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Weight-Loss Drugs: How Outliers Like Biohaven, Regeneron Are Taking On The Muscle Dilemma In The Obesity Space – Investor’s Business Daily

Feb 24th, 2024
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People Are Combating ‘Ozempic Face’ Side Effect with Plastic Surgery After Weight Loss – PEOPLE

Feb 24th, 2024
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As the use of weight loss injections continues to trend, many patients are turning to cosmetic procedures to combat side effects like Ozempic face.

Ozempic is an FDA-approved prescription medication for people with type 2 diabetes. It's one of the brand names for semaglutide also known as Wegovy which works in the brain to impact satiety, and is the latest Hollywood weight loss fad.

Last year, Jeniffer Brown started taking Ozempic and was able to lose 40 lbs. within a year, reaching her goal weight of 125 lbs. and no longer being prediabetic without changing her diet or exercise routine.

However, she told the Los Angeles Times that the quick weight loss left her with unwanted loose skin and sunken cheeks. Ozempic face is the term used to describe the at-times gaunt appearance the injected drug can cause, due to the loss of fat.

Dr. Oren Tepper, a New York-based plastic surgeon, has said that it's common for weight loss to deflate key areas of the face, which can result in a person looking more aged.

"When it comes to facial aging, fat is typically more friend than foe," he said. "Weight loss may turn back your biological age, but it tends to turn your facial clock forward."

My face has been what Ive spent the most time on. Its like a melted candle, Brown, 47, told the outlet.

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In order to combat the Ozempic face, she found a plastic surgeon and started getting dermal fillers in her cheeks, jowls and jawline.

It is a dream weight until you spend $25,000 on plastic surgery, and you go every three months to your injector because youve got to just continuously pump Sculptra and fillers trying to keep that skin on your skull, Brown said.

To restore volume in a patient's face, doctors will often perform noninvasive, but expensive, procedures such as injecting Radiesse and hyaluronic acid-based fillers or Sculptra injections, which stimulates collagen production. Doctors can also restore volume with a face lift or by transferring fat from other body parts to the face.

Dr. John Diaz, a Los Angeles-based plastic surgeon, also told the outlet that about half of his patients are on Ozempic or similar weight loss injections.

The patient who is more likely to take Ozempic is someone who is concerned about their weight, and that very same person is the person who is very concerned about their appearance and is more likely to seek a plastic surgeon, he said, noting that

A patient day doesnt go by without dealing with somebody who says, My face has changed, Ive been on this drug and I want to do something about it, added Dr. Alan Matarasso, a New York City-based plastic surgeon. Well see it not only on the face, but in the breasts, in the abdomen, in the thighs. What Ozempic has done is its opened up a whole new class of people who are considering the benefits of plastic surgery.

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Sex and weight loss: I was fat. Now I’m thin. I had no idea what this would mean for sex. – Slate

Feb 24th, 2024
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How to Do It is Slates sex advice column.Have a question?Send it to Jessica and Rich here.Its anonymous!

Dear How to Do It,

Im a single man in my 30s and Ive been very overweight for nearly my whole life. A few years ago, my doctor and I made a medication change and I was suddenly able to lose and keep off weight.

Its a longer, more complicated story than this but Im going to keep it short. Ive always wanted to be thin but it turns out the emotional side of the weight change is harder to deal with than the physical part. Im about to start therapy to deal with this but I do have a practical question.

I always thought I had a smaller-than-average penis, but I still was able to have good casual sex. I learned to please women in other ways and to choose positions that worked around my belly. When I lost weight, I still thought this but about six months ago I had surgery for the loose skin and suddenly my penis is right there and theres more of it. Ive been having sex and every woman has complained that its uncomfortable or that Im hitting her cervix, even when I put in the same amount of effort with oral and fingers that I was doing before. This includes an old friend with benefits from years ago that I recently hooked up with again, so its definitely a me problem.

Are there new positions I need to try? How do I adjust to this change? I still see myself as a fat guy with a small penis and its really hard to change that in the moment. This seems like a great problem to have but its really not and I feel like I suddenly lost all of my skills and my body doesnt feel like mine. Im trying to start dating more seriously, which makes me want to bring my A-game even more.

