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As though the havoc created by GM crops was not adequate, several experimental efforts relating to genetically modified or engineered animals are bringing a wide range of new risks and uncertainties. These include health hazards relating to transfer of diseases from genetically engineered animals to normal animals as well as to human beings. In addition there are the additional risks from consuming the food based on or obtained from genetically engineered animals. Then of course there are grave doubts regarding the scientific basis of the technology and to what extent it can actually succeed in achieving its aim regarding transfer of certain genetic traits, quite from the hazards involved in this, as well as the ethics of playing around with an uncertain technology regardless of serious harm that may be caused to the health and welfare of animals in the process.
Some of the earlier efforts in this direction relating to pigs and sheep turned out to be quite disastrous, as is evident from a review published in The Ecologist. In this widely quoted paper titled The Biotechnology Bubble Dr. Mae-Wan Ho (of Bio-Electrodynamics Lab of the Open University in the UK), Joe Cummins (Professor Emeritus of Genetics in Canada) and Hartmut Meyer summarized the results of several experiments, trials and commercial releases of GMOs, with special emphasis on animals. They wrote : There are many signs of the problems caused in genetic engineering organisms. For every product that reaches the market, there are perhaps 20 or more that fail. It is particularly disastrous for animal welfare.
>> The super-pig engineered with human growth hormone gene turned out arthritic, ulcerous, blind and impotent.
>> The super-salmon engineered, again, to grow as fast as possible, with genes belonging to other fish, ended up with big monstrous heads and died from not being able to see, breathe or feed properly.
>> The clones of the transgenic sheep Dolly are abnormal and eight times as likely to die at birth compared with ordinary lambs.
>> Even products that reach the market are failing, including crops that have been widely planted.
The authors of this widely quoted paper concluded: It is important to realize that the failures are not just teething problems. They are very much the result of a reductionist science and a hit or miss technology. The transgenic foods created are unwholesome, because they involve stressing the developmental and metabolic system of organisms out of balance. There are bound to be unintended effects including toxins and allergens, which current risk assessments are designed to conceal rather than reveal. The major problem is the instability of transgenic lines.
In a note on Risks Associated with GM Farm Animals the Federation of American Farm Scientists has statedThe genetic engineering of farm animals entails certain risks. It is possible, for example, that the experience of novel proteins can cause allergic reactions to susceptible people. There are also potential risks to the environment and problems relating to lack of transparency.
A research paper prepared by the Humane Society of the USA (HSUSA) and titled Welfare Issues with Genetic Engineering and Cloning of Farm Animals has statedDevelopments in biotechnology have raised new concerns about animal welfare as farm animals (may) now have their genomes modified ( genetically engineered ) or copied ( cloned) to propagate certain traits useful to agribusiness such as meat yield or feed conversion. These animals suffer from unusually high rates of birth defects, disabilities and immature deaths.
Further this paper prepared by the HSUSA reviews the recent research in this area to tell usRecent cloning research also reveals high failure rates, premature deaths, and such abnormalities as intestinal blockages, diabetes, shortened tendons, deformed feet, weakened immune systems, dysfunctional hearts, brain, liver and kidneys, respiratory distress and circulatory problems.
According to a review quoted in this paper, less than 5% of all cloned embryos transferred into recipient cows survived. This paper has lamented the lack of regulations in this work to protect the welfare of animals.
These and related concerns should be raised more and more to prevent the genetic modification of animals from becoming as big an environmental and health risk as the technology of GM crops has become.
Bharat Dogra is Honorary Convener, Campaign to Save Earth Now. His books include Indias Quest for Sustainable Farming and Healthy Food, 14 Questions About GM Crops and A Day in 2071.
Excerpt from:
Genetically Modified Animals Bring New Risks And Uncertainties - Countercurrents.org
Sleep, according to cambrige.com in simple definition is to be in a state of rest when your eyes are closed, your body is not active, and your mind is unconscious.
Sleep has a lot of benefits and is arguably the secret to longevity. What causes us to sleep? The production of the hormone melatonin in the brain.
Here are some of its benefits.
Sleep has been proven to benefit the long-term memory of an individual since the consolidation of memory in the brain takes place as we sleep. Research suggests that sleep helps learning and memory in two distinct ways.
First, a sleep-deprived person cannot focus attention optimally and therefore cannot learn efficiently.
Second, sleep itself has a role in the consolidation of memory, which is essential for learning new information. (source Harvard.edu)
Another thing that your brain does while you sleep is processing your emotions. Your mind needs this time in order to recognize and react the right way.
When you cut that short, you tend to have more negative emotional reactions and fewer positive ones. In fact sleep deprivation has been linked to having unstable moods that may lead to depression.
Also, while you sleep, your blood pressure goes down, giving your heart and blood vessels a bit of a rest. The less sleep you get, the longer your blood pressure stays up during a 24-hour cycle.
Sleep offers good recovery to the muscles, it enhances muscle recovery through protein synthesis and human growth hormone release.
According to Sports lab new york.com, this process stimulates muscle growth and recovery.
A 2018 study by the National library of medicine in America stated that individuals who regularly slept less than 7 hours per night were more likely to have higher average body mass indexes and develop obesity than those who slept more.
Studies showed that experimental sleep restriction was associated with increased levels of ghrelin, salt retention, and inflammatory markers as well as decreased levels of leptin and insulin sensitivity.
Again too much of anything is poisonous, and sleeping in excess may cause diabetes and obesity, so it's important to balance your sleep.
Dr.Granton Trevor says ''Sleep is a very good doctor, it restores, rejuvenates, and protects, so develop good sleeping habits and live a high-quality healthy life."
