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NGENLA (somatrogon) is a once-weekly, long-acting therapy created using recombinant technology for paediatric patients aged three years and older, who experience growth failure due to an inadequate secretion of endogenous growth hormone.

Opko Health, a US-based healthcare company, developed the drug as a long-acting human growth hormone (hGH-CTP) for the treatment of paediatric and adult growth hormone deficiency (GHD).

OPKO utilises its exclusive technology to prolong the half-life of hormones without relying on polymers, encapsulation methods, or nanoparticles. The foundation of the technology lies in a natural peptide known as the C-terminal peptide (CTP) derived from the beta chain of human chorionic gonadotropin (hCG).

Opko Health entered a global agreement with US-based biopharmaceutical company Pfizer to further develop and commercialise the drug for the treatment of GHD in both adults and children in December 2014. Additionally, the partnership aims to address growth failure in children born small for gestational age (SGA) who do not exhibit catch-up growth by the age of two years.

The NGENLA is a clear, colourless to slightly light-yellow solution. It is available in single-patient-use, disposable prefilled pen doses of 24mg/1.2ml (20mg/ml) and 60mg/1.2ml (50mg/ml). The pens allow for incremental dosing adjustments of 0.2mg and 0.5mg, respectively, for subcutaneous administration.

The molecule combines the natural peptide sequence of native growth hormone with the 28 amino acids of the CTP. It aims to decrease the frequency of injections for growth hormone replacement therapy in children and adolescents with GHD from a daily regimen to once a week, offering a more convenient treatment option.

Its extended action in the body indicates that patients require only weekly injections, a significant improvement over the daily injections required by traditional growth hormone therapies such as GENOTROPIN (somatropin).

NGENLA is administered subcutaneously through an injection device that allows for precise titration based on patient needs. The drug offers approximately 85% fewer injections, which can be administered any time of the day, not just at night.

The US Food and Drug Administration (FDA) approved NGENLA for the treatment of paediatric GHD in June 2023. The European Commission (EC) had provided marketing authorisation (MA) to the drug in February 2022.

Japans Ministry of Health, Labour, and Welfare (MHLW) approved NGENLA in January 2022, offering it in both 24mg and 60mg pen options.

NGENLA is currently approved in more than 40 markets such as the UK, Canada, Australia, South Korea, Taiwan, India, and Brazil for the treatment of paediatric GHD.

GHD is a condition marked by insufficient secretion of growth hormone from the anterior pituitary gland, which is crucial for childrens growth and maintaining a healthy balance of muscle, bone, and fat tissues.

The condition can be congenital due to genetic mutations or brain structural defects, or acquired later in life through trauma, infection, radiation therapy, or tumour growth. Some cases have no identifiable cause and are deemed idiopathic.

Paediatric growth hormone deficiency (pGHD) affects approximately one in 3,500 to 10,000 children, leading to delayed or restricted growth. Adult growth hormone deficiency (AGHD) is estimated to affect approximately 50,000 individuals in the US alone.

Symptoms of GHD can include a younger appearance, abdominal fat, thin hair, slow tooth development, poor nail growth, delayed facial bone development, teeth eruption, truncal obesity, and delayed skull closure. In children, pGHD can result in significantly shorter stature compared to peers and is associated with delayed physical development.

NGENLA is a novel long-acting human growth hormone receptor (GHR) agonist. It binds to and activates the GHR, which subsequently initiates a series of signal transduction events, triggering changes in growth and metabolism.

The binding causes activation of the STAT5b signalling pathway and the subsequent increase in serum concentration of insulin-like growth factor (IGF-1). GH and IGF-1 are essential for stimulating growth and metabolic functions within the body.

By mimicking the effects of endogenous growth hormone, NGENLA not only promotes linear growth but also enhances protein synthesis and affects the metabolism of carbohydrates, lipids, and minerals.

The FDAs approval of NGENLA was based on a multi-centre, randomised, open-label, active-controlled Phase clinical study. The trials design aimed to compare the once-weekly administration of NGENLA with the once-daily administration of GENOTROPIN (somatropin).

A total of 224 treatment-naive, paediatric patients with GDH were randomised in a 1:1 ratio to receive either NGENLA once-weekly at a dose of 0.66mg/kg/day or somatropin once-daily at a dose of 0.034mg/kg/day.

The primary efficacy endpoint of the study was annualised height velocity at week 52.

After 52 weeks of treatment, the group treated with NGENLA exhibited an annualised height velocity of 10.1cm/year. In comparison, the patients who received daily somatropin demonstrated an annualised height velocity of 9.8cm/year at the end of the same treatment period.

The study successfully demonstrated the non-inferiority of NGENLA compared to somatropin. NGENLA was generally well-tolerated by the participants in the study, showcasing a safety profile that was comparable to that of somatropin.

The most common adverse reactions were injection site reactions, nasopharyngitis, headache, pyrexia, anaemia, cough, vomiting, hypothyroidism, abdominal pain, rash, and oropharyngeal pain.

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NGENLA (somatrogon) for the Treatment of Paediatric Growth Hormone Deficiency, USA - Clinical Trials Arena

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Mar 6th, 2024 | Filed under Human Growth Hormone
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Human Growth hormone (hGH), a potent peptide hormone, has been exploited in some sports and disciplines for decades, initially through extraction from cadavers and later through recombinant DNA technology to mainly improve strength and power, as well as muscular endurance. It stimulates growth, cell reproduction and cell regeneration and is medically used as a prescription drug to treat certain growth disorders in children and adult growth hormone deficiency. hGH has been prohibited in sport since the late 1980s by International Sport Federations and the International Olympic Committee (IOC) and is listed on the World Anti-Doping Agencys (WADA) Prohibited List since its first publication in 2004.

