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Is the Keto Diet Really Safe? – thedailymeal.com

Dec 19th, 2018
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The ketogenic diet, or keto diet, claims to turn your body into a fat burning machine through restricting all forms of carbohydrates to an extremely low level. You can find more detailed information on what the diet looks like and where it came from here. It seems like a buttery, fat-filled fast track to weight loss but is it safe?

Many experts tout the benefits of the keto diet, ranging from diabetes prevention to blood pressure. However, registered dietitian Jackie Arnett Elnahar explained that many, if not all, of these benefits have been proven in studies involving patients with a chronic illness epilepsy or Alzheimers, for instance. They have not been proven for the average dieter.

Studies have shown great improvement in epilepsy and neuroprotective benefits for Parkinsons, Elnahar asserts. In spite of the advantages for some, it is not recommended for the general public.

There are some perceived benefits for those without a chronic illness. For instance, MusclePharm's registered dietitian Kristen Bell explained, Because this diet is high in fat and so low in carbs, most will feel a decrease in cravings, and tend to feel full and more satisfied for longer periods of time.

But this temporary satiation comes at a very real cost.

What are some health risks of the keto diet?Ketogenic diets do have potential concerns and lack of scientific information on the long-term effects, registered dietitian and Arivale coach Ginger Hultin told The Daily Meal. Specifically, there is a possibility of kidney damage, nutritional deficiencies, and side effects including constipation, dehydration, fatigue, and nausea with this diet.

There still is not enough long-term research to confirm that the diet doesnt pose more serious health concerns. We dont know the long-term effects of eating extremely high-fat diets, registered dietitian Cheryl Mussatto explains, which go against the current chronic disease prevention recommendations.

But in the short term, some studies and some personal experiences have revealed that going keto has a number of undesired consequences.

Reducing carb intake to such a low level each day by the elimination of healthy food groups like grains and most fruits can result in nutrient deficiencies, says Mussatto, making it mandatory to use a multivitamin supplement to make up the difference. However, many keto dieters are not aware that they need to supplement to maintain a semblance of perfect health.

Mussatto also mentioned that for those on the keto diet, Constipation can become a problem due to the lack of fiber, along with other digestive issues. A dietary fiber supplement might be something to consider, as well.

What is the keto flu?Many keto dieters experience what is often referred to as the keto flu a temporary spate of flu-like symptoms that occur at the onset of the keto diet.

This wont last longer than a week for most, Bell explains, but you may experience nausea, runny nose, fatigue, and muscle weakness. For this reason, experts recommend being cautious with high-intensity exercise when you first start the diet. Exercise may become more difficult during this period when you are feeling weak and tired.

Are there any groups of people who should never try the keto diet? According to registered dietitians Cheryl Mussatto and Bari Stricoff, yes. They advised that you should not try the keto diet if you are in any of the following categories:

So, health risks considered, does the diet work? A person who follows a ketogenic diet will most likely lose some weight, Mussatto admits. However, once a person stops eating this way and goes back to how they were eating, the weight will come right back on and then some.

And all the experts we queried agreed that the diet is extremely difficult to follow.

Any diet that cuts out entire food groups often results in decreased sustainability, explained registered dietitian Bari Stricoff, and the weight lost will eventually be gained back over time if not more!

Stricoff described the likely cause of the short-term weight loss many people experience on the keto diet initially water weight.

When you stop consuming carbohydrates, your body will deplete your glycogen (stored glucose) for energy, Stricoff explains, The glycogen molecules are held in water, so when the glycogen is depleted, water loss occurs, and weight loss can result.

But when the extreme nature of the diet pushes people off the wagon, glycogen stores are replenished, and weight gain may occur.

If you dont lose weight on the keto diet, or any other diet for that matter, never fear you can accept your body at its natural, comfortable weight. You dont need to follow extreme diets or pose any risk to your health to feel confident and okay. Follow these simple tips to get started on feeling less insecure in your body right now.

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Is the Keto Diet Safe? 4 Potential Dangers to Be Aware Of …

Dec 19th, 2018
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Fact Checked

This Dr. Axe content is medically reviewed or fact checked to ensure factually accurate information.

With strict editorial sourcing guidelines, we only link to academic research institutions, reputable media sites and, when research is available, medically peer-reviewed studies. Note that the numbers in parentheses (1, 2, etc.) are clickable links to these studies.

The information in our articles is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice.

This article is based on scientific evidence, written by experts and fact checked by our trained editorial staff. Note that the numbers in parentheses (1, 2, etc.) are clickable links to medically peer-reviewed studies.

Our team includes licensed nutritionists and dietitians, certified health education specialists, as well as certified strength and conditioning specialists, personal trainers and corrective exercise specialists. Our team aims to be not only thorough with its research, but also objective and unbiased.

The information in our articles is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice.

By Jillian Levy, CHHC

December 14, 2018

Starting in the 1970s, when the Atkins Diet book was first published, low-carb diets have caught the attention of many people trying to lose weight and improve their health. The ketogenic diet (KD), which is both very low in carbohydrates and also very high in fats, has become one of the most talked-about diets in the past several years. With its rise in popularity, its no surprise that the keto diet has recently been the focus of dozens of research studies.

Based on what we know from the available research, is the keto diet safe? The evidence is clear that the KD can reliably help to treat obesity and improve insulin resistance, but the long-term impact of the KD on cardiovascular risk factors, liver disease and glucose tolerance is more controversial. Experts agree that genetics seem to play a role in how different people respond to the KD, meaning some may be more likely to thrive on very low-carb diets, while others are more susceptible to developing side effects.

Below well cover the pros and cons of the keto diet in terms of safety, and discuss tips for reducing the chances that the KD will lead to adverse effects.

What makes the the ketogenic diet unique among low-carb diets is that its characterized by a drastic reduction in carbohydrates (usually less than 3050 grams per day, depending on individual goals) and also a significant increase in fats, as opposed to protein. The goal of the KD is to enter the metabolic state of ketosis, which happens after a few days of strict carbohydrate restriction.

Eating very-low carb depletes glucose reserves (glycogen stored in the liver and skeletal muscle), which means that glucose is no longer sufficient to provide the body with enough energy and another fuel source must be used instead.

This is where dietary fats come into play: depleted glucose reserves leads to the production of ketone bodies that are used as an alternative energy source, especially by the central nervous system, including the brain which has high energy demands. In order to get enough fat and limit carbs, the KD includes plenty of foods like meats, eggs, oils, cheeses, fish, nuts, butter, seeds and fibrous vegetables.

Does the keto diet really work when it comes to improving health?

Is the ketogenic diet safe long-term? No one is exactly sure. Most studies have looked at the KDs effects in humans when the diet is followed for up to one to two years or less.

Longer-term studies conducted on animals have shown the KD may be associated with some adverse events. For example, in rodent studies, some will develop nonalcoholic fatty liver disease (defined as liver damage that is not due to excess consumption of alcohol, viral or autoimmune causes, and iron overload) and insulin resistance when put on the keto diet long-term. Other studies suggest that some individuals may be predisposed to heart-related problems if they eat a very high-fat diet for an extended period of time.

That being said, the keto diet has been shown to be beneficial in many studies, especially among obese men and women. Research shows that the KD can safely help treat conditions including:

Is keto safe for life? In other words,how long is it safe to be in ketosis? As mentioned above, research tells us thatthe keto diet seems to be safest when followed for about 26 months, or up to about two years or so when the individual is being monitored by a doctor.

Some animal studies have found that the KD can contribute to triglyceride accumulation and markers of liver inflammation, possibly because of the higher protein and fat content of the diet compared to other commonly recommended diets (such as the DASH diet or Mediterranean diet for example). (8)

Researchers believe that genetics likely plays a role here, making some people more susceptible to liver problems when following low-carb, high-fat diets. Is the keto diet bad for your kidneys? According to an article released by Harvard Medical School, Patients with kidney disease need to be cautious because this diet could worsen their condition.

