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First Defendant Charged With Violating Anti-Doping Act Pleads … – Department of Justice

May 12th, 2023
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Damian Williams, the United States Attorney for the Southern District of New York, announced that defendant ERIC LIRA pled guilty today for his role in providing banned performance-enhancing drugs (PEDs) to Olympic athletes in advance of the 2020 Olympic Games held in Tokyo in the summer of 2021. LIRA is the first defendant to be charged under the Rodchenkov Anti-Doping Act, signed into law on December 4, 2020, which proscribes doping schemes for the purpose of influencing international sports competitions, including the Olympic Games. LIRA pled guilty before U.S. Magistrate Judge Valerie Figueredo.

U.S. Attorney Damian Williams said:This conviction is a watershed moment for international sport. Lira provided banned performance-enhancing substances to Olympic athletes who wanted to corruptly gain a competitive edge. Such craven efforts to undermine the integrity of sport subverts the purpose of the Olympic games: to showcase athletic excellence through a level playing field. Liras efforts to pervert that goal will not go unpunished.

According to the allegations contained in the Complaint, the Indictment, other filings in this case, and statements during court proceedings:

The charges in this case arise from an investigation of a scheme to provide Olympic athletes with PEDs, including drugs widely banned throughout competitive sports, such as human growth hormone and the blood building drug erythropoietin, in advance of and for the purpose of corrupting the 2020 Olympic Games, which convened in Tokyo in the summer of 2021. LIRA, who claims to be a kinesiologist and naturopathic doctor operating principally in and around El Paso, Texas, obtained unapproved versions of these, and other, prescription drugs from sources in Central and South America before bringing those drugs into the United States and distributing them to, among others, the two athletes referred to in the Indictment. Throughout the scheme, LIRA and an athlete competing for Nigeria communicated via encrypted electronic communications regarding the sale, shipment, and use of LIRAs illegal drugs and specifically discussed the testability of those drugs by anti-doping authorities. LIRA separately communicated with an athlete competing for Switzerland, also via encrypted electronic communications, discussing the use of human growth hormone and erythropoietin. Both athletes tested positive for prohibited substances, and in both cases, LIRA directly and indirectly advised that the athletes should blame the positive drug test on contaminated meat, knowing full well that the drug tests had accurately detected the presence of banned, performance-enhancing drugs.

LIRA is the first defendant charged and convicted pursuant to the recently enacted Rodchenkov Act. On December 4, 2020, the Rodchenkov Act was signed into law, Pub. L. 116-206, and incorporated into Title 21 of the United States Code at sections 2401 through 2404. The Rodchenkov Act prohibits any person, other than an athlete, to knowingly carry into effect, attempt to carry into effect, or conspire with any other person to carry into effect a scheme in commerce to influence by use of a prohibited substance or prohibited method any major international sports competition. 21 U.S.C. 2402.

* * *

LIRA, 43, of El Paso, Texas, pled guilty to violating the Rodchenkov Act, which carries a maximum potential sentence of 10 years in prison.

The maximum potential sentence is prescribed by Congress and is provided here for informational purposes only, as any sentencing of the defendant will be determined by a judge.

Mr. Williams praised the outstanding investigative work of the Federal Bureau of Investigation (FBI) and the FBIs Integrity in Sports and Gaming Initiative. Mr. Williams also thanked the United States Anti-Doping Agency for their support of this investigation.

This case is being handled by the Offices Money Laundering and Transnational Criminal Enterprises Unit. Assistant U.S. Attorneys Sarah Mortazavi and Benjamin Gianforti are in charge of the prosecution.

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First Defendant Charged With Violating Anti-Doping Act Pleads ... - Department of Justice



MeiraGTx Reports First Quarter 2023 Financial and Operational Results – Yahoo Finance

May 12th, 2023
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Raised approximately $60 million in a private placement in May 2023 with investors consisting of several of the Companys top shareholders

On track for BLA submission of botaretigene sparoparvovec (bota-vec, formerly AAV-RPGR) for the treatment of X-linked retinitis pigmentosa (XLRP) in 2024

Company will present 12-month data from bilateral treated cohorts from the AQUAx AAV-hAQP1 Phase 1 study for treatment of Grade 2/3 radiation-induced xerostomia in the second quarter of 2023

Upcoming poster presentations at the American Society of Gene and Cell Therapy (ASGCT) 2023 Annual Meeting highlight the depth and novelty of MeiraGTxs technology platforms for gene and cell therapy

LONDONandNEW YORK, May 11, 2023 (GLOBE NEWSWIRE) -- MeiraGTx Holdings plc(Nasdaq: MGTX), a vertically integrated, clinical stage gene therapy company, today announced financial and operational results for the first quarter ended March 31, 2023, and provided a corporate update.

We are off to a strong start this year with progress across multiple clinical-stage programs and a growing body of data supporting our proprietary gene regulation technology, said Alexandria Forbes, Ph.D., president and chief executive officer of MeiraGTx. Enrollment of the pivotal Lumeos Phase 3 study is going well and we remain on track for a BLA filing in 2024. We are also excited to be progressing towards later stage studies in our wholly-owned programs, including a randomized, double-blind, placebo-controlled, Phase 2 study for the treatment of Grade 2/3 radiation-induced xerostomia, and our randomized, sham-controlled bridging study for our Parkinsons disease program.

Dr. Forbes continued, At this years ARVO Annual Meeting, we presented data from our AI-driven promoter discovery platform illustrating our ability to precisely target specific cells and expression levels with synthetic promoters. In addition we presented immune-response data from the Phase 1/2 trial for the investigational gene therapy bota-vec in patients with XLRP associated with mutations in the RPGR gene. We are also pleased that nine poster presentations showcasing our novel gene and cell therapy platforms will be presented at the upcoming ASGCT Annual Meeting, including the application of our riboswitch technology to precisely regulate CAR-Ts. We are also presenting data demonstrating efficacy in animal models of vector delivered human growth hormone and anti-HER2 antibody in tight dose response to an orally dosed small molecule inducer. This provides support for the broad applicability of our riboswitch gene regulation platform for therapeutic delivery of a range of biologic drugs and cell therapies with enhanced safety and efficacy.

