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Weight Loss Date Calculator | Goal Weight Calculator

Nov 30th, 2018
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Step 1: Your Profile






Current Weight


Goal Weight



How hard do you want to work?

Days needed to acheive weight loss:

There is lots of advice out there on how to cut calories. We’ve found one of the clearest and widely agreed-to sources of information is from the Centers for Disease Control (CDC), the official health organization of the United States. Start with their article on Cutting Calories.

Starting an exercise program is simpler, but there are still some useful guidelines. Try the CDC’s Physical Activity for a Healthy Weight.

While losing weight involves many variables that change from person to person, there is still a core science that can be the basis behind planning a weight loss strategy. The widely-accepted science behind the weight loss calculator is:

The math behind the body weight color coding, something called Body Mass Index (BMI), is applicable and useful for about 95% of the population. It is not useful for highly fit people (who won’t be using this calculator anyway). It is also not useful for very tall people. Use the color coding as a guideline for evaluating your body weight. Don’t use it as a medical diagnosis.

This is a reduction compared to your estimated nominal calorie consumption, meaning the amount of calories you consume while staying the same weight. If you are currently gaining weight, you need to reduce your calories even further.

Keeping track of how many calories you consume is not easy. WebMD has a good food calorie list.

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Weight Loss Date Calculator | Goal Weight Calculator



Weight Loss (Weight Reduction) | How to Lose Weight | Patient

Nov 30th, 2018
Comments Off on Weight Loss (Weight Reduction) | How to Lose Weight | Patient

How weight loss worksThe science

In some respects, it seems quite simple. Your weight depends on how much energy you take in (the calories in food and drink) and how much energy your body uses up (burns):

So, to lose weight, you need a calorie deficit. You can achieve this calorie deficit by:

However, there is now research that shows that this explanation, sometimes called the calories-in/calories-out model, is outdated. There are lots of ways that the different parts of the body communicate with each other to keep body weight the same. There are nerve connections between the stomach and the brain. There are also several hormones involved, including insulin, ghrelin and leptin. The medical term for this is homeostatic feedback. For example:

In other words the body adjusts how much energy you use up depending on how many calories you eat.

The important thing seems to be that certain foods can cancel out these natural feedback systems that should keep our weight the same. High-sugar and high-fat foods taste good and can make us feel good too. By triggering the ‘reward’ centre in our brain, they may be especially good at over-riding these controls.

Foods can be divided into three groups (although most foods are a mixture):

Refined carbohydrates, fructose and sugar-sweetened drinks have been linked with low levels of feeling full (satiety), difficulty controlling our appetite and a lack of excess energy to make up for the extra calories consumed.

There are lots of different ‘diets’ to help someone lose weight. They often target a reduction in a particular food group:

One diet does not suit everyone, probably due to differences in our metabolism. All the diets above have been shown to lead to weight loss, with no one diet being more effective than any other. All effective diets should balance good quality of nutrition with the right balance of energy. In addition, a ‘diet’ should be easy for you to stick to or there will always be the risk that once you stop being on such a diet, you will go back to your old habits and put back on any weight you have lost.

It is best not to lose weight too fast. You should aim to lose weight gradually. If you lose more than a kilogram per week, you may lose muscle tissue rather than fat. This isn’t sustainable weight loss. So, it is recommended that you lose an average of 0.5 to 1 kg per week (about 1-2 lb per week).

Some people naturally have a larger frame than others. But this causes quite a small variation in weight and is accounted for in the range of healthy BMI. There is really no such thing as someone who is big-boned.

Some people lose weight by strict dieting for a short period. However, as soon as their diet is over, they often go back to their old eating habits, with their weight going straight back on. Losing weight, and then keeping it off, needs a change in lifestyle for life. This includes such things as:

Top tip: ask family or friends to help and encourage you to keep to a healthy lifestyle. Consider a lifestyle change for the whole family but do not be put off if you do not get full support.

To lose weight and to keep it off, it is vital that you should be motivated, really want to lose weight and want to improve aspects of your lifestyle. No weight-loss plan will work unless you have a serious desire to lose weight. You may not feel that being overweight or obese is a problem to you. So, you may have little motivation or desire to lose weight. That is fine, so long as you understand the health risks.

Top tip: write down the reasons why you would like to lose weight. Keep referring to this list to motivate yourself.

Based on the recommended rate of weight loss explained above, set yourself a clear weight loss goal with a realistic timescale. Some people aim to get down to a perfect weight. However, this may be a lot of weight to lose for you and you may become fed up about poor progress, and give up. So, you may find it helpful to break up your weight loss goal. For example, you may wish to set yourself a goal to lose 4 kg over the following 4-6 weeks. Once you have achieved that goal, you can set yourself another, etc.

For most people, you can start to get health benefits by losing even just 5-10% of your starting weight. For example, if your starting weight was 100 kg, losing 5-10 kg in weight will produce some health benefits for you, even if you are still not at your ideal weight.

Top tip: aim to lose weight steadily, around 0.5-1 kg per week. For most people, health benefits can come from losing the first 5-10% of their weight. This is often about 5-10 kg.

In addition to setting yourself realistic weight loss targets, it is also helpful to set yourself an action plan. Be realistic and consider what you feel will have the most impact on your weight. For example, if you currently have a piece of cake every day, your action plan could be to reduce this to twice per week only. Your action plan might start with three main goals; then, once you have achieved these goals, you can reset your action plan and think about other changes you might be able to make. The idea is to make small, gradual changes that you can stick to for life.

It is helpful to know how much you normally eat. Try keeping a diary, writing down everything that you eat and drink over a week or so. Include even the smallest of snacks. Are there times of the day that you tend to snack more? Are you eating three meals a day? Are there some snacks that you don’t need? You may find it helpful to discuss your diary with your practice nurse, your doctor or a dietician.

Top tip: don’t forget the drinks. Some drinks contain lots of sugar, including alcohol and many fizzy drinks.

Briefly, a healthy diet means:

You can read more in the separate leaflets called Healthy Eating and the Mediterranean Diet. Also, many books on food and health give details. Your practice nurse or dietician may also be able to help.

Top tip: Remember, some low-fat foods and drinks such as alcohol, sugary drinks and sweets, are still very fattening.

It is important to plan ahead. Perhaps you could plan each day’s meals and recipes the day before, or plan a week’s meals at a time. In this way you will know exactly how much food you will be eating. This is better than looking in the cupboard and fridge before mealtimes or snacks to see what is there.

It is best to separate eating from other activities. This helps you to keep to your planned eating for the day. So, try not to eat whilst on the move, whilst watching TV, during meetings, while driving, etc.

Top tip: plan tomorrow’s eating today.

Do you have any eating habits that can improve?

Top tips: eating three healthy meals each day, including breakfast, is better than skipping meals. Eat slowly, chew longer. Put your knife and fork down between each mouthful.

One step towards improving eating habits is to change the contents of your shopping basket. For example, if you never buy biscuits and sweets, they will not be in the cupboard to tempt you. Most food labels say what is in the food, so this can help you to buy healthier food. It may be helpful to plan a shopping list and stick to it. However, whilst you are learning which are the healthier foods, it may also be helpful to spend some time comparing food labels before deciding on what to buy.

Top tips: do not shop for food when you are hungry; after a meal is best. Remove temptations by changing the contents of your cupboards.

Most people have a standard set of recipes and meals that they repeat. These may be old favourites; however, you may need to adapt these and also find new, healthier recipes.

Top tip: when you are on a weight-reducing diet, try to learn a new healthy recipe each week. When you have reached your goal weight, you should then have plenty of new healthy meal ideas to help keep your weight down.

There is some evidence that eating soup may fill you up for longer. Also, if you have soup as a starter to your meal, you are less likely to overeat for the rest of your meal. If you take, for example, chicken and vegetables and have this with a drink of water, you will feel full for a certain period of time afterwards. However, if you take the same food but blend it with the water to make a soup, eating the soup can keep your hunger satisfied for a longer period. This is thought to be due to the fact that your stomach empties more slowly if you eat soup than if you eat chicken and vegetables and drink water separately. As a result, your stomach wall is stretched for a longer period and messages are sent to your brain switching off the feeling of hunger for a greater period of time.

Top tip: make sure that it is a low-calorie soup that you are eating. Avoid creamy or high-calorie soups.

Your appetite is a very powerful thing. This is why many people find it so difficult to lose weight. It is true that some people feel hungry more often than others. However, feeling hungry does not always mean that your body physically needs food. Sometimes you can feel emotional hunger. For example, feeling hungry because you are tired, bored, fed up, upset, etc.

Think about this and try to resist eating as soon as you feel hungry. Feeling hungry is not bad or dangerous for you. Are you feeling physically hungry or are you just looking for food to fulfil an emotional hunger? If you do have a strong appetite, try to fill up at mealtimes with lots of leafy vegetables and fruit. These have a lot of fibre and bulk but are low in calories. There is also some evidence that foods containing a lot of protein, such as eggs and fish, may be best at making you feel full for longer.

Top tips: drink lots or water and eat lots of vegetables and protein-rich foods to help counter physical hunger. Think about whether your hunger is for emotional reasons.

Many special ‘wonder’ diets are advertised but they are often not helpful. This is because your old eating habits will usually return after a short special diet, and weight often goes back on.

Top tip: it is not usually a special diet that you need, but a lifelong change to a healthier diet as part of a healthier lifestyle.

Many people use drinks full of calories to quench their thirst. Sugary drinks (such as cola, tea and coffee with sugar and milky drinks) all contain calories. Alcoholic drinks also contain a lot of calories. Giving up sugar in your tea or coffee is a simple way to help you to lose weight. Most people really miss the sugar at first but after a week or two without, they have got used to it. One of the easiest ways to cut back on calories is simply to drink water as your main drink. Drinking water just before meals may also help people to lose weight.

Top tips: keep some water in a bottle in the fridge. Chilled water is surprisingly refreshing. The Change4Life website listed in ‘Further Reading and References’ below also gives tips and advice about drink swaps to cut down on the calories.

It is recommended that all adults should aim for at least 30 minutes of moderate-intensity physical activity on at least five days of the week. However, if you are overweight or obese and are aiming to lose weight, if possible you should try to do around 60-90 minutes on at least five days of the week. Experts disagree on how much exercise helps with losing weight. Some recommend that it has to be really vigorous in order to help but few people can maintain this for long. However, there is no disagreement at all about the benefits of exercise for health and to counter the risks of being obese or overweight.

