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There are many benefits of plant-based eating. But is it safe to exclude meat when youve got a whole-grain bun in the oven? Registered dietitian Julia Zumpano, RD, shares her tips for being a pro at pregnancy while still being pro-plants.

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Vegetarian diets are nutritional powerhouses because they are:

The tricky part of eating vegetarian while youre pregnant, explains Zumpano, is that your protein needs increase during those months.

Zumpano says the average pregnant woman needs 71 to 75 grams of protein a day during pregnancy. That number can be even higher due to a number of factors, including if youre carrying multiples. If you want to eat vegetarian during pregnancy, its best to see a dietitian for a personal assessment to know your specific protein needs.

Its definitely doable to eat vegetarian while pregnant I did it myself but you need to plan your meals around protein to ensure youre getting enough, which may also include protein supplements.

A vegetarian diet typically cuts out meat, but there is a lot of grey. Some vegetarian diets include eggs and dairy. A vegan diet has no meat, dairy or eggs. A pescatarian diet is plant-based but includes fish. Is one type better during pregnancy?

If someone is open to less restrictive eating during pregnancy, I try to guide them that way because it can be easier to fill the nutritional requirements, says Zumpano. For example, if someone is vegan but open to dairy during pregnancy, I would encourage that shift so they can get their protein and calcium needs met by food sources.

If youre set on a vegan pregnancy or dont want to adjust your eating habits, youre still good. Youll just need to use a supplement or a vegetarian product like tofu to meet the nutritional needs of you and your baby.

All pregnant women, whether or not they eat meat, need to take a quality prenatal vitamin. If the vitamin doesnt contain enough calcium or folate, you may need additional supplementation.

A high-variety diet can help you meet your nutritional requirements in pregnancy:

There are also some foods you should avoid:

If you want to ensure complete nutrition during a vegetarian pregnancy, its best to plan ahead. Zumpano recommends making a list of the fruits, veggies, proteins and grains youre willing to eat and then planning your meals around them.

Probably the hardest time to successfully eat vegetarian is during the first three months of pregnancy, says Zumpano. If you have morning sickness or nausea, food may not taste good. Or you dont feel like eating for fear it will all come back up. It can be almost impossible to eat a complete diet in this situation.

To avoid having soda crackers as your primary food source, Zumpano recommends:

Youll likely find it easier to meet all your nutritional needs in trimesters two and three (when you dont feel like retching all day). But you can use these tips at all points in your pregnancy to ensure your baby gets the best nutrition for a healthy start in life

These recipes can help you get started in developing a nutritionally complete eating plan:

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Can You Safely Have a Vegetarian Pregnancy? Health Essentials from Cleveland Clinic - Health Essentials from Cleveland Clinic

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Jul 9th, 2020 | Filed under Diet Safely

GREENSBURG As temperatures soar into the 90s this week, and with heat index values near 100 degrees, FEMA is encouraging residents to avoid the dangers of extreme heat by taking some simple steps to protect themselves.

Extreme heat has the potential to be extremely dangerous, said Kevin M. Sligh, FEMA Region 5 acting regional administrator. Regularly check yourself, family members, and neighbors for the signs and symptoms of heat-related illnesses and learn how to respond to them. Its important that we all take an active role to stay safe when excessive heat is forecast in our area.

If you dont have access to air-conditioning at home, find places in your community with AC such as a local cooling center. Remember to keep six feet between yourself and others, and follow guidance provided by local officials to ensure you can cope safely with extreme heat amidst the COVID-19 pandemic.

If youre outside, find shade. Avoid strenuous activity, cover your head with a hat wide enough to protect your face and wear loose, lightweight, light-colored clothing.

Drink plenty of fluids to stay hydrated. If you or someone you care for is on a special diet, ask a doctor how best to accommodate it.

Never leave people or pets in a parked car. Leaving a window open is not enough temperatures inside the car can rise almost 20 degrees Fahrenheit within the first 10 minutes, even with a window cracked open.