Is the keto diet safe for diabetics? Most research shows that yes, it is. However, even though the KD can help reduce insulin resistance while someone adheres to the diets principles and strictly limits their carb intake, these positive effects may be short-lasting. Results from some animal studies show that insulin resistence/glucose intolerance may potentially be increased once carbs are reintroduced back into the diet.

However, other studies show the opposite to be true, especially among severely obese adults. Researchers, therefore, state that the effects of the keto diet on glucose homeostasis remains controversial and depends on the presence of type 2 diabetes before starting the diet, as well as genetic factors.

What are the side effects of the ketogenic diet? Its not uncommon for people beginning the keto diet to experience keto flu symptoms, which can include: irritability, cravings, menstruation issues in women, constipation, fatigue, headaches and poor exercise performance. These side effects are due to the body going through major metabolic shifts and essentially withdrawing from carbs and sugar.

In most cases, keto flu symptoms resolve within a few weeks, or even days, especially if someone eats plenty of whole foods, stays moderately active (such as by walking, but not doing high intensity exercise to begin) and gets enough sleep.

Its not totally clear whether weight loss achieved on the keto diet can be maintained by most adults once the diet ends, both because the diet can be hard to follow and due to the body adapting metabolically. Long-term studies conducted on animals show that weight loss tends to level off after about six months on the diet, and sometimes may start to creep back up.

The keto diet is not intended to be followed long-term, which means that individuals need to find another way to maintain a healthy caloric intake, such as by practicing carb-cycling or keto-cycling.

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Osteoporosis Causes, Symptoms, Treatment & Diet

Dec 16th, 2018
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Medications that prevent bone loss and breakdown

Currently, the most effective medications for osteoporosis that are approved by the FDA are antiresorptive agents, which decrease the removal of calcium from bones. The bone is a living dynamic structure; it is constantly being built and removed (resorbed). This process is an essential part of maintaining the normal calcium level in the blood and serves to repair tiny cracks in the bones that occur with normal daily activity and to remodel bone based on the physical stresses placed on the bone. Osteoporosis results when the rate of bone resorption exceeds the rate of bone rebuilding. Antiresorptive medications inhibit removal of bone (resorption), thus tipping the balance in favor of bone rebuilding and increasing bone density. HRT is one example of an antiresorptive agent. Others include alendronate (Fosamax), risedronate (Actonel), raloxifene (Evista), ibandronate (Boniva), calcitonin (Calcimar), zoledronate (Reclast), and denosumab (Prolia).

Bisphosphonates decrease the risk of hip fracture, wrist fracture, and spine fracture in people with osteoporosis and can improve the T-score. Alendronate (Fosamax), risedronate (Actonel, Atelvia), ibandronate (Boniva), and zoledronate (Reclast) are bisphosphonates.

To reduce side effects and to enhance absorption of the medicine, all bisphosphonates taken by mouth (orally) should be taken in the morning, on an empty stomach, 30 minutes before breakfast, and with at least 8 ounces (240 ml) of water (not juice). This improves the absorption of the bisphosphonate. Taking the pill sitting or standing (as well as drinking adequate amounts of liquids) minimizes the chances of the pill being lodged in the esophagus, where it can cause ulceration and scarring. Patients should also remain upright for at least 30 minutes after taking the pill to avoid reflux of the pill into the esophagus. Newer intravenous bisphosphonates, such as ibandronate (Boniva) and zoledronate (Reclast), bypass the potential esophagus and stomach problems.

Food, calcium, iron supplements, vitamins with minerals, or antacids containing calcium, magnesium, or aluminum can reduce the absorption of oral bisphosphonates, thereby resulting in loss of effectiveness. Therefore, oral bisphosphonates should be taken with plain water only in the morning before breakfast. Also, no food or drink should be taken for at least 30 minutes afterward.

Alendronate (Fosamax) is a bisphosphonate antiresorptive medication. Alendronate is approved for the prevention and treatment of postmenopausal osteoporosis as well as for osteoporosis that is caused by cortisone-related medications (glucocorticoid-induced osteoporosis). Alendronate has been shown to increase bone density and reduce fractures in the spine, hips, and arms. Fosamax is taken by mouth once a week to prevent and treat postmenopausal osteoporosis. Alendronate is the first osteoporosis medication also approved for increasing bone density in men with osteoporosis, either in a daily or a weekly dosing schedule.

Fosamax generally is well tolerated with few side effects. One side effect of alendronate is irritation of the esophagus (the food pipe connecting the mouth to the stomach). Inflammation of the esophagus (esophagitis) and ulcers of the esophagus have been reported infrequently with alendronate use.

Risedronate (Actonel, Atelvia) is another bisphosphonate antiresorptive medication. Like alendronate, this drug is approved for the prevention and treatment of postmenopausal osteoporosis as well as for osteoporosis that is caused by cortisone-related medications (glucocorticoid-induced osteoporosis). Risedronate is chemically different from alendronate and has less likelihood of causing esophageal irritation. Risedronate also is more potent in preventing the resorption of bone than alendronate.

Ibandronate (Boniva) is a bisphosphonate for prevention and treatment of postmenopausal osteoporosis. It is available in formulations for both daily and monthly oral use as well as for intravenous use every three months.

Zoledronate (Reclast) is a unique intravenous bisphosphonate antiresorptive medication that is given once every year. This formulation seems to have very good ability to strengthen bones and prevent fractures of both spinal and nonspinal bones. The convenience of once-a-year dosing is obvious. As with all bisphosphonates, patients taking Reclast must be taking adequate calcium and vitamin D prior to and after infusion of the medication for optimal results. Generally, patients are given acetaminophen (Tylenol) the day of the infusion and for several days afterward to prevent occasional minor muscle and joint aches. The infusion lasts approximately 20-30 minutes. Reclast is used to treat and prevent osteoporosis in postmenopausal women and increases bone mass in men with osteoporosis. Reclast is also used to treat and prevent steroid-induced osteoporosis (glucocorticoid-induced osteoporosis). Reclast reduces risk of fractures after a low-trauma hip fracture. Reclast should not be used in patients who have had avascular necrosis or during/prior to pregnancy.

Raloxifene (Evista)

Raloxifene (Evista) belongs to a class of drugs called selective estrogen receptor modulators (SERMs). SERMs work like estrogen in some tissues but as an antiestrogen in other tissues. The SERMs were developed to reap the benefits of estrogen while avoiding the potential side effects of estrogen. Thus, raloxifene can act like estrogen on bone but as an antiestrogen on the lining of the uterus where the effects of estrogen can promote cancer.

The first SERM to reach the market was tamoxifen (Nolvadex), which blocks the stimulative effect of estrogen on breast tissue. Tamoxifen has proven valuable in women who have had cancer in one breast for preventing cancer in the second breast. Raloxifene is the second SERM to be approved by the FDA. Evista has been approved for the prevention and treatment of osteoporosis in postmenopausal women. In a three-year study involving some 600 postmenopausal women, raloxifene was found to increase bone density (and lower LDL cholesterol) while having no detrimental effect on the uterine lining (which means that it is unlikely to cause uterine cancer).

Because of its antiestrogen effects, the most common side effects with Evista are hot flashes. Conversely, because of its estrogenic effects, Evista increases the risk of blood clots, including deep vein thrombosis (DVT) and pulmonary embolism (blood clots in the lung). The greatest increase in risk occurs during the first four months of use. Patients taking raloxifene should avoid prolonged periods of immobility during travel, when blood clots are more prone to occur. The risk of deep vein thrombosis with raloxifene is probably comparable to that of estrogen, about two to three times higher than the usual low rate of occurrence. Evista decreases the risk of spinal fractures in postmenopausal women with osteoporosis, but it is not known if there is a similar benefit in decreasing the risk of hip fracture. (The only agents that are definitely proven to decrease the risk of hip fracture are bisphosphonates and denosumab.)