Anti-doping efforts in the mid-2000s introduced a direct detection method based on growth hormone (GH) isoforms differential immunoassays, followed later by the discovery of novel biomarkers that indicate GH action captured in the GH-2000 test. Comprising biomarkers such as insulin-like growth factor (IGF-1) and amino terminal peptide of type III procollagen (P-III-NP), this biomarker-based approach offers a more comprehensive strategy for detecting GH doping. Implemented during the Olympic Games London 2012, these improved detection methods highlight specific markers that remain relatively stable within individuals, making them better at spotting growth hormone doping. While they also extend the time frame for detecting effects of growth hormone abuse, the test relies on general population limits, which are less sensitive due to significant biological differences among people.

In August 2023, WADA introduced new Athlete Biological Passport (ABP) features, including the new Endocrine Module, marking a significant leap in the detection of hGH abuse in sports. The ABP is a tool used in anti-doping to monitor an athletes biological markers over time to detect any unusual changes that may indicate doping. It helps improve fair play in sports by providing a more comprehensive and individualised approach to detecting performance-enhancing substances and methods. This newly introduced Endocrine Module is the third ABP module alongside the Haematological and Steroidal Modules. It enables the longitudinal and personalised profiling of hGH biomarkers and is expected to increase sensitivity of hGH abuse detection, as a complementary approach to the existing direct detection methods. The new module tracks changes in IGF-1, P-III-NP and the GH-2000 score over time, enabling better testing strategies, focused athlete testing, and the use of specialised analysis to catch doping violations in sport.

To uphold the spirit of fair play and contribute to strengthening the fight against doping, the ITA initiated an important targeted project in the lead up to the Olympic Games Paris 2024 in collaboration with other anti-doping organisations and international sports federations such as the International Skating Union (ISU), the Athletics Integrity Unit (AIU), the Agence Franaise de Lutte contre le Dopage (AFLD), the United States Anti-Doping Agency (USADA), UK Anti-Doping (UKAD) and WADA for the rapid implementation of the Endocrine Module and the establishment of athlete profiles across various sports and disciplines. Using samples provided by the participating organisations, the objective is to ensure that a reliable interpretation of the endocrine passports and athlete profiles can be established.

The work of anti-doping experts depends on the continuous development of the tools and methods available to us to detect prohibited substances, says Dr. Neil Robinson, ITA Head of Science & Medical. With the new ABP Endocrine Module, we now have a new tool at our disposal which we must leverage to detect doping. To ensure that it can be used reliably in our daily activities for the Paris 2024 Olympic Games and beyond, we need to work together to better understand how we can monitor hGH biomarkers levels in athletes bodies over the long term and detect potential abuse. I am very pleased that the ITA can lead this joint effort and thank all the organisations involved for their valuable contributions.

As a first anticipated milestone for the implementation of the Endocrine Module in the anti-doping program of ITAs partner International Federations, the targeted testing will improve the knowledge of the Endocrine Module biomarkers and interpretation of athlete profiles across sports where hGH abuse is expected to bring significant athletic advantages. The targeted testing of athletes already or likely qualified for Paris 2024 paves the way for a more comprehensive anti-doping program for the next Olympic Games. In preparation for Paris 2024, the ITA is working closely with the WADA-accredited anti-doping laboratory in Paris (LADF), enhancing measures against hGH abuse in Olympic disciplines. This collaborative effort aligns with the ITAs commitment to ensuring the integrity of sport and promoting the spirit of fair competition.

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Detecting human growth hormone: the ITA launches a targeted project ahead of Paris 2024 - International Testing Agency

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Feb 24th, 2024 | Filed under Human Growth Hormone
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Uncovering the Link Between Alzheimers and Human Growth Hormone Treatments

A ground-breaking study published in Nature Medicine has shed light on a startling revelation Alzheimers disease may be transmissible under very specific circumstances. This inference was drawn from the long-term observation of patients who had received human growth hormone (hGH) from deceased donors, a practice that ceased in 1985. The particularly interesting aspect of this study is the conceivable connection between Alzheimers disease and prion diseases, which are known to be transmissible.

The discontinued medical practice involved extracting growth hormone from the brain tissue of deceased individuals. This hormone was then administered to patients, typically children, who required it. However, after approximately 200 patients developed Creuztfeldt-Jakob disease (CJD) a condition caused by prions the practice was halted.

Prions, proteins that can fold in multiple structurally distinct ways, can trigger the development of a range of fatal neurodegenerative diseases, including CJD. The study identified five patients with early-onset Alzheimers disease who had received the donated hGH, leading the researchers to conclude that the hGH was the likely cause of the disease in these cases.

While Alzheimers disease is commonly understood as a non-contagious condition, this study indicates that it can be transmitted under extremely rare conditions. In the reported cases, the recipients of the tainted hGH injections developed early Alzheimers disease, showing higher than usual levels of the sticky protein A-beta in their brains. This protein is known to accumulate in the brains of individuals with Alzheimers disease.

It is important to note, however, that the absolute risk of transmission remains very low. The transmission of Alzheimers disease cannot occur through person-to-person contact, but the study does raise concerns about potential risks of transmission through certain medical or surgical procedures.

Despite the small sample size and the need for replication and confirmation, this study opens new avenues for understanding the etiology of Alzheimers disease. The findings suggest that amyloid-beta pathologys transmission in these rare situations may have implications for understanding and treating Alzheimers disease.

The research also underscores the importance of informed caution in the preparation of surgical instruments, handling of tissues, and implementation of therapeutic biologics, particularly those derived from human sources. It also paves the way for further research, which may enrich our understanding of the causes of more typical, late-onset Alzheimers disease.