Moderate physical activity includes: brisk walking, jogging, dancing, swimming, badminton, tennis, etc. In addition, try to do more in your daily routines. For example, use stairs instead of lifts, walk or cycle to work or school, etc. Avoid sitting for too long in front of the television or a computer screen. Take regular breaks whilst working. The good news is that you don’t have to do this physical activity all in one chunk. You can break it up into blocks of 10-15 minutes. See separate leaflet calledPhysical Activity for Health.

Top tip: build your exercise levels up gradually. If you are not used to physical activity, try starting with a 30-minute brisk walk every day and then building up from there.

Just as keeping a food diary can be helpful at the beginning if you are trying to lose weight, it can also be useful as a way to monitor your eating during your weight loss. Studies have shown that keeping a food diary can help people lose weight just through the process of writing things down. You can use the same diary to keep a track of your physical activity levels as well.

It is also important to weigh yourself regularly to monitor your progress. Once weekly is recommended. The first kilogram is the easiest to lose. This is because you lose water from your body at first as well as fat. Be aware that the first kilogram or so may seem to fall off but then the weight loss slows down. This is normal. Also, don’t be disheartened by minor weight increases or levelling off in weight for a few days. Look for the overall trend in your weight loss over several months.

Top tip: regular weighing and encouragement by a practice nurse or dietician may be helpful.

Some people may feel motivated enough and have all the information they need in order to lose weight without any help from others. However, you don’t have to try to lose weight alone. There is a wealth of help available. Ask your doctor or practice nurse for advice. A referral to a dietician may be helpful. One-on-one counselling or group counselling may be available in your area on the NHS. There may also be some local groups to help you increase your physical activity levels.

A number of commercial weight loss groups meet regularly in the UK. In fact, there is some research evidence to suggest that people who join a weight loss group are more likely to be successful in losing weight than those who don’t. There are also internet-based programmes and self-help books that can help you with your weight loss.

Medication to help with weight loss may be an option for some people who want to lose weight. However, there are no wonder medicines available and lifestyle changes to improve your diet and increase your physical activity levels are still important.

In the UK there are two medicines licensed to help with weight loss: orlistat and liraglutide. You can read more about them in the separate leaflets called Obesity (Overweight) and Orlistat (Weight Loss Medicine).

Note: two other medicines, sibutramine and rimonabant, previously used to help with weight loss, are no longer available in the UK because of concerns over their safety.

This may be an option if you are very obese. However, surgery is usually only offered if other ways to lose weight have not worked (including diet, increasing your physical activity levels, and orlistat). Weight loss surgery usually gives very good results and most people do lose a lot of weight. But this is specialist surgery and it is a major operation. In some people, surgery may not be advised because health issues may mean that having an anaesthetic could be dangerous.See separate leaflet called Weight Loss Surgery.

It is natural that you will be tempted by different situations to put you off track with your eating and weight loss. It is important to recognise that holidays, festivals, eating out, etc, may affect your everyday food choices and what you had planned to eat.

Can you identify any tempting situations? Some people find that watching food programmes on TV makes them feel hungry. How about smells from the kitchen from someone cooking who is not aware that you are trying to lose weight? Do you get pressure from family or friends to eat or drink more? Can you avoid tempting situations? If not, think about ways of coping with them. If you are going to be faced with a tempting situation, create a plan of action. For example, if you are going out for dinner your plan of action might be to have a starter and a main course, rather than a main and a pudding – or all three!

Top tip: clean your teeth or take a short brisk walk when you are tempted to eat between meals.

Many people eat as a comfort, or as a way of coping with stress. How do you cope with stress? Is stress, unhappiness, depression, etc, a reason for you to overeat or to binge eat? If so, can you plan alternative strategies? For example, relaxation tapes, going for a walk, talking to a friend, etc.

Top tip: see a doctor if you feel that depression is a problem. Depression can often be treated.

Many people lose weight but at the end of their ‘diet’, the weight goes back on. The main reason this happens is because their weight-reducing diet was only a temporary change to their unhealthy diet and lifestyle. To keep your weight off, it is important that you make permanent changes. This usually means:

It does not mean less enjoyment of food. However, it may take a while to learn to enjoy different foods, meals and recipes. Some people need more support to keep to their new weight than when they were actually dieting and losing weight. A local support group may be able to help.

Top tip: after losing some weight, weigh yourself once every week or two to keep a check on your weight. This way you will see if your weight starts to increase again and you can do something about it early on.

When we slip off track, it’s easy to feel like forgetting the whole thing altogether. Lapses are a very normal part of losing weight and the way you deal with it can either make or break your weight loss success. It’s better to learn from it and move on, rather than giving up completely. If you have a lapse, consider the following points:

Think back to the reasons why you wanted to lose weight in the first place. It can be helpful to consider the positive and successful aspects of your weight loss journey so far. Concentrating on the positive aspects and what you have achieved can help to re-motivate you and remind you not to give up. Tomorrow is another day.

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Weight Loss (Weight Reduction) | How to Lose Weight | Patient



7-Day Diet Meal Plan to Lose Weight: 1,200 … – EatingWell

Nov 30th, 2018
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Lose weight, eat well and feel great with this easy weight loss meal plan.This simple 1,200 calorie meal plan is specially tailored to help you feel energized and satisfied while cutting calories so you can lose a healthy 1 to 2 pounds per week. Each day of this 7-day plan featureshigh protein, high fiber foods (a combination that research shows can help with weight loss by keeping you feeling fuller for longer) and strategically balances calories throughout the day so you won’t feel starved. The calorie totals are listed next to each meal so you can easily swap things in and out as you see fit.Couple this healthy meal plan with daily exercise and you’re on track to lose the weight.

Carve out time at the begging of the week to get meal prep out of the wayand save yourself time during the busy week.1. Make the Ravioli & Vegetable Soup ahead of time to have for lunch on Days 1 & 2.2. Mix up theCarrot-Ginger Vinaigretteand theAvocado-Yogurt Dip.3. Bake theMaple-Nut Granolaor opt for a healthy store-bought granola to save time. Look for a granola that has around 130 calories or less and less than 6 grams of sugar per 1/4 cup.4. Hard boil 2 eggs for Days 4 & 5.5. Make a batch of Easy Brown Rice to use on Days 1, 2 & 5.

Breakfast(271calories)1 servingAvocado-Egg Toast

Morning Snack (61 calories) 1/3 cup blueberries 1/4 cup plain non-fat Greek yogurt

Lunch (341 calories) 2 cups Ravioli & Vegetable Soup 1 Tomato-Cheddar Cheese Toast

Afternoon Snack (93 calories) 3 Tbsp. hummus 1 cup sliced cucumber

Dinner (437 calories) 1 serving Smoky Maple-Mustard Salmon 1/2 cup Easy Brown Rice 1 Tbsp. chopped walnuts 1 cup green beans 1/4 tsp. salt and pepper, divided between the brown rice and green beans 2 tsp. olive oil, divided between the brown rice and green beansToss green beans in olive oil, salt and pepper and roast alongside the salmon. Mix the remaining oil in withthe rice, season with salt and pepper, and top with chopped walnuts for an easy brown rice “pilaf”.

Breakfast(270calories)1 servingAvocado-Egg Toast

Morning Snack (121calories) 5 dried apricots 6walnut halves

Lunch (295 calories)Leftover soup 2 cups Ravioli & Vegetable Soup 1 clementine

Afternoon Snack (93 calories) 3 Tbsp. hummus 1 cup sliced cucumber

Dinner (424 calories) 1 1/2 cups Delicata Squash & Tofu Curry 1/2 cupEasy Brown Rice

Breakfast (267 calories) 1/4 cup Maple-Nut Granola 3/4 cup plain non-fat Greek yogurt 1/2 cup blueberries

Morning Snack (35 calories) 1 clementine

Lunch (354calories) 1 serving Apple & Cheddar Pita Pockets

Afternoon Snack (47 calories) 1/2 medium apple

Dinner (457 calories) 1 serving (1 pepper) Moroccan-Style Stuffed Peppers 2 cups spinachSaut spinach in 1 tsp. of olive oil and a pinch of both salt and pepper (1/16 tsp. each)

Evening Snack (50 calories) 1 Tbsp. chocolate chips, preferably dark chocolate

Breakfast (267 calories) 1/4 cup Maple-Nut Granola 3/4 cup plain non-fat Greek yogurt 1/2 cup blueberries

Morning Snack (83 calories) 1 hard boiled egg 1 tsp. hot sauce, if desired

Lunch (336 calories) 2 cups mixed greens 3 oz. cooked chicken breast 1/2 medium red bell pepper, sliced 1/4 cup grated carrots 1 clementine 2 Tbsp. Carrot-Ginger VinaigretteCombine ingredients & top salad with vinaigrette.

Afternoon Snack (86 calories) 4 dried apricots 4 walnut halves

Dinner (444 calories) 2 1/4 cup Warm Lentil Salad with Sausage & Apple 1/2 cup Quick Pickled Beets

Breakfast (266 calories) 1 cup all-bran cereal 3/4-cup skim milk 1/2 cup blueberries

Morning Snack (101 calories) 2 medium carrots 2 Tbsp. Avocado-Yogurt Dip

Lunch (314 calories) 1 Tomato-Cheddar Cheese Toast 2 cups mixed greens 3 Tbsp. grated carrot 1/2 cup cucumber, sliced 1 hard-boiled egg 1 Tbsp. unsalted dry-roasted almondsTop greens with grated carrot, cucumber, hard-boiled egg, almonds and 1 1/2 tsp. each olive oil & balsamic vinegar.

Afternoon Snack (93 calories) 3 dried apricots 1/3 cup plain non-fat Greek yogurt 1 1/2 tsp. chopped walnuts

Dinner (427 calories) 1 1/2 cups Quick Chicken Tikka Masala 1/2 cup Easy Brown Rice

Breakfast (266 calories) 1 cup all-bran cereal 3/4-cup skim milk 1/2 cup blueberries

Morning Snack (66 calories) 2 Tbsp. Avocado-Yogurt Dip 1 cup sliced cucumber

Lunch (325 calories)Leftover Chicken Tikka Masala 1 1/2 cups Quick Chicken Tikka Masala 1 cup spinachReheat the chicken on top of the spinach in the microwave.

Afternoon Snack (35 calories) 1 clementine

Dinner (507 calories) 2 cups Korean Beef Stir-Fry 1/2 cup, cooked buckwheat soba noodles (about 1 ounce dry noodles)

Breakfast (266 calories) 1 cup all-bran cereal 3/4-cup skim milk 1/2 cup blueberries

Morning Snack (117 calories) 4 Tbsp. Avocado-Yogurt Dip 1 cup sliced cucumber

Lunch (301 calories) 2 cups mixed greens 3 oz. cooked chicken breast 1/2 medium red bell pepper, sliced 1/4 cup grated carrots 2 Tbsp. Carrot-Ginger VinaigretteCombine ingredients and top salad with vinaigrette.

