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Are you looking to lead an active lifestyle? Whether you want to get stronger, increase muscle function, or just stay in shape, strength, and muscle function are key components of any successful fitness regimen. Strength and muscle function play a major role in our ability to move freely and efficiently throughout daily activities. Not only that, but they also have the potential to prevent injury and improve overall health. In this article, well discuss why strength and muscle function matter for your active lifestyle. Well look at how they help us maintain balance and stability while moving through everyday tasks as well as the benefits of incorporating them into your exercise routine. Well also explore some tips on how best to strengthen muscles safely so that you can reach your goals with minimal risk of injury. So lets dive right in!
One of the most important benefits of strength and muscle function is its ability to improve your balance and stability. This is especially important if youre looking to do activities like running, lifting weights, or even just walking. Strong muscles are necessary for supporting the body in proper form while performing movements. When our bodies are properly supported with strong muscles, it gives us much more control over our movements which decreases our risk of injury. Furthermore, strong muscles can help reduce fatigue during physical activity since they require less energy from the body to move through tasks.
In addition to improving balance and stability, strengthening your muscles can also lead to better overall health. Strong muscles help support our bones, tendons, and ligaments which can reduce the risk of injury or disability. Furthermore, stronger muscles make everyday activities like carrying groceries or climbing stairs much easier on the body since they require less energy output. There is also evidence that strengthening your muscles may improve heart health by increasing circulation and reducing blood pressure levels. For example, a recent study found that lifting weights on a regular basis can help reduce the risk of heart disease. Also, stronger muscles can help improve your posture which is important for avoiding pain and discomfort in the body.
If youre looking to start strengthening your muscles, its important to do so in a safe and effective manner. Here are some tips to help you get started:
Start with low-intensity exercises like walking or light weightlifting using lighter weights. Avoid high-intensity activities until your muscles have had time to adjust to the new routine.
Warm up before any activity by stretching and performing dynamic warmup movements such as squats and lunges. This helps prepare the body for physical activity and prevents injury.
Incorporate rest days into your routine. This allows the muscles to recover and repair between workouts.
Make sure you are eating a balanced diet that is rich in protein, healthy fats, and complex carbohydrates. These nutrients will help fuel muscle growth and repair.
Last but not least, stay hydrated! Staying properly hydrated ensures that the body has enough fluid for optimal performance during physical activity.
The body produces hormones such as testosterone and growth hormone that help to regulate muscle development. Testosterone is primarily responsible for developing strength while growth hormone promotes the synthesis of proteins that are needed for muscle growth and repair. As we age, our bodies naturally produce less of these hormones, making it more difficult to gain or maintain muscle mass. Incorporating activities like weightlifting into your exercise regimen can help stimulate the production of these hormones and promote healthy muscle growth. Additionally, getting adequate sleep is essential for optimizing hormonal production which in turn helps to support healthy muscles.
You can even undergo growth hormone therapy and testosterone replacement therapy if you feel that your levels of these hormones are low. For example, if you are taking Sermorelin then you should make sure you are taking the right Sermorelin dosage to maximize its benefits. Also, your doctor will be able to provide you with other advice on how to optimize the production of these hormones in the body.
Your body needs certain nutrients to build and maintain muscle mass, one of the most important being protein. During exercise, our muscles break down proteins into amino acids which are then used as fuel for your workout. Eating foods that are high in protein can help increase the amount of available fuel your muscles have during physical activity and promote muscle growth afterward. Good sources of protein include meats, fish, eggs, nuts, seeds, legumes, and dairy products. Additionally, supplementing with whey protein can also be a great way to get an extra boost of this nutrient after workouts.
Having more muscle mass can also help boost your metabolism. Your basal metabolic rate (BMR) is the number of calories you need to maintain basic bodily functions like breathing and digestion. Having a higher BMR means that you burn more calories at rest, which can be beneficial for weight loss goals. Additionally, engaging in physical activity regularly helps to keep your muscles active and promotes healthy weight management. This means that the more the muscle mass you have, the higher your metabolic rate will be, making it easier to maintain a healthy weight.
Building and maintaining muscle mass requires a combination of proper nutrition, rest, exercise, and hormone regulation. Eating enough protein is essential for fueling your muscles during physical activity and promoting growth afterward. Additionally, having more muscle mass can help boost your metabolism which makes it easier to maintain a healthy weight. Finally, engaging in activities like weightlifting or undergoing therapies such as testosterone replacement therapy may also be beneficial for optimizing the production of hormones that are responsible for building muscle strength. Ultimately, with the right strategies in place, you should be able to achieve your goals when it comes to gaining lean muscle mass!
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Why Strength and Muscle Function Matter for Your Active Lifestyle - Alvinology
Miami Beach, FL, USA - Miami Beach-based company, Peptide Pros, has recently announced a significant increase in customer interest for their Sermorelin Peptides in the first quarter of 2023. The company is excited about this trend and anticipates the demand to continue to increase.
According to Peptide Pros, the increase in interest in their Sermorelin. Sermorelin is also popular because of its versatility. It can be used in a variety of different clinical trials.
A spokesperson from Peptide Pros stated, "We are thrilled to see such an increase in customer interest in our Sermorelin. This demonstrates the growing awareness of the scientific benefits of HGH and the importance of choosing a reliable source for these types of products. At Peptide Pros, we are committed to providing our customers with the highest quality USA peptides, and we are excited to see more people taking advantage of the sales our products offer."
Peptide Pros is renowned for its outstanding customer service, offering comprehensive support to its customers. The company guarantees delivery in the United States and offers free shipping for domestic orders over $175.00.
The company has earned the trust of its customers with competitive pricing, a great selection of products, and reliable customer support. The company provides a user-friendly eCommerce site using which customers can place orders and track their orders' progress until delivery. Peptide Pros also offers a comprehensive rewards program, discounts, and specials, adding to the convenience of managing their accounts directly from the website.
The increase in customer interest for Peptide Pros' Sermorelin Peptides is a testament to the company's commitment to providing high-quality peptides at affordable prices. With excellent customer service, reliable shipping, and numerous benefits of their products, it is no wonder that Peptide Pros has become the number one supplier of Sermorelin and other USA peptides.
About Peptide Pros
Peptide Pros is a reputable peptide supply company that is headquartered in Miami Beach, Florida. The company has established itself as a leader in the peptide supply industry by providing USA peptides of the highest quality at the lowest possible cost. Peptide Pros offers a wide range of peptides, including Melanotan 2, PT-141, GHRP-6, CJC-1295 and Semaglutide, all of which have at least 99 percent or higher peptide purity. Peptide Pros works closely with its manufacturing partners to ensure the strictest quality control of all the peptides it stocks.