While these findings are undoubtedly intriguing, it is essential to emphasize that the circumstances through which these individuals tragically developed Alzheimers are highly unusual. There is no risk that the disease can be spread between individuals or in routine medical care. Experts have stressed that this does not indicate that Alzheimers disease can be passed between people through everyday activities or routine care, and there is no cause for concern for the health of the general population.

Patients now receive synthetic alternatives to hGH, which have been approved for safety. Therefore, there is no need for the general population to reconsider or forego any medical procedures based on these findings. The study provides an interesting perspective on the transmission of Alzheimers disease but should not cause undue alarm.

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Link Between Alzheimer's and Human Growth Hormone Treatments Revealed | Nature Medicine Study - Medriva

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Feb 6th, 2024 | Filed under Human Growth Hormone
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Image by Getty / Futurism

Researchers say they've documented the first ever cases of Alzheimer's disease being transmitted between humans and though it only took place in extremely rare and unusual circumstances, it could provide valuable clues into the underlying mechanisms of the terrible disease.

Their findings, published as a study in the journal Nature Medicine, detail how eight adult patients, only five of whom are still alive, likely acquired the disease through a banned medical procedure performed on them as children in which they were administered human growth hormone extracted from a cadaver's brain. Decades later, they're now showing early signs of dementia, with the earliest experiencing symptoms as young as 38 years old.

The researchers suggest that the procedure inadvertently transmitted a protein called amyloid beta that's considered to have a central role in the development of Alzheimer's disease.

They stress that this does not mean Alzheimer's is transmissible like a cough or the flu. It was spread "iatrogenically" StatNews notes, or only as the result of a medical practice in this case a very seldom used but tragically misguided one.

"I should emphasize these are very rare occurrences, and the majority of this relates to medical procedures that are no longer used," study senior author John Collinge, the director of the University College London Institute of Prion Diseases, said in a news brief, as quoted by CNN.

The practice of using cadaver growth hormones today they're synthesized was banned in the 1980s because it caused another terrifying brain disorder: Creutzfeldt-Jakob disease (CJD), which is transmitted through "misfolded" proteins called prions.

CJD, like Alzheimer's, causes dementia but is even more severe and always fatal. Since both can stem from the same medical procedure, the researchers say their findings support the idea that the beta-amyloids behind Alzheimer's can be transmitted in similar ways to a prion disease, which have been long known to pass between humans.

"It looks like what's going on in Alzheimer's disease is very similar in many respects to what happens in the human prion diseases like CJD, with the propagation of these abnormal aggregates of misfolded proteins and misshapen proteins," Collinge told Stat News.

A key detail is that none of the patients were shown to have genetic mutations known to cause early-onset dementia, despite all of them experiencing symptoms at a relatively young age and well before the cutoff age of 65.

Only one patient had genetic data known to cause late-onset dementia. In addition, none were found to have elevated levels of a protein called tau, Stat notes, which is associated with cognitive decline. As it stands, the only known common factor between the patients is the HGH procedure they received.

The sheer rarity of the circumstances means that it will be tough to bear out the study's findings. Nonetheless, it's already raised useful questions over the nature of Alzheimer's, the exact cause of which remains elusive.

More on neuroscience: Smoking Cigarettes Does Something Horrifying to Your Brain, Scientists Find

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Alzheimer's Spread Through Growth Hormones Extracted From Cadavers, Scientists Say - Futurism

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Feb 6th, 2024 | Filed under Human Growth Hormone
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An article published this week in the prestigious journal Nature Medicine documents what is believed to be the first evidence that Alzheimers disease can be transmitted from person to person.

The finding arose from long-term follow up of patients who received human growth hormone (hGH) that was taken from brain tissue of deceased donors.

Preparations of donated hGH were used in medicine to treat a variety of conditions from 1959 onwards including in Australia from the mid 60s.

The practice stopped in 1985 when it was discovered around 200 patients worldwide who had received these donations went on to develop Creuztfeldt-Jakob disease (CJD), which causes a rapidly progressive dementia. This is an otherwise extremely rare condition, affecting roughly one person in a million.

CJD is caused by prions: infective particles that are neither bacterial or viral, but consist of abnormally folded proteins that can be transmitted from cell to cell.

Other prion diseases include kuru, a dementia seen in New Guinea tribespeople caused by eating human tissue, scrapie (a disease of sheep) and variant CJD or bovine spongiform encephalopathy, otherwise known as mad cow disease. This raised public health concerns over the eating of beef products in the United Kingdom in the 1980s.

Read more: People who lived in the UK in the 'mad cow disease' years may now be able to give blood. The risk of vCJD is tiny

Human growth hormone (hGH) is produced in the brain by the pituitary gland. Treatments were originally prepared from purified human pituitary tissue.

But because the amount of hGH contained in a single gland is extremely small, any single dose given to any one patient could contain material from around 16,000 donated glands.

An average course of hGH treatment lasts around four years, so the chances of receiving contaminated material even for a very rare condition such as CJD became quite high for such people.

hGH is now manufactured synthetically in a laboratory, rather than from human tissue. So this particular mode of CJD transmission is no longer a risk.

The Nature Medicine paper provides the first evidence that transmission of Alzheimers disease can occur via human-to-human transmission.

The authors examined the outcomes of people who received donated hGH until 1985. They found five such recipients had developed early-onset Alzheimers disease.

They considered other explanations for the findings but concluded donated hGH was the likely cause.

Given Alzheimers disease is a much more common illness than CJD, the authors presume those who received donated hGH before 1985 may be at higher risk of developing Alzheimers disease.