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Recent Development Highlights and Anticipated Milestones

Bota-vec for the Treatment of XLRP:

In late April, immune-response data from a Phase 1/2 MGT009 clinical trial (NCT03252847) were presented at the Association for Research in Vision and Ophthalmology (ARVO) 2023 Annual Meeting.

Dosing in the pivotal Phase 3 LUMEOS clinical trial of bota-vec continues and the program remains on track for a BLA submission in 2024.

AAV-hAQP1 for the Treatment of Grade 2/3 Radiation-Induced Xerostomia:

MeiraGTx reported positive clinical data from the AQUAx Phase 1 clinical trial in December 2022, and remains on track to present the full data from the AQUAx Phase 1 study in the second quarter of 2023, including the 12 month data from bilaterally treated subjects.

Based on the favorable safety and efficacy profile of AAV-hAQP1 in the AQUAx Phase 1 study, the Company intends to initiate a randomized, double-blind, placebo-controlled, Phase 2 study evaluating the bilateral administration of two active doses of AAV-hAQP1 in the second quarter of 2023.

AAV-GAD for the Treatment of Parkinsons Disease:

The Company is now dosing patients in the AAV-GAD clinical trial under a new IND with material manufactured in its cGMP facility in London, United Kingdom using MeiraGTxs proprietary production process.

The AAV-GAD trial is a three arm randomized Phase 1 clinical bridging study with subjects randomized to sham control or one of two doses of AAV-GAD.

The objective of the AAV-GAD trial (NCT05603312) is to evaluate the safety and tolerability of AAV-GAD manufactured at MeiraGTxs cGMP facility in London, United Kingdom when delivered to the subthalamic nucleus (STN) of patients with Parkinson's disease.

Completion of enrollment is anticipated in the third quarter of 2023.

Riboswitch Gene Regulation Platform & Vector Engineering:

The Company will exhibit nine poster presentations at the ASGCT 2023 Annual Meeting, including data demonstrating the ability to regulate CAR-T driving increased efficacy and reduced exhaustion in vitro.

ASGCT posters will also show data demonstrating rescue of B.little mouse model via hGH activated using an orally delivered small molecule, as well as AAV-mediated riboswitch-controlled delivery of anti-HER2 antibody suppressing HER2-positive tumorigenesis in a dose response to an orally delivered small molecule.

The Companys next-generation riboswitch-based gene regulation platform can be used to precisely control the expression of any gene delivered in any context with an unprecedented dynamic range using novel, synthetic, orally delivered small molecules.

The Company now has over 40 novel orally available small molecules with high specificity and potency to its riboswitch aptamers moving through PK, biodistribution, and toxicology studies, with the first GMP material for IND currently being manufactured. Two of these small molecules show good brain penetrance to enable activation of genes within the blood brain barrier.

Recent Corporate Developments In May 2023, MeiraGTx closed the previously announced private investment in public equity (PIPE) financing, raising approximately $60 million in aggregate gross proceeds. The financing was entirely led by several of the Companys top holders Perceptive Advisors, Adage Capital, Prosight Management, and 683 Capital Management.

For more information related to our clinical trials, please visit

In addition to the proceeds from the PIPE financing, MeiraGTx had cash and cash equivalents of approximately $68.8 million, as well as approximately $36.3 million in receivables due from Janssen. The Company believes that with such funds, as well as anticipated milestones from Janssen, it will have sufficient capital to fund operating expenses and capital expenditure requirements into the second quarter of 2025.

Financial Results

Cash and cash equivalents were $68.8 million as of March 31, 2023, compared to $115.5 million as of December 31, 2022.

License revenue was $3.3 million for the quarter ended March 31, 2023, compared to $5.6 million for the quarter ended March 31, 2022. This decrease represents decreased amortization of the $100.0 million upfront payment as well as decreased amortization of the $30.0 million milestone payment received in connection with the Janssen collaboration.

General and administrative expenses were $12.8 million for the three months ended March 31, 2023, compared to $11.3 million for the three months ended March 31, 2022. The increase of $1.5 million was primarily due to an increase in legal and accounting fees, consulting fees and other office related costs. These increases were partially offset by decreases in share-based compensation, insurance costs and payroll and payroll-related costs.

Research and development expenses for the three months ended March 31, 2023 were $22.3 million, compared to $23.1 million for the three months ended March 31, 2022. The decrease of $0.8 million was primarily due to a decrease in expenses related to our preclinical programs primarily due to the timing of expenses in our gene regulation program and a decrease in other research and development expenses primarily due to a decrease in share-based compensation, as well as an increase in research funding provided under our Janssen collaboration primarily due to the increase in expenses incurred related to our program for bota-vec for the treatment of XLRP. These decreases were partially offset by an increase in clinical trial expenses primarily due to an increase in expenses related to our Phase 3 Lumeos clinical trial of bota-vec and our expanded Phase 1 clinical trial and Phase 2 clinical trial for AAV-hAQP1, as well as an increase in manufacturing expenses primarily due to the commencement of operations at our Shannon, Ireland manufacturing facility in 2022.

Foreign currency gain was $3.9 million for the three months ended March 31, 2023, compared to a loss of $2.6 million for the three months ended March 31, 2022. The change of $6.5million was primarily due to an unrealized gain on the quarterly valuation of intercompany payables and receivables due to the weakening of the U.S. dollar against the pound sterling and euro during the three months ended March 31, 2023.

Net loss attributable to ordinary shareholders for the quarter ended March 31, 2023 was $30.4 million, or $0.62 basic and diluted net loss per ordinary share, compared to a net loss attributable to ordinary shareholders of $31.0 million, or $0.70 basic and diluted net loss per ordinary share for the quarter ended March 31, 2022.

About MeiraGTxMeiraGTx (Nasdaq: MGTX) is a vertically integrated, clinical-stage gene therapy company with six programs in clinical development and a broad pipeline of preclinical and research programs. MeiraGTx has core capabilities in viral vector design and optimization and gene therapy manufacturing, and a transformative gene regulation platform technology that allows precise, dose responsive control of gene expression by oral small molecules with dynamic range that can exceed 5000-fold. Led by an experienced management team, MeiraGTx has taken a portfolio approach by licensing, acquiring, and developing technologies that give depth across both product candidates and indications. MeiraGTxs initial focus is on three distinct areas of unmet medical need: ocular diseases, including both inherited retinal diseases as well as large degenerative ocular diseases, neurodegenerative diseases and severe forms of xerostomia. Though initially focusing on the eye, central nervous system, and salivary gland, MeiraGTx plans to expand its focus to develop additional gene therapy treatments for patients suffering from a range of serious diseases.

