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Pfizer and Opko Health have filed their once-weekly growth hormone deficiency (GHD) treatment for FDA approval, a decision the agency expects to make by October this year. The news comes after a phase 3 study showed the drug put less of a burden on patients than the established medicine, Pfizers Genotropin.

Genotropin, a recombinant human growth hormone, has been on the market for decades for the treatment of people with GHD. But like other human growth hormone treatments, it must be injected daily, a burden that has spurred research into longer-acting alternatives.

RELATED: Pfizer presents growth hormone data ahead of FDA filing

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The FDA approved the first such treatment for adults with GHD in August 2020: Novo Nordisks Sogroya, which, like Pfizer and Opkos drug, is injected once a week.

Pfizer and Opko teamed up in 2014 to develop somatrogon, with the latter running clinical development and the former getting the drug through approval and then onto the market.

Its Biologics License Application is based on a global phase 3 study that pitted somatrogon against Genotropin in 224 children with GHD who had not been treated before. The study met its primary endpoint, with somatrogon doing no worse than Genotropin on a measure called height velocitythe vertical growth of a child during a unit of timeafter one year.

While somatrogon achieved noninferiority against Genotropin, theres another drug in development that beat the incumbent. In a phase 3 study, children who took Ascendis Pharmas once-weekly drug TransCon hGH grew 11.2 cm, on average, compared to children who received Genotropin, who grew 10.3 cm. The FDA accepted Ascendis regulatory filing in September and expects to make a decision by June 25.

RELATED: 2020's New Drug Approvals | Sogroya

In October last year, Pfizer and Opko presented more data on their prospect from a phase 3 trial that tested a 12-week course of somatrogon followed by 12 weeks of Genotropin or vice versa. The goal of the study was to gauge whether patients and caregivers found the once-weekly drug interfered less in their lives than the incumbent did.

The trial used a life interference scale with possible scores ranging from seven to 35. Higher numbers indicate a greater burden. Somatrogon scored 8.63 on the scale. Genotropin scored 24.13, indicating that patients found the once-weekly product less of a burden.

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Pfizer, Opko's growth hormone med en route to October FDA decision - FierceBiotech

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Jan 9th, 2021 | Filed under Human Growth Hormone

The New Year is often a time to contemplate ones relationship with calories. After months of culturally sanctioned gluttony, we find ourselves suddenly facing a cold empty chasm with a familiar question: will we fill this void with purpose, or leftover eggnog? The pandemic holidays of 2020 were unique, of course. The usual peer-reviewed parade of excesses moved to Zoom, which didnt stop the snacking, lounging and binge drinking that in many homes has, in fact, been in full swing since March.

In the beforetimes, January was the busiest month of the year for gym signups, with the first being the busiest day. In the duringtimes of 2021 it will be more complicated, but losing weight will remain a top resolution.

Weight loss is a problem that stumps so many people, even while the answer could not be more obvious. What other problem can be solved by doing less?

Less eating, that is. Exercise is important for many, many reasons other than calorie burning. But trying to lose weight with exercise alone is like trying to wipe water off the floor without bothering to turn off the faucet thats overflowing the sink. We need to consume fewer calories, which means confronting hunger. Most people who can afford the choice will avoid that feeling, when they should probably make friends with it.

Consider the expression to stay hungry. It means, basically, to stay motivated; to keep after your goals and shape your dreams, rather than to lazily graze upon an all-you-can-eat pasture of your past achievements.

In the context of weight loss, those hunger pangs are the feelings that come from actual work, like the ache in your thighs after leg day at the gym. And new research appears to suggest, meanwhile, that fasting can improve your workoutincluding muscle buildingwhile exercise can increase the caloric burn of a fast. Like some magic pill that burns fat and builds muscle, the budding field of fasted training might be the answer to your New Years blues.

Not to be confused with starvation, fasting is the deliberate refraining from eating. Its an ancient practice tied to many religions and cultures, from Native American vision quests to Ramadan.

Mark Mattson, a professor of neuroscience at Johns Hopkins University, ushered in the modern era of fasting, now known scientifically as caloric restriction, with his 2003 research on mice. The study suggested that long-term calorie-restriction increased the little mammals lifespans. Subsequent work by Mattson and others documented cognitive improvements in mice on calorie-restricted diets, again confirming age-old wisdom. This work helped spawn the popular diet called Intermittent Fasting, or IFing, for short.

IFing focuses on the timing of meals, rather than their content. Most adherents shoot for 16 hours of no eating, including the time spent sleeping. If you sleep for 8 hours, then youd be fasting for about half of your waking time on any given day. One could just as accurately call the diet intermittent feasting, which is part of why its so popular.

Martin Berkhan, the weightlifter, irreverent blogger and owner of the Leangains brand, isnt shy about eating an entire cheesecake in a sitting, or poking fun at people who do sit-ups.Berkhan schedules his workout for the end of his fasting window and follows the workout with a no-holds-barred feast.

Love him or hate him, and regardless of whether you want Grand Canyon abs, Berkhan did a lot to organize the impact of caloric restriction on body building. Intermittent fasting is particularly effective, he says, because human growth hormone is naturally released in the early stages of a fast. Berkhan believes this fasting window is a powerful opportunity for the body to make the most of exercisehe does consume protein just before his regimen of squats, benches and pull-ups, all with hundreds of pounds of added weights, but his belly is not full. The reason he can get away with all the cheesecake is that those big muscles require a lot of energy to work that hard, and they will get that energy from his fat cells after depleting the sugar in his blood.

