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A former Playboy model and television personality, Anna Nicole Smith was "famous for being famous" then she was found dead of an accidental drug overdose.
On February 8, 2007, 39-year-old model, actress, and former Playboy Playmate of the Year Anna Nicole Smith died in Hollywood, Florida. She was declared dead shortly after being found unresponsive in her room at the Seminole Hard Rock Hotel and Casino. In the days leading up to her death, Smith had suffered from multiple health issues, including stomach flu, a fever that reached 105 degrees, and an infection on her backside.
But instead of going to the hospital, she took a cocktail of at least nine different prescription medications, including chloral hydrate, a powerful liquid sedative that had also likely played a role in legendary Hollywood star Marilyn Monroes death. It was bitterly ironic as Anna Nicole Smith had always dreamt of becoming the next Marilyn Monroe someday.
Like Monroe before her, Smith dominated news headlines. Her blonde hair and curves captivated the public, and the media took a deep interest in her personal life. Part of this interest was likely due to Smiths ongoing legal battle to acquire a share of her deceased husbands fortune the 90-year-old oil tycoon J. Howard Marshall II, whom she married in 1994.
Smith, like Monroe, also appeared in several movies, mostly comedies, including Naked Gun 33 1/3: The Final Insult alongside Leslie Nielsen and Priscilla Presley and The Hudsucker Proxy alongside Tim Robbins and Paul Newman. She later starred in her own reality television series in 2002, The Anna Nicole Show, which followed her through her daily life.
During the early 2000s, Smiths star continued to rise, and she was ecstatic to give birth to her daughter Dannielynn on September 7, 2006. But just three days later, her older son, 20-year-old Daniel, died of a drug overdose. Soon afterward, a series of legal battles complicated her life once again.
And just six months after her sons untimely demise, Anna Nicole Smiths death from a drug overdose would make headlines all over the world.
Anna Nicole Smith was born Vickie Lynn Hogan on November 28, 1967, in Houston, Texas. Her father, Donald Hogan, wasnt around much while she was growing up, leaving her mother Virgie Arthur to take care of her.
Speaking with ABC News, Vickie Lynn Hogans childhood best friend Jo McLemore recalled, Vickies childhood life was tough. [Her mother] was very forthright and very strict. And when Hogan turned 15, her mother sent her to live with her aunt in the small town of Mexia, Texas.
Vickie Lynn Hogan didnt mesh with Mexia. She struggled with being bullied, and she longed to get out and make something of herself. Eventually, though, shed had enough with school and dropped out during sophomore year, taking a job at a local fried chicken joint, Jims Krispy Fried Chicken.
When she started working here, we immediately hit it off, McLemore said. One of the memories I have of her is, wed sit here together and stare out the window, and just watch traffic go by. She was so perfect to me.
It was at Krispys that Vickie Lynn Hogan met her first husband Billy Smith, a fellow dropout. She was 17, and he was 16 when they first started dating. Soon, the teens were married, and Vickie Lynn Hogan became Vickie Lynn Smith. The couple welcomed a son, Daniel, when Vickie Lynn was 18.
But another year later, the couple separated, and Vickie Lynn Smith took Daniel with her back to Houston. Smiths mother looked after Daniel while Smith took a job as a dancer at a local strip club to provide for her son.
Then, in 1991, an 86-year-old billionaire named J. Howard Marshall II was wheeled into that club. His wife had recently died, and so had his longtime mistress. Smith agreed to dance for the wealthy octogenarian, and soon enough, he was showering her with gifts and asking her to marry him.
At first, she said no. Before Smith got married again, she wanted to try to make a name for herself on her own. And just one year later, she did.
In 1992, two major milestones happened in the future Anna Nicole Smiths life. Playboy hired her after she mailed in naked photos of herself, and later that year, the fashion brand Guess asked her to model in a series of ads. Her image in the ads was remarkably similar to Marilyn Monroes look.
It was around this time that an agent suggested that Vickie Lynn change her name to Anna Nicole to further help her career, and she agreed to do so.
As a profile on Smith at Biography says, her image drew tons of attention across America. She was the ultimate blonde bombshell.
She was so popular, in fact, that in 1993 she was named Playboys Playmate of the Year. The next year, she made the move into small film roles. Meanwhile, celebrity magazines and tabloids couldnt get enough of her.
Smith, for her part, didnt seem to mind, saying, I love the paparazzi. They take pictures, and I just smile away. Ive always liked attention. I didnt get very much growing up, and I always wanted to be, you know, noticed.
But life as a Hollywood celebrity wasnt all glamorous.
In 1994, Anna Nicole Smith finally agreed to J. Howard Marshall IIs marriage proposal. By then, he was 89 years old. Smith was only 26. Naturally, the marriage came with media scrutiny accusing Smith of marrying Marshall to get her hands on his fortune, knowing that he would probably die soon.
The marriage was indeed short-lived. Marshall died at age 90 in 1995, but he had not included Smith in his will. His son E. Pierce Marshall had been given power of attorney, and Smith spent several years battling him in court for her share of her late husbands estate, claiming that E. Pierce had been the reason why she hadnt been included in the will. The case eventually found its way to the U.S. Supreme Court in 2006. But as The Guardian reported, this issue was still unresolved at the time of Anna Nicole Smiths death.
Amid the ongoing legal battle with her deceased husbands family, however, Smiths personal life remained a focal point for the press especially when she was treated for substance abuse. Smith had been prescribed a variety of medications to treat migraines, stomach problems, seizures, and back pain that she was experiencing as a result of her breast implants. The media latched onto this and simultaneously attacked Smith for gaining weight.
Its hard. I mean, I went through a lot. You know, people, when I gained a lot of weight people thought I was just like, partying, doing this and that, she said in 2000. I mean, Im having seizures, Im having panic attacks.
Still, Anna Nicole Smith remained in the public eye, jumping headfirst into reality TV on E! Television Network. Her series, The Anna Nicole Show, drew in curious audiences and offered insight into Smiths daily life.
The show ran for 28 episodes between 2002 and 2004, but Smith still found herself directionless and searching for the next big thing. And many viewers noted that she frequently seemed confused or disoriented on the show.
In 2003, Smith worked with the weight loss brand, TrimSpa, as a spokesperson. During the course of the campaign, she lost 69 pounds and found renewed energy in her career. Her love life seemed to be looking up, too. She began dating a photographer named Larry Birkhead, and although Birkhead was smitten with her, their relationship didnt last.
At the time, Smith was living with her son Daniel, her assistant, and her attorney/publicist/manager Howard K. Stern. Birkhead moved into the home with Smith, and shortly thereafter, Smith became pregnant with her second child. But around this time, she started to push Birkhead away.