Alzheimers disease is caused by presence of two abnormally folded proteins: amyloid and tau. There is increasing evidence these proteins spread in the brain in a similar way to prion diseases. So the mode of transmission the authors propose is certainly plausible.

However, given the amyloid protein deposits in the brain at least 20 years before clinical Alzheimers disease develops, there is likely to be a considerable time lag before cases that might arise from the receipt of donated hGH become evident.

Read more: Size of brain area linked with cognitive decline even in people with no other warning signs of Alzheimers disease

In Australia, donated pituitary material was used from 1967 to 1985 to treat people with short stature and infertility.

More than 2,000 people received such treatment. Four developed CJD, the last case identified in 1991. All four cases were likely linked to a single contaminated batch.

The risks of any other cases of CJD developing now in pituitary material recipients, so long after the occurrence of the last identified case in Australia, are considered to be incredibly small.

Early-onset Alzheimers disease (defined as occurring before the age of 65) is uncommon, accounting for around 5% of all cases. Below the age of 50 its rare and likely to have a genetic contribution.

The Nature Medicine paper identified five cases which were diagnosed in people aged 38 to 55. This is more than could be expected by chance, but still very low in comparison to the total number of patients treated worldwide.

Although the long incubation period of Alzheimers disease may mean more similar cases may be identified in the future, the absolute risk remains very low. The main scientific interest of the article lies in the fact its first to demonstrate that Alzheimers disease can be transmitted from person to person in a similar way to prion diseases, rather than in any public health risk.

The authors were keen to emphasise, as I will, that Alzheimers cannot be contracted via contact with or providing care to people with Alzheimers disease.

Read more: Young-onset Alzheimers can be diagnosed from as early as 30 and the symptoms are often different

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Alzheimer's may have once spread from person to person, but the risk of that happening today is incredibly low - The Conversation

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Feb 6th, 2024 | Filed under Human Growth Hormone
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Scientists believe that a rare medical treatment withdrawn in the 1980s may have caused some very rare cases of Alzheimer's.

Research published in the Nature Medicine journal suggests the individuals acquired a "rogue protein" that causes dementia from a growth hormone taken from the brains of deceased people, said Sky News.

Although the findings do not mean that Alzheimer's is infectious, the results could have significant implications for our understanding of dementia.

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Researchers studied eight people in the UK who, as children, received cadaver-derived human growth hormone (c-hGH) that had been extracted from the brains of human corpses.

At least 1,848 people received the c-hGH between the 1950s and 1980s. Some died from Creutzfeldt-Jakob disease (CJD), a degenerative brain condition, because the hormone infusions they received contained infectious proteins called prions that cause severe abnormalities in the brain. Prions are proteins that act like "seeds" of disease, explained Live Science, causing healthy proteins to "fold in abnormal, harmful ways".

The new findings indicate parallels between the evolution of Alzheimers and CJD. None of the eight patients in the new study had developed CJD, but five showed symptoms consistent with early-onset Alzheimer's. In three of the patients, biological and autopsy studies supported an Alzheimer's diagnosis, and they were suggestive in a fourth.

Alzheimer's disease is "the most common cause of dementia in the UK", said the NHS. An estimated one in 14 people over the age of 65 has Alzheimer's and other types of dementia, rising to one in six over the age of 80.

Alzheimer's is thought to be caused by the abnormal build-up of proteins in and around brain cells.

"We are not suggesting for a moment that you can catch Alzheimer's disease," said Professor John Collinge, of University College Londons Institute of Prion Diseases, as it is "not transmissible in the sense of a viral or bacterial infection".

Instead, said Live Science, the seed transfer linked to the Alzheimer's cases reported in the new study occurred in a "very specific and extraordinary medical context". And while "in theory", accidental transmissions of Alzheimer's seeds "could be possible in other medical procedures", steps are being taken to avoid any future repeats.

Dr Richard Oakley, associate director of research and innovation at Alzheimer's Society, told Science Media Centre that there was "no cause for concern for the health of the general population", and reiterated that the hormone treatment had not been used since 1985.

No, said Science News. Researchers "can't be certain" that contaminated growth hormone caused these people's Alzheimer's. It is possible that "the underlying childhood conditions that necessitated the growth hormone treatments", or "other medical procedures such as radiation", contributed to early Alzheimer's or cognitive problems.

As well as preventing similar transmissions, experts hope the findings might increase the understanding of dementia.

"One question is what can be done to stop such transmissions in future," said The Economist, and another is what the findings "might mean for treating Alzheimer's, even in people in whom the disease develops spontaneously".

The findings are a potential boost for research into diagnostics and therapies to combat all forms of dementia, as they might open up new treatment possibilities for a disease that is currently incurable.

The study has "revealed more about how amyloid fragments can spread within the brain", Dr Mava May, associate director of research at the Stroke Association, told Science Media Centre. This provides "further clues on how Alzheimer's disease progresses and potential new targets for the treatments of tomorrow".

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How the transmission of Alzheimer's might be possible - The Week

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Feb 6th, 2024 | Filed under Human Growth Hormone
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Sections of mouse brains from the 2018 study. Top line shows control subjects inoculated with synthetic growth hormone, lower two lines show subjects inoculated with c-hGH. E and h show CAA while f and i show amyloid beta plaque deposition. Credit: Purro et al, 2018/UCL

Five middle-aged people have been diagnosed with Alzheimers disease as a result a now-discontinued medical treatment the patients received in childhood, according to a new study. This is the first evidence of Alzheimers disease in living people that appears to have been medically acquired.