Exercising with an empty belly is not for everyone. But if youre willing to push against your comfort zone, it does get easier. Mattson told the health blog Inverse that it takes about a month before the hunger pains from a skipped meal go away, which coincides with the period when you can measure and feel the diets benefits, including insulin sensitivity in those with diabetes, lower blood pressure and even a lower resting heart rate. Fasting increases blood levels of ghrelin, a hormone that suppresses appetite, thereby making you less hungrya counterintuitive idea thats confirmed by virtually anyone who gives fasting a serious try.

Like any diet or health regime, intermittent fasting or fasted training only work if you stick to them. Americans act with a sense of entitlement about food, that its all ours for the taking and dont you tread on that right. But dont you want to see your own abs once, or once more, before its too late? You dont need to run up Mt. Everest every morning to get there. Just be cool with being a little hungry. Its the price of progress.

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Intermittent Feasting - The Source Weekly

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Jan 9th, 2021 | Filed under Human Growth Hormone

The Top-10 Inside With Brett Hawke Podcasts of 2020

Inside withBrett Hawkehas become a cant-miss podcast that catches up with some of the biggest names in the sport. Led by Brett Hawke, who swam at Auburn and represented Australia at two Olympic Games, the podcast looks at iconic moments and rivalries, among other storylines.Hawke gave us his top 10 podcasts of 2020, topped by the Russian rocket Alexander Popov.

10. Michael Klim

Klim took time out of his schedule to sit with fellow Australian OlympianBrett Hawkeand discussed a variety of topics on the Inside with Brett Hawke Podcast. Hawke conducted a superb interview with Klim, chatting with his former Aussie teammate about a variety of topics from moving from Poland to Australia, to his struggles at the 1996 Olympics to theiconic 4100 freestyle relay victory and defeat of the United States that Klim jumpstarted at the 2000 Olympic Games in Sydney.

During his career, Klim ranked as one of the worlds elite freestylers and butterflyers, earning six Olympic medals along the way. His leadoff leg of 48.18 on the Aussie 400 freestyle relay at the 2000 Olympics enabled Australia to hand the United States its first loss in the event in Olympic history. More, Klim was the star of the 1998 World Championships in Perth, where he captured seven medals, including titles in the 200 freestyle and 100 butterfly. That competition also yielded a silver medal in the 100 freestyle and a bronze in the 50 freestyle, and the fact that Klim medaled in three freestyle distances and the 100 fly demonstrated his range.

9. Nathan Adrian

Adrian has been one of the most consistent sprinters of the last 10 years, establishing himself as a mainstay on the U.S. National Team since making his first team in 2008. He talked about how he has been able to stay consistent (6:50) over the years and what he gets out of each practice. Adrian went over his early days at Cal (11:00) when he was joining lanes with past NCAA champions Duje DraganjaandMilorad Cavicin his freshman season in 2006.

Adrian talked about the stress of seeing the heat sheet on race day (13:00) and how he is able to approach his race plan rather than think about the opposition and who is lining up alongside him. He talked about his 100 freestyle in London where he won the gold medal over heavy favorite James Magnussen(22:50) of Australia, and became the first American to win the 100 freestyle since 1988. Adrian mentioned the day he saw Magnussen swim a 47.1 in the 100 freestyle at Australian Trials and how he reacted to the news in training.

8. Ryan Murphy

Murphy is the reigning Olympic champion in the 100 and 200 backstroke and the current long course world record holder in the 100 back. He won eight individual NCAA titles while at Cal Berkeley, sweeping all four years in the 100 and 200 back, as well as winning four relay titles in 2014 and 2015. He swam for the LA Current in the 2020 ISL season and is still one of the top backstrokers in the world.

7. James Magnussen

Magnussen went over his 2011 world title in the 100 freestyle and how he rapidly improved from third at the 2010 Australian Trials to gold medalist at the 2011 Worlds, including fully dedicating himself to being a professional swimmer (17:50), and using disappointment to fuel himself to be on Australias Worlds relays (21:30).

Magnussen shared some specific sets he did (26:50) to perfect his 100 freestyle back 50, and why he limited the number of training sessions per week (30:30). He won the World title at age 20 (36:00), and also led off Australias gold medal winning4100 freestyle relay teamwith a 47.4 to stamp himself as a contender in the100 freestyle(38:30).

James Magnussen followed that up with a 47.10 at the 2012 Olympic Trials (43:00), although he didnt feel good in the warm-up before the race, but still knew he was going to swim fast. Although Magnussen was the top swimmer in the world leading into the 2012 Olympics, he had a disappointing showing in London (50:00) with a fourth place in the 4100 freestyle relay and silver medal in the 100 freestyle, getting beat byNathan Adrianby 0.01. Magnussen went over what went wrong in the lead-up to the Olympics, believing he didnt race as much as he should have before the Games, and how he felt overwhelmed from all the hype.

6. David Marsh

Marsh was set to be inducted into the International Swimming Hall of Fame in 2020 before it had to be pushed to 2021 due to the pandemic. Marsh has coached on four US Olympic teams, including being named as the head coach of the US womens team in 2016 that won eight total gold medals. Marsh currently coaches at Team Elite in San Diego with a number of Tokyo Olympic hopefulsKathleen Baker,Jacob PebleyandMichael Chadwick.

5. Cody Simpson

Simpsons interview came right after he qualified for the Australian Olympic Trials in the 100 butterfly at a meet in San Diego. Simpson, who had enjoyed a career in pop music in his teens, has been training with Hawke in Los Angeles. Before Simpson found stardom in the music industry, and also celebrated acting and modeling success, he was an age-group swimming star in Australia and harbored dreams of racing at the Olympic Games. As a youth,Simpson was a Queensland age-group champ in the 100 butterfly and 200 individual medley. While those victories arrived in 12-and-under competition, anyone familiar with the sport recognizes the talent racing at any level in Queensland.