Toward the end of her pregnancy, she and Stern moved to the Bahamas. There, on September 7, 2006, she gave birth to her daughter Dannielynn. Stern, who was said to be the father, was with Smith in the delivery room.
Smiths son Daniel joined her two days later as she was in recovery, but the next day, Smith woke up to find Daniel dead next to her. He had died of a drug overdose, but it was never made clear where he got the drugs from. The loss devastated her. The media reported on Daniel Smiths death heavily.
Anna Nicole Smith then became embroiled in another legal battle, this time over her newborn daughter. Birkhead, now Smiths ex-boyfriend, claimed that he was Dannielynns father. Smith insisted that Dannielyns father was her current partner Howard K. Stern. But while Stern was officially listed on Dannielynns birth certificate, the issue of her paternity was far from settled.
In early 2007, Anna Nicole Smith was interested in purchasing a boat and decided to go to Florida with Stern and a group of friends to buy one there. But while traveling to Hollywood, Florida on February 5th, she became ill. Her backside began to ache, likely because she had just gotten injections for vitamin B12 and human growth hormone there before she left.
By the time she arrived in Florida, she had a fever of 105 degrees. This was likely brought on by the pus-filled infection on her buttocks from the injections of so-called longevity drugs, according to The New York Times.
Over the course of a few days, Smith suffered a number of other health issues in her room at the Seminole Hard Rock Hotel and Casino, including stomach flu and pungent sweating. Though many of her friends who she had traveled with urged her to go to the hospital, Smith refused.
Birkhead, Smiths ex-boyfriend, later speculated that she didnt go to the hospital out of fear that there would be a big headline in the news about her poor health and she didnt want her illness to be publicized.
Instead, she chose to self-medicate with at least nine different prescription drugs, including chloral hydrate, a powerful sleep aid that was popular in the 19th century but is rarely prescribed in modern times. According to TODAY, Smith was known to drink this liquid sedative directly out of the bottle.
Sadly, this would lead to Anna Nicole Smiths death on February 8, 2007. That day, Stern had briefly left the hotel to keep the couples appointment about the boat they wanted to buy. Smiths friends remained to keep an eye on her and they eventually realized that she was unconscious and not breathing.
The wife of Smiths bodyguard called her husband, who then alerted Stern. The bodyguards wife then tried to resuscitate Smith. It wasnt until the bodyguard arrived that 911 was called, and about 40 minutes total passed before first responders came to transport Smith to the hospital. By then, it was too late Anna Nicole Smith had died of an accidental drug overdose.
And even after her death, the drama surrounding Smiths life continued. The question of Dannielynns paternity went to court, and in April 2007, a DNA test confirmed that the girls biological father was Larry Birkhead. Stern did not contest the ruling and supported Birkhead gaining custody of the girl.
However, Stern later faced legal trouble for his role in enabling Smiths prescription drug addiction. According to ABC News, both he and Smiths psychiatrist Dr. Khristine Eroshevich were both found guilty of conspiracy to give prescription drugs to a known addict in 2010. Smiths doctor Sandeep Kapoor was also charged in connection with the case, but he was acquitted.
In the years since then, Anna Nicole Smiths life has remained a subject of fascination. Like many other famous women before her, Smith is seen as a prime example of a woman who died far too young, and whose troubled life contrasted sharply with her public persona. In the end, her dream of becoming the next Marilyn Monroe was, unfortunately, realized a bit too fully.
After reading about the life and death of Anna Nicole Smith, read about the tragic death of her idol, Marilyn Monroe. Then, explore the tragic life and infamous death of another iconic Hollywood actress, Lupe Vlez.
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Inside The Tragic Death Of Anna Nicole Smith And The Drug ... - All That's Interesting
FDA approval logo | Image Credit: Calin - Calin - stock.adobe.com.
The FDA recently approved a new indication for somapacitan-beco (SOGROYA; Novo Nordisk), a once-weekly subcutaneous injection, to treat children aged 2.5 years and older with growth hormone deficiency (GHD), according to a press release from Novo Nordisk.1
Somapacitan-beco is the first and only once-weekly growth hormone (GH) treatment for children and adults, following this indication approval. The prescription medicine injection (5 mg, 10 mg, or 15 mg) contains human growth hormone, the same growth hormone made by the body, according to Novo Nordisk.1
Somapacitan-beco will be provided in a premixed, prefilled, and portable pen that is stable at room temperature, up to 77 F, for up to a maximum of 72 hours. According to Novo Nordisk, children with GHD can experience short stature and can have an increased risk for other growth-associated problems. GH replacement has been the standard care to improve growth outcomes, however, patients can struggle with a daily injection routine over time.1
A once-weekly growth hormone treatment like Sogroyamay offer a therapeutic alternative for patients and their caregivers interested in a once-weekly option, said Stephanie Seremetis, MD, CMO, and CVP, Rare Disease, Novo Nordisk.1
The expanded indication of somapacitan-beco for children aged 2.5 years and older with GHD is based on phase 3 results demonstrated in the REAL4 study (NCT03811535).2 In the study, 200 treatment-nave patients aged 2.5 to 11 years with GHD were either given once-weekly somapacitan-beco (n = 132) or daily somatropin (n = 68) for 52 weeks.1 Results demonstrated that somapacitan-beco (11.2 cm/year) was comparable to daily somatropin (11.7 cm/year) for the primary endpoint of annualized height velocity. Nasopharyngitis, headache, pyrexia, pain in extremity, and injection site reactions were adverse reactions in the REAL4 study, occurring in more than 5% of patients.1
According to Novo Nordisk, somapacitan-beco leverages albumin-binding technology, which delays elimination of somapacitan-beco. As a result, in vivo half-life and duration of action is prolonged.1
Children with closed bone growth plates and children with Prader-Willi syndrome that are severely obese or have breathing problems, should not use somapacitan-beco. Novo Nordisk plans to make somapacitan-beco available for both adult and pediatric patients in the coming months.1
References:
1. FDA approves once-weekly Sogroya for the treatment of children living with growth hormone deficiency. Novo Nordisk. April 28, 2023. Accessed May 1, 2023. https://www.novonordisk-us.com/content/nncorp/us/en_us/media/news-archive/news-details.html?id=166098
2. A research study in children with a low level of hormone to grow. Treatment is somapacitan once a week compared to Norditropin once a day (REAL4). clinicaltrials.gov. Updated April 25, 2023. Accessed May 1, 2023. https://clinicaltrials.gov/ct2/show/NCT03811535
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FDA expands approval of somapacitan-beco injection to children ... - Contemporary Pediatrics
Modified May 03, 2023 16:52 GMT
Former pitching star Roger Clemens' wife Debbie Clemens testified that she had been given a shot of human growth hormone by her husband's former trainer Brian McNamee, who claimed to have also given Clemens the same injection.