Alzheimers disease is typically caused by a buildup of amyloid-beta protein as an individual ages. However, these patients appear to have acquired the disease in middle age due to transmission of the amyloid-beta protein as part of medical treatment decades prior.

The patients described in the new Nature Medicine paper, now between 38 and 55 years old, had all been treated as children with a type of human growth hormone extracted from pituitary glands from deceased individualsknown as cadaver-derived human growth hormone, or c-hGH.

c-hGH was used to treat at least 1,848 people in the UK between 1959 and 1985 for various causes of short stature. It was withdrawn in 1985 after scientists recognized that some c-hGH batches were contaminated with prions (infectious proteins) after some patients contracted Creutzfeldt-Jakob disease (CJD).

This latest paper focuses on eight people at the National Hospital for Neurology and Neurosurgery in London who had all been treated with c-hGH in childhood, often over several years. Five of them had symptoms of dementia, and either had already been diagnosed with Alzheimers disease or would otherwise meet the diagnostic criteria. A sixth person met the criteria for mild cognitive impairment.

All patients were between 38 and 55 years old when they started displaying neurological symptoms. The unusually young age at which the symptoms developed suggests the patients did not have the typical Alzheimers, which is associated with old age. Additionally, for five patients in which samples were available for genetic testing, researchers were able to rule out inherited Alzheimers disease.

As c-hGH treatment is no longer used, there is no risk of any new transmission via this route. There have been no reported cases of Alzheimers acquired from any other medical or surgical procedures.

There is no suggestion whatsoever that Alzheimers disease can be transmitted between individuals during activities of daily life or routine medical care. The patients we have described were given a specific and long-discontinued medical treatment which involved injecting patients with material now known to have been contaminated with disease-related proteins, said lead author John Collinge, director of the University College London Institute of Prion Diseases and a consultant neurologist at University College London Hospital.

However, the researchers caution that their findings highlight the importance of reviewing measures to ensure there is no risk of accidental transmission of amyloid-beta via other medical or surgical procedures.

In 2018, the same team of researchers showed that archived samples of c-hGH were contaminated with amyloid-beta protein anddespite having been stored for decadesstill transmitted amyloid-beta pathology to laboratory mice when injected. The scientists proposed then that individuals exposed to contaminated c-hGH who did not succumb to CJD in the immediate aftermath might eventually develop Alzheimers disease.

These newest results suggest the researchers 2018 hypothesis was correct.

Overall, the results could have implications for understanding and treating Alzheimers disease in the future, as well as other neurological conditions share similar disease processes to CJD.

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Alzheimer's Linked to Discontinued Medical Treatment in UK - Laboratory Equipment

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Feb 6th, 2024 | Filed under Human Growth Hormone
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Many people believe that growth hormone is only for making muscles bigger or improving skin health. But growth hormone has many other benefits besides these. If you use it correctly, it can help you lose fat and get more stamina, as well as strengthen your immune system and make you sleep better.

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Imagine you are eating more calories than you need every day. You have to watch out for gaining too much fat. You want to stay lean even when you are bulking.

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Read More: Best HGH Supplements And Boosters 4 Top Human Growth Pills - NASP Center

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It increases your metabolism and helps control your hunger. It also helps increase fat burning in your body, which lets you get rid of the extra fat, without having to go back to starving diets.

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Muscle pumps are more than just temporary sugar-filled pumps. They help increase the size of muscle fibers, which makes them look bigger and harder.

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This is because of the amino acids in the formula. The amino acids L-Glutamine and L-Citrulline Malate increase the amount of nitric oxide in your body, which leads to strong muscle pumps and more blood flow.

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#4 - GenF20 Plus The best option for lubricating your joints during workouts

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One of the clear signs of ageing is having joint pain and noisy joints that nobody likes.

As we grow older, this happens more often. You are running every day and then you hear a cracking sound in your knees or hips, which makes you go to the doctor.

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Look at GenF20 Plus, which is a growth hormone-releaser that improves the lubrication of your joints all over your body. It is a supplement that has amino acids that boost the production of HGH in your body.

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One of the main roles of growth hormone in your teenage years is to make your bones and cartilage grow, which also helps to keep your joints healthy.

As you get older, your body makes less of this important hormone and your joint health suffers. GenF20 Plus helps to reverse this by increasing the production of HGH in your body.

This leads to more bone density, which makes your bones stronger and more able to handle the wear and tear. This also helps to reduce the swelling and inflammation of your joints, which makes you more mobile and flexible.

You also need to remember the role of GH in speeding up recovery. GH is one of the main hormones that is responsible for repairing and regenerating your muscles.

This is why you need to keep your GH levels high for the best performance at the gym and not worry about joint pain or stiffness. GenF20 Plus will help you do just that!

If you are an athlete, or someone who wants to stay fit, healthy, and active, you should focus on keeping your GH levels at their best.

GenF20 Plus helps you do that and also gives you many other benefits, such as more muscle mass, more energy, and better mood. You can expect to experience:

No more joint or muscle pain or soreness

For a long time, people thought that soreness was a sign of progress.

But the truth is that it will only slow you down and cause joint problems if you dont manage it well. GenF20 Plus helps to shorten the recovery time by reducing the muscle pain that lets you train more effectively.

It does this in many ways. It improves the healing of your ligaments and tendons, making them less prone to injuries. It also boosts the production of collagen and improves joint lubrication.

It also activates satellite cells, which help to heal and grow your muscles, resulting in better performance.

Better joint Lubrication

The main benefit of GenF20 Plus GenF20 Plus for athletes is that it reduces swelling and inflammation in joints and joints, making them more mobile and flexible.