4. Yannick Agnel

2012 Olympic 200 freestyle championYannick Agnelof France weighed in onBrett Hawkespodcastabout the status of the 200 freestyle in the swimming world right now, sayingDanas Rapsysis the only swimmer who swims the 200 freestyle the right way.

There is only one way to dominate and win a 200 freestyle, Agnel said, referencing the need to take an attacking style. When Im watching swimming now, the only guy that knows how to swim a 200 freestyle is Danas Rapsys. And you know what, if it wasnt for him to have shaken the blocks in Gwangju, he would have won.

3. Bob Bowman

Bowman talked about the long journey of coaching Phelps (9:40) throughout his entire career from when he was 11 in 1996 until he was 31 in 2016. He went over his views on swimmer development (12:30) in the early years of their career and how looking at immediate goals and having a plan is key to developing champions. Bowman discussed his path to how Phelps ended up in his lap at Baltimore and how he didnt end up on the path he thought (16:40).

Bob Bowman went over how he handles being at an Olympic Games and the mental pressures that come with it (25:30) and what his scheduled daily routine looks like. Another thing he thought was important was treating every meet as it was important and not saving yourself for bigger meets (30:00).

Bowman mentioned how his next dream is to win an NCAA title (36:45). He is currently in his sixth season atArizona State Universityand the mens team was seeded to finish seventh at the 2020 NCAAs before the meet was cancelled.

2. Ian Thorpe

Thorpe went over the difficulties of the lead-up to the Sydney Olympics when he was breaking world records left and right (5:00), as well breaking his ankle in late 1999. On top of that, he was accused of taking human growth hormone and it took a lot out of him. Thorpe also talked about the legendary 200 freestyle final in Sydney in 2000 when he lost toPieter van den Hoogenband(11:00) and how that loss fueled him for the next four years to eventually win gold in Athens 2004 (36:00).

Ian Thorpe also famously anchored the 4100 free relay team that won gold in 2000 over the Americans, but had split a suit right before the final (24:00) and had to rush to put on a wet suit that he wore earlier in the night for the 400 freestyle. It was a stressful situation but he was able to make it on the deck for the final and swim in a truly historic race.

Thorpe detailed how the Aussies won their first Olympic gold medal in that relay, breaking the US streak in the event (27:30), and hearing that roar of the Australian crowd when he was on the block against US sprinterGary Hall, Jr.Thorpe took on superstar status after 2000 and Hawke and Thorpe reminisced (32:30) on times when they were in Japan when he would meet fans at events.

1. Alexander Popov

Popov, a native of Russian, had moved to Australia in 1993 with coachGennadi Touretskiand he went over how he moved to Australia and when he met the host Hawke in Australia. Popov joined Touretski in 1990 and two years later became the Olympic champion in two events. Leading into those Olympics, Popov went over some sets with how he gained the confidence to take down the almightyMatt Biondiof the United States (12:00).

Alexander Popov went through his training regimen (15:56) and how his injury prevention techniques influenced the athletes at the Australian Institute of Sport. Popov was best known for his distance per stroke in sprint swimming, which was generally thought to be a tempo-driven event and he went over how he was able to master that (19:00) in his career.

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The Top-10 Inside With Brett Hawke Podcasts of 2020 - Swimming World Magazine

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Jan 9th, 2021 | Filed under Human Growth Hormone

Anne Terese Gennette

May 31, 1956 - December 24, 2020

"A Life Well Lived"

Anne, at the age of 64, died after a brief illness. She is the first daughter of Tom and MaryAnne Gennette .

Anne lived her life in the Kelso-Longview area and was an active Kelso Hilander sports fan, graduating from Kelso High in 1978. Anne loved attending her high school reunions, where she was well liked and voted "Most Spirited". Anne participated in Special Olympics sports including softball, swimming, bowling, track and won many medals that she enjoyed showing to friends and family.

Anne was born with intellectual and physical disabilities that caused her to stop growing at the size of a six year old. At the age of 14 she became part of a research program for Human Growth Hormone at Seattle Children's Orthopedic Hospital. Anne grew 10 inches in 10 years to reach her height of 4 feet 11 inches tall.

Anne completed vocational training with the Adult Developmental Center, Residential Resources and Life Works. She had multiple jobs in the community in office buildings, restaurants and fabric stores. She enjoyed the YMCA Goodtimes program where she met many lifelong friends. Anne faithfully attended the Immaculate Heart of Mary Catholic Church, and participated in the Religious Experience (REX) program for people with and without disabilities. In addition, Anne was politically active advocating for People First as a spokesperson at the state level. She enjoyed traveling especially with her sister, Donna and cousin, Mary, to places such as Disneyland, Alaska, and Hawaii, where she kissed a dolphin. As a crafter, Anne enjoyed painting bird houses, ceramics, knitting hats, and gifting them to friends and family with joy and enthusiasm.

She is survived by mother, MaryAnne, sisters Donna Gennette, Raphielle Chynoweth, and nephews, T.J and Liam Chynoweth; aunts Shirley Knudeson, Linda Waterman, Suzie Cowan, Adrienne Stacey and numerous cousins.

She is preceded in death by her father, Tom Gennette, grandparents Art and Jessie Noseda; Hector and Mathilda Gennette, great grand parents Jack and Ethel Noseda, Mary Richardson; Aunts Patricia Turk, Martha Gratton, Marge Lyster, Uncles Jim Gennette, John Turk, Dale Knudeson and Dave Waterman.