Read the rest here:
Benefits of good sleeping habits - The Star Kenya
Nootropics are a relative newcomer in a booming supplement market, promising benefits and enhancements to those seeking a cognitive edge. However, theyve gained popularity quickly and are now firmly positioned as a top contender vying for prime space in your supplement regimen.
At their best, nootropics can do everything from improving your attention and focus to even enhancing your working memory. However, nootropic supplements are not all created equal.
The trick is, knowing what to look for in a top-tier nootropic supplement and how to choose one that best suits your goals. Well discuss the proven benefits of nootropics, featured in Kageds Mindset supplement, and how they can boost performance, motivation, focus, mood, and cognition. This means enhanced productivity, higher-quality output on your creative work, and lasting, dialed-in work sessions where everything seems to go right.
Kaged Mindset
KAGED's nootropic supplement boasts seven science-backed ingredients to aid your focus, energy, and mental stamina.
Editors Note:The content onBarBendis meant to be informative in nature, but it should not be taken as medical advice. When starting a new training regimen and/or diet, it is always a good idea to consult with a trusted medical professional. We are not a medical resource. The opinions and articles on this site are not intended for use as diagnosis, prevention, and/or treatment of health problems. They are not substitutes for consulting a qualified medical professional.
Nootropics are a class of supplements broadly defined as any compound that can enhance cognitive performance and mental functioning. There are two types of nootropics: lab-created and naturally found, such as herbs.
Nootropics are also called smart drugs because they can boost memory, motivation, attention, focus, and creativity. Research has also found some nootropics can improve symptoms of depression, anxiety, and general mood. (1)(2) Nootropics show many promising benefits for people with impairments and healthy individuals looking for a brain boost.
Some of the most well-studied and evidence-backed nootropics found in Kaged Mindset include:
[Related: Kaged Pre-Kaged Elite Pre-Workout Review]
The incredible power of increased attention, focus, mood, and motivation that nootropics provide can be felt in all aspects of your life.
Finding the motivation to push through a grueling workout or even to get to the gym can be tough. And staying focused and motivated to plow through a challenging project for work can zap the willpower of even the most dedicated employee.
While no supplement is a miracle drug, scientific literature has shown that nootropics may provide a boost for those days (months, years) when keeping on task and performing your best requires a little push. Here are some of the top benefits of nootropics you should know.
Motivation can be elusive and hard to come by, especially with busy lives packed wall to wall with projects, deadlines, appointments, and commitments. Nootropics such as Alpha-Glycerylphosphorylcholine (Alpha GCP) and others can boost motivation and help you conquer your to-do list and training sessions.
A randomized, placebo-controlled human study published inNutrients found subjects who took nootropic supplements experienced increased motivation, especially at night often the most challenging time to get motivated for many people when the couch is calling. Interestingly, the subjects felt their motivation increased throughout the two weeks of supplementation. Those taking the placebo did not experience these effects.(3)
Another study published in theJournal of the International Society of Sports Medicinecompared nootropic supplements with traditional caffeine-packed pre-workout. The researchers found that nootropics can be just as effective at boosting motivation and other cognitive functions as caffeine, but without any jitteriness or other unwanted side effects. (11)
One of nootropics most touted benefits is an increased ability to focus. Distraction reigns in todays tech-based society with constant interruptions from notifications, emails, and Zoom calls. While no one can expect to be hyper-focused all hours of the day, a few hours of flow can help you smash through critical tasks during your work week. (12) In the gym, more focused attention on your working muscles and effort level can vastly improve your results. (13)
Nootropics may allow you to keep on task, despite mental fatigue. (1) Some compounds keep your brain topped up with the energy it needs to feel fresh and focused, improving your ability to stick to task. Other compounds assist in upregulating hormones like serotonin, dopamine, and noradrenaline that keep you sharp and productive. (14)
Nootropics are making waves as a memory enhancer both in the medical community and for the general population. Promising research shows neuroprotective effects from certain compounds that may even combat dementia and age-related cognitive decline. (15) Research shows improved memory recall, spatial memory, and working memory.
Some of these compounds work by preventing the breakdown of acetylcholine, which is crucial for learning and memory. They can also support brain cell mitochondria, which means your brain stays fueled with energy for a more optimal functioning memory. As if that werent enough, nootropics can boost brain antioxidants to protect brain cells from damage and increase cell longevity. (16)
Stress is a tricky beast. It can stem from physical, mental, and emotional roots, but your body responds to stress similarly regardless the cause. So, if youre stressed out at work and then try to hit PRs in the gym, you may be pouring too much stress on an already taxed system.
When this happens, stress hormones can increase, including catabolic ones that prevent muscle gain (or even decrease muscle tissue) and wreak havoc on your overall health. Everything from your sleep to your libido can be affected, piling on more stress, and kicking off a vicious cycle. Nutrition and supplementation can play a huge role in warding off stress, and nootropics are one way to shield yourself from the worst of it.
Research published inNutrientsreveals that nootropics can help you stay sharp and think clearly even during bouts of stress, which typically leave your brain feeling scrambled. (1) Other nootropic compounds can ward off stress hormones, helping your brain resist their damaging effects. (6)
[Related: What Top Lifters Want in a Pre-Workout Stack]
The researchers who published on stress hormones inNutrientsfound that certain nootropic compounds can also boost mood in people with depression. (14) They can also boost brain levels of serotonin, which has long been linked with better moods and less risk of depression. Study participants who consistently take some nootropics report better overall mood after a few weeks. (1)
Putting all this research together, its clear that nootropics can promote productivity. While its likely not healthy to be all systems go all the time, everyone can use a productivity boost now and again.