Debbie in 2012 disclosed that she allegedly took PEDs prior to the Sports Illustrated Swimsuit shoot with the former Red Sox star to appear youthful.
According to McNamee, Roger Clemens requested that McNamee inject Debbie Clemens with the human growth hormone in 2003 before a photo shoot for Sl magazine.
Clemens said that she had trouble falling asleep the night after getting the shot because of circulation problems. She talked about notifying her husband about the injection over the phone. She claimed that Roger "wasn't happy with Brian" about the situation, and wasn't present during the consumption of the drug.
According to Jason Grimsley, a former pitcher who filed a federal lawsuit, Roger Clemens was one of numerous athletes who reportedly used PEDs in 2006.
Former New York Yankees pitcher Andy Pettitte, a former teammate of Roger Clemens, testified that Clemens admitted to using the human growth hormone between 1999 and 2000. The use of drugs by his wife was something he was alluding to.
Following his denial of using performance-enhancing drugs, Roger Clemens was facing a second trial on federal charges of lying to a U.S. congressional committee.
The Oversight and Government Reform Committee of the House of Representatives was looking into drug use in Major League Baseball at the time.
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When former Red Sox star Roger Clemens' wife was caught in PED scandal to appear youthful on SI Cover - Sportskeeda
Picture this: You've been driven and motivated to hit the gym or get your miles in day in and day out. You've got your post-workout recovery dialed in with a quality massage gun and stretching regimen. Your diet and supplementation are on point. Yet despite having put in all this work, you still feel like you're lagging behind. Why?
Probably because you're a terrible sleeper or at least, haven't given your nighttime habits enough thought.
Sleep can be one of the most vital keys to your overall fitness, affecting everything from your cognitive state and energy levels to how well your muscles bounce back to normal post-workout. But to make the most of your bed time each and every night, your sleep hygiene needs to be in order.
The phrase "sleep hygiene" refers to the habits you practice in relation to your normal sleep behavior. These include keeping a proper environment for slumber, abstaining from influential food and drink prior to bed, reducing stress throughout the day and more.
A good comparison would be how regular brushing and flossing affects your oral health. Like your typical toothbrushing habits, sleep hygiene can be improved upon. All that's necessary is to invest in the practice and remain dedicated to improvement.
A good night's sleep can help you awaken with a recharged battery and clear mind, but the benefits of a Zs-catching session aren't just reserved to cognitive function. Your muscles and aches can greatly benefit from your dedication to healthier sleep hygiene, too.
During your slumber, your body is still at work repairing cells, restoring energy and releasing molecules like hormones and proteins. One of those hormones, according to the National Academy of Sports Medicine (NASM), is the human growth hormone (HGH). This surge of the vital hormone can occur roughly every two hours during sleep, leading to better healing, recovery and growth across your musculature and more.
Yet, it's plenty difficult to reap the benefits of this hormone secretion and cellular repair if you're tossing and turning night in and night out. This begs the question, how can you make it so every night isn't an RPE 10 to catch some Zs? Here are a few tips to help make nighttime a more approachable endeavor, and how you can set yourself up for the best sleep ever with every PM session.
As an adult, its advised to shoot for at least seven hours of sleep per night. Well, like any other endeavor, how can you expect to meet that quota if you dont have a plan in place?
To give yourself a better shot of meeting your nighttime slumber numbers, try to develop a routine that sees you getting into bed (and getting up in the morning) at the same times each and every day. This can help reinforce your bodys sleep-awake cycle as it learns to adapt to your schedule. Soon enough, youll find yourself getting tired at the right time before bed and naturally rising without the added stress of a buzzing alarm clock.
Power naps might sound great on paper, but when it comes time to really hit the hay, these small breaks from your normal daytime routine can spell nothing but trouble. Naps lasting longer than two hours throughout the day have been shown to cause sleep deprivation during regular nighttime slumber, so it's best to save the sheep counting for when it matters most.
Of course, we all have different personal schedules, and a small nap may be vital to keep you running at peak performance throughout the day. If you feel your napping habits are interfering with your slumber, consider swapping out your normal nap time for shorter breaks of roughly 30 minutes. Additionally, try to keep your naps to earlier in the day, as this can allow your body to naturally tire itself down to a depleted state ideal for nighttime rest.
We all know your diet plays a role in your physical fitness while awake, but did you know it can affect your evening performance, too? To help set your body up for sleeping success, try to avoid large meals immediately before hitting the pillow. This can allow for more efficient digestion as the nutrients make their way into their proper locations without keeping your engine running longer than needed.
Its also best to avoid stimulants and other inhibitors before bed, including caffeine, nicotine and alcohol. While a nightcap beverage may make you feel tired at first, its effects on cognitive function can leave you tossing and turning more often than not.
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Most if not all of us have an unhealthy relationship with our tech tools, but trust me you can sacrifice a few scrolls for the sake of better sleep. Many of our smartphones, TVs, tablets and other devices omit whats known as blue light, and prolonged exposure can lead to negative impacts on our Circadian rhythms.
In addition to lessening blue light exposure, turning off your electronics before hitting the hay and subsequently leaving them alone throughout the night can lessen the number of distractions your brain encounters. This can allow your mind to power down more easily, creating a level, quiet state that further promotes drifting off to sleep.
Comfort plays a big role in how effective your night shift is, too, and your brain and body are more likely to turn down for the evening if the conditions are prime for counting sheep. This means giving your bed a few quick upgrades with a new mattress, pillows, bed sheets, and other linens for a cozier nighttime experience. You can also expand this makeover to your entire room with dimming shades, white noise machines and more.
It can also help to keep your bedroom a little chillier than the rest of your abode for the sake of better sleep. Studies show that temperatures between 60 and 67F can be great for allowing your body to cool down properly as you lie down with enough heat to promote wakefulness when you rise. Cooling blankets and pillows can also be helpful for these circumstances.
Like your kitchen, garage or home office, your bedroom should also have a role to play in regards to your daily habits. While it might sounds enticing to stay under the comforters as you work from home, doing so can actually trick your brain into a more active state, associating wakefulness with your bed itself. This association can be hard to break when you go to truly use your mattress, sheets and pillows for their intended activity rest.
Its best to leave your sleeping arrangements for just this purpose by keeping your active hours separate from the location entirely. If you do find yourself struggling to nod off at the end of the day, a helpful tip is to leave the room for roughly 20 minutes, then returning once your mind has had time to turn down further. This can promote that notion of bed equals sleep more, resulting in a smoother transition to slumber time.