For more information about Peptide Pros or to contact the company, please visit: https://www.peptidepros.net/
Peptide Pros
Media Relations Team
1-888-995-1591
Miami Beach
FL
United States
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Peptide Pros announces increased interest in their Sermorelin Peptides at the beginning of 2023 - EIN News
It was early 2022 when friends here in LA first started sharing their peptide therapy experiences with me. One was on a regimen for fertility in preparation for banking her eggs, another for muscle gains, and yet another for weight loss. The Ozempic controversy had yet to swirl into mainstream consciousness, and I was amazed to hear about their results.
Initially, I spoke with Functional Medicine Nurse Practitioner, Toni Tizon-Damiano of Roots Wellness who offers sermorelin, CJC1295, and semaglutide peptide injections in her practice. Through Toni, I began to learn about the growing promise of peptide therapies to target a wide range of needs from anti-aging to deepened sleep and improved brain health.
As I widened my research, I found that certain top biohackers had been quietly naming peptide injections as an exciting area of progress for years. Insulin, for example, is a peptide and has been around for over 100 years. As is nearly always the case, its taken time and possibly a bit of media controversy for many of the lesser known peptide treatments to become more accessible and better understood.
As the semaglutide (Ozempic) craze has grown, it has triggered valid concerns of a return to diet culture. That craze brought my research to a halt and I hesitated to cover the topic at all. Were on a positive trajectory of body positivity in this decade in a way I hope to see continue.
After polling our readers on Instagram, you let us know that the interest was there, and I decided to publish these insights from three pros, all of whom offer a wide variety of peptide therapies in their practices. Peptide therapies are so promising across an important cross-section of health concerns beyond just weight loss. Across the board, in my look at peptide therapy offerings, Ive found a wide-variety of therapies with claims related to all of the below:
+ Better sleep quality+ Improved immunity+ Improved bone density+ Reduction in body fat+ Increased metabolism+ Increased lean muscle mass+ Accelerated wound healing+ Thicker hair+ Tightening of the skin+ Better athletic recovery+ An overall increase in energy+ Balance with other hormones+ Improved libido and sexual performance+ Improved cognition+ Improved joint pain+ Improved mood
Peptides are not new: A lot of research on peptides has been going on for decades, mostly in Europe, and not the US, acccording to Dr. Jacey Folkers of Joi Womens Wellness, I would assume this is because we have been going through a strong pharmaceutical boom during this time. However, I believe peptides should be a large focus for medicine in the United States moving forward. Unfortunately, Im not confident this will be the case. Hopefully, education and awareness of the benefits of peptides continues to spread so that more and more individuals can experience what they can do for their health and the health of their loved ones.
Were sharing a few of the most notable peptide therapies you should know about below, but first
An important note on Ozempic + Weight Loss:Semaglutide and some other peptides target obesity, appetite control and chronic blood sugar imbalances specifically. While supporting weight loss in obese individuals is key for many preventative health measures, please think twice about any treatment that reduces appetite if medical obesity is not a health issue for you.
Many of us, myself included, actually need more nutrition in our daily diets for optimal health not less. Before approaching any peptide therapy that could effect your appetite, consider working with a nutritionist first to do some personal testing. I recommend long-time TCM contributors Brigid Titgemeier, MS, RDN, LD, IFNCP, holistic nutritionist Kelly LeVeque, and Jennie Miremadi, alicensed integrative clinical nutritionist who also specializes in healing from disordered eating.
Lets start with a few peptides therapies Ive been fascinated to learn more about
SS-31 | According to Dr. Heather Smith-Fernandez of Peptology, SS-31 is a peptide that helps to dysregulate the production of mitochondrial free radical production (mitochondrial-derived ROS) and is therefore being looked as a global anti-aging molecule.
BPC-157 has been experimentally demonstrated to accelerate the healing of many different wounds, including tendon-to-bone healing and superior healing of damaged ligaments. This peptide has been known to exhibit analgesic (pain relieving) characteristics. Those who suffer from discomfort due to muscle sprains, tears and damage may benefit from treatment with this peptide. You can download Peptologys free guide to peptide treatment therapies here.
Cerebrolysin | Also called FPE-1070. The neuroprotective properties of the nootropic peptide Cerebrolysin help to protect neurons from lactic acidosis and prevent the formation of free radicals. Cerebrolysin has been studied in memory loss, concentration decline, Parkinsons Disease, Alzheimers Disease, MS, TBI, and stroke.
CJC1295 | According to Functional Medicine Nurse Practitioner, Toni Tizon-Damiano this growth hormone peptide is one of the most popular peptides used at her practice.With growth hormone peptides, it is important to understand that were not injecting growth hormone itself. These peptides simply enhance the signaling to our pituitary to secrete more of our own supply of growth hormone.
The popular use of growth hormone peptides started after studies found that patients were injecting growth hormone and having negative outcomes. The use of peptides provided some of the benefits of enhancing our own natural supply of growth hormone without the negative side effects
Low growth hormone can cause an individual to feel fatigue, brain fog, depressed, mood changes, low libido, weaker muscle function or a decrease in the ability to gain muscle, an increase in fat and so much more.
Growth hormone is responsible for childhood development, but is also important in adulthood. Growth hormone is responsible for many functions in our body that we lose as we age. After age 30, there is a steady decline of growth hormone produced by our body. This decline is often due to aging but also to toxin exposure, oxidative stress, disease, lack of sleep, obesity, inflammation and of course, chronic stress.
DSIP or Delta sleep-inducing peptide | According to Dr. Jacey Folkers of Joi Womens Wellness, DSIP is a naturally occurring substance originally isolated from rabbit brains in 1977. DSIP has been described as a sleep-promoting substance rather than a sedative. Clinical uses for DSIP exist and the peptide has been used for the treatment of alcohol and opioid withdrawal with some success.
Semaglutide (Ozempic, Wegovy) | Semaglutide is a GLP-1 peptide (glucagon like peptide receptor agonist), says Nurse Practitioner, Toni Tizon-Damiano. Semaglutide has been prescribed for those with type 2 diabetes to help lower hemoglobin A1C (3 months blood sugar). These patients found that they were not only lowering their A1C, but also losing weight. Semaglutide helps to increase insulin secretion to decrease blood sugar in turn, decreasing appetite. Many of my clients are experiencing faster weight loss, lower cholesterol, lower hemoglobin A1C and potentially lowering their risk for cardiovascular related deaths.
Semaglutide was first developed in 2012 with 1 mg injection (Ozempic) first approved as a treatment for type 2 diabetes in 2017. The FDA approved semaglutide in 2021 for chronic weight management in adults with obesity or overweight with at least one weight-related condition (such as high blood pressure, type 2 diabetes, or high cholesterol).
