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Sermorelin vs Ipamorelin

Sermorelin and ipamorelin peptides are very similar in many ways. Despite their similarities, however, these two peptides are different enough that their applications can be tailored for specific needs. Both peptides stimulate the natural secretion of growth hormone, but they do so via different receptors. As a result of their effects on growth hormone (GH) levels, Ipamorelin and Sermorelin both cause increased fat burning and muscle building, enhanced long bone growth, decreased inflammation, and improved wound healing. However, their actions via different receptors result in these two peptides having slightly different ancillary effects.

Sermorelin vs Ipamorelin: Receptor Science

Sermorelin is an analogue of growth hormone-releasing hormone (GHRH) and binds to the GHRH receptor (GHRH-R). Ipamorelin, however, is a ghrelin analogue and binds primarily to the growth hormone secretagogue receptor (GHS-R). While both peptides can be referred to under the umbrella category of growth hormone releasing peptides, their different receptor binding preferences mean they have different effects on GH levels.

At baseline, Sermorelin potentiates GH release and helps to extend GH highs. It is best thought of as extending GH peaks and prolonging the amount of time that GH levels are elevated while preserving the normal ebb and flow (pulsatile secretion) of GH throughout that day. Ipamorelin, on the other hand, is better thought of as dramatically raising GH levels, sometimes by as much as 13 times above baseline levels. Ipamorelin has dramatic, but short-lived effects on GH levels.

Sermorelin and Growth Hormone Potentiation

The GHRH-R is the primary receptor on the anterior pituitary gland for controlling growth hormone release. When stimulated, it causes the release of growth hormone. Research shows that Sermorelin binding to the GHRH-R is effective at concentrations as low as 0.4x10-15M[1]. This makes Sermorelin an extremely potent GHRH agonist and approximately 50 times more potent than naturally occurring GHRH. This is the reason that it was originally referred to as a super-active analogue of growth hormone releasing hormone[2].

Interestingly, Sermorelin tends to not cause massive increases in GH levels when it is administered. It does, however, augment the duration of GH release. That is to say, while Sermorelin definitely increases GH levels, its primary effect is to extend the duration of GH release, helping to maintain peak levels for longer periods of time[3]. By extending the release of GH, Sermorelin does, in fact, raise GH levels but it also smooths out the peaks of GH release and widens them a bit. This does not, however, obliterate the normal pulsatile secretion of GH, which is important for minimizing side effects. In fact, Sermorelins biggest benefit is the fact that it preservers the normal physiologic pattern of GH release, thus mitigating side effects like swelling, joint pain, and excessive long bone growth[4].

Ipamorelin and Growth Hormone Peaks

Ipamorelin (as well as ghrelin) is an amplifier of GH pulsatility and is speculated to play a role in creating a set point for insulin-like growth factor 1 levels[5]. Research has shown that subcutaneous administration of Ipamorelin causes an intense spike in growth hormone levels just 5-15 minutes after injection followed by a relatively rapid decline. Thus, ipamorelin does not really potentiate GH secretion like Sermorelin does. Instead, ipamorelin is better thought of as boosting maximum levels of growth hormone output for a very short duration of time. Depending on when and how ipamorelin is administered, this could mean augmenting peak GH levels or raising trough levels. Thus, timing of ipamorelin administration can, to some extent, affect the peptides effects.

Ipamorelin, at its ED50 (50% of the maximum effective dose), causes plasma GH levels to increase to approximately 65 ng/mL in animal models. Normally, growth hormone levels in men are below 5 ng/mL while in women they are below 10 ng/mL. This means Ipamorelin administration raises GH levels by anywhere from 6.5 to 13 times the maximum level. In children, growth hormone levels range from 0-20 ng/mL based on age. Ipamorelin has a short half-life of two hours. When administered, it causes maximum GH release after about 40 minutes followed by an exponential decline[6].

This rapid on, rapid off property of Ipamorelin is a holdover from its natural counterpart, ghrelin. Recall that ghrelin and Ipamorelin can both stimulate appetite. This occurs via binding to the GHS-R and subsequent release of neuropeptide Y. Given that it takes time to eat and digest food, it makes sense that ipamorelin would have its maximum effects approximately 40 minutes after injection (or release in the case of ghrelin). This gives the peptide its best chance of making using of nutrients for building muscle, bone, connections between neurons, and more.

Sermorelin vs Ipamorelin: Structure and Route of Administration

Sermorelin is made up of the first 29 amino acids from the much larger, naturally occurring GHRH peptide. It is the smallest fraction of GHRH than retains all of the properties of the parent molecule. Weighing in at 3357.9 g/mol, Sermorelin is a relatively large, heavy peptide that must be injected sub-cutaneous to be absorbed. It is not orally bioavailable. As a result of its large size, Sermorelin has a more significant three-dimensional structure than Ipamorelin and is thus is a little less stable in terms of storage half-life.