For more information, please visit

Forward Looking StatementThis press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements contained in this press release that do not relate to matters of historical fact should be considered forward-looking statements, including, without limitation, statements regarding our product candidate development and anticipated milestones regarding our pre-clinical and clinical data, reporting of such data and the timing of results of data and regulatory matters, as well as statements that include the words expect, will, intend, plan, believe, project, forecast, estimate, may, could, should, would, continue, anticipate and similar statements of a future or forward-looking nature. These forward-looking statements are based on managements current expectations. These statements are neither promises nor guarantees, but involve known and unknown risks, uncertainties and other important factors that may cause actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements, including, but not limited to, our incurrence of significant losses; any inability to achieve or maintain profitability, raise additional capital, repay our debt obligations, identify additional and develop existing product candidates, successfully execute strategic priorities, bring product candidates to market, expansion of our manufacturing facilities and processes, successfully enroll patients in and complete clinical trials, accurately predict growth assumptions, recognize benefits of any orphan drug designations, retain key personnel or attract qualified employees, or incur expected levels of operating expenses; the impact of the COVID-19 pandemic on the status, enrollment, timing and results of our clinical trials and on our business, results of operations and financial condition; failure of early data to predict eventual outcomes; failure to obtain FDA or other regulatory approval for product candidates within expected time frames or at all; the novel nature and impact of negative public opinion of gene therapy; failure to comply with ongoing regulatory obligations; contamination or shortage of raw materials or other manufacturing issues; changes in healthcare laws; risks associated with our international operations; significant competition in the pharmaceutical and biotechnology industries; dependence on third parties; risks related to intellectual property; changes in tax policy or treatment; our ability to utilize our loss and tax credit carryforwards; litigation risks; and the other important factors discussed under the caption Risk Factors in our Quarterly Report on Form 10-Q for the quarter ended March 31, 2023, as such factors may be updated from time to time in our other filings with the SEC, which are accessible on the SECs website at These and other important factors could cause actual results to differ materially from those indicated by the forward-looking statements made in this press release. Any such forward-looking statements represent managements estimates as of the date of this press release. While we may elect to update such forward-looking statements at some point in the future, unless required by law, we disclaim any obligation to do so, even if subsequent events cause our views to change. Thus, one should not assume that our silence over time means that actual events are bearing out as expressed or implied in such forward-looking statements. These forward-looking statements should not be relied upon as representing our views as of any date subsequent to the date of this press release.



Media:Jason Braco, Ph.D.LifeSci


FortheThree-Month Period Ended March31,



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Operating expenses:

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MeiraGTx Reports First Quarter 2023 Financial and Operational Results - Yahoo Finance



Healthcare Specialty Enzymes Market to Reach USD 3.5 Billion by 2032 with 7.2% CAGR: Reports and Data – EIN News

May 12th, 2023
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The global healthcare specialty enzymes market size was USD 1.86 Billion in 2022 and is expected to reach USD 3.5 Billion by 2032, and register a CAGR of 7.2%

Specialized enzymes are utilized in a broad range of processes, such as the production of food and beverages, textiles, detergents, paper and pulp, and animal feed, among others. In healthcare, enzymes are employed for research, diagnostics, medicines, and biotechnology. The pharmaceutical industry uses enzymes to produce biologics, which are increasingly being used to treat chronic diseases like cancer, autoimmune disorders, and rare genetic diseases. Enzyme replacement therapy (ERT) is also becoming more popular, with successful treatment of genetic disorders like Gaucher disease, Fabry disease, and Pompe disease, among others.

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Market revenue growth is also being driven by the rising demand for personalized treatment. Enzymes play a crucial role in creating biologics tailored to an individual's unique needs, as they are employed in the development of personalized medicine. Additionally, increasing research and development expenditures and the emphasis on creating novel specialty enzymes are driving market revenue growth. Industry participants are investing heavily in R&D to develop new specialty enzymes that can be used in a variety of ways. However, new entrants may face entry barriers due to the technical and specialized nature of the industry, the focus on R&D, and the scarcity of skilled professionals.

Segments Covered in the Report

Type Outlook:

The global healthcare specialty enzymes market can be segmented into four types: protease, lipase, carbohydrase, and others. Protease, which is used in the breakdown of proteins, is expected to generate the highest revenue during the forecast period. In 2019, the revenue generated from protease was USD 0.6 billion, which is projected to reach USD 1.1 billion by 2032. Lipase, which breaks down fats, is the second-largest revenue-generating type, with a projected revenue of USD 0.9 billion by 2032. Carbohydrase, which breaks down carbohydrates, is expected to experience significant growth during the forecast period, with a projected revenue of USD 0.6 billion by 2032.

Application Outlook:

The healthcare specialty enzymes market can also be segmented based on application into four categories: digestive health, pharmaceuticals, research and biotechnology, and others. Digestive health is expected to generate the highest revenue during the forecast period, with a projected revenue of USD 1.3 billion by 2032. The increasing prevalence of digestive disorders and the demand for digestive enzyme supplements are the primary drivers of revenue growth in this segment. The pharmaceutical industry uses specialty enzymes to create biologics, and the segment is projected to generate revenue of USD 0.9 billion by 2032. The research and biotechnology segment is expected to experience significant growth, with a projected revenue of USD 0.8 billion by 2032. Enzymes are utilized in a variety of research applications, including genomics, proteomics, and drug discovery. The "others" segment, which includes applications in the food and beverage industry and animal feed, is projected to generate revenue of USD 0.5 billion by 2032.

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Strategic development:

Roche Holding AG made a significant move in its diagnostic portfolio and the molecular diagnostics market by acquiring TIB Molbiol GmbH, a top supplier of PCR assays. This acquisition, which took place on September 9, 2021, is expected to enhance Roche's presence in the field.