Selank | This peptide has pronounced anxiolytic activity and acts as a stable neuropsychotropic, antidepressant, and anti-stress drug that relieves aggression and fear reaction in different animal species. Selank also has a nootropic action, which promotes the formation of memory and learning processes, and tremendous immunomodulatory activity.
Sermorelin is a peptide analogue of growth hormone-releasing hormone. It was first developed within the United States during the early 1980s. By 1997, the FDA approved its use and sale via prescription.
Yes, peptides have been around and researched much longer than most people realize. Sermorelin acts in a very specific way and is valued for its therapeutic possibilities. It does not affect the levels or actions of glucose, insulin, prolactin, cortisol, thyroid hormones and a host of other compounds within the body. Instead, sermorelin stimulates the body to increase its production of human growth hormone which improves the efficiency of the bodys metabolism. Because Sermorelin increases the bodys metabolism and improves energy levels, it has also been shown to have a beneficial effect on weight loss in people who want a more natural approach.
We also asked Dr. Jacey Folkers to weigh in further on the controversies surrounding semaglutide, from reduced access to diabetes meds, the narrative around weight loss culture even Ozempic face. He shared this with us:The latest data shows that over 73% of US adults are overweight or obese with obesity as the leading risk factor for type 2 diabetes. Whats more, cardiovascular disease remains the leading cause of death in America.
Both obesity and diabetes mellitus are important independent risk factors for the development of cardiovascular disease. We tend to categorize people based on official diagnoses, but just because a person struggling with weight or obesity has not been diagnosed as a diabetic does not necessarily mean they do not have the same health risk factors as a person who has. Medication that can help prevent and even reverse the chronic metabolic conditions that lead to diseases linked to diabetes and obesity should not necessarily be limited to one specific diagnosis.
Semaglutide can dramatically change the trajectory of a persons health by helping improve the metabolic and blood sugar imbalances many Americans have. For the most part, type 2 diabetes and obesity are conditions with significant lifestyle contributing factors. Semaglutide can help people make changes in their lifestyle that will benefit their health. It can help excess weight come off and blood sugar levels to improve, which can lead to overall better health.
When it comes to the discussion around Ozempic face, this side effect should not be blamed on the medication itself. When dosed appropriately, semaglutide can help facilitate a steady and gradual weight loss experience for many patients. With all medications, the dose is extremely important, as everyone responds to medications a bit differently. If a patient is being monitored well and dosed appropriately, their weight loss can be managed at a more gradual rate and prevent extremely fast drops in body mass, which can lead to Ozempic face.
Overall, peptides have far less side effects compared to pharmaceutical medications. Peptides have a pleiotropic effect (more than one effect) on the body and functions in the body in a more natural way. Medications often are meant to have a single direct effect and change or inhibit a naturally occurring pathway in the body. For example a COX2 inhibitor has a single targeted inhibition, and because of that, we get a whole bunch of side effects. The medication is forcing a response to occur in the body, whereas a peptide will moreso guide the bodys own built-in healing process to function better.
Tizon-Damiano notes that growth hormone peptides specifically are not safe for anyone that has a known cancer and have not been well studied in those with thyroid disorders. I require lab testing, vital signs, weight and BMI. Monitoring Insulin like growth factor (IGF-1) and other basic labs are crucial. IGF-1 is a biomarker that is the most important at mirroring what our growth hormone is doing. It has been studied in aging and the key is not to be too high or too low but to be balanced.
I urge people to commit to their peptide regimen for the full 6 months and then cycle off at least 30 days between to make sure that the body will continue to produce its own natural supply of growth hormone and wont develop resistance to it.
Tizon-Damianos patients most often see results in 3-6 months after daily injections that must be kept in the refrigerator. Side effects from peptide injections can include nausea and/or dizziness that commonly diminish once the body adjusts to the peptide.
The needles involved in peptide injections are very small, nonetheless most of them require injecting 5 out of 7 nights per week on an empty stomach.
Peptide injections usually range from $150-$300 per month depending on the peptide.
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6 Peptide Therapies According to Pros - What You Should Know - The Chalkboard Mag
Generic name: sermorelin acetate [ser-moe-REL-in-AH-seh-tate]Brand name: Geref
Diagnosing and treating growth hormone deficiency in children. It may also be used for other conditions as determined by your doctor.
Sermorelin acetate is a growth hormone-releasing agonist. It works by stimulating the pituitary gland to release growth hormone.
Contact your doctor or health care provider right away if any of these apply to you.
Some medical conditions may interact with sermorelin acetate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
Some MEDICINES MAY INTERACT with sermorelin acetate. Tell your health care provider if you are taking any other medicines, especially any of the following:
This may not be a complete list of all interactions that may occur. Ask your health care provider if sermorelin acetate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Use sermorelin acetate as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about how to use sermorelin acetate.
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Facial flushing; headache; nausea; pain, redness, or swelling at injection site; paleness; strange taste in mouth; vomiting.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch .
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include changes in heart rate and blood pressure.
Store sermorelin acetate in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Store away from heat, moisture, and light. Do not store in the bathroom. Keep sermorelin acetate out of the reach of children and away from pets.
This information is a summary only. It does not contain all information about sermorelin acetate. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
Issue Date: June 3, 2015
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medical Disclaimer
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Sermorelin acetate: Indications, Side Effects, Warnings - Drugs.com
Effective treatment of adult-onset growth hormone insufficiency: Sermorelin is an effective and attractive treatment of adult-onset GH insufficiency. Unlike rhGH, sermorelin does not stimulate IGF-1 production in the liver and instead stimulates the pituitary gland to produce and secrete endogenous hGH, giving it a number of clinical advantages over exogenous hGH.
Notably, according to a 2006 article by Richard Walker, overdoses of endogenous hGH are difficult if not impossible to achieve as the effects of sermorelin are regulated by negative feedback involving the inhibitory neurohormone, somatostatin.
Sermorelin is not associated with the pro-cancer and pro-diabetes side effects linked to long-term hGH therapy, and is thus heavily researched to treat adult-onset GH insufficiency along with being used in longevity medicine for preserving youthful anatomy and physiology [5].
Positive effects on body composition: Sermorelin has been identified as one of several growth hormone secretagogues (GHS) that can help manage body composition in hypogonadal males. In a 2020 paper, Deepankar et al. noted that sermorelin can significantly improve body composition (in hypogonadal males) while ameliorating specific hypogonadal symptoms such as fat gain and muscular atrophy [6].
While the authors suggest that sermorelin could be used to achieve lean mass gain in both hypogonadal males and men with subclinical hypogonadism, to date, there is no published research that has investigated sermorelins effect on body composition in healthy subjects, highlighting an area for further research.