Source: PubChem

Ipamorelin is substantially smaller than Sermorelin at just5 amino acids and 711.868 g/mol. It is a derivative of GHRP-1, which is itselfa derivative of met-enkephalin. Though the most common route of administrationfor Ipamorelin is via sub-cutaneous injection, the peptide is also orallyactive and can even be absorbed though the nasal mucosa.

Source: PubChem

Ipamorelin vs Sermorelin: Lean Body Mass

Both Sermorelin and Ipamorelin favor the development of lean body mass over fat mass, but Sermorelin is the more potent of the two. This arises from the fact that Sermorelin is both a growth stimulator and a fat burner while Ipamorelin is a more general growth stimulator. That is not to say that Ipamorelin isnt effective, it is, but ipamorelin isnt as strictly favorable of lean body mass deposition as Sermorelin. This difference arises from the fact that Ipamorelin is a ghrelin analogue and ghrelin favors food intake in general. Its growth hormone boosting properties shift the overall balance away from fat deposition and toward lean body mass deposition, but the Ipamorelin peptide is best thought of as a general weight boosting peptide while Sermorelin is best thought of as a more exclusive booster of lean body mass. In fact, Sermorelin is often referred to as a lipolytic or fat-burning peptide.

Both peptides stimulate the development of bone and other connective tissue, but Ipamorelin appears to have the advantage in this realm. In fact, ipamorelin is so effective in boosting bone density and mineralization that it has been investigated as a potential treatment for corticosteroid-induced bone loss as well as osteoporosis[7], [8].

When it comes to muscle growth, Sermorelin is probably the big winner, though this can be debated endlessly. Sermorelin not only boosts muscle hypertrophy and hyperplasia, it reduces fat mass and thus causes a shift in body chemistry toward lean body weight. In other words, Sermorelin will always favor the production of lean body mass even if diet is not perfectly geared toward muscle development. Ipamorelin, on the other hand, is more of a mixed bag. It will always cause muscle growth, but ipamorelin may channel some of those calories into fat deposition as well.

Ipamorelin vs Sermorelin: Anti-Aging Properties

Both Ipamorelin and Sermorelin, via their GH releasing potential, have potent anti-aging properties. Sermorelin, however, is the clear front runner in this particular face off. Sermorelin has been shown to improve joint function, skin thickness, skin collagen structure, wound healing, cardiac fibrosis, strength, and metabolism. According to Dr. Richard Walker, Ph.D., of the International Society for Advanced Research in Aging, Sermorelin helps to preserve more of the growth hormone axis than most other GHRH analogues, resulting in a more youthful hormone profile. In other words, if you took profiles of GH biochemistry throughout an individuals lifetime, you would find that Sermorelin tends to dial back that chemistry to a more youthful setting.

Ipamorelin as Pain Reliever

One of the biggest differences between Ipamorelin and Sermorelin lies in the fact that Ipamorelin triggers the release of neuropeptide Y. This peptide is an important neurotransmitter in the control of appetite and food preference, but it also plays an important role in how we perceive pain. In fact, the connection between food and good feelings is likely due, in part, to the effects of neuropeptide Y.

Research in rats indicates that Ipamorelin may help to reduce pain perception by has much as 2-fold. This is particularly true of visceral pain, which is to say stomach pain. Visceral pain is difficult to treat, so ipamorelin offers a potential starting point for understanding how to better control the pain associated with conditions like irritable bowel syndrome, Crohns disease, ulcerative colitis, and more. There are also potential applications in neuropathic pain syndromes like diabetic neuropathy and degenerative disk disease[9].

Sermorelin and Sleep

Research in rats shows that Sermorelin is an effective regulator of the sleep cycle. Sleep and aging go hand int hand, with one affecting the other such that older people often have less adequate less restful sleep. Sermorelin appears to achieve its sleep benefits by regulating orexin release from specialized neurons in the brain. Orexin is an important neurotransmitter in sleep regulation and Sermorelin appears to boost orexin secretion. This leads to an increase in non-REM slow-wave sleep, which is associated with more restful sleep, improved immune function, better wound healing, and happier mood[10], [11]. Its effects on sleep may be one of the reasons that Sermorelin is a potent anti-aging peptide.

Sermorelin vs Ipamorelin: Summary

Sermorelin peptides and Ipamorelin peptides are more similar than they are different, but that doesnt mean there arent distinctions between these two growth-promoting peptides. Practically speaking, Sermorelin is the all-around peptide. It promotes lean body mass gains, boosts fat burning, and fights the effects of aging. It is also a more holistic simulator of the GH axis and, as such, helps the body to maintain youth-like patterns of GH secretion.