This is accomplished by increasing the density of cartilage, which creates an enveloping layer between joints. It also assists in lubricating joints, allowing better movement and reduced stiffness.

In the end, you'll be able to do more repetitions as well as push the body to the limit without having to worry about injury.

This can also result in improved performance when running and playing sports. Runner's knee? Tennis elbow? All of these problems can be avoided by making use with GenF20 Plus!

GenF20 Plus is a supplement that helps your body make more GH, which is a hormone that affects many other hormones like testosterone and IGF-1.

These hormones make you feel more energetic and happy. You can also focus better and stay fit when you use GenF20 Plus.

Did you know that ATP is the main fuel for your muscles? GenF20 Plus can help your body produce more ATP, which lets you perform at your best every time.

GenF20 Plus is also great for your joints and muscles. It helps them heal faster and stay healthy.

GenF20 Plus is not just good for your joints and muscles, it can also improve your overall performance.

With almost double the amount of GH in your body, you can expect to do better in everything you do.

GenF20 Plus costs only $69.00 for one month. You dont have to buy a lot of it at once. You can start with one month and see how it works for you.

If you like the results and are happy, you can buy more and save money.

This makes GenF20 Plus one of the cheapest and most effective ways to increase GH in your body. But, the experts say that you should take a GH supplement for at least 3 months before you notice any big changes.

GenF20 Plus - Our opinion

GenF20 Plus is the best GH supplement you can find. It is natural and safe.

It has many benefits, from better joints and muscles, to more research support.

It is also very affordable and easy to get.

If you want to give your body a boost and improve your performance, GenF20 Plus is the perfect choice for you! Check it out now and enjoy the benefits of more GH in just 3 months.

Click here to get the best price for GenF20 Plus

#5 #5 Provacylthe best GH supplement to reverse the effects of male menopause.

Some people call it hormone drop. We think thats too mild. The term male menopause might be more accurate to describe what happens when mens testosterone and GH levels start to go down.

Provacyl is a natural supplement that helps you balance your hormones and reverse the effects of male menopause. It makes you feel healthier and happier.

It has been proven by science to increase the levels of luteinizing hormone (LH) and GH in men, which helps you restore your natural testosterone levels.

The main ingredients of Provacyl are a strong mix of amino acids and Deer Velvet Antler extract, both of which have been tested for their positive effects on hormone balance.

The result is a big increase in not only GH, but also other male hormones in your body.

Male menopause is not a recognized medical condition, but it is a real problem that affects many men.

Provacyl helps you deal with this problem by increasing the levels of LH and GH in your body.

These hormones are responsible for making testosterone, which helps you feel more energetic and well.

The levels of GH are also linked to the levels of IGF-1. This is important for muscle growth, faster recovery and better heart health.

Additionally, Provacyl helps to reduce the effects of cortisol on the body, decreasing stress levels and assisting men to feel healthier overall.

In our current environment growing numbers of people are placing greater importance on their outer appearance, and they are regularly making visits to the gym in order to improve their physical as well as their externally perceived traits.

At the moment it isn't really making an impact if something is done to improve the patient's health.Or just to increase the number of people who follow an individual on Instagram.

A positive trend that is only interpreted positively could be the reality that a growing percentage of folks are reaching the conclusion that to look, feel and feel healthy it is essential to take proper care of their bodies as well as take part in activities that are active.

One instance is the rapid growth in bodybuilding's popularity and bodybuilding, which is evident not just in males but also among females.

However If someone has ever had the opportunity to alter the appearance of their body you are aware of how difficult the process is.

Building muscle is not easy at all.

Some people choose to add HGH to their steroids or HGH plans to get better results in fitness and performance. This is one of the many reasons for doing this.

So, we will compare HGH and steroids in this article so you can understand how they are different and decide which one is better for you.

HGH

First, lets talk about HGH.

HGH stands for Human Growth Hormone. HGH is a natural hormone that your body makes. It is a strong hormone that helps you grow and develop. It also affects your muscles and bones. When the hormone is ready, the pituitary gland in your brain sends it to your blood to do its job.

When it gets to your blood, it goes to your liver. There, it helps increase the levels of other hormones in your body.

Some of them, especially testosterone, can help you build muscle.

Thats why people often use HGH with testosterone steroids like testosterone enanthate. HGH also does many other things. It also gives users many benefits, which we will talk about next.

Read more:
HGH Over The Counter 2024: Exploring Access to Human Growth Hormone Supplements - Deccan Herald

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Many people believe that growth hormone is only for making muscles bigger or making skin smoother. But growth hormone can do much more than that. If you use it correctly, it can help you lose fat and get stronger, as well as improve your immunity and your sleep quality.

It also helps you stay energetic throughout the day. It also helps you recover faster and better from your workouts.

Here are the best HGH supplements:

1) HGH X2 Crazybulk: Click Here To Buy Overall the best HGH Supplement on the market

2) Ibuta 677: Click Here To Buy - Powerful GH Secretagogue for mass

3) GenF20 Plus: Click Here To Buy Clinically Proven HGH Supplement

4) HyperGH 14X: Click Here To Buy Natural HGH Releaser for Maximum Muscle Gains

5) Provacyl: Click Here To Buy Best overall Anti Aging supplement for Women

This is how Ibuta 677 can help you achieve more.

Bulking made easy

Staying fit all year is not easy. It needs a lot of hard work and discipline in your diet and exercise to keep your body mass.

Imagine you are eating a lot of calories every day. You need to watch out for gaining too much fat. You want to be lean even when you are bulking.

You need to change your lifting or your cardio, and adjust your diet. Everything has to be updated to make sure you keep gaining muscle.

But Ibuta 677 can make it easier for you by helping you stay full for longer and making muscle fibers faster and giving you anabolic support to keep your gains.