Bristol-Myers Squibb Company announced a strategic partnership with Schrdinger, a well-known provider of sophisticated molecular simulations and Machine Learning (ML) software, on June 17, 2021. The collaboration was aimed at speeding up drug discovery and development by combining Schrdinger's expertise in computational chemistry with Bristol-Myers Squibb's experience in drug discovery and development.

Competitive Landscape:

The global healthcare specialty enzymes market is highly competitive and has numerous large and medium-sized players that contribute a significant share of market revenue. The report includes several major companies that are involved in the market, including Abbott Laboratories, BASF SE, Bristol-Myers Squibb Company, Danisco A/S, DSM N.V., E. I. du Pont de Nemours and Company, Johnson & Johnson, Lonza Group AG, Neutrogena Corporation, Novo Nordisk A/S, and Roche Holding AG.

These major players are employing a variety of strategies to remain competitive in the market, such as mergers and acquisitions, strategic agreements and contracts, and the development, testing, and introduction of more effective products. These strategies allow them to expand their market presence and increase their revenue.

Furthermore, these companies are also investing heavily in research and development to create innovative and advanced products that can cater to the increasing demand for personalized treatment and specialized enzymes. This is expected to help the companies to maintain their market position and increase their market share.

The global healthcare specialty enzymes market is highly competitive and has numerous large and medium-sized players that contribute a significant share of market revenue. The report includes several major companies that are involved in the market, including Abbott Laboratories, BASF SE, Bristol-Myers Squibb Company, Danisco A/S, DSM N.V., E. I. du Pont de Nemours and Company, Johnson & Johnson, Lonza Group AG, Neutrogena Corporation, Novo Nordisk A/S, and Roche Holding AG.

These major players are employing a variety of strategies to remain competitive in the market, such as mergers and acquisitions, strategic agreements and contracts, and the development, testing, and introduction of more effective products. These strategies allow them to expand their market presence and increase their revenue.

Furthermore, these companies are also investing heavily in research and development to create innovative and advanced products that can cater to the increasing demand for personalized treatment and specialized enzymes. This is expected to help the companies to maintain their market position and increase their market share.

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Overall, the global healthcare specialty enzymes market is expected to witness significant growth during the forecast period due to the increasing prevalence of chronic diseases and the growing demand for personalized medicine. The major players in the market are well-positioned to take advantage of this growth by implementing effective strategies and investing in research and development.

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Healthcare Specialty Enzymes Market to Reach USD 3.5 Billion by 2032 with 7.2% CAGR: Reports and Data - EIN News



Inside The Tragic Death Of Anna Nicole Smith And The Drug … – All That’s Interesting

May 12th, 2023
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A former Playboy model and television personality, Anna Nicole Smith was "famous for being famous" then she was found dead of an accidental drug overdose.

On February 8, 2007, 39-year-old model, actress, and former Playboy Playmate of the Year Anna Nicole Smith died in Hollywood, Florida. She was declared dead shortly after being found unresponsive in her room at the Seminole Hard Rock Hotel and Casino. In the days leading up to her death, Smith had suffered from multiple health issues, including stomach flu, a fever that reached 105 degrees, and an infection on her backside.

But instead of going to the hospital, she took a cocktail of at least nine different prescription medications, including chloral hydrate, a powerful liquid sedative that had also likely played a role in legendary Hollywood star Marilyn Monroes death. It was bitterly ironic as Anna Nicole Smith had always dreamt of becoming the next Marilyn Monroe someday.

Like Monroe before her, Smith dominated news headlines. Her blonde hair and curves captivated the public, and the media took a deep interest in her personal life. Part of this interest was likely due to Smiths ongoing legal battle to acquire a share of her deceased husbands fortune the 90-year-old oil tycoon J. Howard Marshall II, whom she married in 1994.

Smith, like Monroe, also appeared in several movies, mostly comedies, including Naked Gun 33 1/3: The Final Insult alongside Leslie Nielsen and Priscilla Presley and The Hudsucker Proxy alongside Tim Robbins and Paul Newman. She later starred in her own reality television series in 2002, The Anna Nicole Show, which followed her through her daily life.

During the early 2000s, Smiths star continued to rise, and she was ecstatic to give birth to her daughter Dannielynn on September 7, 2006. But just three days later, her older son, 20-year-old Daniel, died of a drug overdose. Soon afterward, a series of legal battles complicated her life once again.

And just six months after her sons untimely demise, Anna Nicole Smiths death from a drug overdose would make headlines all over the world.

Anna Nicole Smith was born Vickie Lynn Hogan on November 28, 1967, in Houston, Texas. Her father, Donald Hogan, wasnt around much while she was growing up, leaving her mother Virgie Arthur to take care of her.

Speaking with ABC News, Vickie Lynn Hogans childhood best friend Jo McLemore recalled, Vickies childhood life was tough. [Her mother] was very forthright and very strict. And when Hogan turned 15, her mother sent her to live with her aunt in the small town of Mexia, Texas.

Vickie Lynn Hogan didnt mesh with Mexia. She struggled with being bullied, and she longed to get out and make something of herself. Eventually, though, shed had enough with school and dropped out during sophomore year, taking a job at a local fried chicken joint, Jims Krispy Fried Chicken.

When she started working here, we immediately hit it off, McLemore said. One of the memories I have of her is, wed sit here together and stare out the window, and just watch traffic go by. She was so perfect to me.

It was at Krispys that Vickie Lynn Hogan met her first husband Billy Smith, a fellow dropout. She was 17, and he was 16 when they first started dating. Soon, the teens were married, and Vickie Lynn Hogan became Vickie Lynn Smith. The couple welcomed a son, Daniel, when Vickie Lynn was 18.

But another year later, the couple separated, and Vickie Lynn Smith took Daniel with her back to Houston. Smiths mother looked after Daniel while Smith took a job as a dancer at a local strip club to provide for her son.

Then, in 1991, an 86-year-old billionaire named J. Howard Marshall II was wheeled into that club. His wife had recently died, and so had his longtime mistress. Smith agreed to dance for the wealthy octogenarian, and soon enough, he was showering her with gifts and asking her to marry him.

At first, she said no. Before Smith got married again, she wanted to try to make a name for herself on her own. And just one year later, she did.