Watch for heat cramps, heat exhaustion, and heat stroke. The Centers for Disease Control and Prevention provides a list of warning signs and symptoms of heat illness and recommended first aid steps.

For more information and tips on being ready for extreme heat, visit http://www.ready.gov/heat.

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Tips to stay safe in the heat | Local News - Greensburg Daily News

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Jul 9th, 2020 | Filed under Diet Safely

As human beings, we experience a broad variety of emotions. Sometimes these feelings follow a simple and predictable path.At other times, they shift direction and elevate faster than a brand-new roller coaster. Such situations when you quickly go from happiness to anger (or vice versa) are known as mood swings.

And if youre the kind of person who experiences lots of mood swings, you may have wondered what to do about them.

Internal changes that take place throughout our lives influence our mood, but its not just whats happening inside that determines how we feel; we also respond to whats happening around us, Nancy Schimelpfening writes for VeryWellMind.com.

External changes to our lives and in our environments, such as increased stress at home, school, or work, can also influence our emotions.

In other words, moods are constantly fluctuating and changing and some mood swings are totally justifiable. For example, your mood could suddenly pivot from frustrated with life to exhilarated if you win $1 million on a scratch-off lottery ticket.

Its the ones that cant be explained so easily that we have to become more aware of. If you seem to suffer mood swings frequently and without warning, this could be a sign of an underlying condition that needs to be addressed by a licensed healthcare practitioner.

Potential causes include:

Self-diagnosing the root cause of mood swings isnt recommended. Its much safer to see a doctor if you suspect theres a key underlying factor that causes your changes.

In addition to seeing a doctor to obtain an official diagnosis and treatment plan, here are four simple tips you can employ to manage mood swings and reclaim your life.

Balance will always be an operative term. Assess your lifestyle and look for any areas where you do not feel stabilized, and do your best to bring any extremes back to a baseline standard. You especially need balance in terms of sleep, diet, work, exercise, and relationships.

Which underlying health issues do you have that could have an impact on your moods? As previously mentioned, a leaky gut might be to blame. By taking a leaky gut support supplement, you could bring balance back to your gut and ensure you get all the benefits of a healthy diet. If a condition such as Celiac disease is to blame, a switch to a gluten-free diet could do wonders. Whatever the case, dont let any underlying issues control you.

If you experience mood swings, you should avoid ingesting anything thats likely to alter your mood in any way. This includes all stimulants, such as alcohol and caffeine. Youre much better off drinking water and caffeine-free tea.

Show yourself some kindness and practice regular self-care. This might entail exercise, meditation, pampering yourself, or taking a nap. The objective is to give your mind and body sufficient space to rejuvenate on a daily basis.

Moods and feelings are normal, so we shouldnt revile them. However, rapid, unprovoked shifts from one extreme to the other are unhealthy and dangerous.

If you experience sudden mood swings that cant be neutralized through simple actions like the ones highlighted in this article, you should schedule an appointment with your doctor.

This content is sponsored by Larry Alton.

Photo credit: Shutterstock

Originally posted here:
4 Tips To Safely Manage Your Mood Swings and Become Happier and Healthier - The Good Men Project

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Jul 9th, 2020 | Filed under Diet Safely

Photo by Jay Bouchard

Your skin is dry, and you're sucking wind. But why, exactly? We talked to a physician to learn more about how elevation impacts us so drastically.

You finally did it: You packed the U-Haul trailer, towed it across the country, and made it safely to Denverwhich was exhausting enough. But now, as you carry your belongings up to your second-floor apartment, youre pausing every few stairs to catch your breath. Maybe that roadside diet (too many gas station hot dogs?) is weighing you down, but whats more likely is that your body is reacting to an abrupt change in elevation.