While its not a great idea to stare at your phone for hours before bed, these devices can still help you create a soothing sleep environment through a number of pathways. Plenty of sleep apps are designed to help with meditation, journaling, soundscapes and more. Using these tools to your advantage can put you in a better state for slumber, creating an effective, efficient relationship between your devices and your sleep hygiene.
To go a step further, some sleep apps utilize your phone or smartwatchs accelerometer to track your body tendencies throughout the night, charting your sleep data for a detailed look at how well youre resting from a qualitative and quantitative perspective. This style of digital tool can also be great to inform you of other pre-bed habits and how theyre truly impacting your rest.
Yes, your rest can actually benefit from the activity its trying to help, too. A proper exercise regimen can boost serotonin levels in the brain and decrease the presence of cortisol, resulting in improved sleep duration and quality. There are some parameters, however, to create the best relationship between sleep and training.
For one, studies show that early morning workouts can be more positive for sleep than later evening sessions. Additionally, your activities should be vigorous, but not overly aggressive or intense. Overtraining has been linked to poor sleep quality in the past, so while your body may be clamoring for a rest in these scenarios, said slumber may be less impactful.
Play around with your workouts and schedule to find what generates the best results for you. Doing so can create a cyclical, symbiotic relationship between your sleep and fitness where everyone wins especially you.
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Your Sleep Hygiene Needs Work Here's How to Improve Your ... - Gear Patrol
Intermittent fasting is fast becoming the go-to diet for achieving different health goals, most importantly, weight loss. Many celebrities, business tycoons, and famous entrepreneurs have endorsed this transformative fasting strategy as the sure-shot way to a healthier mind and body.
Intermittent fasting is an eating pattern where you fast for a certain number of hours a day and reserve calorie intake to a small eating window. When you do this, in the fasting period, your body uses up the glycogen stores it utilizes for energy and undergoes a metabolic switch. With this metabolic switch, the body enters a state known as ketosis, where the liver produces ketones from the stored fat reserves to use as an energy source.
There are several intermittent fasting techniques, the most common being 16/8, where you fast for 16 hours and eat calories in the eight-hour feeding window. Some fasters like to do the 5/2 fasting schedule, where they eat normally for five days of the week, and on two non-consecutive days, they limit calorie intake to 500-600 calories. Yet more advanced fasters prefer to go for OMAD fasting (one meal a day), 36-hour fasts, and monk fasts, with extreme fasters also taking it as far as a 60-hour fast.
Many variants of intermittent fasting exist, like water fasting and fat fasting, each with its own special benefits. People also work out towards the end of the fasting period to lose fat and gain muscle simultaneously.
Despite its growing popularity, one of the most overlooked benefits of intermittent fasting is its significant impact on collagen production within the body. We need collagen, a protein, for healthy skin, nails, joints, and hair. Recent research suggests that intermittent fasting can assist in stimulating the bodys production of collagen. This article examines the relationship between intermittent fasting and collagen production, supporting the theory with scientific studies and research. Keep reading to discover the connection between intermittent fasting and collagen synthesis.
Among the different kinds of proteins in the human body, collagen is the most abundant, accounting for 30% of the total protein composition. It is a building block for muscles, skin, tendons, bones, ligaments, and other kinds of connective tissue. You can also find collagen in the blood, intestinal lining, and organs.
All proteins are made from amino acids, and collagen is no exception. Proline, glycine, and hydroxyproline are collagens main amino acids. These three amino acids are grouped to form protein fibrils in the famous triple helix structure.
The main role of collagen is to provide strength, structure, and support to the body. Its specific roles are:
To date, researchers have identified 28 types of collagen. The differentiation is based on the molecule assembly, the cell components, and the location of the collagen in the body. All these different collagen fibrils consist of a triple helix structure.
Here are the main types of collagen as well as their various functions:
Here are the different factors that can affect collagen production in the body:
Apart from these factors, it has also been found that fasting, especially intermittent fasting, can increase collagen production. We shall take a look at this phenomenon now.
Intermittent fasting can stimulate collagen synthesis in multiple ways. Check them out here:
It has been proven that intermittent fasting can increase and enhance the secretion of an important hormone, Human Growth Hormone (HGH). HGH is a very important regulator of collagen production in the body. HGH stimulates collagen production in two ways. Firstly, it helps the fibroblasts differentiate into myofibroblasts, cells that produce collagen. Secondly, HGH upregulates collagen gene expression.
A study published in the Nutrition Research journal revealed that 24-hour intermittent fasting led to an immense increase in HGH levels in both women and men [1]. Another study proved that a 37.5-hour fast elevated basal HGH concentration by 10-fold and additionally reduced the metabolic clearance of HGH. [2]
As we know, HGH is essential for collagen synthesis. This increase in HGH levels during intermittent fasting suggests that the latter is a very useful tool for increasing collagen production in the human body.
Cancer.gov defines autophagy as A process by which a cell breaks down and destroys old, damaged, or abnormal proteins and other substances in its cytoplasm (the fluid inside a cell). The breakdown products are then recycled for important cell functions, especially during periods of stress or starvation.
As the body ages, it gets increasingly exposed to free radicals from the food we eat, the air we breathe, and the different products we use daily. This stresses out the individual cells and causes them to get damaged faster than normal. These damaged cells can linger in connective tissues and organs, causing inflammation and disease. Autophagy removes the task of maintaining these useless and inefficient cells in the body. It frees it to fight inflammation, deter diseases, and line the body up for optimal functioning.
After age 30, the fibroblasts in the skin begin to store more waste, slowing down the collagen-producing and autophagy rates. This then causes a deterioration of the fragility and integrity of the skin and leads to sagging and wrinkled skin. Hence, an increased autophagy rate will help clean the fibroblasts, removing unwanted cellular debris and slowing down the signs of skin aging.
A study found that intermittent fasting induced autophagy in mice, helping remove dead and damaged cells and produce healthy and new cells. [3]
As we know, autophagy is crucial for collagen synthesis, and increased autophagy rates brought about by intermittent fasting lead to improved and increased collagen synthesis by inference.
Intermittent fasting can reduce body inflammation in many ways. It reduces oxidative stress by producing antioxidants, promotes autophagy, lowers insulin levels, activates anti-inflammatory pathways, and modulates the gut microbiome, all contributing to reduced inflammation.
A study found that intermittent fasting reduces chronic inflammation in mice by activating an anti-inflammatory pathway known as the Nrf2 pathway. [4]
As we know, inflammation is a big cause of collagen breakdown. Hence, the above reduction in inflammation in the mice suggests that intermittent fasting can help protect collagen.
There are several ways in which intermittent fasting can improve gut health. Firstly, it improves the motility of the gut, helping the digestive system move food through the GI tract. Secondly, it improves the gut microbiota, modulating the composition of the trillions of microorganisms residing in the gut. Thirdly, it refines the gut barrier function by increasing mucus formation, reducing inflammation, and finally enhancing the absorption of nutrients from the gut.