In 1992, two major milestones happened in the future Anna Nicole Smiths life. Playboy hired her after she mailed in naked photos of herself, and later that year, the fashion brand Guess asked her to model in a series of ads. Her image in the ads was remarkably similar to Marilyn Monroes look.

It was around this time that an agent suggested that Vickie Lynn change her name to Anna Nicole to further help her career, and she agreed to do so.

As a profile on Smith at Biography says, her image drew tons of attention across America. She was the ultimate blonde bombshell.

She was so popular, in fact, that in 1993 she was named Playboys Playmate of the Year. The next year, she made the move into small film roles. Meanwhile, celebrity magazines and tabloids couldnt get enough of her.

Smith, for her part, didnt seem to mind, saying, I love the paparazzi. They take pictures, and I just smile away. Ive always liked attention. I didnt get very much growing up, and I always wanted to be, you know, noticed.

But life as a Hollywood celebrity wasnt all glamorous.

In 1994, Anna Nicole Smith finally agreed to J. Howard Marshall IIs marriage proposal. By then, he was 89 years old. Smith was only 26. Naturally, the marriage came with media scrutiny accusing Smith of marrying Marshall to get her hands on his fortune, knowing that he would probably die soon.

The marriage was indeed short-lived. Marshall died at age 90 in 1995, but he had not included Smith in his will. His son E. Pierce Marshall had been given power of attorney, and Smith spent several years battling him in court for her share of her late husbands estate, claiming that E. Pierce had been the reason why she hadnt been included in the will. The case eventually found its way to the U.S. Supreme Court in 2006. But as The Guardian reported, this issue was still unresolved at the time of Anna Nicole Smiths death.

Amid the ongoing legal battle with her deceased husbands family, however, Smiths personal life remained a focal point for the press especially when she was treated for substance abuse. Smith had been prescribed a variety of medications to treat migraines, stomach problems, seizures, and back pain that she was experiencing as a result of her breast implants. The media latched onto this and simultaneously attacked Smith for gaining weight.

Its hard. I mean, I went through a lot. You know, people, when I gained a lot of weight people thought I was just like, partying, doing this and that, she said in 2000. I mean, Im having seizures, Im having panic attacks.

Still, Anna Nicole Smith remained in the public eye, jumping headfirst into reality TV on E! Television Network. Her series, The Anna Nicole Show, drew in curious audiences and offered insight into Smiths daily life.

The show ran for 28 episodes between 2002 and 2004, but Smith still found herself directionless and searching for the next big thing. And many viewers noted that she frequently seemed confused or disoriented on the show.

In 2003, Smith worked with the weight loss brand, TrimSpa, as a spokesperson. During the course of the campaign, she lost 69 pounds and found renewed energy in her career. Her love life seemed to be looking up, too. She began dating a photographer named Larry Birkhead, and although Birkhead was smitten with her, their relationship didnt last.

At the time, Smith was living with her son Daniel, her assistant, and her attorney/publicist/manager Howard K. Stern. Birkhead moved into the home with Smith, and shortly thereafter, Smith became pregnant with her second child. But around this time, she started to push Birkhead away.

Toward the end of her pregnancy, she and Stern moved to the Bahamas. There, on September 7, 2006, she gave birth to her daughter Dannielynn. Stern, who was said to be the father, was with Smith in the delivery room.

Smiths son Daniel joined her two days later as she was in recovery, but the next day, Smith woke up to find Daniel dead next to her. He had died of a drug overdose, but it was never made clear where he got the drugs from. The loss devastated her. The media reported on Daniel Smiths death heavily.

Anna Nicole Smith then became embroiled in another legal battle, this time over her newborn daughter. Birkhead, now Smiths ex-boyfriend, claimed that he was Dannielynns father. Smith insisted that Dannielyns father was her current partner Howard K. Stern. But while Stern was officially listed on Dannielynns birth certificate, the issue of her paternity was far from settled.

In early 2007, Anna Nicole Smith was interested in purchasing a boat and decided to go to Florida with Stern and a group of friends to buy one there. But while traveling to Hollywood, Florida on February 5th, she became ill. Her backside began to ache, likely because she had just gotten injections for vitamin B12 and human growth hormone there before she left.

By the time she arrived in Florida, she had a fever of 105 degrees. This was likely brought on by the pus-filled infection on her buttocks from the injections of so-called longevity drugs, according to The New York Times.

Over the course of a few days, Smith suffered a number of other health issues in her room at the Seminole Hard Rock Hotel and Casino, including stomach flu and pungent sweating. Though many of her friends who she had traveled with urged her to go to the hospital, Smith refused.

Birkhead, Smiths ex-boyfriend, later speculated that she didnt go to the hospital out of fear that there would be a big headline in the news about her poor health and she didnt want her illness to be publicized.

Instead, she chose to self-medicate with at least nine different prescription drugs, including chloral hydrate, a powerful sleep aid that was popular in the 19th century but is rarely prescribed in modern times. According to TODAY, Smith was known to drink this liquid sedative directly out of the bottle.

Sadly, this would lead to Anna Nicole Smiths death on February 8, 2007. That day, Stern had briefly left the hotel to keep the couples appointment about the boat they wanted to buy. Smiths friends remained to keep an eye on her and they eventually realized that she was unconscious and not breathing.

The wife of Smiths bodyguard called her husband, who then alerted Stern. The bodyguards wife then tried to resuscitate Smith. It wasnt until the bodyguard arrived that 911 was called, and about 40 minutes total passed before first responders came to transport Smith to the hospital. By then, it was too late Anna Nicole Smith had died of an accidental drug overdose.

And even after her death, the drama surrounding Smiths life continued. The question of Dannielynns paternity went to court, and in April 2007, a DNA test confirmed that the girls biological father was Larry Birkhead. Stern did not contest the ruling and supported Birkhead gaining custody of the girl.

However, Stern later faced legal trouble for his role in enabling Smiths prescription drug addiction. According to ABC News, both he and Smiths psychiatrist Dr. Khristine Eroshevich were both found guilty of conspiracy to give prescription drugs to a known addict in 2010. Smiths doctor Sandeep Kapoor was also charged in connection with the case, but he was acquitted.