Ipamorelin is the more potent of the two peptides. Its effects are large, but relatively short-lived. Ipamorelin is a gainer peptide. It builds lean body mass, but also builds overall body mass. It is a potent stimulator of bone growth and has some pain fighting properties as well.

There has been some research investigating the effects of combining Sermorelin and Ipamorelin. Because these peptides affect two different receptors, their actions when combined tend to be synergistic. Unfortunately, the research in this area is limited, so there isnt a great deal of data on how the combination of these two peptides can help to improve appetite, alter body composition, fight off cardiovascular disease, slow the progression of aging, and promote general good health. In the end, both Ipamorelin and Sermorelin have been studied extensively, but individually, for their significant impacts on GH. Both peptides are effective, but have slightly different ancillary effects that have driven researchers in different directions as they explore potential applications for ipamorelin peptides and sermorelin peptides.

Resources

[1] M. L. Heiman, M. V. Nekola, W. A. Murphy, V. A. Lance, and D. H. Coy, An extremely sensitive in vitro model for elucidating structure-activity relationships of growth hormone-releasing factor analogs, Endocrinology, vol. 116, no. 1, pp. 410415, Jan. 1985, doi: 10.1210/endo-116-1-410.

[2] V. A. Lance, W. A. Murphy, J. Sueiras-Diaz, and D. H. Coy, Super-active analogs of growth hormone-releasing factor (1-29)-amide, Biochem. Biophys. Res. Commun., vol. 119, no. 1, pp. 265272, Feb. 1984, doi: 10.1016/0006-291x(84)91647-4.

[3] A. Grossman et al., Responses to analogues of growth hormone-releasing hormone in normal subjects, and in growth-hormone deficient children and young adults, Clin. Endocrinol. (Oxf.), vol. 21, no. 3, pp. 321330, Sep. 1984, doi: 10.1111/j.1365-2265.1984.tb03477.x.

[4] R. F. Walker, Sermorelin: a better approach to management of adult-onset growth hormone insufficiency?, Clin. Interv. Aging, vol. 1, no. 4, pp. 307308, 2006, doi: 10.2147/ciia.2006.1.4.307.

[5] Y. Sun, P. Wang, H. Zheng, and R. G. Smith, Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor, Proc. Natl. Acad. Sci. U. S. A., vol. 101, no. 13, pp. 46794684, Mar. 2004, doi: 10.1073/pnas.0305930101.

[6] J. V. Gobburu, H. Agers, W. J. Jusko, and L. Ynddal, Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers, Pharm. Res., vol. 16, no. 9, pp. 14121416, Sep. 1999, doi: 10.1023/a:1018955126402.

[7] N. B. Andersen, K. Malmlf, P. B. Johansen, T. T. Andreassen, G. rtoft, and H. Oxlund, The growth hormone secretagogue ipamorelin counteracts glucocorticoid-induced decrease in bone formation of adult rats, Growth Horm. IGF Res., vol. 11, no. 5, pp. 266272, Oct. 2001, doi: 10.1054/ghir.2001.0239.

[8] J. Svensson et al., The GH secretagogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female rats, J. Endocrinol., vol. 165, pp. 56977, Jul. 2000.

[9] E. N Mohammadi, T. Louwies, C. Pietra, S. R. Northrup, and B. Greenwood-Van Meerveld, Attenuation of Visceral and Somatic Nociception by Ghrelin Mimetics, J. Exp. Pharmacol., vol. 12, pp. 267274, 2020, doi: 10.2147/JEP.S249747.

[10] B. S. Shepherd et al., Endocrine and orexigenic actions of growth hormone secretagogues in rainbow trout (Oncorhynchus mykiss), Comp. Biochem. Physiol. A. Mol. Integr. Physiol., vol. 146, no. 3, pp. 390399, Mar. 2007, doi: 10.1016/j.cbpa.2006.11.004.

[11] A Good Nights Sleep, National Institute on Aging. http://www.nia.nih.gov/health/good-nights-sleep (accessed Nov. 22, 2020).

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Sermorelin vs Ipamorelin: Best Guide in 2021

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Nov 19th, 2021 | Filed under Sermorelin

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Nov 19th, 2021 | Filed under Sermorelin

Sermorelin Cost:

Because of low Sermorelin prices, the synthetic growth hormone-releasing hormone analogue has long been favored in research investigating the effects of enhanced human growth hormone (HGH) levels. It is also increasingly used in the clinical setting as alternative to HGH in the diagnosis and treatment of HGH deficiency. Sermorelin acetate costs, however, are not the only thing that make the peptide of interest to researchers and clinicians alike. Sermorelin has a favorable side effect profile and a number of proven benefits that are of interest to those investigating anti-aging, wound healing, metabolic processes, and sleep physiology.