If you can focus, pay attention to detail, be motivated to complete tasks, and feel good doing it, theres no surprise that productivity might skyrocket from these effects. Moreover, safe and effective nootropic compounds are a much better way to go than some of the more risky methods used by college students and executives looking for an edge. (17)
Interestingly, the ways nootropics act on the brain can extend to other physical actions, including power output and muscular strength. TheJournal of the International Society of Sports Nutritionstates that Alpha-CPC boosts peak force production during exercise. When a supplement has the potential to boost exercise performance, its called ergogenic.
Using a randomized, placebo-controlled, crossover design, seven men with at least two years of resistance training experience took Alpha-GPC or a placebo 90 minutes before training. Results showed the men who took Alpha-GPC could produce 14% more explosive power during bench pressing than the placebo group. They also had a lower RER (respiratory exchange ratio), which means they werent struggling as hard to recover their breath after their sets. (18) Similar results have been found when testing vertical jump explosiveness. (19)
Researchers believe this effect may be due to an increase in human growth hormone (HGH) from Alpha-GPC. HGH is an anabolic hormone that helps build muscle and decrease fat tissue. This makes Alpha-GPC both a nootropic and ergogenic aid.
When choosing a nootropic supplement, not all options are created equal. Knowing what to look for is the key to getting your moneys worth and achieving the effects you are hoping for.
First and foremost, you want to ensure your chosen nootropic contains elite ingredients that have been well-studied and are positioned in the scientific literature as effective and safe. Some of the most extensively researched compounds include the ones mentioned above: Alpha-GPC, phosphatidylserine, huperzine A, and acetyl-l carnitine.
Kaged Mindset contains these ingredients, plus others that work to support brain function and general health. These additional supports include vitamin C for antioxidant and immune system benefits, B complex for energy, and Ioniplex, a fulvic acid mineral complex that contains trace minerals like calcium, zinc, chromium, copper, and iron.
In the world of supplementation, there is little regulation or overwatch. Companies that stand by their products and provide third-party testing should be the top contenders for space on your supplement shelf. Kaged Mindset uses third-party testing to ensure the ingredients are pure and potent.
While caffeine can be a nootropic and workout enhancer, there are several caveats. First, the energy you might get from caffeine essentially borrows from your energy levels later. Caffeine highs usually result in a crash-and-burn effect, which isnt helpful if you still have stuff to do after the effects wear off.
Secondly, caffeine can cause jittery, nervous, restless, or even anxious energy that isnt smooth or controlled like the kind you can get from other nootropics. Kaged Mindset skips the caffeine and offers a hefty dose of Alpha-GPC, shown in the literature to work just as well without the jitters. (20)
Thirdly, caffeine can cause some people to experience gastrointestinal issues (thats a delicate way of describing it) that can interfere with your workout or flow state. And no one wants to be interrupted by a lengthy bathroom visit during peak performance.
Caffeine can also interrupt the quantity and quality of sleep. It has a 6 to 8-hour half-life, with some people being affected more than others. Even if you can fall asleep immediately after a double espresso, it doesnt mean that sleep is restorative. This means youre likely better off taking caffeine in the early morning hours exclusively for best results, limiting the flexibility of it as a nootropic. (21)
Last, you build a tolerance to caffeine. While you might feel great taking caffeine today, if you take a lot of it daily, you wont get the heightened energy and focus you did the first time.
Mindset comes in a caffeine and caffeine-free version, so whether youre looking for a clean boost of caffeine or need a non-caffeinated version later in the day that wont impact your sleep, Kaged has you covered.
Kaged Mindset
KAGED's nootropic supplement boasts seven science-backed ingredients to aid your focus, energy, and mental stamina.
Nootropics are an excellent choice if you want to supercharge your focus, increase attention, boost motivation, and sharpen your memory. Kaged Mindset is packed with evidence-backed powerhouse ingredients that help your brain function optimally, all with a caffeine-free (optional), smooth ride of mental energy. Whats more, third-party testing for potency and purity ensures youre getting the best bang for your buck.
Take Kaged Mindset about 30 minutes before your work or gym session for the best results. When using it for workout enhancement, you might notice improved mind-muscle connection due to enhanced focus ability, increased motivation, and power output. Taking it before a workflow session could help you power through a project with improved attention to detail and clarity of thought.
See the rest here:
7 Benefits of Nootropic Supplements - BarBend
It may currently be grabbing the headlines because of excitement over its weight-loss drug, Wegovy, but Novo Nordisk is a company that has a record of innovation dating back a century.
Denmark's biggest company and the world's biggest maker of insulin celebrates its centenary this year, having been founded in 1923, just two years after the discovery of insulin itself by the Canadian scientists Frederick Banting, John Macleod and Charles Best.
The finding prompted August Krogh, a Danish professor who had just won the Nobel Prize in physiology or medicine, to travel to Canada at the urging of his wife Marie, a renowned scientist in her own right, who had just been diagnosed with diabetes.
At the time, diabetes was incurable, so being diagnosed with it represented a death sentence.
Macleod invited Krogh to visit him in Toronto and there gave him permission to continue experimenting with his team's findings back in Denmark.
Within months Krogh was treating patients suffering from diabetes in Copenhagen, having formed a business called Nordisk Insulinlaboratorium in partnership with another scientist, Hans Christian Hagedorn.
The latter ended up falling out with and firing two of his employees, Thorvald and Harald Pedersen, who subsequently set up their own business called Novo Terapeutisk Laboratorium.
The rival firms competed ferociously before they came together in 1989 to form Novo Nordisk.
One very interesting aspect of the two businesses is that they each set up their own charitable foundations.
Macleod, when allowing Krogh to continue his work in Scandinavia, did so on the condition that Krogh would not profit personally from the discovery and that profits made from it would be invested in new research that would support the fight against diabetes.
The Pedersen brothers, likewise, had set up their own charitable foundation in 1951.