You will not even notice how easy it is to stay big all year-round.

Read More: Best HGH Supplements 4 Top Human Growth Pills - NASP Center

Lose fat while you gain weight

As we said, big gains do not have to be uneven and soft.

Ibuta 677 can help you keep your body lean and increase your muscle mass.

It increases your metabolism and helps control your hunger. It also helps increase fat burning in your body, which lets you get rid of the extra fat, without having to go back to crash diets.

This is because HGH can increase the amount of hormone sensitive lipase, an enzyme that is responsible for breaking down the fat in your fat cells.

So, you will stay healthy and fit without having to go back to crash diets or long exhausting exercises.

Improve blood flow and pump up your muscles

Muscle pumps are more than just temporary sugar-filled pumps. They help increase the size of muscle fibers, which makes them look bigger and harder.

By increasing the amount of GH in your body, Ibuta 677 can increase your blood vessels and improve your pumps.

This is because of the amino acids in the formula. The amino acids L-Glutamine and L-Citrulline Malate increase the amount of nitric oxide in your body, which leads to strong muscle pumps and increased blood flow.

You will be able to get a beautiful looking body easily and without having to use steroids or additives.

Ibuta-677 cost

Like the rest of the amazing collection from CrazyBulk, Ibuta 677 also costs $69/00 to buy a months supply. This is a great deal, folks. The price of the HGH enhancer prescribed by a doctor is $300 per month.

This way, you will get a cheap and safe way to build muscle and lose weight without having to worry about harmful side effects.

Also, buying for two months will give you the offer of one month. Basically, you buy a two-month supply and get three months of Ibuta 677."

Ibuta 677 - Our opinion

If you want to increase the amount of growth hormones in your body naturally, you can use Ibuta 677, which is a type of substance that stimulates the production of growth hormones. It is different from the usual growth hormone enhancers and it is a very good choice.

It helps you to gain more muscle and lose more fat easily and safely. It also makes your veins more visible and keeps you lean without using any legal hormones or steroids.

It does not matter if you are a beginner or an expert in bodybuilding, you will find something for you.

Why wait? Try CrazyBulks Ibuta-677 and take your body to the next level.

Click here to get the best price for Ibuta-677.

#4 - GenF20 Plus The best option for lubricating your joints during training

GenF20 Plus

One of the signs of getting old is having joint pain and cracking joints, which nobody likes.

As we age, this happens more often. You are running every day and then you hear a popping sound in your knees or hips, which makes you go to the doctor.

To avoid these problems, you need to be careful early on and make sure your joints are well-lubricated and healthy.

Look at GenF20 Plus, which is a supplement that releases growth hormone and improves the lubrication of your joints in your body. It is a supplement that has amino acids that increase the production of HGH in your body.

It also has deer antler velvet and L-arginine, which help to reduce joint stiffness and inflammation. When you use it regularly, you will see an improvement in your mobility and flexibility in a few weeks!

How does GenF20 Plus help joint health?

One of the main roles of growth hormone in your teenage years is to make your bones and cartilage grow, which also helps to keep your joints healthy.

As you get older, your body makes less of this important hormone and your joint health suffers. GenF20 Plus helps to reverse this by increasing the production of HGH in your body.

This leads to more bone density, which makes your bones stronger and more able to handle the wear and tear. It also helps to lower the swelling and inflammation in your joints, which makes you more mobile and flexible.

You also need to remember the role of GH in speeding up recovery. GH is one of the main hormones that is responsible for repairing and regenerating your muscles.

That is why you need to keep your GH levels high for the best performance at the gym and not worry about joint pain or stiffness. GenF20 Plus will help you do that!

The benefits of GenF20 Plus GenF20 Plus

If you are an athlete or someone who wants to stay fit, healthy, and active, you should focus on keeping your GH levels at their best.

GenF20 Plus helps you do that and also gives you many other benefits, such as more muscle mass, more energy, and better mood. You can expect to experience:

No more joint or muscle pain or soreness

For a long time, people thought that soreness was a sign of progress.

But the truth is that it will only slow you down and cause joint problems if you do not take care of it. GenF20 Plus helps to reduce the recovery time by lowering the muscle pain that lets you train more effectively.

It does this in many ways. It increases the healing speed of your ligaments and tendons, which makes them less prone to injuries. Its production of collagen and improves joint lubrication.

It also activates satellite cells, which help to heal and grow your muscles, which leads to better performance.

Healthier joints

One of the main reasons why athletes use GenF20 Plus is that it helps them reduce pain and swelling in their joints, making them more flexible and agile.

This happens because GenF20 Plus increases the thickness of the cartilage, which acts as a cushion between the joints. It also helps to make the joints more slippery, allowing smoother movement and less stiffness.

This way, you can do more exercises and push your body to the limit without worrying about getting hurt.

This can also improve your performance when you run or play sports. Do you have problems with your knees or elbows? You can avoid them by using GenF20 Plus!

More energy and mood

GenF20 Plus not only increases the production of GH in your body, but also balances other hormones like testosterone and IGF-1.

They are responsible for giving you more energy and a better mood. You can feel more focused and alert when you use GenF20 Plus, helping you to stay in shape.

Did you know that ATP is the main source of energy for your muscles? GenF20 Plus can help you produce more ATP in your body, which lets you work at your best every time.

The benefits of using GenF20 Plus for your joints and muscles are huge.

We have only talked about the joint health benefits of using GenF20 Plus, but it is also a great performance enhancer.

With almost a 200% increase in the natural production of GH, you can expect to see improvements in every aspect of your life.