Sermorelin is a peptide hormone analogue of growth hormone-releasing hormone (GHRH), which means it stimulates the release of GH from the anterior pituitary. Sermorelin is actually one of the earliest peptide hormone analogues produced and has been used in research and clinical settings for nearly thirty years.

Sermorelin is a shortened, synthetic version of GHRH, consisting of only the first twenty-nine amino acids of the larger protein. It retains most of the functions of GHRH and is capable of binding to the GHRH receptor, with equal affinity to native GHRH, after subcutaneous injection. It is thought to be the shortest fragment of GHRH that is still fully functional.

By stimulating the release of HGH (and in fact growth hormone in a number of animals), Sermorelin causes the same biochemical actions as GHRH. These include the production of insulin-like growth factor 1, increased long bone growth, muscle hypertrophy/hyperplasia, enhanced wound healing, improved energy metabolism, and changes in the immune system. Though Sermorelin has been found to stimulate growth in a reliable, reproducible manner, the peptide is of greater interest for its effects on wound healing, body composition, sleep, and the aging process.

Before getting into the major research interests in Sermorelin, it is important to note that Sermorelin acetate costs far less than many other GHRH analogues. This is, in part, due to the fact that Sermorelin has been around for a very long time and has been the subject of a great deal of research. As a peptide hormone, Sermorelin is easy to produce and purify. The use of HGH to treat HGH deficiency in children costs approximately $1500-$2000 per month while Sermorelin, used in the exact same setting, costs just $200 per month. That means that Sermorelin prices are nearly eight times lower than HGH costs.

Now, it might be tempting to think that HGH deficiency would best be treated with HGH supplementation. This logic is often used to justify the high costs of HGH, but it isnt accurate. Sometimes, direct HGH replacement is the right answer, but sometimes it can do just as much harm as good. This is as true in the research setting as it is in the clinical setting. The benefits of Sermorelin are discussed below and go far beyond the low cost of Sermorelin Acetate.

One of the biggest challenges in HGH supplementation is maintaining normal physiologic secretion patterns of HGH. In all mammals, humans included, growth hormone is secreted in an ebbing and flowing pattern, with levels varying throughout the day and in response to various biochemical conditions within the body. This is referred to as a pulsatile secretion pattern. Preserving this pattern, even if different highs and lows of GH are desired, is beneficial in reducing side effects while maximizing benefits. In other words, the pattern of GH secretion is more important than absolute blood levels of the hormone in maximizing benefit and reducing side effects.

Exogenous administration of GH is well known to obliterate normal physiologic secretion patterns. This happens due to the standard negative feedback cycle. When GH is administered, levels of the hormone in the body skyrocket, signaling the brain to stop releasing GH. This results in what is known as a square-wave pattern of hormone release, with levels of GH getting very high and then very, very low. This square-wave pattern results in the enhancement of some of the side effects of GH (e.g. excessive long bone growth, edema, joint pain, and damaging effects on the liver, heart, and other organs). Research shows that preserving the normal pattern of GH ebb and flow can help to mitigate these effects, even as overall levels of the hormone increase[1].

The administration of drugs, hormones, and other products in a square-wave pattern tends to enhance a process known as tachyphylaxis. In tachyphylaxis, the body adapts to the high levels of a particular substance by reducing the number of receptors for that substance. For instance, if GH hormone levels are too high (or moderately high for too long) the body may respond by producing fewer GH receptors. This is essentially a physiologic mechanism for reduce the effects of a substance when the body cannot simply reduce the presence of the substance itself. In other words, the body is ignoring the high levels of GH by taking away the receptors that it needs to bind to. This leads to the same outcomes as lower levels of GH and can be exceptionally problematic during long-term administration.

The only way to overcome tachyphylaxis to a particular substance and restore its effects is to stop using it for a period of time. This is referred to as a drug holiday. Drug holidays are effective, but have two drawbacks. First, they reduce or eliminate the benefits of therapy while the substance in question is being withheld. So, not only does the tachyphylaxis itself reduce the benefits of treatment, but so too does the need to go without GH for a given period of time. This can slow the response to treatment and, in some cases, reduce overall benefit to something less than the potential maximum.

The other drawback to a drug holiday is that it can precipitate a withdrawal condition when there is no GH present. This happens because exogenous administration of GH can completely suppresses the bodys natural production of the hormone. It can take some time for levels to recover, which can result in a period of very low energy, poor wound healing, and increased risk of infection.