So the merger that formed Novo Nordisk in 1989 also saw the creation of the Novo Nordisk Foundation which, with an endowment of more than $93bn, is the world's biggest charitable foundation.
That foundation remains the biggest single shareholder in Novo Nordisk.
To put its wealth into context, the foundation has billions more in the bank than the much better-known Bill and Melinda Gates Foundation.
Read more:The weight loss injections taking TikTok by storm
Scientific breakthroughs
Novo Nordisk's focus on insulin has led to a number of breakthroughs over the years.
Novo's experimentations with fermentation as a way of producing drugs led to the invention of a detergent enzyme made by the process and, eventually, the business became so large that it was eventually spun off as a separate company, Novozymes, in 2000.
Novo Nordisk and Novozymes are, respectively, the biggest and 11th biggest quoted companies in Denmark. The former, with a stock market valuation of DKK1.77trn (212bn), would be the biggest company in the FTSE-100 if it was listed in London.
Other scientific breakthroughs achieved down the years include products such as human growth hormone and oral contraceptives, as well as an ever-evolving array of delivery mechanisms for insulin, including Novopen, the world's first insulin pen device and GLP-1, a tablet which does away with the need for insulin injections.
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The creation of Wegovy
It was this relentless research into diabetes and Novo Nordisk's work on hormones that eventually led to the creation of Wegovy.
The product, semaglutide, was originally developed as a treatment for type 2 diabetes and had been developed alongside liraglutide, a related product that had been specifically developed to tackle weight loss, which is now marketed under the brand name Saxenda.
It was only over time that semaglutide became to be seen more as a treatment for obesity than type 2 diabetes.
Initially, the company was sceptical.
Lars Fruergaard Jorgensen, who became Novo Nordisk's chief executive at the beginning of 2017, said in one of his earliest presentations to investors that working on treatments to tackle obesity had been a "graveyard" for the pharmaceutical industry in the past.
At the time, a number of treatments had been discontinued by rivals, with healthcare insurers in the US - the biggest market for such treatments - reluctant to pay for them, and the weight loss benefits they delivered thought to be only negligible.
That was what marked semaglutide, which works by mimicking the effects of hormones which control the appetite, as significant. The weight loss it delivers was greater than for rival products.
The breakthrough also came at a crucial time for Novo Nordisk. Between August 2015 and November 2016 its share price had fallen by 47%, amid concerns the company was too dependent for its earnings on mature insulin treatments that were coming under pricing pressure, particularly in the crucial US market.
It was a bold decision by Mr Fruergaard Jorgensen to step up investment in obesity treatments.
He told investors at the end of 2017: "We are making a bet on obesity, and we believe we can ride it based on lifting efficacy. And that will create the market."
Pay offs for Novo Nordisk
That bet has paid off in spades.
The product, christened Wegovy for commercial use, was made available to US patients in June 2021 and, despite problems with supplies, has garnered a huge following.
Mr Fruergaard Jorgensen told investors last month that, during the first few weeks of the year, Wegovy prescription trends had accelerated to record levels.
He went on: "The uptake underlines the significant unmet need for patients with obesity. Many patients have been waiting for all doses of Wegovy to be available again, which has created a pent-up demand."
Those investors who stuck with the company between 2015 and 2016 - among them, the renowned British investor Terry Smith - have been rewarded for their patience.
From the low point of November 2016, shares of Novo Nordisk have more than quadrupled in value.
Not that Mr Fruergaard Jorgensen is stopping there.
Investment in future treatments
Mindful of past accusations that the company has been too dependent on diabetes, he has been investing in other therapy areas, including Alzheimer's disease, haemophilia - a natural extension of the company's work in injectable medicines - chronic kidney disease, non-alcoholic fatty liver disease, sickle cell disease and cardiovascular disease.
The company's work in these areas has not received as much attention as perhaps it deserves.
Mr Fruergaard Jorgensen has freely admitted that "these are high-risk areas [in which] we might not succeed" - but has noted that, if Novo Nordisk does, it will be "among very few companies, if any, to take those markets and help those patients".
That might sound like shooting for the moon.
But the hundreds of millions of patients who suffer from these conditions will be hoping that this giant Danish enterprise, backed staunchly by a foundation with very clear humanitarian objectives, can achieve similarly exciting breakthroughs in its second century.
Read more here:
Novo Nordisk: How weight loss jab bet paid off for Denmark's biggest firm as it plans to take on more diseases - Sky News
I eat too much and don't exercise enough. It's a common refrain, typically spoken while looking between your bare feet at the numbers on a scale, and it reinforces the ingrained belief that we could lose weight if only we burn off more calories than we consume.
That notion, however, ignores three causes of weight gain that have little to do with that second helping of spaghetti you had at Nana's on a lazy Sunday afternoon.
Scientists say the old, "eat less, move more" idea oversimplifies the solution to obesity, which is a complex problem. They point to the rising rates of obesity, which now affects 40 percent of the U.S. population as proof that this theory is outdated and misleading.
"Conceptualizing obesity as a disorder of energy balance restates a principle of physics without considering the biological mechanisms that promote weight gain," the authors of a perspective in a 2021 edition of The American Journal of Clinical Nutrition wrote. In other words, putting on weight is not about how much food you're eating but what you're eating, when you're eating it, and how it affects you metabolically as you get older.
Obesity is multifactorial, involving genetics, lifestyle, food choice and environment. Read on for three things you're doing that are likely causing the numbers on your scale to edge up.
READ THIS NEXT: Snacking on This Helps You Lose Weight and Sleep Better, New Study Says.