In the years since then, Anna Nicole Smiths life has remained a subject of fascination. Like many other famous women before her, Smith is seen as a prime example of a woman who died far too young, and whose troubled life contrasted sharply with her public persona. In the end, her dream of becoming the next Marilyn Monroe was, unfortunately, realized a bit too fully.

After reading about the life and death of Anna Nicole Smith, read about the tragic death of her idol, Marilyn Monroe. Then, explore the tragic life and infamous death of another iconic Hollywood actress, Lupe Vlez.

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Mama June Shannon Reveals Whether or Not Shed Use Ozempic to Lose Weight – Life&Style Weekly

May 12th, 2023
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With so many celebrities rumored to be taking Ozempic to lose weight, June Mama June Shannon has shared her thoughts on the drug and whether or not shed use it to drop additional pounds.

I dont want to try Ozempic because, honestly, Ive heard about so many bad side effects, June, 43, told the Daily Mail in an interview published on Thursday, May 11.

It is using a drug that isnt really prescribed to do that. Theyre using a diabetic drug to take care of weight loss, the From Not to Hot star continued about the semaglutide.

As a recovering drug addict, June said she would feel uncomfortable taking the once a week injectable. No offense to people out there that are doing it, but its just not for me. I want to stay clean. Im not judging anyone but its not for me. The TLC star is currently three years sober after completing a rehab stint inFebruary 2020.

When it comes to her current weight, June revealed where shes at. Ive only put on back on 100 pounds and I was actually putting back on that weight before I got sober. Ive literally been at 241 pounds for almost two years, God pretty much wants me where Im at right now.

Eventually in your weight loss journey, you hit a sort of plateau and Ive plateaued at 241. I dont drink soda, I dont drink tea, I dont snack like I used to and all that. I dont move on the scale now, front or back, she continued.

A number of high profile celebrities have admitted to using Ozempic with dramatic results.

Tesla founder Elon Musk lost 30 pounds through its use. In a November 2022 tweet when asked by a fan what his weight loss secret was, theTwitter ownerresponded, Fasting + Ozempic/Wegovy plus no tasty food near me. Ozempic and Wegovy are the same semaglutide medication, but the latter is available in higher doses.

Real Housewives of New JerseystarDolores Catania credited Ozempic for her weight loss and newly slimmed down figure during an April 4 appearance onWatch What HappensLive.

Dolores told hostAndy Cohen that shed been taking the semaglutide for the past six weeks, and said that not one of her costars isnt also using Ozempic to lose weight. I wasnt going to come to the reunion looking any bigger than anyone else, so I got on the bandwagon, she quipped.

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Weight Loss Wednesday: Experts weigh in on TikTok diet videos –

May 12th, 2023
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NEW ORLEANS If you've turned to social media to lose weight, you're not alone.In fact, as you will see, billions look just on TikTok alone, for advice.

So, is that a good idea.

TikTok is not just where Gen Z posts dance videos, it's where people are turning to lose weight. So, we turned to the experts for the science.

So, people are sharing mostly healthy diets, but the most healthy diets they aren't sharing enough, said Dr. Melinda Sothern, Professor Emerita, LSUHSC School of Public Health.

They are not going to have the best information for what your entire diet should look like, but they could give you some very nice specific recipe ideas, said Dr. Jake Mey,

Assistant Professor of Research in Integrated Physiology and Molecular Medicine Laboratory at Pennington Biomedical Research Center.

YorkTestis a lab that tests for food sensitivities. And it rated the top 50 diet trends on TikTok, and number one with more than 10 billion curious viewers, is the extremely low carb, high fat keto diet.

So, keto diets are extreme, but they have been studied and they have been shown to be safe if they're physician supervised, But it's not a long term lifestyle is the problem. People with disordered eating would never be on this type of restrictive diet, said Dr. Sothern.

Good old fashioned calorie counting was second with around half the views, more than five and a half billion.

Calorie counting is not recommended, because it's basically, it forces you just to ignore the nutrient value of foods. When you reduce calories and you're focused on only calories, that has been associated with disordered eating, explained Dr. Sothern.

Third is the low carb diet, removing the starchy carb foods like rice, bread, and pasta, but keeping the nutritious carbs like veggies, and berries. That helps prevent spiking your insulin which promotes storing belly fat.

Fourth and fifth on the list are vegan and vegetarian diets, which are good, but need a dietician's advice on where to get good protein.

There may be supplements that are going to be highly recommended for you, to make sure that you get the certain nutrients that you just can't get well out of a vegan diet. Some of those would be vitamin B-12 or your omega fatty acids, both of which are critically important for overall health and wellness, said Dr. Mey.

On intuitive eating, LSU Health's Dr. Melinda Sothern says there is emerging research suggesting it is beneficial to think and plan, what and where you're going to eat, and to develop a schedule. It's about changing your relationship with, and behavior around food, and not mindlessly snacking.

But Dr. Jake Mey of Pennington Biomedical Research Center says this diet is not for everyone.

That's probably great if you were an always skinny person, your body's just telling you the right ways to eat, but what we know about obesity now is that people that struggle with weight or have obesity, have a disruptive biology that's telling them to eat the wrong way, or too much, said Dr. Mey.

Intermittent fasting only allows eating during a specific time window that you choose.

Keto diet, combined with intermittent fasting, has recently been shown to be effective and that's because you can go on and off of it, said Dr. Sothern.

And when it comes to the dairy-free diet, she says low fat dairy is recommended for weight loss with its high protein and calcium.

The Dairy-free trends and the gluten-free trends are a little concerning to me. I would stay away from unless you have a known intolerance to something like dairy products or gluten products, said Dr. Mey.

And both doctors say if science and health were to guide TikTok users, two proven diets would be high on the list, Mediterranean only ranked 26 and DASH ranked down at 47.

And the first thing I thought was where is our Mediterranean diet trend. Where is our DASH diet trend? I mean those have the best evidence behind them and we know they're some of the healthiest dietary patterns out there, but they're just not trendy, right? That's the problem, said Dr. Mey.

TikTok does not allow dangerous diets or ones that promote eating disorders, like the water diet where no food is eaten for 24 hours.