Changes

Sex advice from Rich and Stoya, plus exclusive letter follow-ups, delivered weekly.

Jessica Stoya: The first thing that comes to mind is the Ohnut.

Rich Juzwiak: Yeah, thats what I was thinking.

Jessica: Its kind of like a doorstop for your penis. Its a ring that goes around the base of the penis, and its wide enough that it tends to compress and stop penetration (it comes with a few stackable rings so you can control the depth). With it, you dont have to think about specific positions or learn shallow thrusting. You get the sensation of really going at it with your member but it helps prevent cervix punching, which is painful.

Rich: Although some women do enjoy it, right? Some people like that.

Jessica: Yes, but apparently none of the women this guy is having sex with like it.

Rich: Right. So definitely try the Ohnut. Weve gotten questions a few times when the penis is so thick thatthe answer is kind of like: practice, stretch, look for someone else. Length is more easily fixable. Another option, and this may bemore difficult for heterosexual people than it is for gay people, would be to target size queens. Then its like a win-win. You may have better luck there.

Jessica: Yes. And as far as positions, you essentially do the opposite of the positions youve been using to get deep penetration. So for doggy, the arching of the back and the bending at the hips brings everything sort of forward. If the receptive partner lays flat on their belly on the bed, then that reduces the depth of penetration. The same thing goes with missionary: Where you might previously have had them on their back with their legs up and feet in the air, you instead want to have their legs down and be in between their legs, on the side like a spoon. You can angle the bodies in a more parallel way instead of at an angle, which tends to curve the penis a bit and keep part of it outside of the receptive partners body. But then you want to be careful with thrusting so you dont break your penis because that can happen. Its rare but its a risk.

Rich: Yeah. How about her on top? What do you think about that?

Jessica: Oh, God. Everybody talks about women on top like, Its so great because you can control the depth of penetration. Youre basically doing squats.

Rich: Right.

Jessica: If the penis is too long, youre doing squats. Its miserable. That is not a gift that youre bestowing on your partner. Its a boatload of work. So if they want to get on top, great, but dont present it as: How about you get on top so you can control everything? Understand that its a lot of physical strain to be on top. And hes in his 30s, so the people hes dating are probably in their 30s. At 37, I can tell you joints start to get a little creaky.

Rich: Hard on the knees.

Jessica: Yeah, I know. There are exercises that can help with stamina for the partner who will be on top. But thats something thats not going to help our letter writer, and it would be quite off-putting if someone presented me with, You get to be on top, heres a list of exercises you can do to make it easy. I would be like, What?

Rich: Congratulations, more work.

Jessica: But I do want to talk about the concept of a great problem to have. I feel like often well sarcastically or self-deprecating call something a great problem to have, or other people will enviously refer to it that way. But ultimately, they are still problems, and adjusting to a change, even if its something that we ourselves wanted and consider good, is still a difficult endeavor.

Rich: Its also wrapped up in his changing self-image. I think that if this happened and everybody that he had sex with was like, Oh my God, your dick is so big and I love it, and it feels better than before, there would have been a much different outcome for him. So I think that its kind of an unfortunate situation because no matter what we know about societal standards and what people value, it can still be difficult to go through a metamorphosis and then to have something externally again, kind of causing the question of: Who am I? Was this worth it? Even though its what youre supposed to want. That can certainly complicate the situation.

Honestly, I wish that he had different experiences with people appreciating his now-longer presenting penis because I think it wouldve made the transition a lot easier. I see straight guys on Feeld talk about their big dicks all the time. It might be distasteful to some, but I bet advertising it could get some takers. Incidentally, its a positive that hes still hooking up with people and hasnt given that up. His libido is there and hes able to keep interacting in this space. Anyway, having people go after and appreciate his bigger dick could show him at least that it isnt always a hindrance, but an actual positive in some cases. Its a very subjective kind of thing. I suspect his letter to us is largelya product of circumstance.

Jessica: Yeah. I do see at the end of his letter that hes trying to date more seriously, and if that means optimizing his hookup rate, great. Put it out theretastefullythat you have a big dick. Thats a near-impossible task but aim high.