A study has conclusively shown that intermittent fasting improves overall gut health. [5]
Now, the gut is where most of the nutrients necessary for collagen synthesis get absorbed. Hence, a healthy gut can ensure that the body has all the ingredients it needs for the production of collagen, and this can be made possible through intermittent fasting.
Collagen is a great way to help you achieve your weight loss goals, but youre probably using it wrong. When used correctly, it can help prevent snacking, reduce cravings, and help you get to your weight loss goals.
The biggest mistake that you are making is that you are using collagen as your main protein source. If you do this, you will lose weight, but it will be in the form of a loss in muscle and bone mass, leading to a decrease in metabolism, which you do not want.
To achieve healthy weight loss, use collagen supplements in tandem with a rich protein source. Suppose you are making a collagen supplement smoothie. We suggest you reinforce this smoothie with a rich source of protein, like Greek yogurt or even another protein supplement.
If you use bone broth, you can sip on it but do not use it as a replacement for protein. Rather, use it as an add-on to a meal. For example, you can sip on bone broth while relishing a chicken salad. This gives you collagen and a complex protein.
Strictly speaking, yes. Collagen intake during fasting periods will break your fast. Even if you eat hydrolyzed and unflavored collagen peptides, remember that each scoop of collagen contains 30 calories.
The collagen tissues in our body are responsible for forming tendons, ligaments, and bones. However, you can lose collagen in your body if you are exposed to UV rays, if you consume tobacco, or if you take excessive sugar, as well as with age. Additionally, chronic stress can make you lose collagen.
It has been observed that new collagen growth can take anywhere from 4 to 12 weeks to complete.
Collagen supplements can make you feel satiated. This helps with weight loss and the prevention of hunger pangs when you are doing intermittent fasting. Collagen has this effect because it is a form of protein.
The top foods rich in collagen are bone broth, eggs, meat, fish, and spirulina.
The link between intermittent fasting and collagen production is multi-faceted and complex. Collagen is a crucial protein that is indispensable to the human body as it maintains the function and structure of different organs and tissues. Studies have shown that fasting can increase the secretion of human growth hormone and promote the process of autophagy, both of which directly or indirectly influence the production of collagen.
The intricate relationship between collagen synthesis and intermittent fasting impacts longevity and health. If we can increase collagen production by fasting intermittently, it could help arrest age-related issues with skin, joint health, and the density of our bones. Again, nowadays, collagen supplements are quite popular, and their efficacy can be increased if we better understand the relationship between fasting and collagen production.
Collagen production is influenced by various factors, including lifestyle, exercise, and nutrition; intermittent fasting is one of many ways collagen synthesis can be promoted. The fascinating link between intermittent fasting and collagen production needs further exploration and study so that we can come to a better understanding of their complex relationship.
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Intermittent Fasting and Collagen Production Fitness Volt - Fitness Volt
Editor's note: This article has been corrected to state in all instances that TransCon PTH (palopegteriparatide) is meant to treat adults with hypoparathyroidism.
Shares of Ascendis Pharma (ASND 6.48%) rose more than 19% Monday morning after the Danish pharmaceutical company received a critical response letter (CRL) from the Food and Drug Administration (FDA).
The biotech company specializes in therapies to treat rare endocrinology diseases and various cancers. Its shares are down more than 30% so far this year.
The reason the stock went up rather than down following a CRL is it gave some clarity to the situation around TransCon PTH (palopegteriparatide), which is in phase 3 clinical trials to treat adults with hypoparathyroidism. While the FDA cited concerns about the company's manufacturing control strategy, it did not say it had concerns about the clinical data from Ascendis and did not request any additional clinical studies.
All this means the problem is something Ascendis can more easily fix, while the need for more clinical trials could easily delay the drug's launch by two years, and that's if Ascendis satisfied any FDA concerns. Ascendis said it plans to request a Type A meeting soon with the FDA.
"We are committed to working collaboratively with the FDA and, because the agency did not suggest that additional phase 3 studies may be needed to demonstrate the product's safety and efficacy, we believe we are well prepared to address their concerns," said Jan Mikkelsen, Ascendis Pharma president and CEO, in a press release.
Ascendis only has one FDA-approved therapy, Skytrofa. It is a once-weekly human growth hormone to treat pediatric growth hormone deficiency. In the first quarter, thanks mainly to Skytrofa, the company reported revenue of 31.6 million euros ($34.8 million), up 394% year over year.
The company had a net loss of 110.9 million euros ($122.4 million), thanks mainly to higher expenses related to the company's clinical oncology programs. Ascendis said it had, as of March 31, 585.7 million euros ($646.2 million), which is enough at its current burn rate to fund operations into early 2025.
Jim Halley has no position in any of the stocks mentioned. The Motley Fool has no position in any of the stocks mentioned. The Motley Fool has a disclosure policy.
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Why Shares of Ascendis Pharma Are Climbing Monday - The Motley Fool
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As an athlete, you know how to bring the heat to your training regime. But bring too much (literal) heat to your sleep routine, and you risk sabotaging your sports-specific goals.
Theres a temperature sweet-spot for optimal sleep and exercise recovery, says Pete McCall, an exercise physiologist. And slumbering in a room outside of that range may cause your recovery to suffer, he says.
It may also lead to performance issues. One 2020 review published in the International Journal of Sports Medicine found that inadequate sleep can decrease reaction time and accuracy, as well as worsen judgment and decision making. But logging Zzzs isnt just important before a long day on the trail, its also essential following a day of exercise.
When you exercise, you create tiny microscopic tears in your muscle fibers, McCall explains. As concerning as that sounds, the fibers repair themselves while you sleepand become stronger through the process. Without adequate rest, your recovery is hindered.
One 2023 review published in Current Issues in Sports Science found that a lack of sleep decreases human growth hormone levels. Without the requisite levels of this hormone, which triggers the release of a protein essential for muscle regrowth, the repair process is impeded. Additionally, a 2015 study published in the Journal of the American Medical Directors Association found that testosterone levels, which regulate the rate at which amino acids can do work on the torn muscle fibers, decreased in individuals who experienced sleep disturbances.
Temperature is one of the main things that can lead to sleep struggles, says sleep psychologist and the director of sleep health at Sleepopolis Shelby Harris. People typically get the most optimal shut-eye in 60- to 67-degree rooms, she says. If youre dozing off in a room much cooler than that, you risk impacting your cardiac autonomic response, and if youre snoozing at a temperature above that, you risk night sweats, wakefulness, and decreased REM. Rapid eye movement sleep is the stage of sleep when testosterone production is at its highest, explains McCall. If that stage is hijacked by high temperatures, your athletic recovery will suffer, he says. Youll also be at an increased risk for injury, chronic stress, and overtraining syndrome. So, how exactly can you avoid that?