Calcitonin (Calcimar, Miacalcin) is a hormone that has been approved by the FDA in the U.S. for treating osteoporosis. Calcitonins come from several animal species, but salmon calcitonin is the one most widely used. Calcitonin can be administered as a shot under the skin (subcutaneously), into the muscle (intramuscularly), or inhaled nasally (intranasally). Intranasal calcitonin is the most convenient of the three methods of administration.

Calcitonin has been shown to prevent bone loss in postmenopausal women. In women with established osteoporosis, calcitonin has been shown to increase bone density and strength in the spine only.

Calcitonin is a weaker antiresorptive medication than bisphosphonates. Calcitonin is not as effective in increasing bone density and strengthening bone as estrogen and the other antiresorptive agents, particularly bisphosphonates. In addition, it is not as effective as bisphosphonates in reducing the risk of spinal fractures and has not been proven effective in reducing hip fracture risk. Therefore, calcitonin is not the first choice of treatment in women with established osteoporosis. Nevertheless, calcitonin is a helpful alternative treatment for patients who cannot tolerate other medications.

Common side effects of either injected or nasal spray calcitonin are nausea and flushing. Patients using Miacalcin Nasal Spray can develop nasal irritation, a runny nose, or nosebleeds. Injectable calcitonin can cause local skin redness at the site of injection, skin rash, and flushing.

Teriparatide (Forteo) is a synthetic version of the human hormone, parathyroid hormone, which helps to regulate calcium metabolism. Unlike other medications for osteoporosis that reduce the resorption of bone, teriparatide very effectively promotes the growth of new bone. Forteo is self-injected into the skin. Because long-term safety is not yet established, it is only FDA-approved for 24 months of use. It reduces spinal fractures in women with known osteoporosis, but it is not known if there is a similar reduction in the risk for hip fracture. Generally, after a two-year course of teriparatide the patient is switched to bisphosphonate therapy to maintain bone density.

The latest treatment approved for osteoporosis is denosumab (Prolia), an injectable antibody that blocks a chemical messenger that plays a role in promoting bone thinning by the bone cells that are responsible for bone resorption. Prolia strengthens bone by increasing its density and reduces fractures. Prolia is administered by twice yearly injections under the skin. Denosumab is used for the treatment of postmenopausal women with osteoporosis at high risk for fracture, defined as a history of osteoporotic fracture, or multiple risk factors for fracture, or patients who have failed or are intolerant to other available osteoporosis therapy. Denosumab can cause increased risk of infections and low blood calcium levels (hypocalcemia).

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Oxandrolone – Wikipedia

Dec 8th, 2018
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OxandroloneClinical dataTrade namesOxandrin, Anavar, othersSynonymsVar; CB-8075; NSC-67068; SC-11585; Protivar; 17-Methyl-2-oxa-4,5-dihydrotestosterone; 17-Methyl-2-oxa-DHT; 17-Methyl-2-oxa-5-androstan-17-ol-3-oneAHFS/Drugs.comMonographMedlinePlusa604024PregnancycategoryRoutes ofadministrationBy mouthDrug classAndrogen; Anabolic steroidATC codeLegal statusLegal statusPharmacokinetic dataBioavailability97%[2]Protein binding9497%[2]MetabolismKidneys (primarily), liver[1][2]Elimination half-lifeAdults: 9.410.4 hours[2][3]Elderly: 13.3 hours[3]ExcretionUrine: 28% (unchanged)[3]Feces: 3%[3]Identifiers

C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C)O)CC[C@@H]4[C@@]3(COC(=O)C4)C

Oxandrolone, sold under the brand names Oxandrin and Anavar, among others, is an androgen and anabolic steroid (AAS) medication which is used to help promote weight gain in various situations, to help offset protein catabolism caused by long-term corticosteroid therapy, to support recovery from severe burns, to treat bone pain associated with osteoporosis, to aid in the development of girls with Turner syndrome, and for other indications.[4][5][6] It is taken by mouth.[4]

Side effects of oxandrolone include symptoms of masculinization such as acne, increased hair growth, voice changes, and increased sexual desire.[4] Uniquely among most AAS that are active by mouth, it seems to have little risk of liver damage.[4][7] The drug is a synthetic androgen and anabolic steroid, hence is an agonist of the androgen receptor (AR), the biological target of androgens such as testosterone and dihydrotestosterone.[4][8] It has strong anabolic effects and weak androgenic effects, which give it a mild side effect profile and make it especially suitable for use in women.[4]

Oxandrolone was first described in 1962 and was introduced for medical use in 1964.[4] It is used mostly in the United States.[4][9] In addition to its medical use, oxandrolone is used to improve physique and performance.[4][10] The drug is a controlled substance in many countries, so nonmedical use is generally illicit.[4][11][12][13]

Oxandrolone has been researched and prescribed as a treatment for a wide variety of conditions. It is FDA-approved for treating bone pain associated with osteoporosis, aiding weight gain following surgery or physical trauma, during chronic infection, or in the context of unexplained weight loss, and counteracting the catabolic effect of long-term corticosteroid therapy.[14][15] As of 2016[update], it is often prescribed off-label to quicken recovery from severe burns, aid the development of girls with Turner syndrome, and counteract HIV/AIDS-induced wasting. Oxandrolone improves both short-term and long-term outcomes in people recovering from severe burns and is well-established as a safe treatment for this indication.[5][6] It is also used in the treatment of idiopathic short stature, anemia, hereditary angioedema, alcoholic hepatitis, and hypogonadism.[16][17]

Medical research has established the effectiveness of oxandrolone in aiding the development of girls with Turner syndrome. Although oxandrolone has long been used to accelerate growth in children with idiopathic short stature, it is unlikely to increase adult height, and in some cases may even decrease it. Oxandrolone has, therefore, largely been replaced by growth hormone for this use.[18] Children with idiopathic short stature or Turner syndrome are given doses of oxandrolone far smaller than those given to people with burns to minimize the likelihood of virilization and premature maturation.[18][19]

Many bodybuilders and athletes use oxandrolone for its muscle-building effects.[4] It is much more anabolic than androgenic, so women and those seeking less intense steroid regimens use it particularly often.[4] Many also value oxandrolone's low hepatotoxicity relative to most other orally active AASs.[4]

Like other AASs, oxandrolone may worsen hypercalcemia by increasing osteolytic bone resorption.[14] When taken by pregnant women, oxandrolone may have unintended effects such as masculinization on the fetus.[14]

Women who are administered oxandrolone may experience virilization, irreversible development of masculine features such as voice deepening, hirsutism, menstruation abnormalities, male-pattern hair loss, and clitoral enlargement.[18][14][19] Oxandrolone may disrupt growth in children, reducing their adult height.[20][bettersourceneeded] Because of these side effects, doses given to women and children are minimized and people are usually monitored for virilization and growth abnormalities.[18][19] Like other androgens, oxandrolone can cause or worsen acne and priapism (unwanted or prolonged erections).[14][20] Oxandrolone can also reduce males' fertility, another side effect common among androgens.[20] In an attempt to compensate for the exogenous increase in androgens, the body may reduce testosterone production via testicular atrophy and inhibition of gonadotropic activity.[14]

Unlike some AASs, oxandrolone does not generally cause gynecomastia because it is not aromatized into estrogenic metabolites.[21] However, although no reports of gynecomastia were made in spite of widespread use, oxandrolone was reported in a publication in 1991 to have been associated with 33cases of gynecomastia in adolescent boys treated with it for short stature.[22][23] The gynecomastia developed during oxandrolone therapy in 19 of the boys and after the therapy was completed in 14 of the boys, and 10 of the boys had transient gynecomastia, while 23 had persistent gynecomastia that necessitated mastectomy.[22][23] Though transient gynecomastia is a natural and common occurrence in pubertal boys, the gynecomastia associated with oxandrolone was of a late/delayed onset and was persistent in a high percentage of the cases.[22][23] As such, the researchers stated, "although oxandrolone cannot be implicated as stimulatory [in] gynecomastia", a possible relationship should be considered in clinicians using oxandrolone in adolescents for growth stimulation.[22][23]

Uniquely among 17-alkylated AAS, oxandrolone shows little to no hepatotoxicity, even at high doses.[7][unreliable medical source?][24] No cases of severe hepatotoxicity have been singularly attributed to oxandrolone.[24] However, elevated liver enzymes have been observed in some people, particularly with high doses and/or prolonged treatment, although they return to normal ranges following discontinuation.[24] In any case, oxandrolone may be among the safest 17-alkylated AASs in terms of hepatotoxicity.[7][unreliable medical source?]