At a mile high, Denver is one of the highest cities in North America (we rank third in elevation for state capitals, behind Santa Fe, New Mexico at 7,200 feet and Cheyenne, Wyoming at 6,000.) While some newcomers might not be impacted by the thin air, others will struggle for days and, sometimes, weeks. It might affect your sleep, your exercise, your skin, and more. To understand what happens to the bodyand what you can do about itat elevation, we chatted with Eric Lung, associate medical director at Sky Ridge Medical Center.

Our bodies compensate [for thinner air] by breathing a little heavier. That does a couple of things. We lose fluid, and we become more dehydrated, Lung says.Were losing water in different ways. Just by breathing more.

Compounding the loss of fluid, the air is extremely dry, and sweat evaporates quicklymeaning people might not be aware theyre losing so much water. Lung explains that when these things happen and the body begins compensating, it can go into whats called respiratory alkalosis which might result in fatigue, headache, or insomnia. The most common remedy is hydration. Even before you arrive at elevation, you should be drinking lots of water. That way, by the time you roll into Denver with your sights set on a stiff IPA, you wont be operating from such a hydration deficit.

Speaking of that stiff IPA, we know Denver has a reputation for craft beer and legal bud. And, of course, people come here with specific intentions of indulging in those pleasures. Nobodys gonna say: Come to Colorado, dont drink craft beer for two days. Thats not going to happen, Lung says. But he does stress caution: dont indulge in too much too quickly, especially because alcohols impact will be more severe at elevation (again, hydrating is key), and some of the legal weed might hit harder than what youre used to.

If possible, take it easy the first few days after you arrive. Lung says that most people will be able to acclimate in Denver after a few days, but he sees issues when people try to do too much out of the gateslike driving into the mountains and recreating at even higher elevations. People can begin to experience severe altitude sickness at around 8,000 feet, and many of Colorados mountain towns sit at or above that elevation (Breckenridge, for example, is at 9,600 feet, and even nearby destinations like Conifer are over 8,000.) Be careful if summiting a fourteener was the first thing on your bucket list: At elevations that high, you might develop swelling in your lungs or brain, and the only remedy is to descend to a lower elevation.

Jay edits and writes stories for 5280.com and assists the magazine with overall digital strategy.

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How to Deal With High Altitude When You Arrive in Colorado - 5280 | The Denver Magazine

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Jul 9th, 2020 | Filed under Diet Safely

As temperatures soar into the 90s this week, with heat index values near 100 degrees, the FEMA Region 5 office in Chicago is encouraging residents to avoid the dangers of extreme heat by taking some simple steps to protect yourself.

Extreme heat has the potential to be extremely dangerous, said Kevin M. Sligh, FEMA Region 5 acting regional administrator. Regularly check yourself, family members, and neighbors for the signs and symptoms of heat-related illnesses and learn how to respond to them. Its important that we all take an active role to stay safe when excessive heat is forecast in our area.

1. If you dont have access to air conditioning at home, find places in your community with AC, such as a local cooling center. Remember to keep six feet between yourself and others, and follow guidance provided by local officials to ensure you can cope safely with extreme heat amidst the COVID-19 pandemic.

2. If youre outside, find shade. Avoid strenuous activity, cover your head with a hat wide enough to protect your face and wear loose, lightweight, light-colored clothing.

3. Drink plenty of fluids to stay hydrated. If you or someone you care for is on a special diet, ask a doctor how best to accommodate it.

4. NEVER leave people or pets in a parked car. Leaving a window open is not enough - temperatures inside the car can rise almost 20 degrees Fahrenheit within the first 10 minutes, even with a window cracked open.

Link:
Extreme Heat is in the Forecast: Tips to Stay Safe - Pike County News Watchman

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Jul 9th, 2020 | Filed under Diet Safely

Should the elderly stay home during the Covid crisis, how do we know if they are depressed, what can we do to raise their spirits? We asked four Israeli experts for their advice

By: Nicky Blackburn

Its a tough time everywhere in the world right now, as the numbers suffering from Covid-19 continue to rise. And hardest hit of all are the elderly.