Plans for a rosary, funeral Mass and memorial will be announced at a later date. Remembrances can be made to Lifeworks/ARC at 906 New York Street, Longview, WA 98632, or the Immaculate Heart of Mary Catholic Church 2200 Allen Street, Kelso, WA, 98626.

Published by The Daily News on Jan. 3, 2021.

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Anne Terese Gennette Obituary - Longview, WA | The Daily News - Legacy.com

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Jan 9th, 2021 | Filed under Human Growth Hormone

The Global Human Growth Hormone Drugs Market provides a basic overview of the industry including definitions, classifications, applications and industry chain structure. The Human Growth Hormone Drugs Market analysis is provided for the international markets including development trends, competitive landscape analysis, and key regions development status. The report provides key statistics on the market status of the Human Growth Hormone Drugs Market manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the industry.

ReportsnReports has published the latest research study onGlobal Human Growth Hormone Drugs Market 2021 by Manufacturers, Regions, Type and Application, Forecast to 2026focusses on a complete overview of the market with a detailed description of the global market. The report focusses on accurate data, present industry activities, growth opportunities, new product inventions.

The report covers the present scenario and the increased prospects (2021-2026) of this worldwide Human Growth Hormone Drugs Market. It emphasizes the dynamics of the market such as internal and external driving forces, restraining factors, risks, challenges, threats, and opportunities.

To estimate the industry dimensions, the report believes the total addressable market by the significant players round many segments. The complete view is linked with the progress of this global Human Growth Hormone Drugs Market by the significant players involved in this business.

Human Growth Hormone Drugs Market Research Report @ http://www.reportsnreports.com/contactme=3977281

Segment by Type, the Human Growth Hormone Drugs market is segmented into:

Segment by Application:

Global Human Growth Hormone Drugs Market: Regional Analysis

The Human Growth Hormone Drugs market is analysed and market size information is provided by regions (countries). The report includes country-wise and region-wise market size for the period 2015-2026.

It also includes market size and forecast by Type and by Application segment in terms of sales and revenue for the period 2015-2026.

Research Report @ http://www.reportsnreports.com/contactme=3977281

Global Human Growth Hormone Drugs Market: Competitive Analysis

This section of the report identifies various key manufacturers of the market. It helps the reader understand the strategies and collaborations that players are focusing on combat competition in the market.

The comprehensive report provides a significant microscopic look at the market. The reader can identify the footprints of the manufacturers by knowing about the global revenue of manufacturers, the global price of manufacturers, and sales by manufacturers during the forecast period of 2015 to 2019.

The Major Players in Global Human Growth Hormone Drugs Market Include:

Report @ http://www.reportsnreports.com/purchasme=3977281

Table of Contents:

Chapter 1 - Human Growth Hormone Drugs Market Overview

Chapter 2 - Global Human Growth Hormone Drugs Market Competition by Manufacturers

Chapter 3 - Human Growth Hormone Drugs Retrospective Market Scenario by Region

Chapter 4 - Global Human Growth Hormone Drugs Historic Market Analysis by Type

Chapter 5- Global Human Growth Hormone Drugs Historic Market Analysis by Application

Chapter 6 Company Profiles and Key Figures in Human Growth Hormone Drugs Business

Chapter 7 - Human Growth Hormone Drugs Manufacturing Cost Analysis

Chapter 8 - Marketing Channel, Distributors and Customers

Chapter 9 - Market Dynamics

Chapter 10 - Global Market Forecast

Chapter 11 - Research Finding and Conclusion

Chapter 12 - Methodology and Data Source

List of Tables:

Table 1. Global Human Growth Hormone Drugs Sales (K Pcs) Growth Rate Comparison by Type (2015-2026)

Table 2. Global Human Growth Hormone Drugs Sales (K Pcs) Comparison by Application: 2020 VS 2026

Table 3. Global Human Growth Hormone Drugs Market Size by Type (K Pcs) (US$ Million) (2020 VS 2026)

Table 4. Global Key Human Growth Hormone Drugs Manufacturers Covered in This Study

Table 5. Global Human Growth Hormone Drugs Sales (K Pcs) by Manufacturers (2015-2020)

Table 6. Global Human Growth Hormone Drugs Sales Share by Manufacturers (2015-2020)

Table 7. Global Human Growth Hormone Drugs Revenue (Million USD) by Manufacturers (2015-2020)

Table 8. Global Human Growth Hormone Drugs Revenue Share by Manufacturers (2015-2020)

Table 9. Global Market Human Growth Hormone Drugs Average Price (USD/Pcs) of Key Manufacturers (2015-2020)

Table 10. Manufacturers Human Growth Hormone Drugs Sales Sites and Area Served

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Global Human Growth Hormone Drugs Market Analysis | By Company Profiles | Size | Share | Growth | Trends and Forecast To 2026 interpreted by a new...

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Dec 31st, 2020 | Filed under Human Growth Hormone

As 2020 comes to a close, Big Molecule Watch once again reviews the top developments in the biologics and biosimilars space for 2020. Please keep an eye out this week for posts identifying the most important regulatory, market, and legal developments impacting biosimilars. We start today with our picks for the most significant U.S. regulatory developments related to biosimilars in 2020:

1.FDA and FTC Announced Collaboration to Support Biosimilars Market

In February, the U.S. Food and Drug Administration and the Federal Trade Commissionreleasedajoint statementsignaling collaboration to advance competition in the market for biologic products. According to theFDApress release, [t]his joint statement describes key steps the agencies will take to address false or misleading promotion about biosimilars within their respective authorities and deter anti-competitive behavior in this space. In March, the two agencies held apublic workshopto discuss their collaborative efforts.