Research reveals that Sermorelin, by preserving normal GH secretory patterns, is not subject to tachyphylaxis in the same way that exogenous GH is[2]. Because of the way in which Sermorelin works, it is subject to normal physiologic feedback mechanisms and therefore has less effect on GHRH receptor density and overall numbers. Essentially, the administration of Sermorelin leads to higher levels of GH without affecting levels of GHRH and GH receptors in the body[1]. Thus, drug holidays are generally not needed.

NOTE: The benefits of Sermorelin are more relevant to adults than to children. This is because children are physiologically different than adults due to a number of factors. For instance, long bone growth that occurs after the closure of the growth plates can lead to deformity and other serious problems in adults. For children, careful supplementation with GH can take advantage of the fact that growth plates are still active. Research in this area suggests that Sermorelin may be a safer alternative for adults in a number of ways, though extensive clinical trials for this indication have yet to be conducted.

Sermorelin has been shown to have a number of positive effects on wound healing. It not only increases the rate of tissue regeneration, but decreases scar formation, reduces inflammation, and helps to mitigate risk of infection. It may also have an antioxidant effect, helping to improve overall tissue health and shift the balance of cytokine production away from inflammatory pathways[3].

Of note, Sermorelin is beneficial for more than just cutaneous (skin) wound healing. Research shows that Sermorelin can help people recover following a heart attack and can reduce the long-term problems associated with scar formation in heart tissue. Rat models of heart attack reveal that Sermorelin can protect cells from death, increase the production of collagen and other extracellular matrix components, increase the rate of new blood vessel growth, and reduce levels of damaging inflammatory cytokines[4], [5]. The net results are reductions in scar extent and overall density of scar tissue. In the heart, this can mean the difference between heart failure and full recovery.

Of course, the other primary application for improved wound healing is in diabetes. Diabetic ulcers and wounds are slower to heal than average and more prone to infection. Sermorelin may help to shift this balance and, as explained in the next section, may even help to reverse some of the other sequelae of diabetes. In fact, Sermorelin may be beneficial in promoting wound healing in a number of immune compromised conditions (e.g. HIV).

As an added aside to the benefits that Sermorelin has on wound healing, there is good research to show that Sermorelin, via its effects on HGH, can increase collagen production and thus improve the structure of skin. Importantly, Sermorelin appears to be associated with increases in skin density. Skin tends to thin and become more fragile with age. By halting and even reversing this process, Sermorelin helps to fight yet another one of the effects of aging.

GH can be thought of as promoting lean body mass over fat mass. Higher levels of GH are associated with increased bone and muscle density as well as reduced adipose tissue. Researchers have, in recent years, been interested in how Sermorelin might be used to promote healthy body composition and fight the effects of diabetes, metabolic syndrome, and obesity. Given the low cost of Sermorelin, it is an ideal candidate for these applications.

The ability of Sermorelin to burn fat is of particular benefit in the aging process because GH levels tend to decrease with age and the risk of developing conditions like diabetes or metabolic syndrome increases. By promoting lean body mass, Sermorelin may not only be able to help ward off disease, it may, as research indicates, help to support health and promote well-being[6]. This is due in part to the fact that Sermorelin shifts energy balance and food preference, helping not only to promote the formation of lean body structure (e.g. muscle) but also shifting food preferences away from fatty options toward those foods that are rich in protein, vitamins, and minerals necessary for supporting bone and muscle growth.

Sleep and longevity are inextricably linked, though the exact nature of that link has not been fully elucidated. Suffice it to say that quality sleep is associated with improved mood, better health, superior brain function, and reduced effects of aging. Believe it or not, sleep and body composition are also linked. While it is often stated that sleep apnea is caused by obesity, the opposite is also true. It is becoming increasingly clear that sleep apnea may, in fact, be a primary driver of certain behavioral changes that lead to obesity.

Unraveling the links between sleep and good health has presented a challenge to researchers for decades. Some progress has been made in our understanding the mechanics of how sleep happens, but very little is known about how quality sleep happens. What we know for certain is that orexin, a potent chemical produced by highly specialized neurons in the brain, is required for proper sleep cycle transitions. Sermorelin, it turns out, boosts orexin secretion and helps to promote proper sleep biochemistry[7], [8]. Thus, even without understanding the nuances of the sleep cycle, scientists can confidently say that Sermorelin improves sleep parameters and leads to better outcomes in the metrics associated with good sleep.

In terms of longevity and aging, sleep is crucial. During sleep, the brains waste clearance system (called the glymphatic system) is orders of magnitude more effective. In fact, without sleep, metabolic byproducts and other toxins accumulate in the brain and eventually lead to dysfunction and even cell death. There is even some evidence that a defective glymphatic system (perhaps as a result of sleep disorder) may be one of the underlying causes of degenerative brain diseases like Alzheimers Disease. The decline in neurogenesis, which is associated with age, may ultimately be a consequence of poor sleep. Research suggests that Sermorelin may help to preserve neurogenesis, a function that may be a result of its benefits on sleep in addition to its GH stimulating properties.