Afternoon Snack (42 calories) 5 dried apricots

Dinner (494 calories) 1 serving (1/4 pizza) Wild Mushroom Pizza with Arugula & Pecorino

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7-Day Diet Meal Plan to Lose Weight: 1,200 … – EatingWell



Sermorelin Cost & Benefits: Discover the Price of Monthly …

Nov 28th, 2018
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hGH Replacement Therapy has been a popular Anti-Aging and performance enhancing treatment since as early as 1990, but unfortunately, use of hGH does not come without risks.

Sermorelin Acetate has become a popular alternative as it enables you to obtain the benefits of hGH Therapy, without the associated risks.

This article looks more closely at the benefits of Sermorelin injections as a hGH alternative and the cost associated with it.

To begin with, it is a good idea to have an understanding of what Sermorelin Acetate is and what role it plays when administered via injection.

Scientifically Sermorelin acetate is referred to as growth hormone releasing factor 129 NH2-acetate, this is because it is a peptide which contains the first 29 amino acids that make up growth hormone produced in our bodies.

This contributes to Sermorelins function as a growth hormone secretagogue (a substance which causes another substance to be secreted Wikipedia) in this case, the substance whose secretion is promoted is growth hormone.

For this reason, Sermorelin is often also referred to as an hGH stimulator and is considered an excellent alternative to hGH.

One important thing to understand about Sermorelin is that it promotes healthy function of the pituitary (the gland responsible for our bodys production of hGH) during the aging process.

This is a far cry from aggressive administration of hGH which can, in fact, negatively impact normal pituitary function.

Another distinct advantage of using Sermorelin instead of hGH is the cost involved.

hGH typically costs $1000+ per month of treatment, Sermorelin is a much more affordable option with 3 months treatment of Sermorelin costing significantly less than just one month on hGH.

In fact, Sermorelin is available at as low as $290 per month for a 9mg vial.


Anti-Aging Peptides

Sermorelin 9mg



From $292 per month

Performance Peptides

Sermorelin 9mg

GHRP-2 9mg

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From $317 per month

Besides the obvious advantages of Sermorelin injections detailed above, you may want to know how you can benefit from using this therapy.

Perhaps the easiest way to understand the potential benefits of hGh replacement therapy is to look at the symptoms of hGH decline and the effect hGH replacement has on those symptoms.

These are detailed below:

Changes in body composition due to decreasing levels of hGH are reflected by a decrease in lean body mass (muscle) and an increase in fat mass.

Correcting hGH levels has been shown to reverse this state by improving muscle mass and reducing fat.

Research indicates that hGH deficiency in adults contributes to a reduction in bone density and therefore increased risk of osteoporosis.

It has also been shown that hGH replacement therapy for greater than 12 months results in improved bone mineral density and hence, lower risk of osteoporosis.

Due to changes in body composition detailed above, muscle strength is understandably compromised. As hGH therapy corrects body composition and improves muscle mass, muscle strength also improves.

The best results are gained after 12 months of hGH therapy.

By improving bone mineral density and increasing muscle mass and strength, hGH therapy can help to prevent joint deterioration that is a feature of arthritis.

Optimal growth hormone levels are also essential for health of connective tissue such as the Synovium found in joints.

Exercise performance is reduced in individuals with growth hormone deficiency. This appears to be partially due to reductions in bone density and muscle mass but also in part due to a reduction in oxygen uptake.

hGH therapy for 6 months has been shown to improve exercise performance by improving muscle mass and also oxygen uptake

There is evidence of a greater risk of heart disease in individuals with growth hormone deficiency and it has been hypothesized that this is due to a greater propensity to develop premature atherosclerosis (a build-up of plaque inside the arteries which increases risk of heart attack and stroke).

Growth hormone deficiency also results in changes in heart size and function. These changes have been demonstrated to be reversed after 6 months hGH therapy.

Growth hormone deficiency results in a reduced resting metabolism and replacement therapy reverses this decrease. hGH therapy has also been shown to increase protein synthesis, increase fat oxidation, normalize carbohydrate metabolism and reduce LDL (bad) cholesterol.

These favorable effects on metabolism may in part explain some of the other benefits of hGH including improved hearth health and body composition.

A reduction in skin thickness and all-important skin collagen is another result of growth hormone deficiency. Both conditions are improved by hGH therapy.

Although adults with growth hormone deficiency are not normally considered to have a compromised immune system, there is some evidence to suggest that hGH therapy can help regulate immune function.

It has been demonstrated that people with growth hormone deficiency have more difficulty with sexual relationships and reportedly, lower energy levels.

Many individuals have found an improvement in energy, libido and sexual performance following hGH therapy, some men even claiming an improvement in problems with premature ejaculation.

Reduced psychological well-being has been reported in individuals with growth hormone deficiency and hGH replacement has resulted in improvements in mood, energy and general feelings of well-being.

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Sermorelin Cost & Benefits: Discover the Price of Monthly …



Phase 1: Starting the hCG Weight Loss Program Healing …

Nov 25th, 2018
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Dr. Linda Potts, ND, DCRC, RN, MBA, MBE, CNHP—————————————

Contact Us:

Phone: (301) 824-HEAL (4325)Click Here to Contact UsEmail: HealingWaters at

Hours (Eastern Time Zone)Monday-Thursday: 9am-4:30pmFriday: 9am-12:30pmSaturday, Sunday: closed

Appointments are Required for all services.—————————————

Do you live out of the area? No problem!

Health Counseling and other select services are available Nation-wide and Internationally as well as locally serving the Hagerstown and Frederick, MD area.—————————————

Gift Certificates and Payments

Over the past few years, the market has been diluted with hCG products. Practitioners and patients alike have been looking for ways to distinguish the different homeopathic hCG formulas.

In order to evaluate the hCG in any hCG product, there are four key questions to pose to ensure that it is an hCG you want to be putting into your body:

Is the hCG made as a real homeopathic, hand succused, by an FDA approved manufacturer that has substantial expertise in making homeopathics?

Our hCG product is a real homeopathic, hand succused (a process to ensure a homeopathic actually works), in an FDA registered facility that is regularly inspected by the FDA.

What is the source material for the hCG?

Many hCG formulas use raw hCG that is sourced from foreign countries and/or are made from animal-based hCG. Our hCG is actually from pregnant human female urine sourced in the USA. It is the most expensive hCG and can only be sourced in small quantities.

Does the hCG product have an NDC number?

An NDC is a National Drug Code number that is given when the product is registered with the FDA. Our hCG professional formula has been registered with the FDA and has an NDC number.

Is the hCG in a formula that optimizes its strength and efficacy?

Our homeopathics are designed and formulated using comprehensive ingredient principals and are made using burgi groups and desbiochords, the latest formulation advancements in homeopathy. This formulation process creates stronger and more potent homeopathics. A single ingredient homeopathic (like a straight hCG) cannot be made as effective and strong as a multiple ingredient homeopathic. Dr. Bruce Shelton, MD, MD(H), one of the foremost US homeopathic experts, carefully formulated our comprehensive hCG formula with 15 other ingredients to optimize and strengthen the overall performance. In addition, our homeopathic compound is formulated specifically to you. State-of-the-art technology is utilized to design the compound with respect to what is optimal for you individually. To our knowledge, no one else can provide this level of service.

Ideal weight is a rather subjective term. We arent trying to create a false idea of what is ideal because even in the charts that are available, there are wide differences in the scale that is used. What we would like is for YOU to be comfortable with YOU. Your body knows its optimal weight. Its when you feel your best physically and mentally.

With that in mind, use the following chart as a guide to start. As a rule of thumb, when you try to touch your right thumb and middle finger around your left wrist, if they overlap slightly, you are small framed. If they touch, you are medium framed. If they do not touch, you are large framed. Again, this is just a starting point. As you decrease your clothing size and you start feeling better, take a look at your goal again and see if it is right for you.

One amazing and wonderful aspect of this weight loss program is that as you reach your optimal weight, the hCG Plus Compound will not allow you to lose more than is right for your body. In other words, you can not keep taking the drops until you weigh 75 pounds. Some people take a break after they lose X number of pounds and start again, but with our program, you dont HAVE to do that. You can stay on as long as you need to reach your optimal weight.

CLICK HERE to view the chart. Remember, use it as a guide and re-evaluate your goal as you feel comfortable.

Although you can lose weight without exercising on our program, that does not mean that you should not exercise. When Linda and I originally did the program without exercising, it was because we wanted to know what results we could get by the diet itself, not because you cant exercise on the program. In fact, we always recommend exercise for fitness of body and mind.

While on the program, there are a few adjustments that need to be considered when exercising. If you have not exercised regularly before starting the program, consult a healthcare professional before starting any exercise program. If you do exercise regularly, you may continue while on the weight loss program. However, you may want to lighten up on your workout initially so as not to overtax your system. The program does not seem to affect muscle tissue so you should not worry about losing muscle tone. You may want to monitor how much and when you drink your fluids, eat your meals or snacks and consider adding an additional supplement of potassium and/or magnesium and adjust for your individual needs.

Light exercise such as brisk walking, swimming, hiking and biking will give you a chance to clear your head, get some fresh air and help you to remove those toxins that are stored in fatty tissues. Remember that your hCG Plus Compound is designed to help you detoxify and move into a more balanced state of mind, too. You should find that as you lose the weight, you will naturally feel more like exercising and being more active. You should feel less aches and pains and be able to move more freely and generally feel more excited about how well your body will move and perform. Be sure to take a few minutes each day to relax and do some deep breathing exercises, too.

So whats stopping you? Start moving today.

Phase 1 is the first indication that this weight loss program is COMPLETELY DIFFERENT than any other program you have ever been on. Yes, this is where you EAT LOTS OF FATS/OILS for two to three days. Notice I did NOT say sugars or breads or fattening foods but FATS and OILS. There are two major reasons for doing this: to start the fat-burning process and to KEEP YOU FROM BEING HUNGRY the first few days on the program. An added benefit is that you tend to not want ANY more fats because you have met your limit!

So, what do I mean by fats and oils? Foods that are high in fats and oils. Avocados, olives, chicken wings, eggs, cheese, butter, sour cream, guacamole, croissants, whipped cream, bacon, mayonnaise, fish oils, tuna, salmon, nuts of all kinds, coconut, fried foods like Bloomin Onions from Outback Steakhouse, Fettucini Alfredo, basically any high-fat, low sugar foods. High sugar foods will make you want more sugar and will not work to curb your appetite so keep to all the high fat, low sugar foods you limit yourself on normally. You will not be able to have these again until you reach your goal weight, so HAVE A BLAST and eat as much of them as you can stand!