Asked to shelter in place for months already, some are now being told they must continue to stay put indefinitely, while others are being told its fine to go out, even while pandemic numbers rise.

As part of a new series, Ask the Experts, we invited readers to send in questions they might have about how to keep elderly friends and relatives healthy and safe during corona, and asked four professionals in the gerontology field to answer them.

The experts are Prof. Efraim Jaul, the Director of Geriatrics at Herzog Medical Center; Yonit Zabari, Director of the Department of Social Work at Herzog Medical Center; Dr. Amnon Raviv, a professional medical clown and college instructor; and Dvora Corn, a Jerusalem-based family and marital therapist specializing in aging, illness and end-of-life issues. She is cofounder of Gisha Lchaim Lifes Door, helping people cope with death and loss.

Find out what they said below.

Question: In many places around the world we seem to be going into a second wave of corona, but some governments are keeping everything open. What should elderly people do in this case? Is it better for old people to just stay at home until this crisis is finally over?

Prof. Efraim Jaul and Yonit Zabari

It is important for older people to go out. Loneliness and staying indoors can be more problematic than corona, causing depression and other issues. One should be careful when outdoors wear a mask, do not stay in closed areas, keep two meters apart, and meet with friends in open areas.

Dr. Amnon Raviv

This is an open question. It is clear now that old people are at risk. Staying at home for long periods of time can be depressing, so if you decide to do this, I recommend you meet your loved ones not only through virtual platforms but also for real. Keep 10 meters distance (from your balcony, for example) and you can meet safely and share your feelings with the family. This is extremely important for your mental wellbeing.

Dvora Corn

The question of how elderly people, or any individual in what has been identified as high risk groups, ought to behave during this health pandemic is complex and highly personal. As with many choices, decision making may be based on a risk-benefit equation which takes into consideration not only physical health but other factors which influence quality of life.

In this corona time, which is fraught with so many unknowns, the capacity to plan is further challenged by the reality that we have no clear end-point and as such one may be challenged to sustain plans or may want to reconsider choices as time progresses.

As a guideline to assist in these challenging times, it is often helpful to begin with an examination of values that one senses are core elements of that persons meaningful existence. For instance, in asking oneself the question What makes my life worthwhile? or even What makes a day a good one for me? we begin to understand those unique activities without which ones life becomes less satisfying or even, tragically, unbearable.

As such, one may opt to run the risk of serious illness and even death, if they deem that a life without these elements (e.g. family connection, or other social interactions, time in nature) is not a life worth living. While this may seem harsh or even irresponsible behavior, as a society we owe this right to every human being to choose how he or she wants to live.

The question, if at all possible, should be posed to the individual elderly person to engage in an honest reflection. It is never too early to engage in The Conversation, examining core values and sharing choices on how to live, especially in the face of potential illness. Many tools to assist in this process exist and some can be found on http://www.lifesdoor.org.

Question: Is there anything old people can do to improve their chances of survival if they do catch corona?

Prof. Efraim Jaul and Yonit Zabari

Eating properly is very important. Drink a lot of liquids; eat fresh fruit and vegetables; meals should be light but ensure to include protein, for example eggs.

Dr. Amnon Raviv

Like any other life-threatening disease you would be able to fight the disease better if your spirit is high. Using lots of humor, lifting the spirit with playing and singing good music, dancing (even in your bed if you dont have much energy), meeting with your beloved ones to share good memories or singing together.

Question: Ive heard that vitamin D helps you fight corona. What level of vitamin D should we be taking every day? Are there other vitamins or food supplements that might help?

Prof. Efraim Jaul and Yonit Zabari

Assuming one is eating healthy as outlined above, Vitamin D 4000 units is recommended on a daily basis. Vitamin D is known to keep bones healthy and reduces depression. If one is not eating a healthy and balanced diet, Vitamin B and B complex vitamin are recommended as well.