Twisting your thermostat to the left each evening is the easiest routine when it comes to sleep temperature regulation. However, you may live in an environment, such as an apartment complex with a central temperature control or an older home without air conditioning, where that isnt possible. These alternative options allow you to ensure youre able to sleep at the optimal temperature.
Sometimes the simplest trick can be the best one. Assuming you live somewhere where it gets cooler at night, opening your windows may be all you need to keep yourself from overheating, says McCall.
You may be overlooking another built-in temperature regulator: your ceiling fan. According to the Department of Energy, overhead fans can help rooms feel 4 degrees cooler. If you dont have a ceiling fan, a well-placed store-bought fan can also do the trick. Plus, a fan can double as a sound machine, helping you drift off easily.
Beyond your built-in sleeping aids, a slew of sleep gizmos and gadgetsranging from cooling sheets and breathable pillows to gel-infused mattress toppers and temperature adjusting mattressescan help keep you comfortable all night long. Mattresses and other devices that regulate temperature while you sleep are sound investments, Chris Winter, a sleep specialist and neurologist, says.
If your partner runs cold, but you dont, opt for a single-person cooling option, such as the Brooklyn Bedding Luxury Cooling Memory Foam Pillow or Moona Cooling Pillow Pad. The former uses a cool gel infusion and copper to promote greater breathability, while the latter uses water and a heat pump. These and similar products keep your overall body temp down by regulating head and neck temperature.
However, if you sleep alone or you and your partner both find yourselves sweating at night, consider purchasing a mattress cooler like ChiliSleep Sleep System or Eight Sleep Pod Cover, or a temperature-regulating mattress like PerformaSleep or Helix Sleep Midnight Luxe.
Its important to note that while temperature regulating devices can be great, they need to be paired with other healthy sleep habits in order to be effective, Winter says.
Beyond regulating your sleep temperature, make sure youre mastering the basics of a solid bedtime routine. Winter recommends strategies such as waking up at the same time every day, limiting exposure to blue light in the evening, and getting sunlight within the first hour of waking.
Its about more than eliminating those restless nights. With better sleep, youll maximize your recovery and performancebe it at the office or on the trail.
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What You're Forgetting When It Comes to Your Sleep - Outside
Understanding the process of a clinical trial and consent is challenging for every participant. But this experience can be considerably more burdensome for the paediatric population, which has the highest dropout rate in clinical research.
As a consequence, certain processes need to be introduced to guide children through a challenging part of their lives. One of them is having an interactive real-life companion that can create comfort and emotional support for children.
In an exclusive interview with Clinical Trials Arena, Aaron Horowitz, founder and CEO of Empath Labs, shares how toy-like companions can aid families through the complex world of healthcare and clinical trials. For over a decade, Horowitz led digital startup Sproutel, which is now rebranding to Empath Labs with a sole focus on clinical trials.
Urt Fultinaviit: What burdens or challenges do children face when enrolling into a clinical trial?
Aaron Horowitz: First and foremost is understanding what a clinical trial is, what is their role in a clinical trial, and why it is important. We know that consent for adults is such a difficult process, and this is only magnified for children, especially children across a wide variety of health literacy backgrounds or abilities.
Then as the trial goes on, there is the need for comfort and emotional support. We have talked to a lot of families that can describe being in a trial as quite scary for kids. There is also a need for education throughout the trial process itself. We are big believers that consent is continuous, so it is important to make sure that children are continuously engaged in the study.
UF: How can technology ease that journey or guide them through a challenging part of their life?
AH: We have been in the field for around a decade of providing technology that can create comfort and emotional support for children while helping them emotionally engage with their care. Our interactive companions are currently used by over 125,000 children around the world. There are other ways that this type of support can be provided but the most critical thing is reaching children at their level.
We know that children speak the language of play, and we reach children with the language that they speak. We use technology to help empower children and put them in the role of caregiver, so they can really understand every single thing that is going to happen. We create these companions that mirror childrens experiences throughout a trial. If theyre getting their blood drawn, so is their companion.
UF: The childs age determines if they are able to complete electronic patient-reported outcomes (ePRO). How does your technology ease the collection of self-reported data collection?
AH: Currently, the Clinical Companions platform does not collect any type of ePRO from children. While we do not collect ePRO data, we collect data on how they are using the platform. There are interesting potential correlations between engagement in the platform and engagement in their care. As we look towards the future, we have all sorts of ideas, from collecting more unstructured data to making survey data more interactive and tactile for kids.
We have learned a lot from our product called My Special Aflac Duck for which we use physical emoji disks that kids can tap to the character to enact these emotions and show their caregivers how they feel. We are developing prototypes in which children can self-report in a way that makes them comfortable and that is not a lengthy survey about their patient experience.
UF: Can technology add-ons increase the price of a clinical trial, resulting in an increased price of medication?
AH: We believe that technology add-ons can be used to make trials more efficient. Obviously, technology add-ons have a cost, and a platform like ours fits within the existing patient engagement budgets of clinical trials. It is cost-neutral from a trial standpoint.
We are working to show that our platform can affect retention and compliance rates. Our aim is to help shorten the clinical study and lower the costs, while still providing immense comfort to kids and empowering them in the study itself.
The dropout rates are quite high in paediatric clinical trials. Theres a wide range of reasons for that, such as the stress that children can go through and the parents perception of how their child is feeling. If you are a parent and your child is really struggling, it is difficult to weigh the cost and benefit of staying in the trial.
UF: What is the future of Empath Labs and how do you plan to improve the challenging conduct of paediatric trials?
AH: Something that we think a lot about is healthcare. Healthcare is composed of two discrete components: health and care. In the past decade, we have made massive advancements on the health side, curing diseases, and developing new treatments. Our vision is to transform the care side of healthcare, by developing patient experiences that are compassionate and empathetic beginning in paediatrics.
I founded this company as a patient because I grew up with human growth hormone deficiency and I gave myself injections every day as a child. I distinctly remember not understanding what was going on during that process.
For the past 11 years, the lens that I bring is wanting every child to understand what theyre going through. While weve done that for the past decade as Sproutel, this year with the launch of Clinical Companions we are focusing on clinical research and have rebranded as Empath Labs.
As Empath Labs, we aim to reshape the patient experience from the drug development process all the way through the continuum of care. The ultimate goal is to accelerate the development of drugs, to help all patients understand what theyre going through, to save money for sponsors, and to do well by doing good.