Dont worry about gaining weight on these 2-3 days! You WILL drop this weight, and much more, the first WEEK you are on the program. Remember, this program works and works FAST!

Plan to start Phase 2 now. Go through the program and READ EVERYTHING. Get your groceries. Plan your meals. Buy your other supplies. Be INTENTIONAL on your goal.


Yes, I know. I sound like a broken record when it comes to cheating. Dont do it! Even a little cheating will set you back a few days, stall your weight loss, make you HUNGRY and make you want to cheat MORE. Is that what you really want? Of course not! This is where you have to look at the REASON you want to cheat and DO SOMETHING DIFFERENT. We dont want you to be on the weight loss program for a long time and neither do you. Stick with it, as written, and you will reach your goal sooner and be LESS HUNGRY. It really works!

If you need help with defining why you are having your cravings, contact us. We are here to help. Remember, though. YOU have to be INTENTIONAL in your mind as to what you are trying to accomplish.

Nothing tastes as good as skinny feels!


We get this question a lot. The bottom line is that you can eat whatever you choose to eat. You are an adult and make your own choices.

These are the same choices, I gently point out to you, that caused you to gain weight and now to decide to lose weight. Dr. Simeon tested, retested and tested again all the possible variations of the hCG with different combinations of food for over 50 years. Remember that it isnt just the calories you are eating, its how the foods work together that helps you lose weight so rapidly and not feel hungry.

Cheating a little on a normal diet doesnt affect much. But on our program, even a little bit of something not on the approved food list will disturb your body chemistry and will have three undesirable consequences: you will set back your weight loss by about three days, you WILL be HUNGRY and your METABOLISM will not get RE-SET. Especially if you eat any form of sugar or fat in Phase 2. Thats why we say so often that this is not a forever diet. Keep on the program as it is until you reach your goal weight and THEN experiment by slowly adding new foods. It happens very quickly when you follow the program.

Other diets, even other hCG based diets, allow different good foods than what is on our food list. We try to stay as true to the original as possible with a few minor changes in protein for vegetarians. Again, 50 years is a long time to catch up to what Dr. Simeon has already done. The way the foods work together is very important.

One other thing. There are MANY variations of the hCG enhanced diet out there. Ours is different in that your Homeopathic hCG compound is not just hCG but has other frequencies imprinted that help to balance your individual body. As you progress on the program, your body changes very rapidly in all aspects physically, mentally and emotionally. Because of this you need more support in all these areas so please contact us with any questions as soon as you notice things so we can make adjustments for you. We want you to succeed quickly and healthfully.

Vegetarians can expect to lose weight on our program at a rate of up to about 1/4 to 1/2 pound per day when closely following the protocol.

The protein substitutions are as follows.

3.5 ounces of meat protein will be replaced with:

eggs- 1 whole egg plus 3 egg whites (1 yolk, 4 whites)

2 cups skim milk (cows milk)

tofu (3.5 oz)

1/2 cup low fat cottage cheese

Soy milk can be used instead of cows milk IF IT HAS NO SUGARS.

These are the only substitutions. Some vegetarians eat fish so that may be an option for you, too. The vegetables, starches, fruits and liquids are exactly the same as our non-vegetarian weight loss program. Of course, your personalized Homeopathic hCG compound will address your individual needs.

I found two more recipe books specifically for the HCG Diet. Varying your food choices makes the program so much easier and fun!

Remember that you have to pay particular attention to which phase of the program you are on for which foods are allowed.

HCG Dieters Gourmet cookbook ($39.99 $24.95) Click HereEspecially for the restrictive Phase 2 portion of the program. Over 200 recipes.

Hcg Weightloss Cure Kevin Trudeau Diet Cook Book ($17) Click Here

Both of these books contain delicious recipes! One of the best ways to achieve your weight goal is to enjoy the food that you are eating. These books give you lots of choices. You can use them even AFTER you reach your weight loss goal, too!

Here are some links to the products we found useful. You can think of this as a quick-start package.

For Aura Patches, supplements and other services, go to or call us at 301-824-HEAL.

For the items below, just click on Kitchen scale, etc. Or CLICK HERE to get it all in one place and have it delivered right to your home!

There is no obligation to buy them here. We just wanted to make it convenient for you and give you an all-in-one place to get what you need to make the program SOOO much easier to follow.

Have fun!

Bathroom scale For weighing yourself accurately to 2/10ths of a pound.

101 Worry Free HCG Diet Recipes A great cookbook for Phase 2.

HCG Diet Made Simple Lots of helpful information plus recipes.

Stevia Plus Powder (Multi-Pack) Our sweetener of choice. 0 calories and no aftertaste.

George Foreman Grill Grills food fast without oil. Easy to clean coating and removable grill plates.

Miracle Noodles 0 calories. Can be used for many of the recipes. Fills your belly and helps you to FEEL full. Or try

Your homeopathic hCG formula is UNIQUE for YOU and will not be the best thing for anyone else. Everyone has different requirements and is adjusted for individual use. That is one of the BIGGEST BENEFITS of a program like ours.

The first item you need to take care of is downloading, printing, signing and returning your Informed Consent form. We need that back BEFORE we can ship your hCG Homeopathic. Click Here to access it.

Follow this link:
Phase 1: Starting the hCG Weight Loss Program Healing …



11 Ways to Boost Human Growth Hormone (HGH) Naturally

Nov 20th, 2018
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Human growth hormone (HGH) is an important hormone produced by your pituitary gland.

Also known as growth hormone (GH), it plays a key role in growth, body composition, cell repair and metabolism (1, 2, 3, 4, 5, 6).

HGH also boosts muscle growth, strength and exercise performance, while helping you recover from injury and disease (4, 7, 8).

Lower HGH levels may negatively impact your quality of life, increase your risk of disease and make you gain fat (9).

Optimal levels are especially important during weight loss, injury recovery and athletic training (10, 11, 12, 13).

Interestingly, your diet and lifestyle choices can have a huge effect on your HGH levels (6, 14).

Here are 11 evidence-based ways to increase human growth hormone (HGH) levels naturally.

The amount of body fat you carry is directly related to your HGH production (3).

Those with higher body fat levels or more belly fat will likely have impaired HGH production and an increased risk of disease.

One study observed that individuals with three times the amount of belly fat as the control group had less than half their amount of HGH (15).

As shown in the graph below, one study monitored the 24-hour release of HGH and found a large decline in those with more abdominal fat.

Interestingly, research suggests that excess body fat affects HGH levels more in men. However, lowering body fat is still key for both genders (15, 16).

One study found that obese individuals had lower levels of IGF-1 a growth-related protein as well as HGH. After losing a significant amount of weight, their levels returned to normal (17).

Belly fat is the most dangerous type of stored fat and linked to many diseases. Losing belly fat will help optimize your HGH levels and other aspects of your health.

Studies show that fasting leads to a major increase in HGH levels.

One study found that three days into a fast, HGH levels increased by over 300%. After one week of fasting, they had increased by a massive 1,250% (18).

Other studies have found similar effects, with double or triple HGH levels after just 23 days of fasting (19, 20, 21).

However, continuous fasting is not sustainable in the long term. Intermittent fasting is a more popular dietary approach that limits eating to brief time periods.

Multiple methods of intermittent fasting are available. One common approach is a daily eight-hour eating window with a 16-hour fast. Another involves eating only 500600 calories two days per week (22, 23).

Intermittent fasting can help optimize HGH levels in two main ways. First, it can help you drop body fat, which directly affects HGH production (24, 25, 26, 27).

Second, it’ll keep your insulin levels low for most of the day, as insulin is released when you eat. Research suggests that insulin spikes can disrupt your natural growth hormone production (28, 29).

As shown in the graph below, one study found large differences in HGH levels on the fasting day compared to the eating day (30).

Shorter 1216-hour fasts likely help as well, though more research is needed to compare their effects against full-day fasts.

When taken alone, arginine may boost HGH.

Though most people tend to use amino acids like arginine alongside exercise, several studies show little or no increase in HGH levels (31, 32, 33).

However, when arginine was taken on its own without any exercise there was a significant increase in this hormone (32, 33).

Other non-exercise studies also support the use of arginine to boost HGH.

One study examined the effects of taking either 45 or 114 mg of arginine per pound (100 or 250 mg per kg) of body weight, or around 610 or 1520 grams per day.

They found no effect for the lower dose, but participants taking the higher dose saw around a 60% increase in HGH levels during sleep (34).

An increase in insulin can lower HGH production.

Refined carbs and sugar raise insulin levels the most, so reducing your intake may help optimize growth hormone levels (24, 25).

One study found that healthy individuals had 34 times higher HGH levels than people with diabetes, as well as impaired carb tolerance and insulin function (35).

Along with directly affecting insulin levels, excess sugar intake is a key factor in weight gain and obesity, which also affect HGH levels.

That said, the occasional sweet treat will not impact your HGH levels in the long term.

Aim to achieve a balanced diet since what you eat has a profound effect on your health, hormones and body composition.

Your body naturally releases significant amounts of HGH, especially at night (36, 37).

Given that most meals cause a rise in insulin levels, some experts suggest avoiding food before bedtime (25).

In particular, a high-carb or high-protein meal may spike your insulin and potentially block some of the HGH released at night (38).

Keep in mind that insufficient research exists on this theory.

Nevertheless, insulin levels normally decrease 23 hours after eating, so you may wish to avoid carb- or protein-based meals 23 hours before bedtime.

GABA is a non-protein amino acid that functions as a neurotransmitter, sending signals around your brain.

As a well-known calming agent for your brain and central nervous system, it’s often used to aid sleep. Interestingly, it may also help increase your HGH levels (39).

One study found that taking a GABA supplement led to a 400% increase in HGH at rest and a 200% increase following exercise (40).

GABA may also increase HGH levels by improving your sleep, since your night-time growth hormone release is linked to sleep quality and depth (41, 42).

However, most of these increases were short-lived and GABA’s long-term benefits for growth hormone levels remain unclear (39, 40).

Exercise is one of the most effective ways to significantly raise your HGH levels.

The increase depends on the type of exercise, intensity, food intake around the workout and your bodys own traits (43, 44, 45, 46, 47, 48, 49).

As shown by the black bars in the graph below, very large increases in HGH were seen in a weight lifting session with limited rest periods (10, 46).

Due to its metabolic nature and increase in lactic acid, high-intensity exercise increases HGH the most. However, all forms of exercise are beneficial (43, 44).