The standard American diet (or SAD, for short) is loaded with processed, rapidly digested carbohydrates that are as addictive as they are delicious. Think potato chips, cookies, doughnuts, frozen pizza, hot dogs, fast-food hamburgers, fried chicken, and ice cream. Soda and other sugar-sweetened beverages lead the list of quickly absorbed sugar bombs: An American Journal of Clinical Nutrition study found that women gained an average of 17 pounds over four years when they drank sugary beverages.ae0fcc31ae342fd3a1346ebb1f342fcb
"These foods stimulate the release of the stress hormone cortisol and appetite hormones such as insulin, dopamine, and ghrelin, all of which play a role in cravings," says registered dietitian and nutritionist Blanca Garcia, RDN, a nutrition specialist for Health Canal. She explains that eating highly processed carbohydrates prompts the body to secret insulin, which signals fat cells to store calories.
"Insulin inhibits the production of human growth hormone, which is responsible for optimal muscle mass, and triggers a rise in the stress hormone cortisol that increases visceral body fat," endocrinologist Florence Comite, MD, founder of the Comite Centers for Precision Medicine & Health, tells Best Life. "By fixing a patient's metabolism, they start to build muscle again and reduce the storage of fat. That's how we can stop diabetes in its tracks, stop heart disease, and reverse aging."
Numerous studies have shown that people who sleep less tend to consume more calories and high calorie processed carbohydrates. One of the most recent, published in 2022 in JAMA Internal Medicine, tracked 80 overweight people for four weeks. For the first two weeks, they followed their normal sleep routine, getting less than 6.5 hours of sleep per night. During the second two weeks, the group of 80 was split into two. One group continued to follow their normal sleep patterns, while the people in the test group were counseled on improving their sleep hygiene with the goal of increasing their sleep duration to 8.5 hours. The group that improved their sleep habits slept for more than an hour longer each night than the group that didn't receive counseling. Researchers found that the people who extended their sleep consumed an average of 270 fewer calories each day. They also lost roughly a pound during the final two weeks, while the control group gained weight.
"People focus on diet and exercise and don't realize how much more important sleep is to weight management," says Comite, who explains that what you may eat before bedtime can influences how well or poorly you sleep.
Comite suggests stopping eating at least two hours before your bedtime. If you must have something, she says, choose a light protein snack with a bit of carbohydrate. Avoid a high-carb snack, which will drive the release of insulin, and suppress growth hormone and melatonin, the hormone that regulates sleep cycles, says Comite. Over time, research suggests, a disrupted circadian rhythm can lead to the onset of metabolic disease.
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Getting older virtually guarantees weight gain, unless you've been blessed with genes that keep you lean. But even if you aren't genetically immune to weight gain, there's something you can do to buck the trend that comes with age: Build up your muscles.
"After about age 30, your levels of the hormone testosterone begin to drop and you begin to lose muscle, a process called sarcopenia," Comite explains. Muscle burns calories, even at rest, so if you have less muscle and don't reduce your calorie intake, you'll likely put on weight. The remedy for this age-related muscle loss/fat gain is regular strength training, she says. She also recommends eating more protein, the building block of muscle, and says we should shoot for 1.6 grams per kilograms of your body weight per day if you're working out with weights.
As with any medical advice you read online, it's best to check in with your healthcare provider to find out what's best for you. If you're sleeping eight hours a night, avoiding processed foods and sugary beverages, working out with weights, and the scale is stubbornly creeping up, make an appointment.
"Ask your doctor to prescribe a blood test to check your free testosterone, which is essential for muscle growth, as well as metabolic health markers like fasting glucose, insulin, and thyroid balance," Comite recommends.
See more here:
3 Things That Make Weight Gain Almost Inevitable (Besides ... - Best Life
If you're seeking to increase muscle mass, boost strength, and achieve greater results from your training This guide is designed perfect for you. We've looked at the top supplements to build muscle available on the market to find what products are the most efficient.
Click Here to Buy Muscle Growth Supplement price and offers
Each of the muscle building supplements below was evaluated using several factors like reviews, ingredients, price effectiveness, value, and. If you're trying to get slim and lean or to add the muscle mass you need to make your body look better the supplements for building muscle listed below are an excellent place to begin.
Best Supplements for Muscle Growth
Review of the Top Supplements for Muscle Building of 2023
#1. D-Bal MAX The best supplement for Lean Muscle Mass
D-Bal MAX is a renowned supplement for muscle growth that replicates those of Dianabol which is a banned anabolic steroids. This supplement could provide the same incredible gains that you would get from Dianabol but without the harmful negative side effects.
Benefits
D-Bal MAX has many benefits to your fitness routine. This supplement to your muscles is able to:
How It Works
D-Bal MAX provides these advantages by utilizing a meticulously formulated mixture with natural components. This supplement has only ingredients that are safe and safe for your body needs to aid in internal processes and improve your overall health and well-being.
One of the supplements' most potent natural components is magnesium. Magnesium is a cofactor of over 300 enzymes in your body, triggering many biochemical reactions. This mineral aids in the synthesis of protein muscles function, as well as energy production. All of which helps to increase the strength of your muscles.
The majority of people acquire magnesium from their diets the body eliminates this element via sweat and urine. A magnesium supplement will allow your body to have more accessibility to the cofactor and create the above-mentioned benefits.
Zinc is yet another important ingredient that is a key ingredient in the D-Bal MAX. The trace mineral is believed to play an important part in the creation of two main male sexual hormones, testosterone and the human growth hormone.
Testosterone plays a role in a variety of physical processes, including the growth of muscle. The majority of men experience decline in testosterone levels as they the advancing years. A zinc supplement will help you build more muscle mass because it lets you have access to the more essential hormone.
You might not be aware however, vitamin C plays a significant part in the development of muscle. Vitamin C can help protect your muscles against damage which allows you to reap the long-term benefits of intense training. Humans are among the few species that are unable to make the vitamin C they need on their own. This makes supplements essential for gaining these advantages.