Another thing that happens during sleep and is associated with aging is tissue and DNA repair. As with waste clearance in the brain, these processes are much more efficient during sleep than they are when we are awake. Adequate sleep helps to ward off cancer and infection, improve scarring, and accelerate wound healing. In short, good sleep is an important component of maintaining good health and thus longevity.

In summary, sleep is clearly linked to mood, longevity, and good health. Mood changes are clearly linked to eating behavior and sleep appears to be directly linked not only to eating behavior, but to food preference and energy homeostasis. Research has shown time and time again that adequate sleep is necessary in the maintenance of a healthy body mass and a robust immune system. At least some of Sermorelins impact on body mass, longevity, and overall health is attributable to its influence on the sleep cycle.

HGH treatment has been used for everything from HGH deficiency to warding off the effects of aging. It suffers from two major problems however: cost and serious side effects. Sermorelin is under active research, in part, because it solves both of these problems. Sermorelin costs nearly eight times less than HGH to produce and its side effect profile is substantially better. Scientists are investigating this peptide, which is already used in the clinical setting, to better understand how to harness its benefits. Increased production of sermorelin in the future may help to reduce costs every further, helping to widen the gap between sermorelin prices and prices for other GHRH analogues as well as HGH.

[1] R. F. Walker, Sermorelin: a better approach to management of adult-onset growth hormone insufficiency? Clin. Interv. Aging, vol. 1, no. 4, pp. 307308, 2006, doi: 10.2147/ciia.2006.1.4.307.

[2] S. T. Wahid, P. Marbach, B. Stolz, M. Miller, R. A. James, and S. G. Ball, Partial tachyphylaxis to somatostatin (SST) analogues in a patient with acromegaly: the role of SST receptor desensitization and circulating antibodies to SST analogues, Eur. J. Endocrinol., vol. 146, no. 3, pp. 295302, Mar. 2002, doi: 10.1530/eje.0.1460295.

[3] L. Recinella et al., Anti-Inflammatory, antioxidant, and behavioral effects induced by administration of growth hormone-releasing hormone analogs in mice, Sci. Rep., vol. 10, no. 1, p. 732, Jan. 2020, doi: 10.1038/s41598-019-57292-z.

[4] Bagno Luiza L. et al., Growth HormoneReleasing Hormone Agonists Reduce Myocardial Infarct Scar in Swine with Subacute Ischemic Cardiomyopathy, J. Am. Heart Assoc., vol. 4, no. 4, p. e001464, doi: 10.1161/JAHA.114.001464.

[5] R. M. Kanashiro-Takeuchi et al., New therapeutic approach to heart failure due to myocardial infarction based on targeting growth hormone-releasing hormone receptor, Oncotarget, vol. 6, no. 12, pp. 97289739, 2015, doi: 10.18632/oncotarget.3303.

[6] D. K. Sinha et al., Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males, Transl. Androl. Urol., vol. 9, no. Suppl 2, pp. S149S159, Mar. 2020, doi: 10.21037/tau.2019.11.30.

[7] B. S. Shepherd et al., Endocrine and orexigenic actions of growth hormone secretagogues in rainbow trout (Oncorhynchus mykiss), Comp. Biochem. Physiol. A. Mol. Integr. Physiol., vol. 146, no. 3, pp. 390399, Mar. 2007, doi: 10.1016/j.cbpa.2006.11.004.

[8] A Good Nights Sleep, National Institute on Aging. http://www.nia.nih.gov/health/good-nights-sleep (accessed Nov. 22, 2020).

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Sermorelin Cost: What to know in 2021 - PeptideSciences.com

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Aug 28th, 2021 | Filed under Sermorelin

There are only a few publications that discuss tolerance of hypothalamic and pituitary hormones during breastfeeding. In a series of studies on the contraceptive effect of 600 g of buserelin, a luteinizing hormone-releasing hormone (LRH) antagonist administered nasally, a dosage of 12 g was reported for the fully breastfed infant. Oral bioavailability is poor, so a toxic effect on a breastfed child is not to be expected (Fraser 1989).

The thyrotropin-releasing hormone (TRH) protirelin releases prolactin. Its lactation-promoting use has been discussed (Peters 1991). Toxic effects on a breastfed infant are not to be expected; however, studies are lacking.

Desmopressin is found in the mothers milk in only limited amounts. Oxytocin, which has long been used to induce labor and for postpartum uterine involution, promotes the milk ejection reflex, and has not been shown to be toxic for the infant.