Potential anti-aging benefits: A 1992 study identified sermorelins potential anti-aging benefits after nine young male test subjects (22 to 33 years old) and ten elderly male test subjects (60 to 78 years old) were administered the peptide. The study found that short-term subcutaneous sermorelin injections enabled healthy male test subjects to reverse age-related decreases in GH and levels of IGF-I [7].
A 1997 single-blind randomized placebo-controlled trial found that elderly male and female test subjects who received nightly subcutaneous injections of sermorelin for 16 weeks experienced a significant increase in skin thickness. The peptide was found to produce significant increases in lean body mass in male test subjects and notable increases in libido and wellbeing. Male test subjects gained an average of 1.26 kg of lean body mass by the end of the trial [8]
Sermorelin and heart health: Sermorelin has been investigated alongside other GHRH agonists as a potential treatment for myocardial infarction scarring in swine [9]. The 2015 study found that sermorelin offered a number of benefits in post-heart attack animal models, which included:
As a result, there is research interest in sermorelins heart health-related benefits, namely in its potential to treat problems resulting from cardiac remodeling and ability to heal damage in myocytes following a heart attack.
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Sermorelin | Reviews, Dosage & Clinical Trials - Peptides
Our bodys size, health, and overall composition are largely determined by its ability to produce growth hormones, which are generated from the anterior pituitary gland, a tiny gland at the base of the brain. One of these hormones is thehuman growth hormone(HGH), which facilitates growth in children and maintains organ and tissue health throughout ones life. However, as we get older (or, in the case of certain disorders, from childhood), our bodys ability to produce HGH diminishes, resulting in some of the changes we commonly associate with the aging process.
To that end, there has been a large interest in using synthetic HGH to stave off the aging process, which can ostensibly help maintain muscle and bone mass even into middle age and our later years. While HGH is often available for those suffering from specific childhood growth hormone deficiencies, it is becoming more common in adult therapies as well.
Despite this popularity, there are a number of concerns about the use of synthetic HGH in hormone replacement therapies; to that end, many patients consider hormone therapies involving sermorelin acetate as a safer, more ethical replacement.
Sermorelin acetate, or factor 1-29 NH2acetate, is a growth hormone releasing hormone (GHRH) naturally produced by the brain. Its goal is to encourage the pituitary gland to produce and secrete human growth hormone (HGH). Its not a growth hormone by itself, but instead a growth hormone secretagogue, a separate hormone that stimulates the production of HGH by binding specific receptors to increase HGH production and secretion.
When we are young, our bodies produce sermorelin acetate, allowing our pituitary gland to facilitate the production of HGH. HGH has theeffectof regulating body composition and fluids, as well as facilitating muscle and bone growth, increasing metabolism and improving heart function. In order to produce the levels of HGH required to grow and maintain healthy brain and organ tissue, the body must produce equivalent levels of sermorelin acetate to facilitate its production in the pituitary gland.
HGH is extremely important to human beings during childhood, as it facilitates the growth that occurs during the first twenty years of our lives. As with other hormones like testosterone, the human body typically produces the highest amounts of sermorelin acetate during puberty, leveling off in their twenties and beginning to slowly but steadily diminish once a person enters their thirties and forties. Older men tend to be more likely to suffer from lower levels of sermorelin acetate, as the aging process has slowed down the bodys production of the hormone.
As men age, they can be more likely to suffer fromadult-onset growth hormone deficiency(AGHD), a phenomenon characterized by a relative increase in fat mass, and a commensurate decrease in muscle mass. Sufferers also experience lower energy levels, anxiety and depression. Furthermore, AGHD sufferers also have maladjusted lipid levels, raising their levels of LDL-cholesterol and triglycerides.
Overall, as HGH levels begin to slow down as we get older, we begin to experience the effects commonly associated with aging. These include weight gain, lower muscle mass, lower bone density, insomnia, and changes in our own personality and self-regard. Many different metabolic changes begin to occur, which can lead to greater risk for heart disease, diabetes, metabolic syndrome. These relate closely to many of the common causes of death for people over fifty years of age.
Unlike other hormones like testosterone, sermorelin has an extremely short half-life approximately eleven to twelve minutes after administration, most sermorelin is rapidly cleared from circulation. Most adults have aclearance valueof 2.4 to 2.8 liters per minute (L/min).
There are a number of factors that can contribute to the onset of AGHD:
When the human body fails to produce sufficient levels of sermorelin, the pituitary gland is not motivated to produce HGH, leading to the following side effects:
While these physiological symptoms can have an effect on your physical health, having AGHD corresponds with real, practical deficits in your everyday life:
As we get older, our physical appearance begins to change in ways we often cant expect and do not want. However, by encouraging the stimulation of HGH, we can safely and effectively stave off those effects and increase our quality of life.
Growth hormone stimulationtherapy (GHST) is a regimen that involves administering supplements of sermorelin acetate into the body as a replacement for the bodys natural production of the hormone. This is particularly useful for people who experience lower than usual levels of sermorelin production, as well as those who would like the benefits of HGH without taking it directly.
Sermorelin therapy is simple, especially when thoroughly supervised by a wellness professional. Patients are given a prescription of a multi-dose, injectable vial, which contains a powder disk containing sermorelin acetate. The powder combines with bacteriostatic water to form the solution found in the injectable vial.
Mostsermorelin therapy regimensinvolve the patient self-administering a dose into the body fat, just under the skin with a small needle. Most regimens will involve injecting you with more frequent doses of sermorelin at the beginning of therapy (known as a loading period), then tapering off over time. Sermorelin encourages drowsiness since growth hormones are typically released by the body when were asleep; its recommended that patients take their doses right before bedtime.
When this sermorelin is administered into the body, it goes to the pituitary gland and binds to the appropriate receptors, encouraging the pituitary gland to produce greater amounts of HGH. Given this added stimulation, the pituitary produces more HGH than a body suffering from AGHD or otherwise diminished growth hormone production would normally make. This encourages the kind of health and physiological benefits that come with the HGH levels of a younger person.
While there are absolutely instances of people directly taking HGH to improve their overall strength and well-being, especially athletes and older people hoping to minimize the effects of the aging process. However, the use of this therapy isextremely controversial, as there have been noted reports of serious side effects in some patients. The Code of Federal Regulations, for instance, prohibits the use of HGH in adults, save for some special cases like those suffering fromdwarfism or AIDS.
Some concerns about the direct application of HGH therapy include the mitogenic nature of the hormone, which may awaken latent cancers or lead to diabetes and other disorders. Other potential side effects include early development of carpal tunnel syndrome, increased resistance to insulin, edema (swelling of the arms and legs), muscle and joint pain, and gynecomastia in men. While research is still pending on the long-term effects of HGH therapy, it is generally considered to be fairly risky and not worth pursuing.