Oxandrolone greatly increases warfarin's blood-thinning effect, sometimes dangerously so.[25] In April 2004, Savient Pharmaceuticals published a safety alert through the FDA warning healthcare professionals of this.[26] Oxandrolone can also inhibit the metabolism of oral hypoglycemic agents.[14] It may worsen edema when taken alongside corticosteroids or adrenocorticotropic hormone.[14]

Like other AASs, oxandrolone is an agonist of the androgen receptor, similar to androgens such as testosterone and DHT.[4] This increases protein synthesis, which increases muscle growth, lean body mass, and bone mineral density.[6]

Compared to testosterone and many other AASs, oxandrolone is less androgenic relative to its strength as an anabolic.[4][27] Oxandrolone has about 322 to 633% of the anabolic potency and 24% of the androgenic potency of methyltestosterone.[4] Similarly, oxandrolone has as much as 6times the anabolic potency of testosterone and has significantly reduced androgenic potency in comparison.[4] The reduced ratio of anabolic to androgenic activity of oxandrolone often motivates its medical use in children and women because less androgenic effect implies less risk of virilization.[4] The bodybuilding community also considers this fact when choosing between AASs.[4]

As oxandrolone is already 5-reduced, it is not a substrate for 5-reductase, hence is not potentiated in androgenic tissues such as the skin, hair follicles, and prostate gland.[4] This is involved in its reduced ratio of anabolic to androgenic activity.[4] Due to the substitution of one of the carbon atoms with an oxygen atom at the C2 position in the A ring, oxandrolone is resistant to inactivation by 3-hydroxysteroid dehydrogenase in skeletal muscle.[4] This is in contrast to DHT, and is thought to underlie the preserved anabolic potency with oxandrolone.[4] Because it is 5-reduced, oxandrolone is not a substrate for aromatase, hence cannot be aromatized into metabolites with estrogenic activity.[4] Oxandrolone similarly possesses no progestogenic activity.[4]

Oxandrolone is, uniquely, far less hepatotoxic than other 17-alkylated AASs, which may be due to differences in metabolism.[24][4][1][3]

The oral bioavailability of oxandrolone is 97%.[2] Its plasma protein binding is 94 to 97%.[2] The drug is metabolized primarily by the kidneys and to a lesser extent by the liver.[1][2] Oxandrolone is the only AAS that is not primarily or extensively metabolized by the liver, and this is thought to be related to its diminished hepatotoxicity relative to other AAS.[1][3] Its elimination half-life is reported as 9.4 to 10.4hours, but is extended to 13.3hours in the elderly.[2][3] About 28% of an oral dose of oxandrolone is eliminated unchanged in the urine and 3% is excreted in the feces.[3]

Oxandrolone is a synthetic androstane steroid and a 17-alkylated derivative of DHT.[28][29][4] It is also known as 2-oxa-17-methyl-5-dihydrotestosterone (2-oxa-17-methyl-DHT) or as 2-oxa-17-methyl-5-androstan-17-ol-3-one, and is DHT with a methyl group at the C17 position and the C2 carbon replaced with an oxygen atom.[28][29][4] Closely related AASs include the marketed AAS mestanolone (17-methyl-DHT), oxymetholone (2-hydroxymethylene-17-methyl-DHT), and stanozolol (a 2,3-pyrazole A ring-fused derivative of 17-methyl-DHT) and the never-marketed/designer AAS desoxymethyltestosterone (3-deketo-17-methyl-2-DHT), methasterone (2,17-dimethyl-DHT), methyl-1-testosterone (17-methyl-1-DHT), and methylstenbolone (2,17-dimethyl-1-DHT).[28][29][4]

Oxandrolone was first made by Raphael Pappo and Christopher J. Jung while at Searle Laboratories (now part of Pfizer). The researchers first described the drug in 1962.[4][30][31] They were immediately interested in oxandrolone's very weak androgenic effects relative to its anabolic effects.[30][4] It was introduced as a pharmaceutical drug in the United States in 1964.[4]

The drug was prescribed to promote muscle regrowth in disorders which cause involuntary weight loss, and is used as part of treatment for HIV/AIDS.[4] It had also been shown to be partially successful in treating cases of osteoporosis.[4] However, in part due to bad publicity from its illicit use by bodybuilders, production of Anavar was discontinued by Searle Laboratories in 1989.[4] It was picked up by Bio-Technology General Corporation, which changed its name to Savient Pharmaceuticals, which following successful clinical trials in 1995, released it under the brand name Oxandrin.[4] BTG subsequently won approvals for orphan drug status by the Food and Drug Administration for treating alcoholic hepatitis, Turner syndrome, and HIV-induced weight loss.[4] It is also indicated as an offset to protein catabolism caused by long-term administration of corticosteroids.[4]

Oxandrolone is the generic name of the drug and its INN, USAN, USP, BAN, DCF, DCIT, and JAN, while ossandrolone is or was formerly the DCIT.[28][29][32][9][33]

The original brand name of oxandrolone was Anavar, which was marketed in the United States and the Netherlands.[4][34] This product was eventually discontinued and replaced in the United States with a new product named Oxandrin, which is the sole remaining brand name for oxandrolone in the United States.[4][35] Oxandrolone has also been sold under the brand names Antitriol (Spain), Anatrophill (France), Lipidex (Brazil), Lonavar (Argentina, Australia, Italy), Protivar, and Vasorome (Japan), among others.[4][29][34][36] Additional brand names exist for products that are manufactured for the steroid black market.[4]

Among those using oxandrolone for nonmedical purposes, it is often referred to colloquially as "Var", a shortened form of the brand name Anavar.[37][38][39][self-published source]

Oxandrolone is one of the few AASs that remain available for medical use in the United States.[35] The others (as of November 2017) are testosterone, testosterone cypionate, testosterone enanthate, testosterone undecanoate, methyltestosterone, fluoxymesterone, nandrolone decanoate, and oxymetholone.[35]

Outside of the United States, the availability of oxandrolone is quite limited.[4][9] With the exception of Moldova, it is no longer available in Europe.[4] Oxandrolone is available in some less-regulated markets in Asia such as Malaysia.[4] It is also available in Mexico.[4] Historically, oxandrolone has been marketed in Argentina, Australia, Brazil, France, Italy, Japan, and Spain, but it appears to no longer be available in these countries.[4][29][34][9]

In the United States, oxandrolone is categorized as a Schedule III controlled substance under the Controlled Substances Act along with many other AASs.[11] It is a Schedule IV controlled substance in Canada,[12] and a Schedule 4 controlled drug in the United Kingdom.[13]

Oxandrolone is sometimes used as a doping agent in sports. Cases of doping with oxandrolone by professional athletes have been reported.