2. New FDA Draft Guidance Documents

The FDA issued two draft guidance documents relevant to biosimilars in February. First, the FDA issued adraft guidanceon Promotional Labeling and Advertising Considerations for Prescription Biological Reference and Biosimilar Products. This draft guidance addresses the truthful and non-misleading manner in which data and information concerning reference or biosimilar products must be presented. Second, the FDA issued a draft guidance titled Biosimilars and Interchangeable Biosimilars: Licensure for Fewer Than All Conditions of Use for Which the Reference Product Has Been Licensed. In November, the FDAreleased an additional draft guidance on this topic entitledBiosimilarity and Interchangeability: Additional Draft Q&As on Biosimilar Development and the BPCI Act.According to theFDA, the draft guidance is intended to inform prospective applicants and facilitate the development of proposed biosimilars and proposed interchangeable products, as well as describeFDAs interpretation of certain statutory requirements added by the BPCI Act.

3. FDA Launch of Searchable Purple Book

In late February, theFDAlaunched the online version of the Lists of Licensed Biological Products with Reference Product Exclusivity and Biosimilarity or Interchangeability Evaluations, colloquially known as the Purple Book. The searchable database contains information about FDA-licensed biological products, specifically, licensed biosimilar and interchangeable products and their reference products.

4. FDA Issued Final Definition of Biological Product

Also in February, theFDA issued afinal ruleregarding the definition of biological product, which interpreted the word protein to mean any alpha amino acid polymer with a specific defined sequence that is greater than 40 amino acids in size. TheFDAstated that this new interpretation will reduce regulatory uncertainty by adopting a bright-line approach that will reduce the amount of time spent byFDAstaff and industry in determining whether a product is a biological product.

This final rule also addressed the transitionof insulin, and some other products such as human growth hormone (somatropin), pancrelipase, chorionic gonadotropin, follitropinalfa, and menotropins, from regulation as small molecule drugs to biologics.

5. Impact of Covid-19 Pandemic on Biosimilars

It would not be a 2020 year-end post without mentioning the impact of the Covid-19 pandemic on biosimilars. Due to travel restrictions, the FDA was unable to complete inspections of manufacturing facilities, leading to delays in approval of Revances DaxibotulinumtoxinA for Injection biologic and deferred action on Spectrums ROLONTIS (eflapegrastim) BLA.

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Year in Review: Top U.S. Biosimilars-Related Regulatory Developments of 2020 - JD Supra

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Dec 31st, 2020 | Filed under Human Growth Hormone

Global Therapeutic Protein Market 2020 by Manufacturers, Type and Application, Forecast to 2025 comes as one of the hard-to-find market data reports published by MarketsandResearch.biz that determine the market growth and market share for the estimated forecast period. The report examines trends, industry development, industry structure, supply and demand, industry capacity, marketing channels, and leading industry participants. The report shows several business perspectives on important factors such as key geographies, major key players, opportunities, drivers, restraints, and challenges. Historical data and long-term forecasts through 2020 and 2025 are an important part of this global Therapeutic Protein market research document. The study contains an examination of dynamic aspects such as industrial structure, application, classification, and definition.

What It Consist of?

The report involves classified segmentation of market covering product type, application, players, and regions. The research determines the competitive landscape of the market share, market size, for the estimated forecast period. The report covers the recent and futuristic Therapeutic Protein market share of each region alongside the significant nations in the respective regions. The research consists of info graphics and diagrams that show easy to understand examination of the global market. It provides an insight into the aspects within this segment that may encourage or demote the expansion of the global industry.

NOTE: Our report highlights the major issues and hazards that companies might come across due to the unprecedented outbreak of COVID-19.

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Key players profiled in the report include: Amgen, Eli Lilly, Baxter International, Abbott Laboratories, Diasome Pharmaceuticals, AstraZeneca, Generex Biotechnology, Chugai Pharmaceutical, Boehringer Ingelheim, GeneScience Pharmaceuticals, Genentech

Next, the report uncovers the gaps and opportunities to derive the most relevant insights from our research document to gain global Therapeutic Protein market size. For the region, type, and application, the sales, revenue, and market share, growth rate are key research objects. Here the report considers the key aspects such as areas of operation, production, and product portfolio as well as company size, market share, market growth, production volume, and profits.

Market segment by type, the product can be split into: Monoclonal Antibodies, Erythropoietin, Insulin, Interferon, Human Growth Hormone, Follicle Stimulating Hormone, Blood Clotting Factors

Market segment by regions/countries, this report covers: Pharmaceutical Companies, Healthcare Service Providers, Research Organizations, Academic Research Institutes, etc.

The report offers examination and growth of the market in these districts covering: North America (United States, Canada and Mexico), Europe (Germany, France, UK, Russia and Italy), Asia-Pacific (China, Japan, Korea, India and Southeast Asia), South America (Brazil, Argentina, etc.), Middle East & Africa (Saudi Arabia, Egypt, Nigeria and South Africa)

The next section of the report takes a close review of the challenges and threats prevalent in the global Therapeutic Protein market. The report also includes classified information and intelligence related to geographical expanse, regional overview, as well as vital details associated with country-specific developments that have also been addressed in the report.

