided to give it a try.

My first appointment there I told her my wife had done the 30-10 weight loss program. Emily told me the founders of 30-10 were part of Ideal Wellness but broke off and started their own business. They both are protein and vegetable diets, with no sweets or carbohydrates. Supplements make sure clients get the vitamins they need.

What makes Ideal Wellness better than the highly advertised 30-10 weight loss program, in my mind, is not only the lower cost but the lifetime of coaching. Once I reach my goal weight I no longer have to buy their scientifically balanced food products, which cost $99 a week. They will put me on a plan of eating regular foods to sustain my weight. By the way, Ive lost 27 pounds in six weeks, and eight total inches. My wife joined this week.

Once I reach my new goal, I will continue to go in to be weighed once a month. If I gain five pounds, I told them I will go back on the weight-loss program. That way, I should never weight more than five pounds above my goal weight the rest of my life.

That has been a huge problem for me in the past. Im a yo-yo dieter. Id lose the weight but gain it back. Also, to help me for the rest of my life, Ideal Wellness coaches will be there to encourage me. Often times I will hit a goal, then stay there. Then get discouraged and start gaining. With a life coach, they can help push me through that wall.

The program is working much faster than I thought it would. I lost 16 pounds in the first two weeks, and 6 inches. Belly fat always has been hard for me to lose, but I lost 3 inches there and already am back into jeans I havent worn for years. My Body Mass Index is dropping fast, too.

Ill admit the food, and the amount you eat, isnt like going to a 4-star restaurant. But it does the job. And it works so well its easy to stay on. But I sure look forward to dinners when I can have up to 8 ounces of lean meat and four cups of vegetables. Its real food.

If you have a sweet tooth, Ideal Wellness has dessert products available as snacks that can solve that problem. There also are salty snacks, such as soy nuts, that I like.

I particularly enjoy the omelette, oatmeal and pancake mixes for breakfast and the soup mixes for lunch.

Im not the only one who has done well on this diet. Many of the counselors who work there have lost dozens of pounds using Ideal Wellness. There are pictures all over the walls of before and after shots of clients. And Ive included mine in this story, even though I plan to keep going.

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