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Primary Hypogonadism VS Secondary Hypogonadism …

Dec 7th, 2018
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Most men who require hormone replacement therapy with testosterone have some form of testicular injury or primary hypogonadism. In other words, the problem is all in their balls. Those of us who have secondary hypogonadism often have perfectly functioning testes, but the problem lies elsewhere in whats known as the Hypothalamus Pituitary Testicular Axis (HPTA), which is responsible for keeping our male hormones in proper balance.

The problem with secondary hypogonadism, is that the treatment actually CAUSES primary hypogonadism by introducing exogenous (external) testosterone into the system. To understand that, first lets go over some basics

Hypothalamus:Among other things, this part of your brain sends GnRH (gonadotropin releasing hormone) down to instruct the pituitary gland to create more LH and FSH.

Pituitary Gland:Among other things (like growth hormone), this gland at the base of your brain secretes LH (luteinizing hormone) and FSH (follicle stimulating hormone), which travel down to the testes / gonads to instruct them to create more testosterone.

Testes / Gonads:Endocrinologists might get upset that I use these terms interchangeably. Oh well, screw em. You get the point. Your balls get the message from your pituitary gland to make more testosterone.

The Axis:The important thing to remember about the hypothalamus pituitary testicular axis (HPTA), also sometimes called thehypothalamic-pituitary-gonadal axis (HPG), is that it does not run only in one direction. The body tries to reach homeostasis a healthy balance of these hormones and the entire system can fall out of whack once you start introducing any of these hormones from outside sources. Which brings me to

The Problem With Taking Testosterone to Treat Secondary Hypogonadism:First of all, lets be clear I take testosterone to treat my secondary hypogonadism. Thats because there is currently no choice. Why cure something when you can have a customer for life? Why treat my bodys inability to create enough GnRH when that would require research money and you already have a product that fixes my symptoms ?

Digression aside, the problem with introducing an external source of testosterone is that eventually your gonads see that they are no longer needed. They pack their bags, or rather pack INTO their bags, and practically disappear over time. Now guess what? Not only do I have secondary hypogonadism, which might have been made even worse, but I now have a classic case of primary hypogonadism to deal with if I the medical community should ever find a treatment for secondary hypogonadism.

Heres an idea Why dont pharmaceutical companies make GnRH and market that to the endocrinologists so they can treat the source of my problem? Am I being naive here? Is there more to it than my not-medically-trained mind understands?

All gripes aside, I do feel great. Sure Ill be tied to this drug like a prisoner for the rest of my life, but I feel ten years younger. Im happy, confident, strong, lean, sharp, motivated, and a lot more fun in the bedroom. And Ive yet to see any CONVINCING studies about the long-term health dangers of testosterone replacement in hypogonadal men. Heart disease? Prostate cancer? Show me the studies? These are often-quoted side-effects, but all I hear are doctors deducing them because, for instance, taking away a mans testosterone seems to help with pre-existing conditions of prostate cancer. But that is not a cause-and-effect relationship. Just because removing testosterone helps treat or minimizes the recurrence of prostate cancer, doesnt mean it causes prostate cancer. Does it? OK, ok, thats anothe post entirely

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Glossary | Scarleteen

Dec 7th, 2018
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abortion

A procedure to intentionally end a pregnancy before a birth. Miscarriage is also sometimes called "spontaneous abortion," even though it is usually not intended.

Purposeful harm or mistreatment of another person, which can be verbal, emotional, physical or sexual. An ongoing pattern or cycle of such mistreatment or harm can characterize an abusive relationship.

In the context of sexuality, an abbreviation for asexual.

People older than you who probably drive you batty. Or, people whose age in years exceeds the legal age of majority; people considered to be adults by law.

A state or demonstration of fondness or care for someone, which may or may not be sexual.

The age at which a person is considered in law to be able to consent to sexual activity. Someone above this age who has sex with someone below it can often be charged with statutory rape, even if the younger person wants to consent.

When two people are of different ages or life stages, usually with a substantial difference.

A chosen or felt lack of gender identity.

Behaving in a pushy, forceful or violent way.

Acquired immune deficiency syndrome (AIDS) is a very serious and often deadly disease of the immune system caused by HIV. AIDS itself can not be caught from another person, but those with AIDS have HIV, which is sexually transmissible. AIDS requires medical treatment.

When a penis is inserted into and held by the anus while partners move their bodies as feels good to them for the purpose of sexual stimulation.

Sexual activity involving the anus. Anal sex may include stimulation with fingers, the mouth, a penis, sex toys, or other objects or body parts.

Oral sex for, on or to the anus.

The body, parts of the body, or physical structure of organisms like people, animals or plants.

Being neither distinguishably masculine nor feminine (or a mishmosh of both), in dress, appearance, behavior or identity, either by choice or by circumstance.

The external opening to the rectum, located between the buttocks.

Not having an interest in romantic relationships.

A state of sexual excitement and interest that sends messages to the brain which create physical changes and sensations, such as increased blood pressure, erection, lubrication, loosening of the vaginal or anal muscles, and increased physical sensitivity.

In the context of human sexuality, someone who either does not experience or has not yet experienced any sexual desires at all, or who has experienced/does experience sexual desires, but not a desire to enact them with other individuals.

To be self-assured, self-confident. To stand up for oneself in a positive, nonviolent way.

The state or condition of being independent and/or having the right to independence.

An imbalance in the vaginal environment, including pH changes, that occurs when different types of bacteria outnumber the normal, needed and healthy bacteria. It often requires some from of treatment, but sometimes will go away on its own.

Describes sexual play and/or relationships involving exchanges of power and pain. B = bondage, D = discipline and/or dominance, S = submission and/or sadism, M = masochism.

Made up of two things or parts; a system with only two possible options or parts.

Prejudice against bisexuality and bisexual people.

Any number of methods people use to intentionally prevent unwanted pregnancy, including the condom, the cervical barrier, the implant, the patch, the pill, the rhythm method, the ring, the shot, the IUD, spermicide and withdrawal.

A term for sexual orientation which either describes a person who can be sexually and emotionally attracted to both men and women or merely to people of more than one gender.

A stage of very early fetal development. If cell development continues and a blastocyst implants in the uterus, it will become an embryo and create a pregnancy.

A slang term for a state of vasocongestion that becomes temporarily painful. Called "blue balls" because in those with testes, discomfort is also felt there, but people with vulvas can experience this too, and discomfort then is often felt in the uterus or clitoris.

Our sense, awareness and perception of our body in appearance and function as it relates to our sense of self.

Glandular tissue, fat, connective tissue and skin on the chest.

Describes a person who is intentionally masculine in appearance, behavior, dress, identity or sexual attitude. Often used in relation to femme. Most often used in the LGBT community, but can refer to people of any orientation. However, some people see use of the word "butch" as an insult.

Describes someone who does not engage in sexual activity, usually by choice.

A birth control device which is inserted into the vagina to cover the cervix and prevent sperm from entering. Diaphragms, cervical caps and contraceptive sponges are kinds of cervical barriers.

The opening to the uterus, the bottom of which is at the back end of the vagina.

A method of keeping track of fertility by keeping careful notes on the dates of a woman's period, as well as her temperature and cervical mucus. This is often used by people who are trying to get pregnant but is NOT an effective birth control method, as it fails frequently due to fluctuations in a woman's cycle and the fact that sperm can live in a woman's reproductive tract for several days. Also called "fertility awareness".

A slang term used to describe either the hymen/corona or something which signifies someone has not done something for the first time. "Popping the cherry" often describes doing something sexual for the first time, even though with first-time sex, there are not usually cherries or the popping of anything.

A very common bacterial infection/STI. It can infect the cervix, urethra, testicles, fallopian tubes, and/or ovaries. It can also infect the throat when acquired through oral sex. Chlamydia requires medical treatment.

A surgical removal of the foreskin from the penis, most often done in infancy, and most often done because of cultural or religious beliefs, parental aesthetic preferences or concerns about health. In some cases, circumcision is done at other times of life and/or for medical reasons.