But if what he means is that he wants to date to find a relationship, I am concerned that he might be putting undue pressure on himself to bring his A game. Some relationships do start with amazing, blazing-hot sex and develop into committed mutually respectful relationships. And also some relationships start out by being more emotionally and intellectually intimate, and the sex gets better as time goes on. So dont think you have to blow a womans mind to have a chance at a relationship with her. Sometimes the relationship is what enables the mind-blowing sex.

Rich: Thats very true.

Im a procrastinator; my partner is a do-it-yesterday-er. Earlier this year, I was kvetching about doing my taxes. My partner, by way of motivation, said Get em done and Ill blow you. Because my partner is very Good at That, I got to work immediately, but was held up by some missing paperwork.

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Sex and weight loss: I was fat. Now I'm thin. I had no idea what this would mean for sex. - Slate

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Indias Drugmakers Look to Tap Weight-Loss Market with Versions of Wegovy – BioSpace

Feb 24th, 2024
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Pictured: Man prepares his semaglutide injection pen/iStock, imyskin

Indian pharma companies have started developing their own versions of Novo Nordisks top-selling weight-loss medicine Wegovy (semaglutide), hoping for a piece of the multibillion-dollar obesity market, according to Reuters.

Indias Sun Pharma, Cipla, Dr Reddys and Lupin have all indicated that they have started working on their own versions of Wegovy. Systematix analyst Vishal Manchanda told Reuters that Sun Pharma is developing its own novel and patented treatment for obesity and type 2 diabetes, which will have to go through clinical trials.

Dr Reddys and Cipla are making a copy of the innovator drug, more like a generic version, Manchanda said.

Novos Wegovy and Eli Lillys Zepbound (tirzepatide) are currently dominating the weight-loss market, which analysts say could reach up to $150 billion to $200 billion in value in the coming years. In 2023, Novos GLP-1 saleswhich include Wegovy for obesity and Ozempic (semaglutide) for diabetescame in at more than $6 billion.

While Lillys Zepbound was only approved in November 2023, it still managed to rake in $175 million during the fourth quarter of 2023. Its type 2 diabetes counterpart Mounjaro (tirzepatide), which has also been used off-label for weight loss, brought in $2.2 billion in the most recent quarter.

Like the Indian pharmas, other companies are trying to join the highly lucrative obesity market. These include Regeneron, which is positioning its investigational trevogrumab and garetosmab as adjuncts for the top-selling GLP-1 receptor agonists. Both of Regenerons antibodies work by preserving muscle, seeking to improve the quality of weight loss and preventing muscle atrophy.

Regeneron is planning to trial trevogrumab and garetosmab in combination with tirzepatide or semaglutide.

Amgen has also started work on its own weight-loss candidate MariTide, which simultaneously activates the GLP-1 receptor while blocking the GIP hormone receptors. The pharma posted Phase I data for its candidate earlier this month, showing that it could elicit longer-lasting effects than currently available treatments.

Competitors could be a welcome addition to the weight-loss market. Since the respective launches of Wegovy and Zepbound, Novo and Lilly have struggled to meet the markets insatiable demand for their obesity medications, leading to widespread shortages of these products.

The growing gap between supply and demand has allowed counterfeit and compounded products to thrive, which the World Health Organization (WHO) said last month could have disproportionate consequences on patients who actually need these treatments.

Falsified medical products have been known to lack efficacy and/or cause toxic reactions, the WHO said. They are neither approved nor controlled by competent authorities and may have been produced in unhygienic conditions by unqualified personnel.

Tristan Manalac is an independent science writer based in Metro Manila, Philippines. Reach out to him on LinkedIn or email him at tristan@tristanmanalac.com or tristan.manalac@biospace.com.

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Photos from Stars’ Candid Quotes About Their Weight Loss Journeys – E! NEWS

Feb 24th, 2024
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1 /22

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Yep, the talk show host is standing a little taller these days. Informed by doctors she was pre-diabetic, "I dropped weight because I've been listening to my doctora couple years I didn't," the singer explained to People. "And 90 percent of the time I'm really good at it because a protein diet is good for me anyway."