However, with sermorelin therapy, the only HGH being produced is that generated naturally by the bodys pituitary gland. All the treatment does is increase the levels of GHRH in the body, thus signaling to the body to synthesize HGH on its own. This side-steps many of the potential side effects and long-term potential problems of HGH therapy, while achieving similar results. By motivating the body to produce HGH on its own, sermorelin therapy is generally considered safer and more ethical.
Semorelin therapy is perfectly safe and healthy, particularly when a regimen is supervised by wellness professionals, in conjunction with recommended lifestyle changes such as diet and exercise.
Synthetic sermorelin has existed for quite some time on the commercial market as an alternative to the synthetic rhGH, meant to treat stunted growth in children; however, it is much better suited to use in adult anti-aging therapies (and far safer than HGH) for thefollowing reasons:
In short,sermorelin therapyis a much safer and preferable alternative to HGH therapy, particularly for older patients. Rather than risking the potential side effects of HGH, including overdose and building up a resistance to the hormone, GHST simply encourages the body to increase more of what it naturally produces.
If sermorelin therapy is something you would like to get involved with, the best plan is to seek outwellness professionalsthat specialize in anti-aging hormone therapies, particularly sermorelin treatments. With their help and supervision, you can begin an effective regiment of sermorelin therapy, in conjunction with properdiet, exercise, and other lifestyle changes.
If you live in either of these areas, we offer testosterone replacement therapy in Miamiandtestosterone replacement therapy in LA.
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Sermorelin 101: What Is Sermorelin? | Sermorelin Side Benefits & Side ...
Researchers interested in experimenting with sermorelin may be curious about the best way to administer this peptide. This sermorelin dosage calculator and guide draws upon past research and summarizes the doses used in previous sermorelin studies. By consulting this data, peptide researchers may gain an insight into how to dose sermorelin in future experiments and trials.
For researchers unfamiliar with sermorelin, this guide will also offer a complete overview of the benefits and side effects associated with this compound and any statistically significant benefits observed in past research.
Those interested in pursuing sermorelin research can find details of our preferred peptide vendor at the end of this guide. This vendor can ship research-grade sermorelin to researchers worldwide and come highly recommended.
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Buy Sermorelin from the #1 online Peptides vendor in the world...
Disclaimer: Peptides.org contains information about products that are intended for laboratory and research use only, unless otherwise explicitly stated. This information, including any referenced scientific or clinical research, is made available for educational purposes only. Peptides.org makes every effort to ensure that any information it shares complies with national and international standards for clinical trial information and is committed to the timely disclosure of the design and results of all interventional clinical studies for innovative treatments publicly available or that may be made available. However, research is not considered conclusive. Peptides.org makes no claims that any products referenced can cure, treat or prevent any conditions, including any conditions referenced on its website or in print materials.
Sermorelin acetate is a peptide made up of a chain of 29 amino acids. It is commonly referred to as sermorelin and was previously sold under the brand names Geref and Gerel. It is synthesized to resemble endogenous growth hormone-releasing hormone (GHRH) [1].
Sermorelin works by interacting with the bodys endocrine system. Since it resembles endogenous GHRH, it produces a similar effect, which is to bind to receptors that tell the pituitary gland to release more growth hormone into the bloodstream.
The result? Growth hormone (GH) levels increase.
What is growth hormone? An essential part of the bodys tissue construction process.
Growth hormone, also called human growth hormone (HGH), is involved in many biological functions including the reproduction of cells and the repair of tissue [2]. Because GH is so important for the growth and repair of tissue, there is currently strong research interest in the extent to which HGH may improve body composition and performance.
However, administering exogenous HGH directly to test subjects can produce a range of serious side effects, including swelling, joint pain, carpal tunnel syndrome, and an increased risk of diabetes [3]. It may also increase the risk of certain types of cancer, such as Hodgkins Lymphoma [4]. These risks mean that HGH research is strictly regulated and tightly controlled.
Thats the beauty of sermorelin research.
Rather than administering HGH directly, researchers can use sermorelin to increase HGH levels in test subjects by naturally stimulating the pituitary gland to release more endogenous HGH. Instead of spiking HGH to supraphysiological levels, sermorelin is believed to produce a gradual increase in HGH in a stable, predictable way.
In the next section, well take a look at the main benefits and uses of sermorelin.
So, what are the Sermorelin benefits? Well, there are quite a few.
In 1997, sermorelin received U.S. Food and Drug Administration (FDA) approval for the treatment of growth hormone deficiency (GHD) in child and adult patients. It was available under the trade name Geref and was also used as a diagnostic agent to check pituitary gland function.
However, the USFDA withdrew approval for Geref in 2008 and it was subsequently discontinued. While the manufacturer stressed that this was for reasons unrelated to safety or efficacy, the simple fact is that sermorelin no longer has any recognizer therapeutic use. In other words, it is a research chemical and is not approved for human use.
As sermorelin is able to increase GH levels in human test subjects, there is strong interest among peptide researchers as to whether it may offer the following benefits:
In summary, while sermorelin is a research chemical and no longer has FDA approval, ongoing research indicates that it may offer a wide range of benefits. Hopefully, researchers interested in exploring sermorelin can consult the relevant literature when calculating sermorelin dosage.
Well now explore the documented sermorelin side effects.
Sermorelin appears to offer several benefits, but are there any sermorelin side effects?
Firstly, researchers need to know that the decision to withdraw sermorelins FDA approval was for reasons other than safety or efficacy. There is no research to date that has linked sermorelin to any clinically significant adverse effects in test subjects.
In general, sermorelin is considered by most researchers to be well-tolerated by test subjects [12]. Side effects from sermorelin administration are rare and not severe. Some of these more mild side effects include:
More rarely, some test subjects have reported the following side effects:
To minimize the risk of test subjects experiencing side effects as a result of sermorelin administration, researchers are advised to consult the relevant literature when designing an experiment.
In the following section, well outline how this research chemical has been used in past studies.
Researchers interested in working with sermorelin may use this sermorelin dosage calculator during the design and planning phases of the research process. Below, the main doses used in past sermorelin studies are highlighted along with any general guidance that researchers may need to be aware of.
Sermorelin acetate usually comes in powder form. Prior to administration, researchers must first reconstitute it with bacteriostatic water by injecting water with a large mixing syringe against the glass wall of the vial. This water must be swirled, gently, around the vial until all of the powder is dissolved.
Researchers should follow the directions for how much water to add. For a 15 mg vial of sermorelin acetate, 7.5 ml of bacteriostatic water is typically required. Note that 10 units on an insulin syringe usually equates to 200 mcg of sermorelin.
Reconstituted sermorelin must be refrigerated and kept away from heat, light, moisture. It can be stored for up to 90 days. Researchers are advised to discard any sermorelin that is cloudy or contains particles.