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Q&A: Improving paediatric clinical trials with the language of play - Clinical Trials Arena
Md Saiful Islam Khan
Ascendis
Price is what you pay. Value is what you get. - Warren Buffett
In biotech investing, you tend to earn the most tremendous profits by investing in companies early in their growth phase. That is to say, you can get multiple-fold gains by picking highly promising clinical-stage innovators. Despite their higher risks, you can manage them by forecasting upcoming big data releases. Now, early product-stage companies can still have more upsides. However, they'll be modest. As such, these companies would be similar to the "cigar butt plays" that Warren Buffett spoke about. While not glamorous, they still have one last puff left.
On that note, I want to bring to your attention a cigar-butt play named Ascendis Pharma (ASND). Asides from its lead drug (Skytrofa) generating increasing sales, the company is advancing its other drug TransCon PTH for hypoparathyroidism. As you know, the company recently encountered a regulatory setback. Whether the company can resolve this situation significantly affects the investing thesis on this stock. In this research, I'll feature a fundamental analysis of Ascendis and share with you my expectation of this intriguing equity.
StockCharts
Figure 1: Ascendis chart
As usual, I'll present a brief corporate overview for new investors. If you are familiar with the firm, I recommend that you skip to the next section. Based in Copenhagen, Denmark, Ascendis Pharma is focused on the innovation and commercialization of drugs to serve the unmet needs in endocrinology and oncology.
Leveraging its TransCon technology platform, the company has successfully launched an approved drug dubbed Skytrofa (lonapegsomatropin-tcgd) to treat pediatric growth hormone deficiency. That aside, there is another promising pro-drug coined TransCon PTH which is under regulatory review for adults suffering from hypoparathyroidism.
Ascendis
Figure 2: Therapeutic pipeline
As you can see, Ascendis' value is powered by the TransCon pro-drug delivery technology. As you know, I'm not a big fan of pro-drug. Instead, I prefer a completely novel mechanism of action. But here's how it works. You have an active parent drug that is attached to a TransCon "linker."
The binding of the drug to its linker creates stability and thereby prevents its clearance from circulation. Once injected, the linker will be cut at strategic sites in the body to release the parent drugs. After dislodged, the parent molecules kicked in while the linker is being eliminated in the kidneys
Ascendis
Figure 3: TransCon pro-drug delivery platform
As a once-weekly lonapegsomatropin injection for kids one year or older (suffering from inadequate growth hormone section), Skytrofa is FDA-approved back in August 2021. The key advantage of Skytrofa is that it can be stored at room temperature and has a low-volume injection via a device that lasts as long as 4 years. As you can appreciate, the Skytrofa approval and launch are important for Ascendis because it's a validation of the TransCon drug delivery.
Ascendis
Figure 4: Skytrofa for pediatric growth hormone deficiency
Over 12 months into the launch, Skytrofa sales have been ramping up significantly. For 4QFY2022, its revenues tallied at 17.1. FY2022 figure registered at 51.1M. Without any label expansion, sales growth should take Skytrofa to at least 100M within the next few years.
Ascendis
Figure 5: Skytrofa sales growth
To boost sales growth, Ascendis is aggressively expanding Skytrofa labels as well as penetrating into additional markets. Precisely speaking, you can expect the company to launch Skytrofa into the European market in Q3 this year.
As shown below, Ascendis is penetrating Skytrofa into the Asian markets. Furthermore, there are ongoing label expansions for Adult growth hormone deficiency (GHD) plus Turner's syndrome and for achondroplasia. Taking all that together, you can expect this franchise to become a blockbuster in the coming years.
Ascendis
Figure 6: Skytrofa growth and expansion
In terms of the timeline, you're looking at many expansions this year. Whenever there are multiple catalysts stacked in close succession, the stock usually does quite well. In Q4, you'd have the data release for adult GHD which can give the share price a significant boost.
Ascendis
Figure 7: Building a leading global growth hormone portfolio
Before we dive into the biggest regulatory catalyst, you should take a look at the underlying science/medicine of hyperthyroidism. Due to either a deficiency or absence of the parathyroid hormone (i.e. PTH), afflicted patients exhibit various symptoms of low blood calcium and high phosphate. After all, PTH facilitates the absorption of calcium and the elimination of phosphate.
As you can see, the lack of calcium reabsorption in the blood causes excessive calcium to be excreted through the urine. Ultimately, low blood calcium (i.e., hypocalcemia) and high urinary calcium (i.e., hypercalciuria) lead to a multitude of symptoms as shown below. They include heart arrhythmia, brain abnormality, respiratory, etc.
Ascendis
Figure 8: Underlying science/medicine of hypoparathyroidism
Now, conventional therapy focuses on calcium replacement and Vitamin D supplementation for symptomatic hypocalcemia, hypercalciuria, and poor quality of life. While there is some efficacy, you'd still need the PTH to mobilize the calcium and phosphate.
That aside, taking excessive calcium supplement or phosphate binders have its own adverse effects which leads to low compliance and poor outcomes. They include chronic kidney diseases, liver and brain calcifications, cardiovascular complications plus bone damage.
Ascendis
Figure 9: Current treatment for hypoparathyroidism
As elucidated above, you can imagine that the more efficacious approach is to replace PTH. Back in 2022, the FDA already approved a once-daily injection of PTH coined Natpara. From the Phase 2 (PaTH Forward) and Phase 3 (PaTHway Global and Japan) clinical studies, you can appreciate that TransCon PTH provides an excellent solution for patients. After all, nearly all patients on TransCon PTH no longer need to use conventional therapy. Simply put, TransCon PTH works and it could be a better solution than Natpara.
Ascendis
Figure 10: Strong TransCon PTH data
Safety-wise, the studies shown above also showed no adverse effects. Moreover, the PaTHway Japan trial demonstrated that TransCon PTH was well tolerated and the urinary calcium level was normalized. As you'd expect, the majority (i.e., 12 of 13) of patients easily cleared the primary composite endpoints (i.e., normalized blood calcium and no longer needing conventional therapy).
Ascendis
Figure 11: PaTHway Japan's robust results
As you can see, TransCon PTH has the Prescription Drug User Fee Act (PDUFA) set for April 30. In a nutshell, that's the final day for the FDA to issue an approval decision. Like a curve ball, Ascendis recently stated that the FDA issued a deficiency notice on its New Drug Application (i.e., NDA) filing re TransCon for PTH. That event caused the share price to tumble roughly 40%. According to the President and CEO (Jan Mikkelsen),
This notification from FDA relates to their review of our NDA, and since the NDA deficiencies were not disclosed in the letter, we are eager to work with FDA to learn, understand, and address them. This development a month from the agencys PDUFA action date may lead to a delay in the FDAs final regulatory decision on the TransCon PTH NDA. The safety of patients remains our highest priority and, since our NDA submission, no new safety signals have been observed to date in our ongoing TransCon PTH Phase 2 and Phase 3 clinical trials or in our Expanded Access Program (EAP) program and these programs continue unchanged.