D-Bal MAX includes two amino acids: Larginine and L-lysine. L-arginine acts as a precursor to the production of nitric oxide and is directly linked to increased muscle strength through exercise. Furthermore, L-lysine enhances the release of growth hormones and collagen production.
Additionally, you'll find the amount of 200 milligrams caffeine within the D-Bal MAX formula equivalent to 2 cups of coffee. The caffeine content will help you feel alert and energetic without producing anxiety or jitters. It also makes removing sweet coffee drinks out of your diet more straightforward.
Ingredients/Formula
In total, the D-Bal MAX formula is made up of the following natural components:
What's the Best Option?
Although D-Bal MAX could benefit those who want to increase muscular growth, this supplement is ideal for those who are looking for a natural substitute to Dianabol.
Click Here to find the lowest price and exclusive discounts on D-Bal Max
#2. The CrazyBulk Bulking stack Ideal for Bulking Cycles and Bodybuilding
Bodybuilders typically combine three to four steroids in order to achieve the best results. Although we do not recommend stacking steroids, it is possible to simulate the effects of a stack of steroids by using your time with the CrazyBulk Bulking Stack.
This set includes four CrazyBulk alternative steroids. The use of all four natural supplements regularly can boost development of muscle and provide a host of other benefits for fitness without the harmful effect of steroids.
Benefits
The CrazyBulk stack for bulking can bring many benefits:
How It Works
The Bulking Stack includes four supplements to increase muscle mass and strength:
The first thing to note is that Testo-Max will be a testosterone booster supplement that can boost the levels of testosterone naturally. The supplement taken in the morning can increase levels of testosterone levels, providing you with energy and strength throughout the day.
Testo-Max also improves your fitness performance which allows you to train more intensely in the gym and meet your fitness goals quicker. You could also notice an increase in muscle mass with the testosterone booster.
Then, Trenorol has ingredients which help your muscles conserve more nitrogen. Nitrogen is a key component of protein, and is an essential ingredient to increase muscle mass. If you're able to access more nitrogen, you'll see more muscle growth and faster fat burning.
Trenorol also boosts the production of red blood cells which allows your muscles access to greater oxygen during workouts that are intense. You could experience greater power and energy while exercising and allowing you to finish longer and more challenging exercises.
DecaDuro will boost the production of nitrogen, giving your body more energy for increasing muscle mass and maintaining your muscle growth. The supplement can also increase collagen production.
Collagen can boost the production of certain protein that are involved in the production of muscle. It can also help strengthen ligaments and tendons, strengthening muscles and aiding the recovery from exercise.
Additionally, D-Bal can speed up gains in muscle, improve strength, ease muscle soreness, and reduce the body fat. This supplement is a revolutionary formula that's seven times more powerful than the predecessor, providing the most the benefits.
Crazy Bulk recommends taking these supplements in the order listed below every day:
Ingredients/Formula
Every one of the 4 steroid options within the CrazyBulk Bulking Stack contains a unique mixture with natural components. It is possible to view the complete Bulking Stack ingredients information on CrazyBulk website.
What is the best option?
Overall, we strongly would recommend CrazyBulk Bulking Stack for bodybuilders who are committed to growing their muscles and bulking up.
Click Here to find the Lowest Cost and Exclusive Discounts on CrazyBulk Bulk Stack
#3. Testo-Max is a great supplement for energy and getting ripped
Testo Max is a testosterone-building supplement that comes from Crazy Bulk that can support maximal levels of natural testosterone levels. This supplement utilizes a clinically tested formula made composed of natural ingredients that have no side effects known to be associated with it.
Benefits
The use of Testo-Max has several advantages:
How It Works
Testo-Max is a naturally-derived complex which contains key male-specific nutrients that help support testosterone in various ways. Although the supplement is made up of 11 ingredients, its three main ingredients make up most of the advantages.
D-aspartic acid is among the most potent muscle-building supplements' natural ingredients. It's a naturally occurring amino acid regulator which can increase the production of the hormone luteinizing (LH).
Luteinizing hormone plays a crucial part in many reproductive and sexual processes in the body. In women, it aids in the ovulation process. In men, it helps with the generation of testosterone.
LH will tell your testes that they need to make more Leydig cells, which are the main source of testosterone in males. The higher the levels of LH your body is able to access to the quicker you'll be able to create testosterone. T levels are a major factor in weight loss and muscle help.
Korean Red Ginseng, also known as red ginger is yet another important component of the Testo-Max formula. This plant extract is a healing herb that has been used by people for centuries to boost general health.
Korean red ginseng in particular has the following advantages:
The plant extract could enhance the serum testosterone levels. But, its primary function is to Testo-Max is to provide several of the benefits as an increase in testosterone production.
Testo-Max also has Fenugreek extract as the main ingredient. Fenugreek is a type of clover that has a scent and a taste like maple syrup. It has many advantages including the increase in testosterone production and lowering blood sugar levels, as well as aiding in the control of appetite.
Fenugreek could also enhance your sexual libido, which can help combat this negative adverse effect of low testosterone in males. A supplement containing the extract of fenugreek can provide numerous advantages that improve overall health and well-being.
Ingredients/Formula
The entire ingredient list for Testo-Max contains the following ingredients:
It is recommended to consume 4 capsules each day of Testo-Max each day in order to get the entire dosage of of these supplements for muscle.
What is the best option?
We suggest Testo-Max for those who want more of a comprehensive approach to building muscle by increasing testosterone.