Describes people who have a gender identity which is traditionally thought to match their assigned sex, and thought to match many or most of the roles, behaviors and appearances culturally expected of that sex. For example, someone who was sexed male at birth and whose gender identity is masculine; who also feels male. Often used in relation to transgender.

Prejudice, discrimination and oppression based on social or economic status/class or perceived or assigned social or economic status.

In a sexual context, usually a word used to suggest not having any sexually transmitted infections. "Clean" is a poor choice of term, however, since it stigmatizes people with illness. Better choices are "negative," "clear" or "STI-free."

A sexual organ both external and internal on the vulva and inside the pelvis of female sex-assigned people that is similar to the penis, but serves no other known purpose besides providing sexual pleasure.

Various ways we express and share feelings or thoughts, such as through speech, written words or symbols, sign language, body language, touch or art.

The onset of pregnancy, marked by implantation of the blastocyst into the endometrium (the lining of the uterus).

A thin sheath or tube of latex or another material, worn over the penis during sex to prevent or reduce the risk of pregnancy and/or sexually transmitted infections.

To agree to do something or give permission. In the context of sex, a person is giving full consent/is consenting when they freely and actively agree to do something sexual with someone else; however, the person still has the right to change their mind at any point. A person is NOT consenting if they do not actively agree, have been forced or pressured in some way or are in a state where they are incapable of full consent (such as when asleep, under the influence of drugs or alcohol, or below the age of consent).

Devices, medications or behaviors used to intentionally aim to prevent pregnancy, including the condom, the cervical barrier, the implant, the patch, the pill, the rhythm method, the ring, the shot, the IUD, spermicide and withdrawal.

A method of birth control that consists of a spongy device filled with spermicide that provides a barrier at the entrance of the cervix.

A newer name for the hymen, a thin membrane without nerve endings that most female-assigned people are born with that is just inside the vaginal opening. It gradually wears away over time due to hormones, vaginal discharges, general physical activity, sex and masturbation and/or childbirth. It does not snap, crackle or pop.

The internal "legs" of the clitoris, which are within the outer labia (labia majora).

Oral sex for, on or to the vulva.

Heather's pug, Sofia.

Virtual (as in, not in person) sexual experiences or encounters which involve text conversations and/or visual exchanges via the Internet.

CMV is one member of a group of herpes-type viruses. It is an STI transmitted through body fluids, and requires medical treatment.

How well something works.

In a sexual context, a discharge of genital fluid, usually (but not always) as a result of sexual stimulation and/or orgasm.

During a pregnancy, the term for the developing cells of an organism until around eight-nine weeks after an ovum was fertilized. After this time, the organism would then be called a fetus.

A method of contraception used to prevent pregnancy after sex or rape has already occurred, rather than used before or during, like most types of contraception.

To put something into action: to actively do something, not just think or feel it.

The lining of the uterus.

In a sexual context, when a kind of sex involves someone putting one body part inside the body part of another person, such as with intercourse. Some people use the word "penetration" instead.

When a body part, such as the penis or parts of the vulva, becomes filled with blood and enlarges and/or becomes more firm.

Various areas of the body with a greater number of sensory nerve receptors than other areas, which people may find particularly sexually stimulating, such as (but by no means limited to) the lips, tongue, palms, fingers, feet, inner thighs, anus, nipples, neck, collarbone, nose, ears, armpits and/or the genitals.

Written, visual or other kinds of media either expressly designed to elicit feelings of sexual desire and/or which people use to elicit those feelings.

A steroid hormone found in the bodies of all people which has several jobs. Like testosterone, people often say it's responsible for things it doesn't usually have much to do with (like mood).

Something that is not divided or shared with others; which excludes others based on a given criteria.

Two tubes that lead from the ovaries to the uterus. If and when an ovum is fertilized by a sperm, fertilization typically happens within the fallopian tube.

Fertility awareness methods of birth control, achieved by charting of fertility, ideally daily via cervical mucus and basal body temperatures, and interpreting that charting to determine when fertility is most and least likely, then abstaining or using a backup method during most fertile times.

Oral sex for, on or to the penis.

A barrier method of contraception somewhat similar to a male condom, but inserted into the vagina rather than put on the penis. It has a flared base that sits on the outer parts of the vulva to hold it in place.

Describes something society associates with or attributes to women and girls or a state, experience or assignment of being female.

Describes a person who is intentionally feminine in appearance, behavior, dress, identity or sexual attitude. Often used in relation to butch. Most often used in the LGBT community, but can refer to people of any orientation.

A method of keeping track of fertility by keeping careful notes on the dates of a woman's period, as well as her temperature and cervical mucus. This is often used by people who are trying to get pregnant but is NOT an effective birth control method, as it fails frequently due to fluctuations in a woman's cycle and the fact that sperm can live in a woman's reproductive tract for several days. Also called "fertility charting" or just "charting".

In humans, the stage of prenatal development after an embryo, usually from about the eighth-ninth week after fertilization.

A term used to describe deep manual sex, where many fingers or a hand are gradually inserted into the vagina or anus.

What some people call sexual activities that are not intercourse which they may do before intercourse or as a "warmup" to intercourse, such as kissing, manual sex or oral sex. However, all kinds of "foreplay" can also be or are kinds of sex, and may sometimes be the only sex people choose to or can engage in at a given time, or altogether.

A loose tube of skin with nerve endings that extends from shaft of the penis to below the glans and which normally covers the head of the penis when it is not erect. Those born with penises are also born with a foreskin, but some foreskins are removed (circumcised) in infancy or later in life for any of a variety of different reasons.

A small fold of skin at the posterior (bottom) end of the vulva.

People who have a sexual relationship that is not romantic, but where they are also (and are supposed to behave like) friends. Often a casual relationship, but not always. FWBs may or may not be exclusive.

Rubbing against the body of another person -- usually with clothes on -- to express sexual feelings or seek out sexual pleasure. "Dry humping" is a form of frottage.

Friends with benefits.

A portion of the internal clitoris 1-3 inches within the vagina on the anterior (front) wall which can be sexually stimulating and which is often associated with female ejaculation.

In the context of sexuality, a word for sexual orientation which either describes a man who is sexually and emotionally attracted to other men, or a person of any sex or gender who is sexually and emotionally attracted to people of the same or a similar sex or gender. Often used alongside lesbian.

Characteristics that are seen or presented as distinguishing between male and female. Gender may or may not include assigned or chosen: sex, social roles, feelings, behaviors and/or presentation or appearance.

Discomfort with an assigned sex and/or gender and/or the gender norms and roles associated with either.

The way people externally communicate gender identity to others through their behavior and their outward, chosen appearance.

A person's own sense of whether and in what sense they feel they might be a man, a woman, a boy, a girl or gender nonconforming.

People who do not adhere to or who protest cultural rules or norms about dress, behaviors or activities for people based on their sex.

What is considered "normal" for a given gender or sex, even if it's not. These ideas may be widespread, or may be specific to a given group, area or historical period of time.

Describes someone whose chosen gender identity is neither masculine nor feminine, is between or beyond genders, which rejects binary gender, or which is some combination of genders.

Kinds of sex people have which involve the vulva, vagina, penis, testicles, anus and/or rectum or any immediate areas surrounding those parts.

External sexual or reproductive organs.

On the penis, the head of the penis. On the vulva, the external portion of the clitoris, beneath the clitoral hood.

G = gay, L = lesbian, B = bisexual, T = transgender. Additional letters sometimes added include Q = queer/questioning, U = unsure, I = intersex, P = pansexual, S = straight allies.

The organs that make ovum or sperm cells (the ovaries and testes respectively).

A bacterial infection/STI which can infect the cervix, uterus, fallopian tubes, urethra, mouth, throat or anus. It requires medical treatment.