She is a Texas girlie after all, "so I like meatsorry, vegetarians in the world!"

The mom to River and Remington is also enjoying exploring her new life in NYC. Walking in the city is quite the workout, she added. And Im really into infrared saunas right now. And I just got a cold plunge because everybody wore me down.

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Weight loss drugs aren’t covered by Obamacare. That may change – STAT

Feb 24th, 2024
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WASHINGTON Drugmakers are doing everything to tap the bottomless well of demand for new obesity drugs, and they might get some government help. The agency that regulates Obamacare insurance is considering a technical change that would require insurers to cover obesity drugs in a market of more than 20 million Americans.

Weight loss drugs are a blessing for patients, a boon for drugmakers, and a potentially huge expense for insurers and taxpayers. Insurers have been slow to cover the drugs, called GLP-1 agonists, and without insurance, it costs upward of $16,000 annually for a drug that must be taken indefinitely.

There is a lot of demand for the drugs, but there are barriers to coverage. Medicare by law is prohibited from paying for obesity drugs. State Medicaid programs dont have to cover them, so most dont.

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More teens turning to weight loss drugs to combat obesity – 9News.com KUSA

Feb 24th, 2024
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9NEWS Health Expert Dr. Payal Kohli talks about new recommendations for children as young as 12 to use weight loss drugs.

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Published: 8:57 AM MST February 23, 2024

Updated: 8:57 AM MST February 23, 2024

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Whitney Way Thore Responds to Weight Loss Comments in Candid Post – Prevention Magazine

Feb 24th, 2024
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For years, intimate scenes from Whitney Way Thores life have been chronicled on her TLC reality show, My Big Fat Fabulous Life. That publicity seems to make some people feel comfortable commenting on her body and her weight. On a recent Instagram post, the 39-year-old was inundated with commenters asking if she had

The post was a casual outfit video that shared the theme of her dads birthday celebration: Mardi Gras. Can anyone guess what were doing to celebrate Dads birthday? , her original caption read. She later edited the post to address the influx of weight loss comments.

I hate addressing this, but no, I have not had medical intervention to lose weight, she wrote. In 2015 (season 1), I weighed 385 pounds. In 2018, I lost 50 pounds. When my mom got sick and eventually died, I lost 50 more. I weigh 285 pounds and I have been this weight for almost a year now. This is the second time in my life Ive lost 100 pounds. Im still very fat.

She continued: Thank you for the compliments, but I really dont like obsessing over my body and I dont like it when others do it either.

Thores mom, Barbara Babs Thore, died in December 2022 of cerebral amyloid angiopathy, a complex cerebrovascular disorder, per People. As shown on her show, Thore cared for Babs until her final days, and was hit hard with griefa significant contributor to her weight loss, she previously told Entertainment Tonight.

I think its obvious that I have lost some weight and that is true. And people say, like, Is it surgery? and Im like, No, its grief, but thanks, she told the outlet in September 2023. On the show, Ill talk about my weight more, but in my personal life, I dont really find it necessary to talk about how much I weigh. Its just not something that I care to focus on and talk about.

When the show premiered in 2015, it set out to document Thores experience with weight gain after she was diagnosed with polycystic ovarian syndrome, an endocrine disorder that impacts hormonal production, reception, and transportation. The series specifically aimed to capture Thores thriving life as a dancer, despite her weight gain. Although she says she has not opted to undergo surgery or use weight loss injections like Ozempicwhich some have also accused her of doingshe isnt one to judge those that do.

Ive been fat now for 20 years and fat in the public eye. I know how hard it is and I do not ever judge a fat person for doing anything that makes their lives easier. I am not that fat person thats gonna say, Oh my gosh, why are they on Ozempic? Why are they losing weight? Theyre betraying me. Its their body. It has nothing to do with me and its hard out here for a blimp, she told ET. It is really difficult to live in bodies like this and there is no judgment from me.

Its clear Thore doesnt like to obsess over her body, and she doesnt think anyone else should either.