Click Here to find the lowest price and exclusive Coupons for Testo-Max
#4. The Crazy Nutrition Mass Gainer Shake with the highest mass-gainer effect to bulk up
Mass Gainer is an energy powder made by Crazy Nutrition, a partner company of Crazy Bulk. This powder comes in chocolate and vanilla flavors and contains a 2:1 carbohydrate-to-protein ratio along with several vitamins and nutrients that boost muscle growth.
Benefits
The act of taking a the Mass Gainer has numerous advantages:
How It Works
If you're trying to build muscle getting enough carbs, protein and nutrients is crucial. Your body requires these ingredients to build muscles and boost your energy levels to perform hard exercises. But, you might become bored of the same meals and seeing no noticeable improvement.
Its Mass Gainer supplement provides an ideal alternative to the usual meals you take in to gain weight. It is a cutting-edge product that has patented scientifically-proven ingredients that boost your digestion and absorption which allows you to reap maximum benefit from the ingredients and not feel uncomfortable or bloated.
The primary ingredient in the powder is the gluten-free oat flour. This ingredient is rich in of complex carbohydrates, which can increase muscle strength, boost digestion, boost healthy blood sugar levels and make you feel fuller.
The supplement also includes certain ingredients that help to boost muscle growth. For instance sweet potato flour contains minerals and vitamins that boost your muscles and help promote an increase in muscle mass. Additionally, creatine monohydrate aids in your body's natural process of producing phosphocreatine within the muscles, which could increase strength, recovery and endurance.
The next step is that Mass Gainer includes CARB10, one of the most sought-after ingredients made from the premium pea starch. Studies have shown that CARB10 can aid digestion and help in the absorbance from the complicated carbohydrates contained in this mass Gainer formula.
Mass Gainer also contains a mix of whey protein that contains Whey protein concentrate as well as Whey Protein isolate. The blend gives you an extensive amino acid profile, which offers greater benefits than typical milk proteins found in powdered protein.
Ingredients/Formula
Mass Gainer contains only whole-food ingredient sources. Interestingly, the formula doesn't contain maltodextrin or other fillers normally used within protein powder.
The supplement is made up of some of the ingredients listed below:
Best for?
Overall Mass Gainer is the best for women and men seeking an amino-acid supplement that takes an scientific approach to building up, and also tastes great.
Click Here to find the lowest price and exclusive Coupons on Crazy Nutrition's Mass Gainer
#5. HGH-X2 is a recommended HGH Booster to help Muscle Development as well as Increased Protein Synthesis
HGH-X2 is an ingredient for building muscle made by Crazy Bulk that mimics the effects of the HGH analog Somatropin. This supplement causes your pituitary glands to release more of the human growth hormone into the bloodstream, which results in numerous advantages.
Benefits
Intaking HGH-X2 may bring many benefits, including:
How It Works
The supplement that helps build muscle contains essential amino acids that aid in HGH production. Therefore taking HGH-X2 could speed up your body's capacity to make the human growth hormone.
Human growth hormone aids in the creation and maintain healthy tissues in your brain as well as other organs. It also regulates muscle and fat production. The pituitary gland is situated at the base of your brain releases HGH.
Although your pituitary gland makes plenty of HGH when you are a kid but this production decreases as you the passage of time. This is why many individuals looking to increase muscle mass take supplements that focus on the production of human growth hormone.
One of the supplement's primary ingredient is an amino acid called L-arginine. L-arginine is one essential amino acids which help to increase HGH production.
The amino acid could provide other benefits for your wellbeing and health like decreasing blood pressure, increasing performance in sports, and assisting the synthesis of muscle protein.
Then, maca root is a well-known supplement that can aid in many processes, including fertility, libido and hormone production. This extract from the root may boost the physique's HGH production. It also has significant amounts of iron as well as iodine which will help maintain your metabolism in a healthy way.
Hawthorn extract from berries is an additional vital ingredient in HGH-X2. This plant extract helps help keep your heart healthy by reducing blood pressure as well as high levels of blood cholesterol. Also, it has flavonoids which are chemical compounds that create antioxidant effects.
Regarding the growth of muscles the extract of hawthornberry will increase the flow with oxygen as well as other nutrients muscles which allows you to build muscles faster and have greater energy and strength during your exercise routine. It can also accelerate the body's elimination of lactic acid, which helps to lessen the fatigue of your muscles.
If you're looking to boost the muscle-building properties of this supplement You could stack this supplement along by combining it with Winsol, Clenutrol, and Tenorol as well, all of which are muscle-building supplements made by Crazy Bulk.
Ingredients/Formula
HGH-X2 has the following principal ingredients:
This product is free of sugar yeast, salt gluten, wheat, shellfish artificial flavorings, sweeteners or other colors.
What is the best option?
HGH-X2 is the best choice for bodybuilders who want to make an increase in human growth hormone to aid in rapid growth of muscle.
Click Here to find the lowest price and exclusive discounts on the HGH-X2
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Steel Supplements - Overview, Reviews, Alternatives - Deccan Herald
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Adult height and health-related quality of life in patients born small ... - Nature.com
According to theGuinness Book of World Records, Robert Wadlow of Alton, Illinois, is the tallest man who has ever lived. He was 8 foot 11 inches and weighed in at 439 lbs. But he had a sad life, plagued with injury due to his towering height and the weight thatput pressure on his joints and feet.
Wadlow died in 1940 at just 22 years old due to a blister on his ankle that became infected and triggered septic shock in his body.
"He is a pre-acromegalic giant of phenomenal size, molded on a vast scale, colossal and stupendous in bulk, truly Gargantuan in all his proportions, and symmetrically built," Charles Humberd, a doctor who studied Wadlow, wrote in a 1937JAMA article.