Here is the YorkTest complete list of the 50 trends:

These Are The Most Popular Diet Trends On TikTok In 2022

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7 Best Machine Exercises for Rapid Weight Loss – Eat This, Not That

May 12th, 2023
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You want to lose weight and you want to lose it fastwe hear you. Well, we will tell you right now: You can skip most machine exercises. Those typical machines you see in the middle of your gym are no match for free weight or bodyweight exercises. Why? Because they stabilize the weight for you and force you into fixed, two-dimensional movement patterns, which is not how your body is designed to move. Thankfully, there are some excellent machines at the gym you can use to get great fat-burning results while still being able to get a total-body benefit. Gear up for seven machine exercises trainers swear by for rapid weight loss.

The below exercises encompass some great cardio options as well as strength ones for more muscle and metabolism. Read on to find out more, and next, be sure to read 7 Simple Dumbbell Exercises To Lose Weight in 30 Days.

If you're looking for a butt-kicking interval session, look no further than sled pushessprinting while pushing against resistance. Unfortunately, not every gym, however, has a sled or artificial turf. In that case, use a treadmill! While the machine is off, just grab the handles and start "running" by pushing the belt backward. Unlike sprinting on a treadmill, using these pushes strengthens your posterior chainglutes, hamstrings, etc.for even better results.

Rows are unbeatable to build strong back muscles, improve your posture, and, of course, burn calories. The great part of using a Smith machine is you can easily adjust the height of the barto make it easier or harderand track your progress to tell if you're getting stronger.

Grab the bar from underneath, pull yourself up, and touch your chest to the bar. Squeeze your shoulder blades together, and keep your body straight like a plank.

RELATED: The 5 Exercises You Should Be Doing at the Gym for Weight Loss

An Airdyne bike is a machine where you can use both your legs and arms to push against resistance. This gives a total-body cardio workout, which will smoke your body and your lungs for tremendous fat loss. (Trust us.) You can do it slow and steady for a longer duration (20 to 30 minutes) or you can go all-out for 15 to 30 seconds and catch your breath before doing it again with interval training.6254a4d1642c605c54bf1cab17d50f1e

The rowing machine is another great calorie-burning tool, but don't let the name fool youa rowing machine is a total-body workout because your lower body is just as important as your upper body in this exercise.

Sit tall with your chest out, your shoulders squeezed, and your lower back flat. Start by fully extending your legs, and then row; then reverse the movement, and repeat.

RELATED: 5 Simple At-Home Exercises To Keep Your Weight Down for Good

A cable machine is arguably the best gym "machine." Because they use pulleys, they offer constant tension and resistance throughout an exercise unlike free weights, which tend to be hardest in the middle and easiest toward the end (depending on the exercise).

Start the movement by squeezing your shoulder blades together. Row and touch the bar to your chest with every repetition. Do not lean backward to cheatyou'll put unnecessary stress on your lower back. To emphasize your back muscles, use a wide grip; to get more arm work, use a narrow grip.

Pull-throughs target your glutes and hamstrings for stronger, sleek legs. Also, they teach you how to properly bend your hips while keeping your lower back safe, which carries over to virtually every physical activity.

Face away from a cable machine, set the height to the lowest setting, and grab the ends of the cable-rope attachment between your legs. While maintaining a neutral back and straight elbows, start with your torso almost parallel to the ground with slightly bent knees. Extend your hips, and stand tall.

If you can't do bodyweight pull-ups, a lat pulldown machine is a great alternativeespecially if you don't have a band for assistance (or can't be bothered). That way, you can gradually build more strength and eventually transition to doing bodyweight pull-ups.

Sit at a lat pulldown machine, and grab the handle about shoulder-width apart with your palms facing away. Keep your torso upright, squeeze your shoulder blades together, and pull the bar toward your collarbone. Keep your chest up as you pull.

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Anthony J. Yeung

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7 Best Machine Exercises for Rapid Weight Loss - Eat This, Not That



Taste The Goodness: 5 Chutneys That Add Zing To Your Weight Loss Journey – NDTV Food

May 12th, 2023
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When you are on a weight loss diet, you often have to give up many of your favourite foods: high-fat ice creams, deep-fried pakoras, cheesy takeaway pizzas and much more. This can make you feel rather demotivated. But it doesn't mean you cannot add some spice and yumminess to your meals. A good way to enhance your experience of eating any dish is to pair some chutney with it. Indian cuisine has so many chutneys to choose from, and most of them are super-healthy too. Opt for the right ingredients, and chutneys can be a helpful companion on your weight loss journey. We have narrowed down 5 quick and easy chutneys that you can start with:Also Read:Chutney Health Benefits - Give Your Meals An Instant Boost Of Good Health

Green chutney is nutritious and easy to make.Photo Credit: iStock

This is one of the most popular chutneys in India, and there exist several versions of it. Hari chutney is typically made with mint (pudina) and/or coriander (dhania) leaves. This gives the chutney its lovely green colour and refreshing flavour. All of the ingredients are wholesome and won't pose a problem for your weight loss journey. Both coriander and mint are considered cooling herbs and are full of nutrients. They are said to ease digestion and boost metabolism, thus helping you manage your weight. Click here for one recipe for Hari Chutney.Also Read:5 Delicious And Healthy Green Dips To Pair With Your Snacks

Tomatoes have a high water content (around 90-95%). They are also rich in fibre. Hence, tomatoes can promote satiety and help you stick to your weight loss goals. They are low in calories and rich in antioxidants and nutrients that promote your overall health. They also have a low glycaemic index, which helps keep your blood sugar levels under control. There are many versions of tomato chutney. For a Bihari-style recipe, click here. You could also make South-Indian style tomato chutney. Full recipe here.

Cucumber chutney is full of amazing flavours

Like tomatoes, cucumbers are also high in fibre and water while being low in calories. They help keep you hydrated and also full for longer. They promote gut health and metabolism, thus aiding in weight loss. Cucumber chutney is another South Indian-style recipe you have to try. It contains the goodness of ingredients such as curry leaves, chillies, cumin, mustard, etc. All of these can also help you with your fitness goals. Click here for the step-by-step recipe.

Although peanuts are high in calories, they are rich in proteins and fibre. They take longer to digest, which can help curb your appetite and help you lose weight. They are also a good source of healthy monounsaturated fatty acids and polyunsaturated fatty acids. Peanuts can provide you with a wholesome energy boost. If you want to make a dry chutney, try making Maharashtrian Shengdana Chutney (Full recipe here). You can also make a refreshing Farali Peanut Chutney, which contains curds. Find the recipe here.