If Ascendis can resolve this situation, the company would be positioned to capture a lucrative market. As depicted below, you can see that the annual occurrence of hypoparathyroidism in the USA is only 3K patients. Hence, this makes hypoparathyroidism an orphan (i.e., rare) condition that warrants a premium reimbursement to foster the lengthy and low success rate of the innovation process.
Ascendis
Figure 12: Hypoparathyroidism addressable market
Given that two doses of a competing drug (Natpara) cost over $10K, you can imagine that its monthly supply would run $150K monthly (i.e., $1.8M a year). And, you can imagine that TransCon PTH would be priced similarly or lower to foster a healthy profit margin. Let's assume some basic calculations at a $1M annual price for TransCon PTH as shown below.
Figure 13: Estimate revenues for TransCon PTH
Just as you would get an annual physical for your well-being, it's important to check the financial health of your stock. For instance, your health is affected by "blood flow" as your stock's viability is dependent on the "cash flow." With that in mind, I'll assess the FY2022 earnings report for the period that ended on December 31.
As follows, Ascendis procured 51.1M for FY22 compared to 7.7M for FY21. As you can appreciate, Skytrofa's sales contributed to the strong revenue ramp-up. That aside, the research and development (R&D) for the respective periods tallied at 379.6M and 295.8M. While I typically view the R&D increase positively, this is too excessive for such a young company.
Additionally, there were 583.1M (10.40 per share) net losses compare to 838.5 (7.00 per share) net decline for the same comparison. Here, it's a positive sign to see that the company is narrowing its net losses. Nevertheless, the figure here is still quite high.
Ascendis
Figure 14: Key financial metrics
About the balance sheet, there were 742.9M in cash, equivalents, and investments. On top of the 51.1M in revenues and against the 561.8M annual OpEx, there should be adequate capital to fund operations into 1Q2024. Simply put, the cash burn is high relative to the cash runway.
Since investment research is an imperfect science, there are always risks associated with your stock regardless of its fundamental strengths. More importantly, the risks are "growth-cycle dependent." At this point in its life cycle, the main concern for Ascendis is whether TransCon PTH would clear the FDA deficiency to gain approval this year.
Even with approval, there is a significant risk that TransCon PTH would flop in commercialization and have some manufacturing issues like Natpara. Moreover, there is a significant risk that Ascendis' growth hormone franchise won't become a blockbuster. As a young company, Ascendis might grow too aggressively and thereby runs into the potential cashflow constraint.
In all, I issued a highly speculative buy recommendation on Ascendis with a 4.2/5 stars rating. Riding the Skytrofa launch for human growth hormone, Ascendis validated its TransCon pro-drug delivery platform. Sales are becoming increasingly significant. Meanwhile, the company is aggressively expanding sales into new territories and pushing for label expansions.
Now, the key to Ascendis' success is whether the company can resolve the FDA deficiency. That depends on the nature of the deficiency, which is yet to be known. Overall, ASND stock seems like a "cigar-butt" play if you are into product-stage biotech with modest gains.
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Ascendis Pharma Stock: A Promising Diversification Play (NASDAQ ... - Seeking Alpha
Ashley Manning is an American real estate developer, entrepreneur and philanthropist. She is also widely known for being Peyton Mannings wife, two-time Super Bowl champion. She also partly owns the Memphis Grizzlies.
Ashley Manning is an animal lover and has been involved in supporting animal-related causes. She has been associated with organisations such as the Indianapolis Zoo and the Tennessee State Parks Conservancy, showcasing her passion for wildlife conservation and animal welfare. She also has three dogs: a chihuahua and two Labrador retrievers.
Ashley Manning was born Louisa Ashley Thompson in Memphis, Tennessee. She is the second of four children of investment banker and real estate entrepreneur Bill Thompson and homemaker Marsha Thompson.
Ashley has two sisters, Leigh Sanders Thompson and Allison Thompson Luter and one brother William Van Thompson III. She graduated with a Bachelor of Arts in Finance and Marketing from the University of Virginia in 1997.
Ashley, the wife of Peyton Manning is 48 years old as of 2023. She was born on 2 December 1974. Her zodiac sign is Sagittarius.
Following in her fathers footsteps, Ashley Manning is a real estate developer. She started as a real estate agent and eventually set up her own company. She is also a minority owner of the Memphis Grizzlies, an NBA team based in Memphis, Tennessee.
She is a dedicated philanthropist who runs PeyBack Foundation, a charity she co-founded with her husband in 1999. PeyBack Foundation empowers at-risk youth by providing growth opportunities and leadership programmes. She has also taken part in fundraising initiatives for breast cancer, a cause she is passionate about being the daughter of a breast cancer survivor.
Ashley Manning has a net worth of $20 million. She makes her money from her real estate company and from being a minority owner of the Memphis Grizzlies.
Peyton met Ashley in 1994 when she was a student at the University of Virginia, and he was getting ready to join the University of Tennessee. Her parents next-door neighbour introduced them, and they stayed together throughout college. They married in 2001, three years after Peyton was drafted to be an NFL quarterback under the Indianapolis Colts.
Ashley has been a constant pillar of support for her husband throughout his illustrious NFL career and has been present at several games, cheering him on. Peyton said he was ready to retire from playing football in 2011 after a neck injury, but Ashley encouraged him not give up. He went on to win the Super Bowl in 2016 with the Denver Broncos.
She has two children, a son named Marshall and a daughter named Mosley. Peyton Mannings wife and children live with him in Denver, Colorado.
Although Peyton Mannings personal life has been private, he has faced some public controversies. In 2016, Ashley, Peyton, and others were implicated in a controversy involving the alleged use of the Human Growth Hormone (HGH) following a documentary by Al Jazeera America. However, after a 7-month investigation by the NFL, no concrete evidence was found to support the allegations. They were both cleared of any wrongdoing.
Peyton Mannings wife is Ashley Manning, born Louisa Ashley Thompson. She is an American businesswoman, real estate developer and philanthropist. She is also a philanthropist, devoted to different causes, including breast cancer.
Legit.ng recently published an article about Lonzo Balls girlfriend, Ally Rossel. Ally is an American model and social media influencer. She rose to fame for her extensive Instagram photos and for being the girlfriend of Chicago Bulls point guard Lonzo Ball.
Ally graduated with a degree in Communications from the University of California, Los Angeles. She is passionate about animals and has often been photographed with different animals, including snakes and her dog Mowgli.
Source: Legit.ng
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Who is Peyton Manning's wife, Ashley Manning? A look at her life - Legit.ng