When sermorelin held FDA approval as a treatment for GHD, it was administered intravenously as a subcutaneous injection. However, sermorelin may also be administered into the muscle as an intramuscular injection.
In terms of the timing of these injections, sermorelin has been administered to test subjects In past studies at night, at least two hours after eating. As HGH levels naturally peak at night, this protocol is believed to enhance HGH secretion.
During the period when sermorelin held FDA approval and was used to diagnose idiopathic GHD in children, it was administered intravenously at a dose of 1mcg per kilogram of body weight.
To date, sermorelin has not been approved for any other purpose and is currently classified as a research chemical. Therefore, based on the available data, researchers interested in experimenting with sermorelin for its purported recovery benefits may administer it in the following way:
While there is strong research interest in the application of sermorelin to improve the appearance of skin and reduce body fat, there is no published research to indicate the dosage at which it may be administered to this end.
Researchers interested in experimenting with sermorelin may consult the available literature regarding the past use of sermorelin as a treatment for GHD. This research indicates that a dose of 1mcg/kg of body weight provides a clinically significant effect in test subjects.
As with anti-aging and weight loss, there is currently very strong research interest in the application of sermorelin to lean muscle increase and athletic performance in test subjects. However, to date, no research has been published to indicate the dosage at which sermorelin may be administered for this purpose.
Based on the available data, doses of 1mcg/kg of bodyweight appear to produce a discernible effect. Researchers interested in exploring these purported benefits of sermorelin may consider this as a starting dose for any experiment they decide to conduct.
Researchers interested in experimenting with sermorelin should note that while this peptide has previously held USFDA approval as a treatment for GHD, it is currently classified as a research chemical and has no recognized therapeutic use.
The best place to buy sermorelin online is Peptide Sciences, a U.S.-based company that provides high-quality, research-grade peptides without additives or fillers.
We love Peptide Sciences because they have a solid track record and get every batch of peptides tested by an independent lab before putting them up for sale.
Here are a few things they do exceptionally well:
Researchers interested in exploring the benefits and side effects of sermorelin may consult Peptides Sciences to discuss their needs.
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Hopefully, this sermorelin dosage calculator and guide has provided a useful starting point for researchers interested in working with this peptide. Although sermorelin is no longer FDA approved, past research findings indicate that further research may be warranted, especially with regards to GHD treatment, long-term safety, and anti-aging effects.
Those interested in finding a reliable, trustworthy sermorelin vendor may consider contacting our preferred supplier, Peptide Sciences.
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Sermorelin Dosage Calculator and Guide | What You Must Know
To properly grow and develop, your body needs human growth hormone (hGH). This is a peptide hormone produced in the tiny part of your brain called the pituitary gland. Although hGH plays its most crucial role during childhood and adolescence, it continues to maintain healthy tissues and organs throughout your life. Because of that, hGH levels that are lower or higher than typical can lead to health problems both in children and adults.
As often is the case with such complicated machines as our bodies, hGH does not act alone. A molecule called the growth hormone-releasing hormone (GHRH) controls hGH by releasing it from the pituitary gland into the bloodstream. If your blood test indicates low levels of hGH, your doctor may recommend injections of a synthetic form of GHRH, called sermorelin.
Keep reading to learn more about sermorelin, its benefits and risks, and when to consider using or avoiding sermorelin injections.
Sermorelin is used to diagnose and treat poor growth in children. Its also sometimes used off-label to treat hGH deficiency in adults. Some research has suggested that it can be beneficial in people with certain recurrent brain tumors.
Children usually benefit the most from sermorelin. One older study reported that a daily injection of sermorelin increased growth rate in 74 percent of children after just 6 months.
Studies investigating benefits of sermorelin in adults are scarce, but researchers have observed that sermorelin injection increases hGH levels in the bloodstream. These findings have led to widespread claims that sermorelin is an anti-aging therapy that can restore your bodys natural hGH production. Indeed, some older research suggests that sermorelin may increase:
However, definitive research to support the anti-aging effect of sermorelin is lacking. The use of sermorelin in healthy adults to reverse the effects of aging and in bodybuilding remains controversial.
Although long-term risks of sermorelin use are not known, its usually well-tolerated. However, as with any synthetic drug, its possible to have an allergic reaction. Let your doctor know about any allergies before taking this medication.
If you notice any of the following symptoms of a severe allergic reaction, call emergency medical services or go to the nearest emergency room:
The most common side effect of sermorelin is caused by its injection under your skin. You may experience any of the following at the site of injection:
These reactions are typically short-lived and disappear without any action. As you get better at self-administering the shots, these symptoms may stop for good.
Other, much less common side effects of sermorelin may include:
Sermorelin may interact with other medications. Drug interactions that may interfere with sermorelin include:
Make sure to let your doctor know about any medications and supplements you take (including vitamins) before starting sermorelin treatment.
Children and youths with poor growth are the primary candidates for sermorelin injections. In this group, sermorelin can help with both diagnosis and treatment of hGH deficiency.
Adults with diagnosed hGH deficiency can also benefit from sermorelin, according to older research. Healthy adults sometimes use this therapy for anti-aging and for bodybuilding; however this use remains controversial due to the scarcity of scientific evidence.
People with certain medical conditions may require additional screening before taking sermorelin and sometimes should avoid this therapy. These conditions include:
You dont need to visit a doctors office for sermorelin injections. Instead, you can self-administer injections at home. Sermorelin is injected subcutaneously, which means under the skin.
To prevent contamination, wipe the rubber vial stopper with an antiseptic before puncturing it with the needle. When injecting, target the fatty tissue just below the skin. Many people inject their stomach or thigh. To avoid bruising and soreness, its best to switch up the location of the injection site. Ask your doctor to show you the best injection technique.
Sermorelin is administered once a day, ideally at night. Your doctor will determine your dosage and length of treatment based on your individual factors.
You may be wondering: If the purpose of sermorelin therapy is to increase the levels of hGH hormone, why cant you just inject hGH? The answer is that many people do. In fact, research suggests that genetically engineered hGH is an effective treatment for both poor growth in children and hGH deficiency in adults. Unfortunately, hGH therapy is associated with numerous risks and side effects. Therefore, it may not be appropriate for some people.
Sermorelin helps your body produce more hGH. Children with growth delays and adults with hGH deficiency may benefit from this therapy. Although some healthy adults take it to prevent aging and for bodybuilding, there is no definitive research suggesting that sermorelin is effective for either of these purposes.
Although this medication is usually well-tolerated, tell your doctor about any allergies and medical conditions you have as well as medications and supplements you take. Check in regularly with your doctor while youre taking it.