Dr. Amnon Raviv

Your physician probably would be able to answer this question, but I can add to the list other very important vitamins you should have: vitamins L, E & H (love, empathy & humor). It would be great if you could have a big quantity of those, as they would strengthen your immune system as well.

Question: How can my family and I lift the spirits of an elderly family member, who is isolated in a nursing home? He can only see his family through a window, which makes him happy, but at the same time frustrated and sad that he cannot physically be in the same room as us. With the lockdown continuing on in California, it is very challenging for him (and us too).

Prof. Efraim Jaul and Yonit Zabari

Meeting with the elderly in an outdoor area (e.g. garden) is very important and should be implemented where possible and as much as possible. Communication must be more than just through a window. We encourage use of tablets, as well as frequent phone calls during the day.

(Israel 21C)

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How to Keep the Elderly Safe and Happy in a Pandemic - The Jewish Voice

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Jul 9th, 2020 | Filed under Diet Safely

In this weeks Forever Home we head to the Humane Society of Chittenden County for some pure sunshine.

Hes a very mellow cat that just loves human attention for sure. He loves pets. Hes only been with us for a few weeks. At the end of June, he came to us. He is ten years old so he is a senior cat but he does have a lot of life ahead of him, said Erin Alamed, Director of Volunteer and Community Outreach for HSCC.

Sunshine, a 10-year-old male cat, was struggling to peacefully coexist with the children in his previous home and landed at h-s-c-c in the hopes of starting over.

So he was really unhappy and a little scared so thats why hes here with us and we couldnt be happier. He s got the sweetest eyes. He loves butt scratches.hes definitely a staff favorite here and hes a nice orange gentleman.

Sunshine hopes to bring his sweet glow to a home without young children. So far he has no history with other cats but has lived with a dog before and would be ok with k-9 siblings.Potential adopters also need to be wellness-minded, as Sunshine will need a little help safely getting down to a healthy weight by controlling his diet.

No special diet for him. He is a bit of a picky eater but we do want him to eat his appropriate meal every day twice a day. So not overfeeding him but also making sure that he eats. Its important that cats eat every day for their health. we are hoping that he will lose a couple of pounds so he can have a longer life.

So if you need a ray of sunshine in your life, forget the outdoors and head to the humane society of Chittenden county to meet this one. Adoptions are by appointment only so contact the shelter to schedule one.

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Forever Home: Heres Sunshine! - Local 22/44 News

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Jul 9th, 2020 | Filed under Diet Safely

July6, 20206 min read

Opinions expressed by Entrepreneur contributors are their own.

You're reading Entrepreneur India, an international franchise of Entrepreneur Media.

As India is taking strict measures to contain the spread of COVID-19, self-quarantine and the temporary lockdown of major establishments including the fitness facilities are presenting some unique challenges to people across the country. While they are sitting safely at home, the stress is taking a toll on their mental and physical health.

Moreover, with limited access to fresh foods, particularly in times when the immune system might need to fight back, individuals are ending up compromising on eating a healthy and varied diet. This may lead to increased consumption of highly processed foods, which tend to be high in fats, sugars, and salt. So, to help people stay healthy and physically active while at home during the lockdown, here are some tips you must consider right away:

Establish a routine emphasizing on healthy eating and exercise

In these times of uncertainty, it is absolutely normal to feel anxious, lethargic, and stressed. Maintaining a daily routine specifically for the quarantine days can help manage some of the stress. We can start by defining and sticking to regular meals 3 times a day along with planning the meals in advance. This will help in better controlling abrupt hunger pangs and also meet our daily nutrient requirements.

Taking unnecessary stress and sitting idle may urge us to binge-eat out of boredom. So, create a designated space for your workout at home and make use of the furniture to do home workouts once in a day. There are numerous fitness experts out there who are constantly posting their home workout videos on social media handles. Follow them and get started.