You can perform repeated sprints, interval training, weight training or circuit training to spike your HGH levels and maximize fat loss (46, target=”_blank”50, 51).

As with the supplement methods, exercise mainly provides short-term spikes.

Then again, over the long term, exercise may optimize your hormone function and decrease body fat, both of which will benefit your HGH levels.

Some exercise supplements can optimize performance and boost your HGH levels.

In one study, 4.8 grams of beta-alanine before a workout increased the number of repetitions performed by 22% (52).

It also doubled peak power and boosted HGH levels compared to the non-supplement group (52).

Another study demonstrated that a sugary sports drink increased HGH levels towards the end of a workout. However, if youre trying to lose fat, the drinks extra calories will negate any benefit from the short-term HGH spike (53).

Studies have shown that protein shakes, both with and without carbs, can boost HGH levels around workouts (48, 49).

The majority of HGH is released in pulses when you sleep. These pulses are based on your body’s internal clock or circadian rhythm.

As you can see from the graph below, the largest pulses occur before midnight with some smaller pulses in the early morning (36, 37).

Studies have shown that poor sleep can reduce the amount of HGH your body produces (42).

In fact, getting an adequate amount of deep sleep is one of the best strategies to enhance your long-term HGH production (37, 42).

Here are a few simple strategies to help optimize your sleep:

Melatonin is a hormone that plays an important role in sleep and blood pressure regulation (54).

Melatonin supplements have become a popular sleep aid that can increase both the quality and duration of your sleep (55, 56, 57, 58, 59, 60, 61).

While good sleep alone may benefit HGH levels, further research has shown that a melatonin supplement can directly enhance HGH production (58, 62, 63, 64).

Melatonin is also fairly safe and non-toxic. However, it may alter your brain chemistry in some ways, so you may want to check with a doctor before using it (65).

To maximize its effects, take 15 mg around 30 minutes before bed. Start with a lower dose to assess your tolerance, then increase if needed.

Several other supplements may enhance human growth hormone production, including:

While all of these supplements may increase your HGH levels, studies indicate theyre only effective in the short term.

As with other key hormones such as testosterone and estrogen having healthy levels of growth hormone is important.

HGH helps your body with metabolism, cell repair and other vital functions.

By following the tips above, you can increase your HGH levels fairly easily.

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11 Ways to Boost Human Growth Hormone (HGH) Naturally



The Vegan Diet Done Safely – Parsley Health

Nov 18th, 2018
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If you think a vegan diet automatically equals a healthy diet, think again!

True it can be packed with veggies, but if youve ever met the vegan with a Diet Coke in one hand and a chocolate brownie (sans the eggs and butter, of course) in the other, you know it can be a thoroughly unhealthy diet.

A vegan diet, by definition, excludes all animal products. No animal flesh. No milk from cows, goats, sheep or other mammals. No eggs. Not even honey. Whats left can vary tremendously from one vegan to the next.

Often people do choose to adhere to a vegan diet for health reasons, but others want to eat lower on the food chain out of respect for animals or to minimize their carbon footprint and help protect the environment.(1)

Thanks to the Seventh Day Adventists and the epidemiologists who studied them, we now have compelling evidence that a vegan diet can be healthier than one that includes meat and fish. Many Seventh Day Adventists follow their churchs doctrine that recommends a vegetarian diet. The researchers found that, compared to non-vegetarians, vegetarians (including vegans and lacto-ovovegetarians) were much less likely to get colon cancer or prostatecancer, or to die from cardiovascular disease or breast cancer.

Among men,lacto-ovo vegetarians (they eat dairy and eggs) were 15% less likely to die from any cause compared with non-vegetarians, and there seemed to be some added benefit to being vegan, as this group was 18% less likely to die from any cause versus the non-vegetarians.(2)

Other studies have looked at the gut microbiota (ie, the bacteria in our stool) in people with different diets and have found that the microbiome in those who eat meat differs from vegetarians, and further differs from that in vegans. Research indicates that the vegan gut has fewer inflammatory bacteria, and more species that protect against inflammation, obesity and type 2 diabetes.(3)

A number of smaller studies reveal additional benefits of the vegan diet, such as one where sedentary people on a raw vegan diet appear to be as heart healthy as the non-vegetarian endurance runners(4). Another research study found that a vegan diet along with support groups and lifestyle changes helped men with prostate cancer control the disease.(5)

But there is such variety in the vegan diets studied and associated interventions that it is hard to make generalizations.

There are strong theoretical reasons to think that there is value in consuming a vegan diet.

For example, the ratio of omega-6:omega-3 fatty acids is ideally no higher than 4:1, but a review article found that, on average, the ratio was 7.65:1 for grain-fed beef and 1.53:1 for grass-fed beef.(6) A study of chickens fed cereal-based feed also had lower omega-3 fatty acid levels compared with the birds given access to pasture.(7)

Diets high in animal protein have been associated with numerous chronic diseases, such as cardiovascular disease, hypertension, type 2 diabetes, and possibly osteoporosis, cancer and overall mortality.(8-12)

Ninety percent of human ingestion of dioxins occurs through animal food. These contaminants increase risk for cancer and developmental, immunologic, and endocrine toxicity.(13) Mercury, another toxin prevalent in our oceans, accumulates in many fish, and can be harmful to our nervous, digestive and immune systems, lungs and kidneys.(14)

One benefit of animal protein is that unlike plant-based protein, animal protein is a complete protein, meaning you get adequate amounts of all the essential amino acids your body cannot make on its own when you eat it.

Vegans have to work harder to consume adequate amounts of complete protein because plant-based proteins are almost all low in one to three essential amino acids. However, any combination of two types of vegan protein in a day (eg, legumes and seeds, or legumes and whole grains, or nuts and seeds, or whole grains and nuts) provides the necessary combination of essential amino acids.(15)

One pitfall to look out for is vegan protein powders. Most powders are not optimized with branch-chain amino acids, and therefore are not highly bioavailable and not a great source of protein. This is why Parsley Healths professional-grade pea-and-rice based Rebuild protein powder is superior to most powders it has been optimized with the addition of the amino acids like leucine required to make it a complete protein.

Another common argument for consuming animal products particularly dairy is calcium. However, on review of studies of dairy and bone strength, the totality of evidence does not point to dairy as necessary. Vegans can get plenty of calcium from their diet without supplements by consuming dark green vegetables and nuts or seeds daily.

Especially good foods are collard greens, kale, almonds and sunflower seeds. Not only that, but they dont need as much calcium as meat-eaters. Thats because animal flesh is acidic, forcing calcium stored in the body (eg, in bones) to be drawn into the bloodstream to buffer the acid.

There are a few nutrients that you do need to pay attention to if you want to try a vegan diet safely.

The first one is vitamin B12. Unless you are eating some really buggy lettuce (which one might argue would make you less than vegan), there is no way to get sufficient B12 as a vegan and it is important to take a supplement, such as our vegan Rebuild protein powder which contains a complete multivitamin.

Iron is also worth consideration, in particular for menstruating women. Although there are many plant-based sources of iron, it is harder for the body to absorb vegan-sources of iron than animal-based sources, so supplementation might be needed.

Next, Omega-3 fatty acids are abundant in certain plant-based foods, like flax, walnuts, chia and hemp seeds. However, our bodies are only able to convert small amounts of plant-based omega-3s into the most beneficial forms our bodies need DHA and EPA. Incomparison, it is much easier to absorb DHA and EPA directly from fish and pasture-raised eggs and meat.

Finally, there is almost no vitamin D in a vegan diet, and most of us (vegan or not) are Vitamin D deficient as we dont get a lot of sun exposure. The better supplemental form of vitamin D is D3, rather than D2. Though D3 frequently comes from animal sources (eg, lanolin from sheeps wool or fish oil) there is a plant-derived D3 from lichen.We recommend routine testing for all vegans and vegetarians to ensure they are getting adequate nutritional support.

On countless occasions I have identified B12, iron and Vitamin D deficiency in my vegan patients which we were easily able to correct with the right supplements, allowing them to safely stay with their vegan diet.

Diets impact more than our bodies, they can impact our mental health powerfully. For example, I had a 52-year-old patient who started a vegan diet high in veggies and without refined grains or sugar. As a result, her bipolar disorder was the best controlled it had ever been, allowing her to finally feel well, mentally and physically, on her medication.

I had another 62-year-old patient who had a cardiac stent placed for a clogged artery and chest pain. Despite the stent and no evidence of any more clogged vessels, the chest pain persisted, but a few months after he started a vegan diet, his chest pain resolved. Dean Ornish, MD, did pioneer work in this area, showing that a vegetarian diet (low-fat, no sugar in this study), along with exercise, stress management, and psychosocial support could successfully reduce angina symptoms and reverse the accumulation of plaque in peoples arteries.(16)

In her book, Radical Remission, Kelly Turner, PhD, wrote about people with cancer who used only alternative means to recover from cancer, and for some, this involved adhering to a plant-based diet high in vegetables and no sugar, meat, dairy and refined foods.(17)

People are unique in terms of what makes them feel well and their comfort with different dietary plans. If you are interested in seeing what effect a vegan diet has on you, do it with the guidance of someone who has experience finding vegan foods that are healthy, satisfying and filled with a sufficient variety of nutrients.

Notice how you feel after 3 weeks on it. Check immune markers such as your white blood cell count and high sensitivity c-reactive protein, as well as cholesterol, to see what impact it has on these markers for some people the positive effects are astounding.

The ideal vegan diet consists of whole foods, lots of vegetables, and nearly zero refined grains and sweets. If you want to try it, just be sure to plan ahead before making this transition, so you dont end up reaching for that vegan chocolate brownie instead of a handful of walnuts when youre hankering for a snack, and keep in mind which nutrients you might need to supplement.

If done this way it can potentially decrease your risk for chronic diseases, such as heart disease and some cancers.

Need to get started with a few delicious vegan recipes? Start your day off by making our Pumpkin Pie Smoothie,check out our Simple Plant-Powered Meals for lunch and dinner ideas or whip up a batch of ourPeanut Butter Energy Balls for the perfect snack!


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The Vegan Diet Done Safely – Parsley Health



Weight Loss Basics – Verywell Fit

Nov 17th, 2018
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The first step to losing weight is coming up with a plan. Are you ready to slim down? By following a few weight loss basics you can learn how to eat a healthy diet, start an exercise program, improve your health, and finally reach your weight loss goal!

There is no shortage of diet plans on the market. There are popular commercial diets like Jenny Craig, Nutrisystem, and Weight Watchers.