An exam usually for those with a vulva/vagina that may involve any of the following: a visual exam of the genitals, a breast exam, a bimanual exam, a speculum exam, a pap smear, STI testing, birth control consultation and other education or healthcare services.

(Pronounced guy-na-coll-o-jist) A doctor that specializes in the health of the female reproductive tract. They may also be referred to as "OB/GYNs" or, informally, "gynos".

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Testosterone Levels Test: MedlinePlus Lab Test Information

Dec 5th, 2018
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What is a testosterone levels test?

Testosterone is the main sex hormone in males. During a boy's puberty, testosterone causes the growth of body hair, muscle development, and deepening of the voice. In adult men, it controls sex drive, maintains muscle mass, and helps make sperm. Women also have testosterone in their bodies, but in much smaller amounts.

This test measures the levels of testosterone in your blood. Most of the testosterone in the blood is attached to proteins. Testosterone that is not attached to a protein is called free testosterone. There are two main types of testosterone tests:

Testosterone levels that are too low (low T) or too high (high T) can cause health problems in both men and women.

Other names: serum testosterone, total testosterone, free testosterone, bioavailable testosterone

A testosterone levels test may be used to diagnose several conditions, including:

You may need this test if you have symptoms of abnormal testosterone levels. For adult men, it's mostly ordered if there are symptoms of low T levels. For women, it's mostly ordered if there are symptoms of high T levels.

Symptoms of low T levels in men include:

Symptoms of high T levels in women include:

Boys may also need a testosterone levels test. In boys, delayed puberty can be a symptom of low T , while early puberty may be a symptom of high T.

A health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.

You don't need any special preparations for a testosterone levels test.

There is very little risk to having a blood test. You may have slight pain or bruising at the spot where the needle was put in, but most symptoms go away quickly.

Results mean different things depending on whether you are a man, woman, or boy.

For men:

For women:

For boys:

If your results are not normal, it doesn't necessarily mean you have a medical condition needing treatment. Certain medicines, as well as alcoholism, can affect your results. If you have questions about your results, talk to your health care provider.

Men who are diagnosed with low T levels may benefit from testosterone supplements, as prescribed by their health care provider. Testosterone supplements are not recommended for men with normal T levels. There is no proof they provide any benefits, and in fact they may be harmful to healthy men.

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Sermorelin Therapy for Anti-Aging & Weight Loss | Diet Doc

Dec 4th, 2018
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What is Sermorelin?

Sermorelin is a formula created to fight the effects of aging and help promote weight loss. This top treatment holds the potential to slow the effects of aging in humans by spurring growth of new tissue, muscles, and synapses in the brain. It even has the potential to help patients think more clearly!

As you age, your body produces fewer hormones, a phenomenon that is considered one of the principal medical signs of aging. Sermorelin therapy encourages the body to naturally produce hormones. Prescription Sermorelin is different from many similar treatments, as it stimulates a natural process rather than requiring patients to directly add hormones to the system. This distinction makes our Sermorelin therapy much less likely to lead to complications.

While results may vary from patient to patient, clinical studies have shown that Sermorelin anti-aging treatment can lead to a range of physical and mental benefits, such as:

Diet Doc is also proud to announce all new Sermorelin with GHRP-2, which is renowned for being the most powerful of the GHRP peptides.

GHRP-2 reduces belly fat via lipolysis, boosts energy levels, increases the skins elasticity, elevates endurance levels, promotes speed healing of wounds, ameliorates vision, and promotes deeper sleep. It will also decrease liver uptake of blood sugar and make liver glucogenesis happen.

This peptide assists with maintenance and function of the islets of the pancreas. Known to offer immune system support, this formula can alsostrengthen the libido in both genders. Those who have experienced loss of libido are good candidates for therapy with this peptide. In addition, people who are struggling to control their weight may find it easier to slim down with the help of GHRP-2. Learn more about our Sermorelin GHRP-2 solution here.

If youre interested in seeing what Sermorelin can do for your health or want to learn more about our anti-aging and weight loss therapies, simply give Diet Doc a call today or send us a message. We will provide a confidential, no-obligation consultation to find out more about you and your priorities, and we will help you move forward to meet your goals.

Disclaimer: The statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease. All information presented here is not meant as a substitute for or alternative to information from healthcare practitioners. Please consult your healthcare professional about potential interactions or other possible complications before using any product. The Federal Food, Drug, and Cosmetic Act requires this notice.

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77 Proven Ways To Lose Weight And Keep It Off (Sorry, No …

Nov 30th, 2018
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Home Weight Loss Diets 77 Proven Ways To Lose Weight And Keep It Off (Sorry, No Miracle Potions Or Quick-Fixes Here)

[Last updated 25th October, 2018]

Want to lose weight and keep it off?

Youre in the right place.

Ive put together the most comprehensive list ofways to lose weight without any miracle potions, crazy diets or other scams you usually come across.

These are all credible and scientifically accurate recommendations that you can implement right now.

But before you go any further,keep thisin mind

All diets work.

Although they can take opposing approaches, all dietsare designed to make you eat fewer calories by restricting certain food groups.

Whetherthe restriction is onprocessed foods, carbs, fats, animal products oreven skipping meals, they all work by limiting the amount of calories you consume (1).

With that in mind,the following weight loss tips and strategies are all proven waysto eat fewer calories or burn additional calorieswith minimal effort on your part. It must be the most complete and accurate list available online

If you already think youve tried it all, go through this list. I guarantee youll discover golden ideas you wish youd thought of years ago.

Warning: this list is huge.

Coconut oil has become very popular in the natural health community.

However, those who want to lose weight should not be adding more into their diet.

Coconut oil is 100% fat and 1 gram of fat contains 9 calories. By comparison, 1 gram of carbohydrate or protein contains only 4 calories per gram.

This means coconut oil is bursting with calories.

For example, just one tablespoon (13.6 grams) of coconut oil is 117 calories. Thats equal to the calories in three oreo cookies, or half a Mars bar (2).

The benefits of coconut oil have also been grossly exaggerated, so its best just to save it for delicious Asian dishes.

Many use their kids as an excuse for having junk food in the house.

Yet in reality, you are in control of purchasing decisions, not them.

And if you believe the foods your children want are not healthy options for you, why would they be for your children?

Fat loss is a lot easier if everyone is eating healthy at home, not just you.

Here are some options if you have fussy kids.

Todays official nutrition guidelines recommend we eat breakfast.

But new research shows its not the most important meal of the day. At least, not for grown adults.

In this large study comparing recommendations to eat or skip breakfast in 309 overweight or obese subjects, there was no difference in weight between groups after 4 months (3).

It simply didnt matter whether people ate or skipped breakfast.

It was always thought that skipping breakfast caused people to be hungrier and eat more calories later in the day. However, turns out this isnt enough to overcompensate for the breakfast that was skipped.

This seems logical, because you are effectively removing an entire meal from your diet each day.

Basically if youre hungry in the morning, eat breakfast. If you arent, dont.

Many people dont even consider a milk coffee to be a snack, let alone a high-calorie snack.

But a 12 oz (350 ml) whole milk coffee, such as a latte or cappuccino, contains 165 calories (4).

Thats almost the same as eating a glazed donut from Krispy Kreme, or two large boiled eggs (5).

If you like coffee andyou need to lose weigh its best to stick to plain, black coffee.

Whole milk in your coffee is one thing, but adding loads of sugar takes it to a whole new level.

High-calorie coffee drinks are actually no better than soft drinks. Theyre loaded with empty calories that can equal a whole meal or more.

Source: starbucks.com

Starbucks 16 oz Unicorn Frappuccino had a whopping 410 calories.

Fair enough if you wanted to try that with a friend (I did), but flavoured coffee should not be a regular part of your diet.