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Sermorelin Therapy Benefits, Uses, Side Effects, Risks, More
Sermorelin vs Ipamorelin
Sermorelin and ipamorelin peptides are very similar in many ways. Despite their similarities, however, these two peptides are different enough that their applications can be tailored for specific needs. Both peptides stimulate the natural secretion of growth hormone, but they do so via different receptors. As a result of their effects on growth hormone (GH) levels, Ipamorelin and Sermorelin both cause increased fat burning and muscle building, enhanced long bone growth, decreased inflammation, and improved wound healing. However, their actions via different receptors result in these two peptides having slightly different ancillary effects.
Sermorelin vs Ipamorelin: Receptor Science
Sermorelin is an analogue of growth hormone-releasing hormone (GHRH) and binds to the GHRH receptor (GHRH-R). Ipamorelin, however, is a ghrelin analogue and binds primarily to the growth hormone secretagogue receptor (GHS-R). While both peptides can be referred to under the umbrella category of growth hormone releasing peptides, their different receptor binding preferences mean they have different effects on GH levels.
At baseline, Sermorelin potentiates GH release and helps to extend GH highs. It is best thought of as extending GH peaks and prolonging the amount of time that GH levels are elevated while preserving the normal ebb and flow (pulsatile secretion) of GH throughout that day. Ipamorelin, on the other hand, is better thought of as dramatically raising GH levels, sometimes by as much as 13 times above baseline levels. Ipamorelin has dramatic, but short-lived effects on GH levels.
Sermorelin and Growth Hormone Potentiation
The GHRH-R is the primary receptor on the anterior pituitary gland for controlling growth hormone release. When stimulated, it causes the release of growth hormone. Research shows that Sermorelin binding to the GHRH-R is effective at concentrations as low as 0.4x10-15M[1]. This makes Sermorelin an extremely potent GHRH agonist and approximately 50 times more potent than naturally occurring GHRH. This is the reason that it was originally referred to as a super-active analogue of growth hormone releasing hormone[2].
Interestingly, Sermorelin tends to not cause massive increases in GH levels when it is administered. It does, however, augment the duration of GH release. That is to say, while Sermorelin definitely increases GH levels, its primary effect is to extend the duration of GH release, helping to maintain peak levels for longer periods of time[3]. By extending the release of GH, Sermorelin does, in fact, raise GH levels but it also smooths out the peaks of GH release and widens them a bit. This does not, however, obliterate the normal pulsatile secretion of GH, which is important for minimizing side effects. In fact, Sermorelins biggest benefit is the fact that it preservers the normal physiologic pattern of GH release, thus mitigating side effects like swelling, joint pain, and excessive long bone growth[4].
Ipamorelin and Growth Hormone Peaks
Ipamorelin (as well as ghrelin) is an amplifier of GH pulsatility and is speculated to play a role in creating a set point for insulin-like growth factor 1 levels[5]. Research has shown that subcutaneous administration of Ipamorelin causes an intense spike in growth hormone levels just 5-15 minutes after injection followed by a relatively rapid decline. Thus, ipamorelin does not really potentiate GH secretion like Sermorelin does. Instead, ipamorelin is better thought of as boosting maximum levels of growth hormone output for a very short duration of time. Depending on when and how ipamorelin is administered, this could mean augmenting peak GH levels or raising trough levels. Thus, timing of ipamorelin administration can, to some extent, affect the peptides effects.
Ipamorelin, at its ED50 (50% of the maximum effective dose), causes plasma GH levels to increase to approximately 65 ng/mL in animal models. Normally, growth hormone levels in men are below 5 ng/mL while in women they are below 10 ng/mL. This means Ipamorelin administration raises GH levels by anywhere from 6.5 to 13 times the maximum level. In children, growth hormone levels range from 0-20 ng/mL based on age. Ipamorelin has a short half-life of two hours. When administered, it causes maximum GH release after about 40 minutes followed by an exponential decline[6].
This rapid on, rapid off property of Ipamorelin is a holdover from its natural counterpart, ghrelin. Recall that ghrelin and Ipamorelin can both stimulate appetite. This occurs via binding to the GHS-R and subsequent release of neuropeptide Y. Given that it takes time to eat and digest food, it makes sense that ipamorelin would have its maximum effects approximately 40 minutes after injection (or release in the case of ghrelin). This gives the peptide its best chance of making using of nutrients for building muscle, bone, connections between neurons, and more.
Sermorelin vs Ipamorelin: Structure and Route of Administration
Sermorelin is made up of the first 29 amino acids from the much larger, naturally occurring GHRH peptide. It is the smallest fraction of GHRH than retains all of the properties of the parent molecule. Weighing in at 3357.9 g/mol, Sermorelin is a relatively large, heavy peptide that must be injected sub-cutaneous to be absorbed. It is not orally bioavailable. As a result of its large size, Sermorelin has a more significant three-dimensional structure than Ipamorelin and is thus is a little less stable in terms of storage half-life.
Source: PubChem
Ipamorelin is substantially smaller than Sermorelin at just5 amino acids and 711.868 g/mol. It is a derivative of GHRP-1, which is itselfa derivative of met-enkephalin. Though the most common route of administrationfor Ipamorelin is via sub-cutaneous injection, the peptide is also orallyactive and can even be absorbed though the nasal mucosa.
Source: PubChem
Ipamorelin vs Sermorelin: Lean Body Mass
Both Sermorelin and Ipamorelin favor the development of lean body mass over fat mass, but Sermorelin is the more potent of the two. This arises from the fact that Sermorelin is both a growth stimulator and a fat burner while Ipamorelin is a more general growth stimulator. That is not to say that Ipamorelin isnt effective, it is, but ipamorelin isnt as strictly favorable of lean body mass deposition as Sermorelin. This difference arises from the fact that Ipamorelin is a ghrelin analogue and ghrelin favors food intake in general. Its growth hormone boosting properties shift the overall balance away from fat deposition and toward lean body mass deposition, but the Ipamorelin peptide is best thought of as a general weight boosting peptide while Sermorelin is best thought of as a more exclusive booster of lean body mass. In fact, Sermorelin is often referred to as a lipolytic or fat-burning peptide.
Both peptides stimulate the development of bone and other connective tissue, but Ipamorelin appears to have the advantage in this realm. In fact, ipamorelin is so effective in boosting bone density and mineralization that it has been investigated as a potential treatment for corticosteroid-induced bone loss as well as osteoporosis[7], [8].
When it comes to muscle growth, Sermorelin is probably the big winner, though this can be debated endlessly. Sermorelin not only boosts muscle hypertrophy and hyperplasia, it reduces fat mass and thus causes a shift in body chemistry toward lean body weight. In other words, Sermorelin will always favor the production of lean body mass even if diet is not perfectly geared toward muscle development. Ipamorelin, on the other hand, is more of a mixed bag. It will always cause muscle growth, but ipamorelin may channel some of those calories into fat deposition as well.