GenF20 Plus Price

GenF20 Plus costs only $69.00 for a one-month supply. The best thing is that you dont have to buy a big package right away. You can start with one month and see how it works for you.

If you are happy with the results and want more, you can upgrade to bigger packages and get a lower price.

This makes GenF20 Plus one of the most affordable and effective ways to increase the production of GH in your body. But, the experts recommend that you take a GH supplement for at least 3 months before you notice any significant changes.

GenF20 Plus - Our opinion

GenF20 Plus is the best natural GH supplement in terms of quality and price.

It has many benefits, from healthier joints to faster muscle recovery - and it is supported by many research studies.

The fact that it is very cheap makes it even more attractive.

If you want to give your body needs to improve your performance, GenF20 Plus is the perfect choice for you! Check it out now and enjoy the benefits of increased GH production in just three months.

Click here to get the best price for GenF20 Plus"

#5 #5 Provacylthe best supplement for GH to reverse the effects of male menopause.

Provacyl

Some people say it is a hormone drop. We think that is too mild. The term male menopause might be the best way to describe what happens when mens testosterone and growth hormone levels start to go down.

Provacyl is a natural supplement that helps you keep your hormones balanced and reverse male menopause and improve your overall health and well-being.

It has been tested and shown to increase the levels of luteinizing hormone (LH) and growth hormone (GH) in men, which helps you get back your natural testosterone levels.

The main ingredients of Provacyl are a strong mix of amino acids and Deer Velvet Antler extract, both of which have been studied and proven to have positive effects on hormone balance.

The result is a big increase in not only growth hormone but also other male hormones in your body.

How can Provacyl help by reversing male menopause?

Male menopause is not accepted as a medical condition by the doctors, but it is a real problem that affects many men.

Provacyl helps you deal with this problem by increasing the levels of luteinizing hormone and growth hormone in your body.

These hormones are needed to make testosterone, which in turn helps you get back your energy and well-being.

The levels of growth hormone are closely linked to the levels of IGF-1. This is important for muscle growth, faster recovery and better heart health.

Also, Provacyl helps you lower the effects of cortisol on your body, reducing stress and helping you feel healthier.

In our current world, more and more people care about how they look, and they often go to the gym to improve their physical and social image.

Right now, it doesn't really matter if something is done to improve your health. Or just to get more followers on Instagram.

A good trend that is only seen as good is that more and more people realize that to look, feel and be healthy, you need to take care of your body and do active things.

One example is the fast growth of bodybuilding and fitness, which is not only for men but also for women.

But if you have ever tried to change how your body looks, you know how hard it is.

Muscle gain is not easy at all.

Some people choose to add anabolic steroids or HGH to their programs with the Human growth hormone (HGH) hoping to get better results and performance. This is just one of the many reasons for this.

See the rest here:
HGH Over The Counter: Updated Insights into Accessing Human Growth Hormone Supplements - Deccan Herald

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Historically, the medical field has witnessed an array of groundbreaking discoveries that have provided deeper insights into the human body and the diseases that affect it. Recently, a significant development has emerged in the field of Alzheimers research and medical history. For the first time, the transmission of Alzheimers disease from cadaveric pituitary tissue for growth hormone has been documented.

The procedures involving the use of cadaveric pituitary tissue for growth hormone are no longer in practice. Yet, this discovery has shed light on its historical use and the potential risks associated with it. The study discovered that recipients of this procedure developed dementia and biomarker changes within the phenotypic spectrum of Alzheimers Disease (AD). The findings suggest that AD-like Creutzfeldt-Jakob disease (CJD) has environmentally acquired iatrogenic forms, along with late-onset sporadic and early-onset inherited forms.

The study also provides insight into prions, human prion diseases, and their relevance in human neurodegenerative diseases. Prions are abnormal, pathogenic agents that are transmissible and are able to induce abnormal folding of specific normal cellular proteins called prion proteins that are found most abundantly in the brain.

The study presents evidence of a rare route through which Alzheimers disease could potentially have been transmitted to some patients after they received human growth hormone from deceased donors brains. The treatment, which has not been used since 1985, found that the growth hormone had the potential to contain fragments of amyloid. A small number of people treated with this went on to develop symptoms of Alzheimers disease. Researchers recommend that medical procedures should be reviewed to ensure that rare cases of Alzheimers transmission like this do not happen.

Researchers at University College London found that out of 8 British children who received human growth hormone from deceased donors, 5 went on to develop early onset Alzheimers disease many decades later. The growth hormone may have contained amyloid beta protein plaques, which build up in the brains of people with Alzheimers disease over time. This research raises concerns about the sterilization of medical instruments to prevent accidental transmission of amyloid beta pathology. However, person-to-person transmission of Alzheimers disease remains incredibly rare and there is no evidence that amyloid beta can be transmitted in other contexts such as during activities of daily life or provision of routine care.

A team of researchers at University College London has reported the first-ever clear evidence of human-to-human transmission of Alzheimers disease through a human growth hormone treatment. The hormone was collected from the pituitary glands of deceased people and injected into children with unusually short stature. This led to the development of early-onset Alzheimers in some cases. The study found that some of the c-hGH samples contained accumulations of amyloid proteins, and animal tests revealed mice administered the contaminated growth hormone developed signs of Alzheimers pathology.

In conclusion, this recent discovery is a significant milestone in Alzheimers research. Its crucial that we continue to study and understand the potential risks and implications of medical procedures involving human tissue. As we deepen our understanding, we can take further steps to ensure the safety and welfare of patients around the globe.

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First Documented Transmission of Alzheimer's Disease from Cadaveric Pituitary Tissue: A Significant Breakthrough in ... - Medriva

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