Eat immunity boosting foods

To fight this pandemic, the body must improve its natural defence system to maintain optimal health and it goes without saying that prevention is better than cure. Since, the medical fraternity has not yet come up with any cure for COVID 19, taking preventive measures is the best possible way to boost your immunity. There are numerous immunity-enhancing superfoods accessible these days that can be included in your diet. They are curcumin, spirulina, amla, etc. Although turmeric as a spice contains only around 3% curcumin, turmeric supplements can be taken for adequate intake of curcumin.

Eat a balanced and varied diet

Although, there are no foods or supplements that can immediately spike our immune system to prevent COVID-19, consuming a balanced diet can keep you healthy from within. A well-balanced diet basically comprises plenty of fruits and vegetables, whole grains, plant and animal proteins, and healthy fats. It can be the best possible way to get the body all the essential nutrients it requires to maintain a normal immune function. Moreover, considering that we are less active during the quarantine days, consume food in small portions and refrain from foods that are high on fat sugar or salt. Also, limit alcohol intake.

Stay active at home - do household chores and cleaning

To avoid feeling lethargic and demotivated while sitting at home, gather yourself and take charge of doing all the household cleaning or chores, now that your house help is not there. This will add some kind of physical activity in your daily routine, benefiting both your body and mind. If you are working from home, take regular breaks in between by stretching and walking around the house or climbing up and down the staircase. You can also have dance sessions with your kids to keep them engaged during the lockdown.

Keep yourself hydrated

Staying hydrated is essential for health in general. Drink no less than 4 litres of water daily. However, for a further refreshing boost, you can add slices of lemon, cucumber, mint, orange slices or berries. You can also consume sugarfree drinks like lemon iced tea, fresh lime soda, fruit juices, coconut water, and more such healthier drink options to keep the body hydrated, especially during this heat.

Get enough sleep

A lack of sufficient sleep can negatively impact your health, both physically and mentally. It also messes up with the immune system, making the body incompetent to fight off infections. Since, you are in no rush to go somewhere during the lockdown days, aim to get at least 7-8 hours of quality sleep daily at night. Stress caused by the COVID-19 spread may have a negative impact on our sleep. So, try to improve your sleeping habits by establishing a sleep schedule for the weeknights. Avoid caffeine, alcohol intake, smoking, and screens before bedtime. Keeping the bedroom quiet, dark, and at a comfortable temperature. You can also try relaxation techniques such as meditation

Sanitize packaged items delivered at home

Even in self-isolation, outside items enter your home. Although cardboard packages pose a low risk of transmitting the virus, the deal is to avoid contact with the delivery guys. However, make sure to wash your hands and sanitize them thoroughly every time you make contact with them. This can help in mitigating the risk and assuage your fears

Practice good hygiene and especially safe food hygiene

Adopting simple hygiene measures can help in protecting you and your familys health. Even during the lockdown, you might be stepping out to buy groceries and essential items or simply getting them delivered at home. Avoid touching your face, eyes, nose or mouth once you touch any object coming from outside. Wash your hands thoroughly with soap and water. If you taking delivery of cooked food, transfer the food on a clean plate and dispose of the packet. Wash your hands thoroughly before eating.

Wash hands frequently

When outside, maintain a distance of at least 3 feet from people, because its the best line of defence. don't touch your face throughout the period while you are outside running errands. Once back home, wash your hands for at least 20-30 seconds in either hot or cold water. They both are equally effective at killing viruses as long as you use soap and do it the right way!

Restrict your screen time

With restricted outdoor movement, many of us might be relying on smartphones, smarts screens, or TV screens for entertainment in the form of watching an endless list of web series, movies, and watching varied types of content on social platforms. While they provide a temporary respite from the stress, spending an excessive amount of time in front of the screens can result in a lack of physical activity and may increase anxiety levels resulting in affecting the mental well-being. So limit the screen time and follow only the credible, trustworthy, and authorised sources for information and updates.