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Global Therapeutic Protein Market 2020 Key Factors and Emerging Opportunities with Current Trends Analysis 2025 - The Courier

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Dec 31st, 2020 | Filed under Human Growth Hormone

Its arguably artificial: this mid-winter demarcation that weve crossed into a new year, much like a road sign announcing Welcome to Delaware! on an otherwise monotonous stretch of highway. Cold weather persists; the return to so-called normalcy is a ways off. But in fact this time of hibernation presents an ideal opportunity to introduce (or reinforce) a few good habits. With day-to-day life more narrowly defined, the hope is that any new improvements will loom larger, registering more clearly as reward. And if they linger in mind, could they just possibly linger in routine?

This is not a bid for rigid resolutions. Who among us can label another persons coping mechanism a vice? Why turn down a delicious source of pleasure in favor of some wan healthful alternative? Instead, consider this seven-point list an excuse to invite more good things into the everyday. Youll find tools for inside-and-out hydration alongside strategies to kick-start a lapsed workout regimen. There are ideas for retooling the home-office for well-being and the bedroom for sleep (and other brain-calming activities). This checklist is hardly comprehensive (we'll save the Dolly Partonworthy bath products for another day). Instead, its more of an easygoing reset. Heres to a new year, a brighter work day, a solid nights sleep.

1. Stay hydrated.

So much of the New Years narrative involves what not to drink. Instead, think about replenishment. Water makes up a solid 60 percent of the body, and that balance is perpetually subject to straindue to perspiration, overactive heating systems, and, yes, those diuretics (coffee, alcohol) perhaps too good to give up. (To each their own.) Keeping the organs and nasal passages hydrated is good for the immune system; the same goes for skin, which is why so many dermatologists recommend a humidifier, such as this ultrasonic model. As for getting in your eight glasses, simple strategies help: A hand-blown carafe offers cheery encouragement; a sleek sparkling-water machine makes for elegant bubbles. And to curb the monotony, try Tomens suite of botanical tinctures, made in consultation with a sommelier. They're as much plant medicine as they are a subtle palate pleaser.

2. Work in comfort.

A heartfelt congratulations to those who have managed to kit out a serene, ergonomically sound home-office this year. For the rest of us, its time to consider a WFH upgrade. A physical therapist would suggest starting with the spinewhether thats investing in an Aeron chair, the 1994 classic engineered to support the back and limbs through desk work, or another solution that improves upon the hunched-laptop position. For those spiritually darkened by early sunsets (or the dread of a post-holiday inbox), an LED lamp for seasonal affective disorder brings in the sunshine, with a streamlined form evocative of the planets. A counterpoint to technology is also in order. A mail-order fern warms up the nest (and will similarly appreciate a humidifier). Meanwhile, the Nue Co.s Forest Lungs fragrance aims to simulate a brain-clearing walk in the woods, using patented technology to recreate the feel-good phytochemicals exhaled by trees.

3. Tap the fungi kingdom.

The fanfare around the mushroom world continues to bloom, as the various phytonutrients and immune-boosting benefits continue to shape conversation. Now, they come in even more upbeat, delicious forms. Rainbo, run by holistic nutritionist Tonya Papanikolov, recently launched targeted, single-mushroom tincturesfrom mood-balancing reishi to antioxidant-rich chaga. The new functional-beverage line Earth & Star pairs mushroom blends with oat milk for an instant refresh; the ceremonial-grade matcha version, with shiitake and turkey tail mushrooms, is a morning eye-opener. Abbe Findley, the herbalist behind Zizia, serves up cordyceps, reishi, and other varieties in her Mushroom Mesquite powderstirred into a warm drink, it's a nutty-sweet pick-me-up. For the culinary-minded, homegrown mushrooms (blue oyster or fuzzy lions mane) arrive via Smallholds kits. Regular misting in exchange for a countertop harvest: sold.

4. Reset your skin.

Its the season for getting back to basics, skin care included. With drier weather comes a counterintuitive need for regular exfoliation. However much a healthy skin barrier is key to keeping moisture in and aggressors out, an excess of dead skin cells at the surface can be a roadblock for beneficial skin-care agents. An exfoliating toner like Augustinus Baderswith gentle hydroxy acids to refine the surface texture, along with soothing botanicalsis a good nightly ritual. Dr. Dennis Grosss new exfoliating pads for the body keep the neck-down territory in check (twice weekly is recommended). Next comes moisture. SupereggErica Chois newly launched skin-care startup, which replicates the beneficial components of the egg using plant-based ingredientsdelivers nourishment without irritation via its Sound Renewal cream; the round vessel is a nod to its Yolk Duplex technology. And for hydration with ceremony, Sisleys body cream blends shea butter with heady saffron-flower extract.

5. Streamline home workouts.

Its the January clich, to talk about fitnessbut probably everyone except the Peloton diehards could use a reboot. If our collective well-being suffered less from holiday excess this year, it continues to feel the weight of this simulated long-haul flight, which has us pottering about the cabin to stretch our legs and not much more. The recent launch of Apple Fitness+ ($10 per month) is a sleek means of shaking things up, with a breadth of mat-based sessions alongside cycling and treadmill workouts, all synched with the brands devices. (A new Apple Watch comes with three months free.) Maybe you miss the communal feel and errant car horns from your usual yoga class? Thats where Sky Ting TV ($20 per month) comes into play, with a mix of live and prerecorded classes from the good-vibes New York studio. Outdoor activitieswise if gruelingcall for thermal leggings, while an LED jump rope perks up an early-morning (or late-night) round of cardio.