Kayla Blanton is a freelance writer-editor who covers health, nutrition, and lifestyle topics for various publications including Prevention, Everyday Health, SELF, People, and more. Shes always open to conversations about fueling up with flavorful dishes, busting beauty standards, and finding new, gentle ways to care for our bodies. She earned a bachelors degree in journalism from Ohio University with specializations in women, gender, and sexuality studies and public health, and is a born-and-raised midwesterner living in Cincinnati, Ohio with her husband and two spoiled kitties.

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Rob Lowe Shares His ‘Concern’ with Weight Loss Injections: ‘What’s the Plan for Longevity?’ (Exclusive) – PEOPLE

Feb 24th, 2024
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Rob Lowe is joining the conversation surrounding popular weight loss aids.

The 9-1-1: Lone Star star, 59, recently spoke to PEOPLE about his Atkins partnership and some of the health goals hes hoping to reach ahead of his 60th birthday next month.

Stressing his commitment to overall health and wellness, the actor shares his concern with people relying on weight loss drugs, referring to medications like Ozempic, an FDA-approved prescription medication for people with type 2 diabetes.

It's one of the brand names for semaglutide also known as Wegovy which works in the brain to impact satiety, and is the latest Hollywood weight loss trend.

I see people who are taking all the new weight loss drugs and that's great, and it's really changed their lives. But my concern always is, okay, now what? Lowe tells PEOPLE. Whats the plan for the longevity of everything?

I never ever talk about diets, I talk about lifestyle, he adds.

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Lowe is known for keeping a toned physique over the years, but he admits that his weakness tends to be his diet often giving in to his raging sweet tooth.

However, he says reeling in his eating will likely come from moderation rather than cutting out his favorites, giving him a better shot at maintaining the lifestyle change.

I'm trying to be even more disciplined now as I'm older just because as you get older, you need to watch what you eat even more than when you were younger, he explains. So I tried to cut sugar completely as my new year's resolution. And now I'm figuring, okay, that's not sustainable for me, but how do I really watch my sugar consumption?

Although hes hopeful about making improvements in his diet, Lowe notes that hes never struggled when it comes to having a good grasp on fitness, boasting that he feels better than Ive ever felt.

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The Waynes World star says hes lucky to have natural motivation and is always willing to stay active.

I can't wait to train or to do something physical, he says. I have very good friends and family that have to be dragged into doing something physical that would be super tough to overcome.

I am blessed that I really enjoy physical exertion and adventure, he adds. So if I'm not on a set, I build my entire day around what activity I'm going to do. It might be a paddle in the ocean, a hike, running sprints on the track, pickleball, tennis. I'm pretty much up for anything.

It's a lifestyle, Lowe tells PEOPLE, noting that his latest health goal is trying to find the balance between longevity and consistency and non-injury and pushing myself as hard as I ever did.

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What Are the Stages of Weight Loss? Dietitians Explain – Men’s Health

Feb 24th, 2024
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NO SURPRISE HERE:

Embarking on a weight loss journey is akin to a marathon, not a sprint, says Dalia Beydoun, R.D. Each persons weight loss journey is unique, with its own timeline, hurdles, and milestones. But for the majority of people, safe and sustainable weight loss takes time."

In general, though, weight loss can be delineated into three stages: rapid weight loss, gradual weight loss, and maintenance. The length of each stage depends on the individual, Michelle Routhenstein, R.D., preventive cardiology dietitian says. Being able to identify these stages may be a key sign of healthy and sustainable weight loss.

Ahead, dietitians spell out what you should know about the difference stages of weight loss, how much weight you can lose safely, and more.

There are a few.

It's not uncommon to see substantial drops in weight right at the beginning of a weight loss journey, as the body adapts to new habits, expands Tiffany Ma, R.D.N.

[This] rapid weight loss stage is the initial, and typically, the shortest stage. This is the time when diet modifications have just begun and there is a significant drop in body weight within a short period, says Beydoun. During this stage, individuals usually experience a pronounced decrease in water weight, likely due to a reduction in glycogen stores which are used up for energy when the body is in a calorie deficit.

This stage can last anywhere from a few days to a few weeks, depending on factors such as starting weight, dietary changes, and physical activity levels," she says. "While rapid weight loss can be motivating, much of the initial drop on the scale can be attributed to fluid loss rather than fat loss."