You’ll also find diet books and online programs like The South Beach Diet or Atkins. So, which one works? Research studies have shown that no single diet is necessarily better than the others. The best diet for you is the diet you can stick to.

To choose the right diet, ask yourself important questions about how much money you can spend, how much time you have to plan and prepare healthy meals, and how much support you have from friends and family.

You might also want to think about why previous diets didn’t work. The answers to these questions will help you find a diet that will meet your needs.

But remember that you don’t have to buy a book or sign up for a membership to enjoy weight loss benefits. You can cut calories and lose weight on your own. Many successful dieters find that by making small changes to their meals and boosting daily physical activity they are able to see real results on the scale. To start your own plan, you need to figure out how many calories to eat each day and how many calories to burn.

It doesn’t matter what kind of diet you choose, all weight loss programs reduce your caloric intake so that your body burns fat for fuel.

To figure out how many calories to cut to lose weight, you need to calculate your daily caloric needs and then reduce that number to create a calorie deficit. You can use a simple online weight loss calculator to figure this out instantly, or you can do a little bit of math to figure your numbers out on your own.

Keep in mind that a deficit of 500 calories per day will help you to lose about 1 pound per week. A calorie deficit of 1,000 calories per day can result in a 2-pound weight loss per week. Cutting more than 1,000 calories from your diet may do more harm than good. Very low-calorie diets should only be followed under a doctor’s supervision.

Now that you know how many calories to eat every day, it’s time to reduce calories for weight loss. There are two ways to reach your calorie goals. You can either eat less food (portion control) or you can eat food with fewer calories. Most dieters combine both approaches for best results.

Portion control will allow you to keep all (or at least most) of your favorite foods in your daily food planyou’ll just need to eat less of them to keep your calorie count in control.

You may find it helpful to cut meal portions in half to consume fewer calories. Some dieters measure food portions with a kitchen scale to find the right amount to eat. Others are able to measure food portions without a scale, simply using their hands or other handy kitchen gadgets.

But it’s also important to learn how to eat lower calorie foods. When you teach your body to crave foods that are naturally low in fat and high in nutrition, you help your body feel full and satisfied. The result? You naturally want to eat less. Look for fresh vegetables, whole fruit, lean protein, low-fat dairy, and healthy carbohydrates that provide fiber and other nutrients.

Luckily, you’ll find that many of the best foods for weight loss are inexpensive, convenient, and easy to find in your local grocery store. When you learn how to plan and prepare meals in advance and fill your refrigerator with diet-friendly foods, you can even save time and money while you slim down.

One of the quickest and easiest ways to lose weight is to change the beverages you drink each day.

Many popular drinks contain hundreds of calories and countless grams of added sugarand some of these drinks are even labeled “healthy.”

Sodas and sweetened teas are usually full of empty calories. Sports drinks often contain more calories than you need, and even juices can do a number on your diet. And your daily trip to the coffee shop? That morning latte can add 500 calories or more to your waistline, depending on how it is prepared.

You might wonder if diet drinks are any better. The answer depends on who you ask. Some weight loss experts and dieters say that diet sodas and other artificially sweetened beverages are a welcome swap when you’re trying to lose weight. Other experts say artificial sweeteners can cause more harm than good. Your best bet may be to drink naturally flavored water to stay hydrated during the day.

Most dieters want to lose weight fast. It’s hard to have patience for slow and steady weight loss. But most experts agree that you should expect to lose weight at a healthy rate of 1 to 2 pounds per week.

It is not uncommon, however, for fast weight loss to happen at the beginning of a new diet plan. In fact, some weight loss programs include a short one- to two-week introductory phase where your eating is more restricted and weight loss happens more quickly. You may lose 3 to 5 pounds during this stage. Some dieters lose up to 10 pounds in the first two weeks of certain plans.

But this quick slim down is often the result of lost water weight. When you cut back on your food intake, and especially when you cut back on your carbohydrate intake, your body loses a lot of water and your weight plummets as a result. The new number on the scale may provide a boost of motivation. But it’s also important to keep those results in perspective.

To lose weight and keep it off you need to lose fat, not water. And it’s important to conserve muscle mass to maintain a healthy metabolism. Experts agree that the best way to reach these goals is to lose weight gradually with steady changes to your diet and exercise plan.

Many successful dieters exercise to lose weight, but adding physical activity can also make you more hungry during the day, increase fatigue, and even cause injury. It’s important to start slowly and build a weight loss workout plan for improved health and fitness.

Before you start any exercise program, you should check with your doctor to make sure that you are healthy enough for vigorous activity. Once you have been cleared, then you can build a program based on activities that you enjoy. Maybe you’d like to start a walking program for weight loss. You can also choose activities like swimming, biking, or even fencing to lose weight.

If you’re not sure where to begin, you can join a gym or hire a personal trainer to get help. There are also many online workouts and home exercise programs that you can do in the privacy of your living room to burn extra calories and improve your level of fitness.

But remember that your non-exercise physical activity matters, too. Your daily steps and non-workout movement (like gardening and doing the laundry) can make a big difference in your weight loss plan. So as you build an exercise program, try to stay as active as possible at work, at home, and when you travel.

As you hit challenges and plateaus in your weight loss journey, you may be tempted to try diet supplements, herbal treatments for weight loss, and other alternative methods to lose weight. Some of these options work, but unfortunately, many of them don’t.

There are very few diet pills that have been proven to help you lose weight. Most weight loss medications that work can only be prescribed by your physician. The diet pills and herbal treatments you see on store shelves are often ineffective and, in some cases, may even cause harm. Talk to your doctor and ask important questions before taking any diet pill or weight loss supplement.

You’ll also find complementary or alternative treatments, like acupuncture, meditation, or massage for weight loss. In some cases, you might find that these treatments are helpful during your dieting journey. They may improve the way you feel about your body and even help you sleep better at night for improved weight loss benefits.

There will be days when you want to give up and you feel like all of your hard work is a waste. At these moments, diet support is essential for long-term success.

At the beginning of your weight loss process, you may find it helpful to share your goals with friends and family members who might be willing to help. Your spouse, your children, neighbors, coworkers, close friends, and even members of your religious community may be willing to cheer you on when the going gets tough.

But if you don’t have a network nearby, there are still options to get help. Your health care provider can provide important medical support for your weight loss journey. They can also provide referrals to a registered dietitian, physical therapist, or behavioral health specialist to help you address challenges as they arise.

There are also online communities to help you through the rough patches. Popular weight loss apps like CalorieCount, MyFitnessPal, and LoseIt provide space for members to ask questions or solve problems. If you joined a weight loss program like Weight Watchers, you can also take advantage of face-to-face or online meetings. You may also find support in homegrown social media groups.

Lastly, you should learn to motivate yourself to reach your goals. There are specific techniques you can use that will boost your confidence and help you to stay motivated on the difficult days, such as keeping a weight loss journal and using positive self-talk.

So, what happens when you’ve tried diet and exercise, you’ve worked your hardest, and you simply can’t lose weight? Don’t give up. It might be time to turn to your doctor for weight loss assistance. There may be a medical cause for your excess weight and a medical treatment that can help.

Your primary care physician is the first place to begin when you’re looking for a medical weight loss solution. He or she can evaluate your complete health history and refer you to a bariatric (weight loss) doctor that can provide more specialized treatment. You can also do some research on your own to find a qualified weight loss doctor in your area.

You and your doctor can explore possible treatments for your weight loss concerns, including weight loss medications, weight loss surgery, and even other non-surgical treatments to help you lose weight. In some situations, losing weight may provide health benefits. In those cases, your health insurance provider may be willing to cover the cost of your treatment.

Weight loss can be a struggle. Even the most dedicated dieters have good days and bad days, often feel defeated, and sometimes want to give up. At Verywell, we understand that your weight loss goals are important to you, and we want to give you the information and the support you need to lose weight. Visit us often to get the tools, tips, and friendly advice you need to make your journey healthy, happy, and successful.

You can get started by exploring these Verywell sections:

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Weight Loss Basics – Verywell Fit



Weight loss calculator percentage by Dr. Halls and Moose.

Nov 17th, 2018
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This page is all about the amazing little weight loss percentage calculator, designed by Dr.Halls and Moose. This handy little tool can help you track your weight loss progress and achieve YOUR weight-loss goals.

Simply add your start weight and current weight in pounds into the boxes below. If you prefer to use kilos, then click on the black down arrow to the right of lbs. After you have added your information, click on the CALCULATE button and the percentage weight loss result will show up in the box saying, Result Below.

Here is Dr Halls Weight Loss Percentage Calculator

Losing weight the healthy way

Whether you are looking to lose 10 pounds or 100 pounds, weight loss should always be done in a healthy fashion. You might desire to lose weight as fast as possible, this can actually be quite unhealthy for your body.In order to successfully lose weight and maintain that weight loss it is essential that you keep track of the overall amount that you have lost and also check your progress on a weekly basis. This post will help you to do just that.

Why do fish always know how much they weigh? Because they have scales.

The American Heart Association advises that no more than 1 to 2 pounds (0.45 to 0.9 Kg) of weight should be lost in a week. Losing more than this may increase your risk of metabolic disorderssuch asdiabetesandglucose intoleranceleading to an increased risk for heart disease and stroke. Rapid weight loss canpromote unhealthy eating patterns as well as leaving you feeling fatigued due to an inadequate daily caloric intake. In addition, losing weight too rapidly increases your risk of gaining back unwanted weight even faster. One medical study investigated weight gain after dieting and suggests that around 95 % of dieters who lose weight, regain it all again (and sometimes more) within one to five years.

Research conducted by Rena Wing suggests that keeping track of your weight is a successful technique towards shedding those unwanted pounds. The key to weight loss tracking, however, is to use the information revealed to quickly make adjustments to any fluctuations in weight or body size. Weighing yourself, although useful in monitoring progress, does not always show the whole picture. If you have incorporated some weight lifting or strength training into your weight loss efforts, than the amount of muscle and tone of your body may be just as important, if not more so, than the figures on the weighing scales. Resistance or strength training has been shown in several scientific studies to increase your basalmetabolic rate and aid fat loss from the body.

Weight loss can be tracked in various ways:-

Weight loss competitions

TV shows such as The Biggest Loser have promoted weight loss in competition form. The weight loss percentage calculator is used as well as weight loss in pounds. The logicbehind this is that the contestants who weigh the most to begin with are more likely to lose a larger amount of pounds per week. This, in part is because the more you weigh the higher the number of calories you burn when you exercise. Hence, the heavier people are expected to lose more weight quicker than the lighter competitors. By using the weight loss percentage calculators, it develops a balanced platform amongst all the participants byanalyzing weight loss in percentage form.