Ipamorelin vs Sermorelin: Anti-Aging Properties
Both Ipamorelin and Sermorelin, via their GH releasing potential, have potent anti-aging properties. Sermorelin, however, is the clear front runner in this particular face off. Sermorelin has been shown to improve joint function, skin thickness, skin collagen structure, wound healing, cardiac fibrosis, strength, and metabolism. According to Dr. Richard Walker, Ph.D., of the International Society for Advanced Research in Aging, Sermorelin helps to preserve more of the growth hormone axis than most other GHRH analogues, resulting in a more youthful hormone profile. In other words, if you took profiles of GH biochemistry throughout an individuals lifetime, you would find that Sermorelin tends to dial back that chemistry to a more youthful setting.
Ipamorelin as Pain Reliever
One of the biggest differences between Ipamorelin and Sermorelin lies in the fact that Ipamorelin triggers the release of neuropeptide Y. This peptide is an important neurotransmitter in the control of appetite and food preference, but it also plays an important role in how we perceive pain. In fact, the connection between food and good feelings is likely due, in part, to the effects of neuropeptide Y.
Research in rats indicates that Ipamorelin may help to reduce pain perception by has much as 2-fold. This is particularly true of visceral pain, which is to say stomach pain. Visceral pain is difficult to treat, so ipamorelin offers a potential starting point for understanding how to better control the pain associated with conditions like irritable bowel syndrome, Crohns disease, ulcerative colitis, and more. There are also potential applications in neuropathic pain syndromes like diabetic neuropathy and degenerative disk disease[9].
Sermorelin and Sleep
Research in rats shows that Sermorelin is an effective regulator of the sleep cycle. Sleep and aging go hand int hand, with one affecting the other such that older people often have less adequate less restful sleep. Sermorelin appears to achieve its sleep benefits by regulating orexin release from specialized neurons in the brain. Orexin is an important neurotransmitter in sleep regulation and Sermorelin appears to boost orexin secretion. This leads to an increase in non-REM slow-wave sleep, which is associated with more restful sleep, improved immune function, better wound healing, and happier mood[10], [11]. Its effects on sleep may be one of the reasons that Sermorelin is a potent anti-aging peptide.
Sermorelin vs Ipamorelin: Summary
Sermorelin peptides and Ipamorelin peptides are more similar than they are different, but that doesnt mean there arent distinctions between these two growth-promoting peptides. Practically speaking, Sermorelin is the all-around peptide. It promotes lean body mass gains, boosts fat burning, and fights the effects of aging. It is also a more holistic simulator of the GH axis and, as such, helps the body to maintain youth-like patterns of GH secretion.
Ipamorelin is the more potent of the two peptides. Its effects are large, but relatively short-lived. Ipamorelin is a gainer peptide. It builds lean body mass, but also builds overall body mass. It is a potent stimulator of bone growth and has some pain fighting properties as well.
There has been some research investigating the effects of combining Sermorelin and Ipamorelin. Because these peptides affect two different receptors, their actions when combined tend to be synergistic. Unfortunately, the research in this area is limited, so there isnt a great deal of data on how the combination of these two peptides can help to improve appetite, alter body composition, fight off cardiovascular disease, slow the progression of aging, and promote general good health. In the end, both Ipamorelin and Sermorelin have been studied extensively, but individually, for their significant impacts on GH. Both peptides are effective, but have slightly different ancillary effects that have driven researchers in different directions as they explore potential applications for ipamorelin peptides and sermorelin peptides.
Resources
[1] M. L. Heiman, M. V. Nekola, W. A. Murphy, V. A. Lance, and D. H. Coy, An extremely sensitive in vitro model for elucidating structure-activity relationships of growth hormone-releasing factor analogs, Endocrinology, vol. 116, no. 1, pp. 410415, Jan. 1985, doi: 10.1210/endo-116-1-410.
[2] V. A. Lance, W. A. Murphy, J. Sueiras-Diaz, and D. H. Coy, Super-active analogs of growth hormone-releasing factor (1-29)-amide, Biochem. Biophys. Res. Commun., vol. 119, no. 1, pp. 265272, Feb. 1984, doi: 10.1016/0006-291x(84)91647-4.
[3] A. Grossman et al., Responses to analogues of growth hormone-releasing hormone in normal subjects, and in growth-hormone deficient children and young adults, Clin. Endocrinol. (Oxf.), vol. 21, no. 3, pp. 321330, Sep. 1984, doi: 10.1111/j.1365-2265.1984.tb03477.x.
[4] R. F. Walker, Sermorelin: a better approach to management of adult-onset growth hormone insufficiency?, Clin. Interv. Aging, vol. 1, no. 4, pp. 307308, 2006, doi: 10.2147/ciia.2006.1.4.307.
[5] Y. Sun, P. Wang, H. Zheng, and R. G. Smith, Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor, Proc. Natl. Acad. Sci. U. S. A., vol. 101, no. 13, pp. 46794684, Mar. 2004, doi: 10.1073/pnas.0305930101.
[6] J. V. Gobburu, H. Agers, W. J. Jusko, and L. Ynddal, Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers, Pharm. Res., vol. 16, no. 9, pp. 14121416, Sep. 1999, doi: 10.1023/a:1018955126402.
[7] N. B. Andersen, K. Malmlf, P. B. Johansen, T. T. Andreassen, G. rtoft, and H. Oxlund, The growth hormone secretagogue ipamorelin counteracts glucocorticoid-induced decrease in bone formation of adult rats, Growth Horm. IGF Res., vol. 11, no. 5, pp. 266272, Oct. 2001, doi: 10.1054/ghir.2001.0239.
[8] J. Svensson et al., The GH secretagogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female rats, J. Endocrinol., vol. 165, pp. 56977, Jul. 2000.
[9] E. N Mohammadi, T. Louwies, C. Pietra, S. R. Northrup, and B. Greenwood-Van Meerveld, Attenuation of Visceral and Somatic Nociception by Ghrelin Mimetics, J. Exp. Pharmacol., vol. 12, pp. 267274, 2020, doi: 10.2147/JEP.S249747.
[10] B. S. Shepherd et al., Endocrine and orexigenic actions of growth hormone secretagogues in rainbow trout (Oncorhynchus mykiss), Comp. Biochem. Physiol. A. Mol. Integr. Physiol., vol. 146, no. 3, pp. 390399, Mar. 2007, doi: 10.1016/j.cbpa.2006.11.004.
[11] A Good Nights Sleep, National Institute on Aging. http://www.nia.nih.gov/health/good-nights-sleep (accessed Nov. 22, 2020).
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Sermorelin vs Ipamorelin: Best Guide in 2021
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