People often incorporate drastic calorie restriction or extreme exercise regimens to hit this rapid weight loss stage quickly, says Routhensteinas you might see wrestlers do right before a weigh-in, or when someone needs to lose a few pounds to fit into a suit for an occasion. This approach can lead to muscle loss, nutrient deficiencies, and potential health risks such as gout attacks and liver issues."

Gradual, or slow weight loss, is the next stage of losing weight. As the body adapts to the changes introduced during the rapid weight loss phase, progress may slow down during the second stage, says Ma. This phase involves a more gradual and sustainable rate of weight loss, typically ranging from 0.5 to two pounds per week.

During this stage, individuals may focus on incorporating healthier eating habits, regular physical activity, and behavior modifications to support long-term weight management. It can last for several months or years, depending on the individual.

The pace of weight loss slows down compared to the initial rapid phase, but it is often more indicative of true fat loss rather than water weight," says Beydoun. You may be losing weight less quickly, but this stage of weight loss is what creates your success for the long haul. It allows for better preservation of muscle mass, reduces the risk of negative health consequences, and promotes long-term weight maintenance.

Once youve reached your goal weight range, your attention shifts to sticking at that weight for the months and years to come. This stage may come unintentionallywhat was once your calorie deficit becomes your maintenance calories as you lose weight.

Weight maintenance refers to the phase following successful weight loss where individuals actively work to sustain their achieved weight through continued adherence to healthy habits and lifestyle changes, says Beydoun. This phase is key for preventing the regaining of weight by anchoring those long term habits. It involves finding a sustainable balance between calorie intake and expenditure without excessive restriction, maintaining regular physical activity, and monitoring progress."

If youre noticing that you dont go directly from rapid weight loss to gradual weight loss, youre not alone.

Between the rapid and gradual weight loss stages, its common to experience intermediate phases of weight fluctuations and plateaus. While weight fluctuations are normal, plateaus may often require adjustments to dietary and exercise strategies, says Beydoun. These stages might make your weight loss journey more challenging, but they do show the value of long term lifestyle changes as opposed to rash, short term extreme diets.

Fluctuation between stages happen when individuals encounter obstacles like plateaus, cravings, and social pressures, Routhenstein says. "Successfully navigating this stage involves adapting strategies, building resilience, and seeking support to overcome setbacks and continue progressing towards long-term weight loss goals."

As we touched on above, to ensure sustainable, healthy weight loss, most people dont want to lose more than two pounds a week.

Rapid weight loss is not recommended, as losing more than two pounds in a week can cause muscle loss and increase the risk of gout attacks and liver scarring, says Routhenstein.

Not all weight loss is fat loss.

Fat loss refers to a decrease in body fat mass specifically, while weight loss encompasses any reduction in overall body weight, including water weight and muscle mass, says Routhenstein. Prioritizing fat loss through healthy lifestyle changes is preferred over simple weight loss for improved body composition and overall health."

The key concept here is zooming in on long-term fat loss over weight loss. It's essential to focus on sustainable fat loss rather than simply chasing a lower number on the scale since preserving lean muscle mass will promote overall health, says Ma. To avoid losing muscle mass while losing weight, prioritize strength training and keep up your protein intake.

Maintenance requires ongoing adherence to the healthy eating habits you participated in while you were losing weight and participating in regular physical activity, and whatever other lifestyle modifications you utilizedlike limiting alcohol and avoiding cigarettes and other drugs, Ma says. It's a lifelong commitment to health and well-being and is often considered the hardest part about ones weight loss journey, emphasizing sustainable habits rather than short-term fixes.

Perri is a New York City-born and -based writer; she holds a bachelors in psychology from Columbia University and is also a culinary school graduate of the plant-based Natural Gourmet Institute, which is now the Natural Gourmet Center at the Institute of Culinary Education. Her work has appeared in the New York Post, Men's Journal, Rolling Stone, Oprah Daily, Insider.com, Architectural Digest, Southern Living, and more. She's probably seen Dave Matthews Band in your hometown, and she'll never turn down a bloody mary. Learn more at VeganWhenSober.com.

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