How to calculate weight loss percentage

As you know if youre reading this, sticking to your weight loss program and tracking your progress can be difficult. Finding out what percentage of body weight you have lost can really help in your weight loss effort alongside setting your goal weight. A scientific review of medical literature between 1993 and 2003 on the benefits of self monitoring in relation to weight loss, concluded that there was ample evidence to demonstrate that self-monitoring is significantly linked with successful weight loss.

The formula for the weight loss percentage calculator is very simple, even for those of us who are mathematically challenged. If you want to work out your percentage weight loss manually here are the sums.

Percentage weight loss iscalculated by taking away (in pounds) your present weight from your starting weight. Next, multiply the result by 100. Now divide this figure by the starting weight and you have your percentage. For instance, if your starting body weight was 200 pounds and your present weight is 180 pounds, subtract 180 from 200. This gives you the total amount of pounds lost, which in this case is 20 pounds. Multiply by 100 which is 2000. Nextdividethis figure by the starting weight, 2000 divided by 200 which is 10 and that is your answer, in this example, 10% of body weight has been lost.

One more example:-

Starting weight: 230 poundsPresent weight: 160 pounds

230 160 = 7070 x 100 = 70007000/230 = 30.434 = around 30 % Total Weight Loss

Arithmetic is fun. Think of a number. Double it. Add six. Half it. Take away the number you started with. Your answer is three.

If you want to successfully lose weight, keeping a food diarycan hugely boost your efforts. A 2008 study of obese women suggests that keeping an accuratefood diary can double your weight loss. In the food journal you should log every mouthful that you eat or drink during the day to monitor your caloric intake. In addition, it can be helpful to note your emotional state at the time of eating to help you identify bad eating habits and patterns. To spur you on and keep track of your progress you could add a column to fill in each week for your weight and percentage weight loss. Studies have also shown that goal setting for weight loss can be very useful, so dont forget to state yours in your diary, for example, lose 10% of your weight in two months.

If you tend to be overweight or obese, even asmallreduction in weight can be very constructive. According to theCenters for Disease Control, just a 5 % to 10 % reduction in weight can have adefiniteresult on your health. So do not give up if you are making slow progress. Other health benefits to even a small reduction in weight include lower cholesterol, blood pressureandblood glucose levels.

When you use the weight loss percentage calculator, they calculate it for you. This gives you an accurate percentage that you can use to track your progress all the time.

Another handy tool you can use

Although you should definitely continue using this weight loss percentage calculator all the time, there is another amazing tool that you can consider using as well!

The Body Mass Index (BMI) Calculators , will give you information about your weight and height. It can also be used to indicate if you are overweight, obese, underweight, or normal. Having a good idea of your body mass index (bmi) and your percentage weight loss can help with your personal weight-loss program. Another interesting statistic to look at is the waist-to-height ratio.

Sometimes, for the morbid obese, diet and exercise alone are not necessarily going to be effective. Obesity is classed as having a Body Mass Index (BMI) of over 30. A 2015 cohort study from the UK that examined digital records over a 10 year period of 278,982 obese men and women had some very interesting results:-

The bad news seems to be that once a person becomes obese the chances of them returning to a normal weight are quite low.

However, the more weight gained the lower the chances of ever returning to, or maintaining a normal weight long term.

Losing just 5 % of the body weight however, did have health benefits and was a lot more achievable with a

However, for the seriously obese losing just 5% 10% of the body weight may not be effective in warding off the long term health problems associated with obesity. Combined with the slim chances of returning to a normal body weightthe National Institute of Health has supported weight loss surgery as a possible solution for long term results.

Surgery for weight loss may be something to seriously consider if you have a BMI over 40 or a BMI over 30 with any related health conditions such as diabetes, high blood pressure, sleep apnea or high cholesterol levels.

As mentioned above, the Body Mass Index (BMI) is a well known tool that divides your weight in kgs by the square of your height in metres. The BMI is useful to find out if you are a healthy weight for your height.

Ideally your BMI should be between 18.5 and 24.9. If your BMI is above this the following classifications apply:-

Another handy way of finding out what your ideal weight should be is to use Dr. Halls very own Ideal Weight Calculator that shows you other peoples ideal weight who are the same age, height, weight and gender as you.

The amount of calories needed per day to maintain your weight, as it is now, depends on many factors which include:-

The recommended amount of calories from the UKs National Health Service (NHS) is around 2,500 (10,460 Kj) for an average adult male and 2,000 (8,368 Kj) for a female.

There is a nice, quick and easy calorie calculator which will work out how many calories you need per day to maintain your weight. You then take the number of calories, add a little exercise and reduce or alter what you eat and Voila! you will make progress with your weight loss.

To lose pounds and keep them off you need a combination of a healthy eating plan and a fitness plan. The key to long-term weight loss is slow and steady. Research has shown that fast weight loss is not maintained in the long term.

Monitoring your daily caloric intake together with keeping a track of your weight loss can be useful tools towards a lean body. As mentioned above, to track weight loss firstly establish your ideal weight and then make use of the weight loss percentage calculator and a body fat percentage calculator. Make sure that you set realistic and achievable weight loss goals in the first place.

Other methods that have been scientifically proven to REALLY help with achieving long-term weight loss are joining support groups such as Weight Watchers or the biggest loser club.

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Dihydrotestosterone – Wikipedia

Nov 16th, 2018
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This article is about dihydrotestosterone as a hormone. For its use as a medication, see Androstanolone.This article is about 5-dihydrotestosterone, an androgen. For the inactive 5 isomer, see 5-Dihydrotestosterone.DihydrotestosteroneNamesIUPAC name


DHT; 5-Dihydrotestosterone; 5-DHT; Androstanolone; Stanolone; 5-Androstan-17-ol-3-one


Dihydrotestosterone (DHT, 5-dihydrotestosterone, 5-DHT, androstanolone or stanolone) is an endogenous androgen sex steroid and hormone. The enzyme 5-reductase catalyzes the formation of DHT from testosterone in certain tissues including the prostate gland, seminal vesicles, epididymides, skin, hair follicles, liver, and brain. This enzyme mediates reduction of the C4-5 double bond of testosterone. Relative to testosterone, DHT is considerably more potent as an agonist of the androgen receptor (AR).

In addition to its role as a natural hormone, DHT has been used as a medication, for instance in the treatment of low testosterone levels in men; for information on DHT as a medication, see the androstanolone article.

DHT is biologically important for sexual differentiation of the male genitalia during embryogenesis, maturation of the penis and scrotum at puberty, growth of facial, body, and pubic hair, and development and maintenance of the prostate gland and seminal vesicles. It is produced from the less potent testosterone by the enzyme 5-reductase in select tissues, and is the primary androgen in the genitals, prostate gland, seminal vesicles, skin, and hair follicles.[2]

DHT signals mainly in an intracrine and paracrine manner in the tissues in which it is produced, playing only a minor role, if any, as a circulating endocrine hormone.[3][4][5] Circulating levels of DHT are 1/10th and 1/20th those of testosterone in terms of total and free concentrations, respectively,[6] whereas local DHT levels may be up to 10times those of testosterone in tissues with high 5-reductase expression such as the prostate gland.[7] In addition, unlike testosterone, DHT is inactivated by 3-hydroxysteroid dehydrogenase (3-HSD) into the very weak androgen 3-androstanediol in various tissues such as muscle, adipose, and liver among others,[5][8][9] and in relation to this, DHT has been reported to be a very poor anabolic agent when administered exogenously as a medication.[10]

In addition to normal biological functions, DHT also plays an important causative role in a number of androgen-dependent conditions including hair conditions like hirsutism (excessive facial/body hair growth) and pattern hair loss (androgenic alopecia or pattern baldness) and prostate diseases such as benign prostatic hyperplasia (BPH) and prostate cancer.[2] 5-Reductase inhibitors, which prevent DHT synthesis, are effective in the prevention and treatment of these conditions.[13][14][15][16]

Metabolites of DHT have been found to act as neurosteroids with their own AR-independent biological activity.[17] 3-Androstanediol is a potent positive allosteric modulator of the GABAA receptor, while 3-androstanediol is a potent and selective agonist of the estrogen receptor (ER) subtype ER.[17] These metabolites may play important roles in the central effects of DHT and by extension testosterone, including their antidepressant, anxiolytic, rewarding/hedonic, anti-stress, and pro-cognitive effects.[17][18]

Much of the biological role of DHT has been elucidated in studies of individuals with congenital 5-reductase type II deficiency, an intersex condition caused by a loss-of-function mutation in the gene encoding 5-reductase type II, the major enzyme responsible for the production of DHT in the body.[13][19][2] It is characterized by a defective and non-functional 5-reductase type II enzyme and a partial but majority loss of DHT production in the body.[13][19] In the condition, circulating testosterone levels are within or slightly above the normal male range, but DHT levels are low (around 30% of normal),[20][bettersourceneeded] and the ratio of circulating testosterone to DHT is greatly elevated (at about 3.5 to 5times higher than normal).[13]

Genetic males (46,XY) with 5-reductase type II deficiency are born with undervirilization including pseudohermaphroditism (ambiguous genitalia), pseudovaginal perineoscrotal hypospadias, and usually undescended testes. Their external genitalia are female-like, with micropenis (a small, clitoris-like phallus), a partially unfused, labia-like scrotum, and a blind-ending, shallow vaginal pouch.[13] Due to their lack of conspicuous male genitalia, genetic males with the condition are typically raised as girls.[19] At the time of puberty however, they develop striking phenotypically masculine secondary sexual characteristics including partial virilization of the genitals (enlargement of the phallus into a near-functional penis and descent of the testes), voice deepening, typical male musculoskeletal development,[12] and no menstruation, breast development, or other signs of feminization that occur during female puberty.[13][19][2] In addition, normal libido and spontaneous erections develop,[21] they usually show a sexual preference for females, and almost all develop a male gender identity.[13][22]

Nonetheless, males with 5-reductase type II deficiency exhibit signs of continued undervirilization in a number of domains. Facial hair was absent or sparse in a relatively large group of Dominican males with the condition. However, more facial hair has been observed in patients with the disorder from other parts of the world, although facial hair was still reduced relative to that of other men in the same communities. The divergent findings may reflect racial differences in androgen-dependent hair growth. A female pattern of androgenic hair growth, with terminal hair largely restricted to the axillae and lower pubic triangle, is observed in males with the condition. No temporal recession of the hairline or androgenic alopecia (pattern hair loss or baldness) has been observed in any of the cases of 5-reductase type II deficiency that have been reported, whereas this is normally seen to some degree in almost all Caucasian males.[13] Individuals with 5-reductase type II deficiency were initially reported to have no incidence of acne,[8][2] but subsequent research indicated normal sebum secretion and acne incidence.[12]