Green mangoes have ample benefits for those on a weight-loss diet. They have a low-calorie content but are rich in fibre. They can increase feelings of fullness, relieve digestive issues and improve your metabolism. Apart from drinking their juice and eating them plain, you can also use them to make a yummy chutney (which you can then store for a longer time). For a nutritionist-approved recipe, click here. You can also try making a different kind of kairi chutney, with more spices and a hint of coconut. Watch the recipe video here.

Now you can enjoy these tasty chutneys guilt-free, and still manage to keep your weight in check!Also Read:Indian Cooking Tips: How To Make Amchoor Powder Or Masala

Disclaimer: This content including advice provides generic information only. It is in no way a substitute for a qualified medical opinion. Always consult a specialist or your own doctor for more information. NDTV does not claim responsibility for this information.

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Taste The Goodness: 5 Chutneys That Add Zing To Your Weight Loss Journey - NDTV Food



Whats The Healthiest Way To Prepare Chicken For Weight Loss? We Asked Experts – Yahoo Life

May 12th, 2023
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Woman preparing chicken for cooking

Whether your want to lose weight or just make healthier meal choices, lean proteins like chicken can help women over 40 reduce fat and build muscle. Experts agree that lean proteins like chicken can also provide your body with protein and energy, and burn more calories than red meat.

To learn more about the healthiest way to prepare chicken for weight loss, we consulted the experts: Lisa Richards, a registered nutritionist, and Jen Welper, the Wellness Executive Chef at the New Mayo Clinic Diet. They said that grillingis the healthiest, weight-loss-friendly way to cook chicken. This is because grilled meats have reduced fat content because fat drips off as the food cooksthat way meals are healthier and it makes it easier to manage a low-fat diet. Plus, reduced fat intake helps lower bad cholesterol levels. Find out more below!

Who doesn't love chicken? This lean protein can be a healthy and affordable meal for anyone looking to lose weight or improve their overall health. Chicken strengthens bones and muscles, helps reduce cholesterol, controls blood pressure, and is rich in vitamins D and B.

While oven-baking chicken can provide a delicious and filling meal, Richards and Welper agree that grilling is often the healthiest way to prepare this lean protein. "Chicken is best cooked without unnecessary added calories from oils and other ingredients," Richards, who founded The Candida Diet, explains. "Grilled chicken is typically the healthiest method of eating chicken, but you must be mindful to avoid adding fats and high-calorie toppings."

Richards continues and says that after eating grilled chicken, "you will be more nourished because you are opting for lean animal protein rather than meat that is high in fat." Eating grilled chicken "on a regular basis can replace meats high in saturated fat that can lead to heart disease and other chronic illnesses," she adds.

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Welper points out that the ingredients you add to your grilled chicken and the "type of cut" you get matter if you want to lose weight. That's why it's important to carefully examine the type of chicken you buy at the store. "With a boneless, skinless, 4-5 ounce chicken breast, grilled would be ideal," she says. "An outdoor grill is not necessary as you can use the cast iron skillets or griddles for this."

"A serving of boneless, skinless chicken breast is under 300 calories, just 6 grams of fat, no carbs, and 53 grams of protein," Richards tells us. "This is an excellent source of lean protein for weight loss. When purchasing chicken breast, always opt for skinless as this is where most of the fat is contained."

Richards concludes that grilled chicken offers you the leanest possible meat with far less fat and calories than any other meat or cooking method. "You may feel more satisfied because of the protein content in grilled chicken," she notes. Protein, she continues, is a "satiating macronutrient that helps the body feel full for longer." Overall, she stresses that regularly eating grilled chicken "can lead to less overeating throughout the day."

So, experts agree that grilling your chicken is the best way to cook them for healthy weight loss. They also suggest cooking with as little oil as possible with unsaturated fats like avocado oil and choosing toppings and herbs that are anti-inflammatory and low-calorie. And, if you're looking for some recommendations, check out these 4 grilled chicken recipes for weight loss!

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Having Lost 35lbs In Incredible Weight Loss Journey, Ayesha … – The Sportsrush

May 12th, 2023
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Stephen Curry and Ayesha Curry are amongst the most popular couples in all of North American Sports. With the former having established himself in the annals of NBA history as an all-time great player, its brought quite a bit of attention to his family. Ayesha is no slouch either as shes a highly motivated entrepreneur and cooking connoisseur by profession. She would recently showcase her successful weight loss journey on social media, leading fans to applaud her for her efforts.

In the midst of her weight loss journey, Steph and the Golden State Warriors are looking to defend their 2022 NBA title in this years Playoffs. After beating Sacramento in 7 games, they find themselves in a 3-1 hole to LeBron James and the Los Angeles Lakers. This is the first time the Warriors have been down 3-1 in a series since their series against the OKC Thunder 7 years ago in 2016.

That series, as everybody knows, ended with Curry and crew coming back from a 3-1 deficit only to blow their own 3-1 lead in those same NBA Finals

With the past two games (Game 3 and Game 4) having been played in Los Angeles at the Crypto Arena, the Warriors werent able to bring their family along for support. They would lose both games.

Now that the series has shifted back to Chase Center for Game 5, fans were quick to notice that Ayesha Curry is courtside cheering her husband on as the Dubs look to win a game at home to hopefully push the series forward.

What many fans have noticed, however, is the positive change that Ayesha put herself through with tons of hard work and dedication. Her weight loss journey led her down the path of losing between 30 to 35 pounds, and she even took to Instagram to show off the journey she had been on.

Ive been kind of through a health journey over the past 3 years now. Ive lost 35lbs over the past year, said Ayesha. Im really excited about it but now I want that definition and I want to feel strong in my skin.

Stephen Curry fans even took to Twitter to give a Jordan Poole-esque reaction to it all, saying Curry started Game 5 on fire because he saw his wife courtside.

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The others couldnt help but compliment how good the celebrity chef looked.

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Some fans noticed how she was rocking the 2010 Warriors logo.

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Having Lost 35lbs In Incredible Weight Loss Journey, Ayesha ... - The Sportsrush


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