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#10 Tips to Stay Healthy During the Self-isolation Days of Covid19 - Entrepreneur

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Jul 9th, 2020 | Filed under Diet Safely

Studies in thousands of people on multiple continents now show the malaria drug hydroxychloroquine does not help patients hospitalized with Covid-19 live longer. But on Tuesday the White House, based on a new study that outsiders greeted with deep skepticism, disagreed.

Now the Food and Drug Administration again risks being pulled into an ugly political fracas over whether to permit more patients to be treated with the drug. It is a debate that threatens to undermine the agencys credibility when it needs it perhaps more than ever.

The FDA cannot afford another misstep if it wants to maintain credibility with American people, which is going to be so essential when doing a broad vaccine program, should we identify a safe and effective vaccine for Covid, said Luciana Borio, who served as the FDAs acting chief scientist from 2017 to 2019.

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At the root of the conflict is the fundamental principle that the FDA uses to evaluate drugs. Decisions are based almost entirely on what is known as a randomized controlled trial, in which patients are randomly assigned to receive a treatment or not. Other types of studies have, again and again, failed to deliver accurate information about medicines benefits and risks, and are used sparingly in making medical decisions. Three randomized studies have now shown no benefit for hydroxychloroquine in hospitalized patients.

The study that sparked the latest controversy was anything but randomized. Not only was it not randomized, outside experts noted, but patients who received hydroxychloroquine were also more likely to get steroids, which appear to help very sick patients with Covid-19. That is likely to have influenced the central finding of the Henry Ford study: that death rates were 50% lower among patients in hospitals treated with hydroxychloroquine.

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On Monday, President Trump, who has long been enthusiastic about hydroxychloroquine and even took the drug himself, tweeted about the results, saying that Democrats had politicized the drug and that the FDA should should Act Now. The presidents trade adviser, Peter Navarro, told reporters that Henry Ford had asked the FDA to issue a new emergency use authorization for the drug. The agency had previously revoked hydroxychloroquines authorization on June 15, based on evidence it was not effective.

Experts were taken aback by the developments.

The medical community has come to the inescapable conclusion that hydroxychloroquine is not effective at treating Covid-19 infections, said Steven Nissen, a cardiologist at the Cleveland Clinic and a longtime clinical trialist. Peter Navarro is not a scientist, he is the presidents trade representative. He should not be advising the public on matters of health.

Nissen and Borio say observational studies simply cannot be used to determine whether a medicine is effective. Again and again they have been wrong. In one famous example, estrogen replacement therapy after menopause was thought to have benefits in preventing heart and other problems; large studies showed this was not the case. In another, a knee surgery for arthritis was shown to have no benefits over medical care.

A paper that showed that hydroxychloroquine was potentially harmful, which was published in The Lancet in May, was met with similar criticism. It was eventually withdrawn.

Observational studies are often used to decide what ideas to test in randomized studies, to make sure that results from randomized studies translate to the real world, and to detect side effects.

But, puzzlingly, Henry Ford has applied for authorization to use hydroxychloroquine for a clearly defined list of clinical uses, including use in clinical trials, the system said in a statement.

We owe it to our patients and our communities to do everything we can to provide safe, effective, affordable treatments, and we will continue to collaborate toward meaningful solutions that address this deadly disease.

Evidence that hydroxychloroquine does not help hospitalized patients the use in its original emergency use authorization, which was designed to allow doctors to access a national stockpile of the drug is mounting.

One study, the RECOVERY study conducted in the U.K., compared 1,542 patients on a particularly high dose of the drug to 3,132 control patients and found no difference in how long patients lived. A second, conducted by the National Institutes of Health, also found no benefit from hydroxychloroquine at higher doses.

Yet, in his interview with the White House press pool, Navarro argued that the studies so far were based on bad science and that the Henry Ford data were evidence enough. He argued that the drug appears to work when given earlier in the disease course than it was in the large randomized studies. He said that rescinding the FDA authorization had a tremendously negative effect on two things.