In genetic males with 5-reductase type II deficiency, the prostate gland is rudimentary or absent, and if present, remains small, underdeveloped, and unpalpable throughout life.[8][4] In addition, neither BPH nor prostate cancer have been reported in these individuals.[14] Genetic males with the condition generally show oligozoospermia due to undescended testes, but spermatogenesis is reported to be normal in those with testes that have descended, and there are case instances of men with the condition successfully fathering children.[21][23]

Unlike males, genetic females with 5-reductase type II deficiency are phenotypically normal. However, similarly to genetic males with the condition, they show reduced body hair growth, including an absence of hair on the arms and legs, slightly decreased axillary hair, and moderately decreased pubic hair.[24][21] On the other hand, sebum production is normal.[24][25] This is in accordance with the fact that sebum secretion appears to be entirely under the control of 5-reductase type I.[25]

5-Reductase inhibitors like finasteride and dutasteride inhibit 5-reductase type II and/or other isoforms and are able to decrease circulating DHT levels by 65 to 98% depending on the 5-reductase inhibitor in question.[26][27][28][20] As such, similarly to the case of 5-reductase type II deficiency, they provide useful insights in the elucidation of the biological functions of DHT.[29] 5-Reductase inhibitors were developed and are used primarily for the treatment of BPH. The drugs are able to significantly reduce the size of the prostate gland and to alleviate symptoms of the condition.[14][30] Long-term treatment with 5-reductase inhibitors is also able to significantly reduce the overall risk of prostate cancer, although a simultaneous small increase in the risk of certain high-grade tumors has been observed.[15] In addition to prostate diseases, 5-reductase inhibitors have subsequently been developed and introduced for the treatment of pattern hair loss in men.[31] They are able to prevent further progression of hair loss in most men with the condition and to produce some recovery of hair in about two-thirds of men.[13] 5-Reductase inhibitors seem to be less effective for pattern hair loss in women on the other hand, although they do still show some effectiveness.[32] Aside from pattern hair loss, the drugs are also useful in the treatment of hirsutism and can greatly reduce facial and body hair growth in women with the condition.[33][16]

5-Reductase inhibitors are overall well-tolerated and show a low incidence of adverse effects.[34] Sexual dysfunction, including erectile dysfunction, loss of libido, and reduced ejaculate volume, may occur in 3.4 to 15.8% of men treated with finasteride or dutasteride.[34][35] A small increase in the risk of affective symptoms including depression, anxiety, and self-harm may be seen.[36][37][38] Both the sexual dysfunction and affective symptoms may be due partially or fully to prevention of the synthesis of neurosteroids like allopregnanolone rather necessarily than due to inhibition of DHT production.[36] A very small risk of gynecomastia has been associated with 5-reductase inhibitors (1.2 to 3.5%).[34][39] Based on reports of 5-reductase type II deficiency in males and the effectiveness of 5-reductase inhibitors for hirsutism in women, reduced body and/or facial hair growth is a likely potential side effect of these drugs in men.[13][16] There are very few studies evaluating the side effects of 5-reductase inhibitors in women. However, due to the known role of DHT in male sexual differentiation, 5-reductase inhibitors may cause birth defects such as ambiguous genitalia in the male fetuses of pregnant women. As such, they are not used in women during pregnancy.[34]

MK-386 is a selective 5-reductase type I inhibitor which was never marketed.[40] Whereas 5-reductase type II inhibitors achieve much higher reductions in circulating DHT production, MK-386 decreases circulating DHT levels by 20 to 30%.[41] Conversely, it was found to decrease sebum DHT levels by 55% in men versus a modest reduction of only 15% for finasteride.[42][43] However, MK-386 failed to show significant effectiveness in a subsequent clinical study for the treatment of acne.[44]

DHT is a potent agonist of the AR, and is in fact the most potent known endogenous ligand of the receptor. It has an affinity (Kd) of 0.25 to 0.5nM for the human AR, which is about 2- to 3-fold higher than that of testosterone (Kd = 0.4 to 1.0nM)[45] and 1530times higher than that of adrenal androgens.[46] In addition, the dissociation rate of DHT from the AR is 5-fold slower than that of testosterone.[47] The EC50 of DHT for activation of the AR is 0.13nM, which is about 5-fold stronger than that of testosterone (EC50 = 0.66nM).[48] In bioassays, DHT has been found to be 2.5- to 10-fold more potent than testosterone.[45]

The terminal half-life of DHT in the body (53minutes) is longer than that of testosterone (34minutes), and this may account for some of the difference in their potency.[49] A study of transdermal DHT and testosterone treatment reported terminal half-lives of 2.83hours and 1.29hours, respectively.[50]

Unlike other androgens such as testosterone, DHT cannot be converted by the enzyme aromatase into an estrogen like estradiol. Therefore, it is frequently used in research settings to distinguish between the effects of testosterone caused by binding to the AR and those caused by testosterone’s conversion to estradiol and subsequent binding to and activation of ERs.[51] Although DHT cannot be aromatized, it is still transformed into metabolites with significant ER affinity and activity. These are 3-androstanediol and 3-androstanediol, which are predominant agonists of the ER.[17]

DHT is synthesized irreversibly from testosterone by the enzyme 5-reductase.[8][13] This occurs in various tissues including the genitals (penis, scrotum, clitoris, labia majora),[53] prostate gland, skin, hair follicles, liver, and brain.[8] Around 5 to 7% of testosterone undergoes 5-reduction into DHT,[54][55] and approximately 200 to 300g of DHT is synthesized in the body per day. Most DHT is produced in peripheral tissues like the skin and liver, whereas most circulating DHT originates specifically from the liver. The testes and prostate gland contribute relatively little to concentrations of DHT in circulation.[8]

There are two major isoforms of 5-reductase, SRD5A1 (type I) and SRD5A2 (type II), with the latter being the most biologically important isoenzyme.[8] There is also third 5-reductase: SRD5A3.[56] SRD5A2 is most highly expressed in the genitals, prostate gland, epididymides, seminal vesicles, genital skin, facial and chest hair follicles,[57][58] and liver, while lower expression is observed in certain brain areas, non-genital skin/hair follicles, testes, and kidneys. SRD5A1 is most highly expressed in non-genital skin/hair follicles, the liver, and certain brain areas, while lower levels are present in the prostate, epididymides, seminal vesicles, genital skin, testes, adrenal glands, and kidneys.[8] In the skin, 5-reductase is expressed in sebaceous glands, sweat glands, epidermal cells, and hair follicles.[57][58] Both isoenzymes are expressed in scalp hair follicles,[59] although SRD5A2 predominates in these cells.[58] The SRD5A2 subtype is the almost exclusive isoform expressed in the prostate gland.[60][20]

The plasma protein binding of DHT is more than 99%. In men, approximately 0.88% of DHT is unbound and hence free, while in premenopausal women, about 0.470.48% is unbound. In men, DHT is bound 49.7% to sex hormone-binding globulin (SHBG), 39.2% to albumin, and 0.22% to corticosteroid-binding globulin (CBG), while in premenopausal women, DHT is bound 78.178.4% to SHBG, 21.021.3% to albumin, and 0.12% to CBG. In late pregnancy, only 0.07% of DHT is unbound in women; 97.8% is bound to SHBG while 2.15% is bound to albumin and 0.04% is bound to CBG.[61][62] DHT has higher affinity for SHBG than does testosterone, estradiol, or any other steroid hormone.[63][62]

DHT is inactivated in the liver and extrahepatic tissues like the skin into 3-androstanediol and 3-androstanediol by the enzymes 3-hydroxysteroid dehydrogenase and 3-hydroxysteroid dehydrogenase, respectively.[8][64] These metabolites are in turn converted, respectively, into androsterone and epiandrosterone, then conjugated (via glucuronidation and/or sulfation), released into circulation, and excreted in urine.[8]

Unlike testosterone, DHT cannot be aromatized into an estrogen like estradiol, and for this reason, has no propensity for estrogenic effects.[65]

DHT is excreted in the urine as metabolites, such as conjugates of 3-androstanediol and androsterone.[66][8]

Serum DHT levels are about 10% of those of testosterone, but levels in the prostate gland are 5- to 10-fold higher than those of testosterone due to a more than 90% conversion of testosterone into DHT by locally expressed 5-reductase.[7] For this reason, and in addition to the fact that DHT is much more potent as an AR agonist than is testosterone,[45] DHT is considered to be the major androgen of the prostate gland.[7]

DHT is available in pharmaceutical formulations for medical use as an androgen or anabolicandrogenic steroid (AAS).[67] It is used mainly in the treatment of male hypogonadism.[68] When used as a medication, dihydrotestosterone is referred to as androstanolone (INN) or as stanolone (BAN),[67][69][70] and is sold under brand names such as Andractim among others.[67][69][70][68][71] The availability of pharmaceutical DHT is limited; it is not available in the United States or Canada,[72][73] but is available in certain European countries.[70][68] The available formulations of DHT include buccal or sublingual tablets, topical gels, and, as esters in oil, injectables like androstanolone propionate and androstanolone valerate.[67][68][71]

DHT, also known as 5-androstan-17-ol-3-one, is a naturally occurring androstane steroid with a ketone group at the C3 position and a hydroxyl group at the C17 position. It is the derivative of testosterone in which the double bond between the C4 and C5 positions has been reduced or hydrogenated.

DHT was first synthesized by Adolf Butenandt and his colleagues in 1935.[74][75] It was prepared via hydrogenation of testosterone,[75] which had been discovered earlier that year.[76] DHT was introduced for medical use as an AAS in 1953, and was noted to be more potent than testosterone but with reduced androgenicity.[77][78][79] It was not elucidated to be an endogenous substance until 1956, when it was shown to be formed from testosterone in rat liver homogenates.[75][80] In addition, the biological importance of DHT was not realized until the early 1960s, when it was found to be produced by 5-reductase from circulating testosterone in target tissues like the prostate gland and seminal vesicles and was found to be more potent than testosterone in bioassays.[81][82][83][84] The biological functions of DHT in humans became much more clearly defined upon the discovery and characterization of 5-reductase type II deficiency in 1974.[14] DHT was the last major sex hormone, the others being testosterone, estradiol, and progesterone, to be discovered, and is unique in that it is the only major sex hormone that functions principally as an intracrine and paracrine hormone rather than as an endocrine hormone.[85]

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Dihydrotestosterone – Wikipedia