Many people eat healthy during the week only to cheat or splurge on the weekend with junk food, restaurant meals and alcohol.

Unfortunately, if you are trying to lose weight then this eating pattern will not work.

The extra calories you consume on the weekend will cancel out any deficit you create during the week.Dr. Spencer illustrates this nicely:

Sustainable weight loss is about lifestyle change, which includes the majority of weekends too.

Many couples fill their plates with the same amount of food.

Generally speaking, over time this will cause one person to gain weight. Calorie requirements vary widely depending on your current weight and how physically active you are.

For example, an active200 lb (90kg)male requires about 2800 calories to maintain his weight.An active 155 lb (70kg) woman requires about 2170 calories. Exceeding those needs will cause fat gain.

For perspective, that600 calorie difference in requirementsis equivalent to a small McDonalds Happy Meal with Coke.

To accurately predict your daily calorie requirements I recommend using Alan Aragonsequation, which is accurate to within 5% of the longer formulas:

I love butter.

It can turn just about any plain dish into a culinary masterpiece.

But its extremely high in calories, which means its not a good idea to increase your consumption.

Not only that, but large quantities of butter appear to be much worse for heart health markers than equal amounts of cheese or cream (6, 7).

For this reason (among others), the craze to bulletproof your diet with butter is dumb.

Its so easy to slather on excessive amounts of a spread like peanut butter, Nutella or margarine.

Trying to eyeball it can be incredibly deceiving.

Source:Ben Carpenter

Use a tablespoon to first measure out how much spread youll have. Getting this right could be huge for your weight loss efforts.

Hara hachi buis a traditional Japanese practice thatroughly translates as eat until you are80% full.

This isin stark contrastwithour typical Western eating pattern, which is to eat until your sides are splitting.

This form of self-imposed calorie restriction seems to work exceptionally well for those who practice it, such as residents of the Japanese islandof Okinawa.

Older Okinawanshave a body mass index (BMI) of 18 to 22, compared with an average of 27 for olderAmericans.Above 25 is considered overweight (8, 9).

Its no wonder Okinawa has the most centenarians (people who live over the age of 100) in the world.

Simplyalteringexpectations of how full you should feel after a mealcan be a powerful mindset shift for those who want to lose weight.

Eating frequent small meals through the day was always thought to be good for weight loss.

The idea was that eating often kept your metabolism high so you would burn more energy, encouraging weight loss.

But it turns out that during digestion, the total amount of food eaten actually determines the amount of energy used, rather than how often you eat (10,11).

So eating three meals of 800 calories will burn the same amount of calories as eating six meals of 400 calories. There is literally no difference.

Eating regularly throughout the day works for some, but if thats not you, stop.

Because theres basically nothing fun you can eat, so you will lose weight.

In all seriousness, it can work because a Paleo eating pattern forces you to cut out most high calorie junk foods, which means youll eat fewer calories.

As you might expect, research shows it can be an effective weight loss diet (12,13).

The question is how long can you maintain a restrictive diet that cuts out all bread, pasta and any sweet treats forever?

Again, because theres basically nothing fun you can eat!

In actual fact animal products are typically far higher in calories compared to plant foods. Especially cheese and processed meat like sausages and bacon.

Cutting out these from your diet will result in fewer calories consumed and weight loss.

The data consistently shows that vegetarians and vegans are thinner than the average person (14,15).

Chicken tenders, nuggets, fish fingers, tater tots (potato gems) and other frozen snacks are a popular treat.

Many even use them as a quick and convenient main meal dish, without realizing just how fattening they are.

Anything that is crumbed or battered and pre-packaged has been covered with vegetable oil. In fact, vegetable oil will be one of the main ingredients.

This basically doubles the calorie content when compared to a non pre-packaged version of the same food.

Source: forthemommas.com

For example, one serving (four pieces) of Tyson brand frozen chicken tenders is 210 calories, or 1263 calories per 100 grams (16).

By comparison, an equal amount of plain chicken breast that you roast in the oven is only 110 calories. Thats half the calories for essentially the same thing, chicken breast.

You will find it really difficult to lose weight if you continue to eat frozen pre-packaged foods.

Goals are important to get you started, but unrealistic weight loss goals will often work against you.

This is shown in data from several weight loss center programs.

It turns out those expected to lose the most weight are in fact the most likely to drop out of a program (17).

This makes sense because if you set the bar way too high, it can be extremely disheartening to not even go close. That can lead to yo-yo dieting and a kind of stop-start inconsistency that doesnt make progress long-term.

A good realistic and modest goal is a 10% drop in weight over one year.

Just like weight gain, weight loss is a marathon, not a sprint.

Research shows our waistlines expand most during the holiday seasons.

Its not much though, withthe average persongaining only1 lb (0.5 kg) between November and January.

However,the problem is we dont lose that extra weight later in the year. The weight gain just builds on itself year on year until one day you actually notice it (18,19).

This certainly doesnt mean you shouldskip your favorite turkey dish or avoid your work Christmas parties.Foodis so much more than just nutrients and calories.

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#1 Branded Weight Loss Pills | CONTRAVE (naltrexone HCl …

Nov 30th, 2018
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One of the ingredients in CONTRAVE, bupropion, may increase the risk of suicidal thinking in children, adolescents, and young adults. CONTRAVE patients should be monitored for suicidal thoughts and behaviors. In patients taking bupropion for smoking cessation, serious neuropsychiatric adverse events have been reported. CONTRAVE is not approved for use in children under the age of18.

Stop taking CONTRAVE and call a healthcare provider right away if you have any of the following symptoms, especially if they are new, worse, or worry you: thoughts about suicide or dying; attempts to commit suicide; depression; anxiety; feeling agitated or restless; panic attacks; trouble sleeping (insomnia); irritability; aggression, anger, or violence; acting on dangerous impulses; an extreme increase in activity and talking (mania); other unusual changes in behavior ormood.

Do not take CONTRAVE if you have uncontrolled high blood pressure; have or have had seizures; use other medicines that contain bupropion such as WELLBUTRIN, APLENZIN or ZYBAN; have or have had an eating disorder; are dependent on opioid pain medicines or use medicines to help stop taking opioids such as methadone or buprenorphine, or are in opiate withdrawal; drink a lot of alcohol and abruptly stop drinking; are allergic to any of the ingredients in CONTRAVE; or are pregnant or planning to become pregnant.

Before taking CONTRAVE, tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbalsupplements. Do not take any other medicines while you are taking CONTRAVE unless your healthcare provider says it is okay.

Tell your healthcare provider about all of your medical conditions including if you have: depression or other mental illnesses; attempted suicide; seizures; head injury; tumor or infection of brain or spine; low blood sugar or low sodium; liver or kidney problems; high blood pressure; heart attack, heart problems, or stroke; eating disorder; drinking a lot of alcohol; prescription medicine or street drug abuse; are 65 or older; diabetes;pregnant; or breastfeeding.

CONTRAVE may cause serious side effects, including:

The most common side effects of CONTRAVE include nausea, constipation, headache, vomiting, dizziness, trouble sleeping, dry mouth, anddiarrhea.

These are not all the possible side effects of CONTRAVE. Tell your healthcare provider about any side effect that bothers you or does not goaway.

Use of CONTRAVE

CONTRAVE is a prescription weight-loss medicine that may help some adults with a body mass index (BMI) of 30kg/m2 or greater (obese), or adults with a BMI of 27kg/m2 or greater (overweight) with at least one weight-related medical problem such as high blood pressure, high cholesterol, or type 2 diabetes, lose weight and keep the weightoff.

CONTRAVE is not approved to treat depression or other mental illnesses, or to help people quit smoking (smoking cessation).

Please see Full Prescribing Information, including Medication Guide, forCONTRAVE.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit http://www.fda.gov/medwatch or call1-800-FDA-1088.

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