One is the ability for American people to use this medicine to protect themselves, Navarro said, and, two, the ability for hospitals, like the Detroit hospital system, to recruit patients for the kind of randomized blind clinical trials that everybody wants to settle once and for all the questions of efficacy and safety.

It is not clear how the FDAs decision to rescind the emergency authorization for hydroxychloroquine affected either. Doctors can prescribe any drug for any use, and conducting a clinical trial requires a different type of approval from the FDA. It is clear that granting a new emergency use authorization based on an observational study would go against decades of experience by medical researchers and regulators around the globe.

A huge amount of scientific attention has been focused on hydroxychloroquine. An analysis Monday by STAT and AppliedXL, a computational journalism company, found that 1 in 6 clinical trials started for Covid-19 involved hydroxychloroquine or a similar drug, chloroquine.

Said Nissen: The sooner we stop talking about hydroxychloroquine, the sooner we can focus attention on more promising therapies.

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A flawed Covid study gets Trump's attention and FDA may pay the price - STAT

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Jul 9th, 2020 | Filed under Diet Safely

The gastrointestinal system, or gut, helps to shield the liver from damage from fructose (a form of sugar found in fruits, honey, and corn syrup)by breaking down the sugar before it reaches the liver, according to a new multi-centre study led by researchers in the Perelman School of Medicine at the University of Pennsylvania.

However, the consumption of too much fructose - particularly in a short period of time - can overwhelm the gut, causing fructose to "spill over" into the liver, where it wreaks havoc and causes fatty liver, researchers discovered.

Consumption of fructose has increased 100-fold over the last century, even as studies have shown that excessive consumption, particularly sweet drinks, are linked to non-alcoholic fatty liver disease, obesity and diabetes.

Studies have shown that the excessive consumption of fructose can be toxic to the liver. When large quantities of fructose reach the liver, the liver uses excess fructose to create fat, a process called lipogenesis. Eventually, people who consume too much fructose can develop nonalcoholic fatty liver disease, a condition in which too much fat is stored in the liver cells.

Until now, it hasn't been clear whether the gut's role in processing the fructose prevents or contributes to fructose-induced lipogenesis and the development of liver diseases.

In the new study, published inNature Metabolism,the team of researchers from Princeton University, the University of Pennsylvania and Weill Cornell medicine, US, aimed to unravel longstanding questions about how the body metabolises fructose.

They studied a key enzyme, called ketohexokinase, that controls how fast fructose is consumed.

They showed, by genetically engineering mice, that lowering the levels of theenzyme in the gut led to fatty livers in the mice. Conversely, the team showed that increasing the level of ketohexokinase in the gut protected from fatty liver. Thus, the researchers found the breakdown of fructose in the gut mitigates the development of extra fat in liver cells in mice.

They also discovered that the rate at which the intestine can clear fructose determines the rate at which fructose can be safely ingested.

"What we discovered and show here is that, after you eat or drink fructose, the gut actually consumes the fructose first - helping to protect the liver from fructose-induced damage,"said the study's corresponding author Dr Zoltan Arany, professor of cardiovascular medicine at Penn.

"Importantly, we also show that consuming the food or beverage slowly over a long meal, rather than in one gulp, can mitigate the adverse consequences."

In addition, the team showed the same amount of fructose is more likely to result in the development of fatty liver when consumed via a beverage as opposed to food. Similarly, the consumer faces an increased likelihood of developing fatty liver when consuming fructose in a single setting compared to several doses spread over 45 minutes.

"Collectively, our findings show fructose induces lipogenesis when the intake rate exceeds the gut's capacity to process fructose and protect the liver," Arany said."In the modern context of excessive availability and consumption of processed foods, it is easy to see how the resulting fructose spillover would drive metabolic syndrome."

Source:Nature Metabolism

Jang. C., et al

"The small intestine shields the liver from fructose-induced steatosis"

https://doi.org/10.1038/s42255-020-0222-9

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Jul 9th, 2020 | Filed under Diet Safely
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