6. Feel good in your body.

If taking care of yourself at home is the ongoing imperative, let that translate to the full spectrum of sensations. That might include a CBD oil by Common Bond, designed to pique the erogenous zones; or a sleek vibrator by Maude, which recently announced Dakota Johnson as its co-creative director. Sensuality just as easily arrives by way of a sustainable cashmere bralette by the wellness-minded brand Live the Processan elevated piece to accompany a morning cycle of cat-cow poses. And for a mellow evening, there is Rose Los Angeless take on Turkish delights. This batch, created with chef Nicole Rucker, incorporates organic apricots and lemon verbena from a family farm in Santa Cruz, along with 5 mg of CBD rosin. (Californians can seek out the brands THC variations for a deeper unwind.)

7. Set the stage for sleep.

The implications of a good nights rest run deep. Its a crucial period for the production of human growth hormone and new cells; a healthy circadian rhythm helps keep hormones in check and cognitive performance running smoothly. It all underscores how important it is to refine the nighttime routine. Lofties new multifunctional alarm clock is designed to take smartphones out of the bedroom, with features like breathwork exercises and white noise to quiet the mind. Bodhas cashmere eye pillow, filled with lavender and chamomile, quiets the visual frame; Rennes Full Moon sleep tincture, with a heavy-duty dose of CBD alongside tulsi and vanilla bean, aims to do the same from the inside-out. And for the proverbial beauty sleep, theres Odacits night cream. Pale pink from pomegranate, the formula includes tested antioxidants (vitamin C, CoQ10) and potent botanicals (blue-green algae, ashwagandha) to carry you through till morning.

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The No-Resolutions Guide to New Year's Wellness - Vanity Fair

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Dec 31st, 2020 | Filed under Human Growth Hormone

Three University of WisconsinMadison professors Charles Mistretta, Denise Ney and Ann Palmenberg have been named fellows of the National Academy of Inventors.

NAI fellowship honors academic inventors who have demonstrated a spirit of innovation in creating or facilitating outstanding inventions that have made a tangible impact on quality of life, economic development and the welfare of society, according to the academy.

UWMadisons newest trio of fellows are responsible for scores of patents, and bring the universitys total academy membership to 10.

Charles Mistretta

Mistretta, an emeritus professor of medical physics, radiology and biomedical engineering, invented digital subtraction angiography, a medical imaging technique that reveals flow (or lack thereof) through blood vessels. The technology is a workhorse of cardiac and neurology clinics, guiding the use of minimally invasive treatments like the placement of stents in blood vessels. He also made important improvements in magnetic resonance imaging techniques serving millions of patients each year, inventing ways to speed up the imaging process, improve resolution and measure the velocity of blood moving in the body.

Denise Ney

Ney, the Billings-Bascom Professor of Nutritional Sciences, invented a way to use GMP, a whey protein produced during cheesemaking, as a safe source of protein for children suffering from a genetic disorder, phenylketonuria (or PKU), that keeps them from safely metabolizing an essential amino acid present in almost all protein-laden foods. Before Neys GMP work, kids with PKU were largely restricted to expensive synthetic dietary supplements that tasted awful. They would often cheat, eating forbidden foods and risking brain damage. Now, GMP-rich foods are made by three companies for PKU patients around the world, and Ney has gone on to show that GMP can also reduce skeletal fragility in women and help with weight loss.

Ann Palmenberg

Palmenberg, the Roland Rueckert Professor of Biochemistry, first described a way to use genetic material called recombinant complementary DNA to make new types of live virus vaccines. Her discovery and application of viral internal ribosome entry sites, called IRES, is the basis for nearly all pharmaceutical drug production using living cells (like yeast) as protein factories including insulin, human growth hormone, interferon and synthetic antibodies. By studying the genomes of viruses and their physical structures, Palmenberg has helped develop panels of new antivirals, vaccines and highly sought-after research reagents used in thousands of labs around the world.

The 2020 fellows class includes 175 inventors from 115 universities and governmental and non-profit researcher institutes around the world. They will be inducted during a ceremony at the academys annual meeting in Tampa in June.

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Dec 8th, 2020 | Filed under Human Growth Hormone

Being sleep deprived is hard for parents of a new baby, but very young kids typically dont sleep long stretches at night. iStock / Special to On the Minds of Moms

Other than warming our hearts, infants and very young children spend more time sleeping than doing anything else. The American Academy of Sleep Medicine recommends children 4 months to 12 months get between 12 and 16 hours in each 24-hour period more than half the day. Before 4 months, there's a wide range of normal so the general advice is to let them do what it seems like their little bodies want to do, since sleep is integral to all the work of growing their bodies and developing brains.

Very young children aren't supposed to sleep through the night, or even for more than a few hours at a time for the first several months of life. Waking is usually a sign of another biological need, such as food or a diaper change. During the night, the simplest way to get them back to sleep is simply to take care of their needs quickly and quietly without turning on the light if possible and get them back to bed.

Studies show that having a nightly bedtime routine is associated with better sleep in children of all ages. For babies, that routine can be as simple as a few minutes of rocking and sharing a favorite lullaby.

Tots who are learning more about boundaries and control can start taking a more active role in their bedtime routine at this age. iStock / Special to On the Minds of Moms

When your baby gets a little bigger, routines are still very important, but they'll want to have more power over things in their life. At this age they're starting to test boundaries, so giving them control over small choices around sleep like what book to read, which side of the bed to put their head on or which stuffed animal to to snuggle. This helps them feel like they have some authority while avoiding power struggles which we all learn eventually that no one really wins.

At this age, kids should be sleeping between 11 and 14 hours a day, including two naps a day at the start of this period, dropping to one nap a day as they turn 2.

Night terrors start appearing in some children around this age. Kids may wake up screaming, unable to properly communicate. Experts recommend doing your best to quietly soothe your child, keep them in bed and help them get back to sleep. Usually children don't wake up fully during night terrors or remember them in the morning. They can be frightening for parent and child, but are generally normal. If they're frequent or are causing daytime sleepiness, talk to your pediatrician.