(Credit: Public domain, via Wikimedia Commons)
While it might seem surprising that a tiny blister could cause the death of such a huge man, being a giant is hard on the human body. The sheer size of his feet the largest in the world at a whopping size 37 meant he was constantly battling foot injuries that were a common threat to his life.
Read More: Biologist Offers Insight on the Human Foot
At age 17, he was hospitalized due to a foot infection. According to Humberd, he had no sensations in his feet and, as a result, was prone to severe infections. What's more, finding shoes that large wasn't just difficult, it was pricey, reportedly costing upwards of $2,000 a pair in today's money. Wadlow toured with the International Shoe Company to offset the cost of each pair which meant he was on his feet too often. And at nearly three feet taller than the average male, this wasn't sustainable.
In 1940, he complained of a fever after riding in a parade for the Manistee National Forest Festival in Michigan. After refusing to go to the hospital, Wadlow went to sleep and did not wake up. His eventual cause of death was an ankle blister due to chaffing from his leg brace, which went untreated. He was buried in a 10-foot 9-inch steel coffin that took 16 pallbearers to carry out of the funeral.
Read More: This Hominoid Is The Closest Thing We Have To Giants Existing
Wadlow had a rare condition called pituitary gigantism, which happens when a child or adolescent has too much human growth hormone (HGH), and, as a result, gets very tall. It's caused by a tumor on the pituitary gland.HGHkeeps telling the body to grow until growth plates calledepiphysesin the body fuse into place, and there's no more room for movement. If the growth plates have fused and the body continues to grow, it can also cause the organs to become enlarged.
Other than extreme height, people with gigantism often have other symptoms, including large hands and feet, gaps in their teeth, enlarged internal organs, excessive sweating, delayed puberty and sleeping problems. And sadly, like Wadlow, those with gigantism don't tend to live long lives because the disease comes with so many complications, including high blood pressure, high cholesterol, heart problems, arthritis, type 2 diabetes, increased risk of cancer, spinal issues and vision loss.
Read More: Rare Form of Dwarfism May Protect Against Diabetes & Cancer
Some research has shown that, on the whole, even being slightly taller can be hard on your health. A June 2022 study published inPLOS Geneticsfound that greater height is linked to a variety of cancers as well as heart problems.
The study followed over 289,000 participants and found that being taller puts you at a greater risk of cardiovascular conditions, varicose veins, conditions of the skin and bones, neuropathy, breast and colorectal cancer and type 2 diabetes.
Another study, published in the May 2002 issue of theWestern Journal of Medicine, found that "compared with northern Europeans, shorter southern Europeans had substantially lower all-cause mortality rates."
Science seems to show that bigger and taller isn't always better. While we may want our kids to grow big and tall, and we may have wished to be taller ourselves, it's not the best thing for our longevity.
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Who Was the Tallest Person to Ever Live? - DISCOVER Magazine
Braves Franchise History
2010 - The Braves reached an agreement with 18-year old Dominican shortstop Edward Salcedo to a reported $1.6 million deal. Salcedo will spend six seasons in the minors and will never reach the major leagues.
2012 - Mike Minor tells the Braves that he wants to be traded if he is not in the teams starting rotation.
1934 - Casey Stengel signs a two-year deal to manage the Dodgers replacing Max Carey.
1960 - Demolition of Ebbets Field begins.
1974 - The California Angels trade Vada Pinson to the Royals in exchange for minor leagueer Barry Raziano. Pinson retired at the end of the 1975 season.
1976 - Major League Baseball owners announce that Spring Training will not open until a new labor contract is agreed to.
1986 - Wade Boggs loses his arbitration case but is still awarded a $1.35 million contract which is the largest ever through arbitration.
1988 - A committee votes to allow the Cubs to install lights and Wrigley Field and play up to 18 night games a year.
1995 - Former NL MVP Kevin Mitchell signs with the Daiel Hawks of the Japanese Pacific League.
2010 - Major League Baseball announces that it will begin testing minor leaguers for human growth hormone.
2015 - The Red Sox agree to a deal with Cuban defector Yoan Moncada to a contract that includes a $31.5 million signing bonus.
Information for this article was found via Baseball Reference, NationalPastime.com and Today in Baseball History.
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This Day in Braves History: Atlanta reaches an agreement with Edward Salcedo - Battery Power
Modified Feb 22, 2023 15:02 GMT
World Series champion Lenny Dykstra was a legendary player on the field but unfortunately Dykstra's personal life was marred by many things, including his arrest due to drug possession charges.
The three-time All-Star once admitted to taking performance-enhancing drugs along with his breakfast and revealed that he did so in order to gain an unfair advantage.
In 2016, Maxim quoted Dykstra replying to a question specifically about HGH (Human Growth Hormone):
Dykstra won the World Series with the New York Mets in 1986 and was a three-time All-Star. Since his retirement, he has been troubled by legal and financial problems.
Dykstra said that when he filed for bankruptcy many years ago, he owed more than $31 million and had only $50,000 in assets. Dykstra allegedly concealed, sold, or destroyed property worth at least $200,000 after filing without the approval of a bankruptcy trustee, according to the prosecution.
For hiding baseball gloves and other artifacts from his playing days that were supposed to be included in his bankruptcy case, Dykstra was given a six-and-a-half-month prison sentence in 2012. Prior to this, he was imprisoned for seven months while he awaited sentencing.
Dykstra allegedly paid private investigators $500,000 to obtain dirt on umpires throughout his playing career, which he subsequently exploited to his advantage.
He claimed in an interview published in 2015 that his attempts at extortion were obvious from the fact that he led the National League in walks, hits, and runs in 1993. Lenny Dykstra also finished second to Barry Bonds in the MVP contest.
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MLB legend Lenny Dykstra once revealed he used to add steroids to his cereal in order to gain an unfair advantage - Sportskeeda