Preschoolers tend to stall the bedtime process, but there are ways to make things go smoothly. iStock / Special to On the Minds of Moms

We all know it when we see it tantrums, emotions running high and hyperactivity. Its what a lack of sleep looks like in a preschooler. When they dont get the recommended 10 to 13 hours of sleep in a 24-hour period, thats when these fun times can rear their ugly heads. While we make our best attempts at getting those squirrly littles safe and sound asleep at a decent time, there are often many hurdles to jump through: the bathroom breaks, the unquenchable Im- going-to-die-if-I-dont-get-a-drink thirst, and the just one more thing pleas.

We get it. Were all tired from a full days worth of adulting, but throwing in the towel here may have some drawbacks because its not only about preventing a bad day. A lot of functions important to growth, health, memory and cognitive development happen during sleep. Nerve cells are rewired, muscles are restored and human growth hormone is released.

Basically, kids need their sleep so they can grow and learn at an optimal rate. If your kid is dealing with some serious FOMO during bedtime that keeps them springing out a bed for just one more thing here are a few things to try:

Prep the brain by turning off screens about one hour before bedtime.

Create a calm environment. As bedtime nears, dim the lights and choose relaxing activities, such as reading or talking.

Stick to a consistent sleep schedule throughout the entire week. Yes, even on weekends, as much as possible.

Involve them in planning their bedtime routine. Whatever relaxing activities you choose to make part of their bedtime ritual, be sure to explain the rules, e.g. number of books, time limits, etc.

Kids age 6 to 9 still need a good amount of sleep, which may require some experimentation before you find the right amount for your child. iStock / Special to On the Minds of Moms

These are some big years for big kids. Theyre becoming more immersed in the large world around them, which means theyre also experiencing more learning, social and emotional challenges than ever before. All the more reason getting the American Academy of Sleep Medicines recommended nine to 12 hours of sleep a day is important.

According to AASM when kids are able to regularly get this amount of good quality sleep their attention, behavior, learning and memory operate at optimal levels. And like everyone else, their quality of life as well as overall mental and physical health are enhanced. Good, ample sleep is like setting the stage for their success.

So how do you know when your kids arent hitting their sleep sweet spot? Here are some signs to look out for from the Cleveland Clinic:

You need to awaken your child three to four times before they actually get out of bed.

Your child tells you they're tired during the day.

They need catch-up sleep on weekends.

They fall asleep during the day.

If these sound familiar, work toward getting back on track. Start bedtime earlier by about 15 minutes per day until you hit the right amount of sleep per night for your child. Also, be sure to stick to a similar schedule on the weekends, staying within the same wakeup and bedtime by 30 to 45 minutes. If you havent already, this may be a good time to start using an alarm clock. And finally, consider a relaxing bedtime routine, which can be helpful for anyone at any age really.

It may sound crazy, but tucking in your tweeners is still a great habit to set the stage for quality sleep. iStock / Special to On the Minds of Moms

This can be a busy time for kids this age, as school activities pick up and homework gets to be more of an actual thing. But parents should not let up on insisting on nice, early bedtimes because while they might seem a little bit old to do the traditional tuck-in, their growing bodies and brains still desperately need that good, quality sleep.

According to the sleepfoundation.org, tweeners require 9-11 hours of sleep per night. And while grumpiness and grogginess will certainly follow a night of inadequate sleep, thats the least of the worries. According to experts, children who do not get enough sleep on a regular basis are at a much higher risk of developing anxiety and depression. And what are kids this age often doing later at night anyway when they should be in bed? They might be sitting on their phones, which can not only contribute to depression and anxiety due to excessive social media, but the screens emit a blue light that stimulates the brain, making it even more difficult for children to fall asleep. Having them put the phones up in the kitchen and tucking them in like theyre little can do wonders for kiddos this age.

Inadequate sleep can also hit children physically in terms of weight gain. Studies show that when kids dont get enough sleep, it disrupts their hormone levels, which regulates appetite and food intake. This can lead to overeating and a craving for sugar and bad carbs. Moral of the story? Tuck them in. You read that right.

Its a common stereotype assigned to teenagers in movies and TV shows. They emerge from a messy bedroom, yawning and running fingers through disheveled hair oblivious to whats going on in the world. Hilarity ensues when mom or dad crack wise about the teen sleeping all day.

The truth is teenagers do need more sleep than the average adult. But despite what Hollywood implies, most teenagers are not getting enough of it.

The American Academy of Sleep Medicine has recommended that teenagers aged 13 to 18 years should sleep 8 to 10 hours per 24 hours. However, in a 2015 survey, the Centers for Disease Control found seven out of 10 teenagers were not getting the minimum eight hours of sleep a night.

If the lack of sleep only meant a few extra yawns at the breakfast table, it would be no big deal. However, doctors say teens who dont get enough sleep have a higher risk of obesity, diabetes, injuries, poor mental health, and problems with attention and behavior.

Parents can do their part to help their teen sleep better, including setting up a media curfew. Require your teen to get off SnapChat, TikTok and all social media and electronics no later than 9 p.m. The brain needs time to unwind and settle into a good nights sleep. And while teens are more likely than other age groups to have active social lives outside the family, encourage your teen to get the same amount of sleep every night. While it might feel good to catch up on your sleep on the weekends, in the long run, getting a solid eight to 10 hours a night is better for your teens mental and physical health.

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Dec 8th, 2020 | Filed under Human Growth Hormone
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