Carbetocin is a synthetic long acting analog of oxytocin, which is used intravenously and intramuscularly. It appears in the mothers milk in minimal amounts (0.00005% of the maternal weight-related dosage) (Silox 1993). There are no data on the use during breastfeeding of the other hypothalamic and pituitary hormones, or their synthetic analogs corticorelin, sermorelin, somatorelin, cetrorelix, chorionic gonadotrophin, gonadorelin, goserelin, leuprolide acetate, menotropin, nafarelin, triptorelin, urogonadotropin, octreotide, somatostatin, tetracosactid, somatropin (growth hormone), follitropin-, follitropin-, urofollitropin, argipressin, lypressin, ornipressin, lanreotide, and terlipressin. This also holds true for the oxytocin-antagonist atosiban and the somatropin-receptor antagonist pegvisomant.

With the exception of oxytocin, hypothalamic and pituitary hormones are seldom indicated during breastfeeding. No toxic effect on the infant has been demonstrated as yet, plus due to its limited oral bioavailability, is this to be expected. Usage for appropriate indications during breastfeeding is allowed.

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Sermorelin - an overview | ScienceDirect Topics

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May 25th, 2021 | Filed under Sermorelin

Growth hormone replacement therapy (GHRT) using recombinant human growth hormone (rhGH) has been embraced by many age management practitioners as one of the most effective methods for opposing somatic senescence currently available. However, its routine use has been controversial because few clinical studies have been performed to determine the potential risks of long-term therapy. Also, certain medical and legal issues have not been resolved causing some practitioners to restrict their use of the product. Some of these issues include the fact that:

Improper dosing can lead to side effects that may be serious in some patients,

Injection of hGH creates unnatural conditions of exposure to the hormone that may erode normal physiology,

The Code of Federal Regulations specifically forbids the use of rhGH in adults except for treatment of AIDS or human growth hormone deficiency (GHD) diagnosed pursuant to regularly accepted guidelines.

While there is a wealth of information showing that long-term administration of rhGH reduces intrinsic disease and extends life in adults suffering pathogenic GHD, consensus on whether extrapolation of those data to the aging condition is justified has not been reached (Perls et al 2005). Most of the major concerns derive from the fact that rhGH is mitogenic and may awaken latent cancers, that improper dose selection may promote metabolic disorders such as diabetes, and perhaps that pharmacological presentation may exacerbate decline of endocrine function by distorting essential hormonal interactions. Of course, all these concerns are speculative and will not be resolved until sufficient scientific evidence for or against GHRT eventually accumulate. In the interim, the value of rhGH in GHRT will continue to be debated; unfortunately based more upon personal prejudice than objective information.

Despite the eventual outcome to the Great Hormone Debate as it has been titled in media articles (Landsmann 2006), certain negative aspects of GHRT using rhGH cannot be disputed and justify searching for a better alternative. For example, square wave or pharmacological presentation of the exogenous hormone cannot be avoided since it is administered as a bolus, subcutaneous injection. Since the amount of rhGH entering the general circulation is not controlled by normal feedback mechanisms, tissue exposure to elevated concentrations is persistent and eventually may lead to tachyphylaxis and reduced efficacy. Also, because the body cannot modulate tissue exposure to rhGH, the practitioner is required to best guess the appropriate dosage based upon little other than serum measurements of insulin-like growth factor-1 (IGF-1) and subjective comments from the patient about perceived responses to the hormone. Thus, it would seem that an alternative method(s) of GHRT that circumvented these problems would be of great value so long as it retained the positive attributes of rhGH.

One possibility that is receiving growing attention is the use of GH secretagogues to promote pituitary health and function during aging. An example of such molecules is growth hormone releasing factor 129 NH2-acetate, or sermorelin, that recently became available to practitioners for use in longevity medicine (Merriam et al 2001). Other alternatives include orally active growth hormone-releasing peptides that are currently being developed by pharmaceutical companies. Some of these have been reported to be effective at improving physical performance in the elderly (Fahy 2006). However, it is unlikely that they will be marketed for several years. On the other hand, sermorelin, an analog of naturally occurring growth hormone-releasing hormone (GHRH) whose activity declines during aging, may presently offer a more immediate and better alternative to rhGH for GHRT in aging (Russell-Aulet et al 2001). The molecule was commercially produced and marketed for many years as an alternative to rhGH for use in children with growth retardation, but it could not compete with rhGH and was withdrawn as a therapeutic entity by the manufacturer. Paradoxically sermorelin failed as a growth-promoting agent in children for the very reason that it is a better alternative for GHRT in aging adults. Growth-deficient children need higher doses of growth hormone than can be achieved by stimulating production of their own hormone, whereas the beneficial effects of sermorelin on pituitary function and simulation of youthful growth hormone secretory dynamics in aging adults have little effect on growth rate in children. Unlike exogenous rhGH that causes production of the bioactive hormone IGF-1 from the liver, sermorelin simulates the patients own pituitary gland by binding to specific receptors to increase production and secretion of endogenous hGH. Because sermorelin increases endogenous hGH by stimulating the pituitary gland, it has certain physiological and clinical advantages over hGH that include:

Effects are regulated by negative feedback involving the inhibitory neurohormone, somatostatin, so that unlike administration of exogenous rhGH, overdoses of endogenous hGH are difficult if not impossible to achieve,

Because of the interactive effects of sermorelin and somatostain, release of hGH by the pituitary is episodic or intermittent rather than constant as with injected rhGH.

Tachphylaxis is avoided because sermorelin-induced release of pituitary hGH is not square wave, but instead simulates more normal physiology,

Sermorelin stimulates pituitary gene transcription of hGH messenger RNA, increasing pituitary reserve and thereby preserving more of the growth hormone neuroendocrine axis, which is the first to fail during aging (Walker et al 1994).

Pituitary recrudescence resulting from sermorelin helps slow the cascade of hypophyseal hormone failure that occurs during aging thereby preserving not only youthful anatomy but also youthful physiology (Villalobos et al 1997).

Finally, there is the question of lawful practice. Unlike rhGH which has legal restrictions on its clinical use, the off-label prescribing of sermorelin is not prohibited by federal law. Thus, it can be carefully employed and evaluated by the practitioner to objectively determine whether it provides greater benefits with less risk to his/her patients. In support of this effort, the Society for Applied Research in Aging will be providing sermorelin free of cost on a competitive basis to practitioners willing to study its effects under protocol conditions and to report the outcomes in a peer-reviewed journal such as Clinical Interventions in Aging. Hopefully, through such efforts we can contribute to development of a paradigm for evidence-based GHRT in clinical age management.

For more information on this effort and to participate in the protocol, please contactmoc.sserpevod@nileromres.

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Sermorelin: A better approach to management of adult-onset ...

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May 25th, 2021 | Filed under Sermorelin

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This informative destination has a plethora of articles regarding all subjects related to HRT

LOS ANGELES--(BUSINESS WIRE)--The physicians at Elite HRT have collaborated on a new website to serve as a one-stop destination for information regarding Hormone Replacement Therapy. This stylish web destination contains numerous articles regarding the potential benefits and detractions involved in various HRT treatments like Human Growth Hormone Therapy (HGH), Testosterone Replacement Therapy (TRT), and Nutraceutical Injections. Elite HRT understands that HRT needs from person to person vary greatly, and hope that this new web design can arm anyone with the information they need to make the right decisions for them.

Elite HRT has worked as on-site and online consultants since 2013, offering medical expertise on innovative new anti-aging and wellness practices. Their treatments are focused on patients goals and individual desires, meaning that no two approaches are exactly the same. To this end they strive to inform their patients as much as possible, equipping them with the knowledge and awareness of all possible hormone therapies so they might know which one is best for them. This information is both cited and sourced to allow patients to do their own research, and to provide transparency so users can understand the science behind these treatments.

Prominently featured on this striking new website are dedicated pages to highlight the different available treatments, so users can compare and contrast each one. These pages focus on HGH injections, Nutraceutical injections, Sermorelin, Testosterone injections, and other low testosterone treatments, highlighting the benefits and potential detractors of each one. Each of these pages is distinct, offering specific nutrients seen in the Nutraceutical treatments and the most prevalent symptoms of low testosterone; this is because each hormone therapy is wholly unique, and taking a one size fits all approach did a disservice to the merits of each individual practice. Elite HRT is pleased with the results, and believe they reflect the diversity of available options.

Online consultations and telemedicine also enable these treatments to be available in rural communities and can help reduce costs by not requiring the use of a dedicated physicians office. As hormone therapies are typically seen as elective and not covered by health insurance plans, Elite HRT works to make these treatments as accessible as possible, including their price. Users can also make use of a local physician for providing physical information and medical history, as part of evaluating the proper treatments for that person.

Elite HRT is proud to offer a one-of-a-kind destination for Hormone Replacement Therapies and all their permutations, so curious users can learn about HGH, TRT, and more from the same destination. With a thorough commitment to providing transparently sourced information and acknowledging the medical professionals who compiled this information, Elite HRT strives to provide information and consultations of the highest quality.

About Elite HRT:

Elite HRT is a telemedicine firm led by a network of physicians specializing in hormone replacement therapies. With unique approaches to HRT, TRT, HGH, and more, Elite HRT works to tailor solutions uniquely created for specific patients, all at affordable rates. Those wanting to learn more and contact Elite HRT can visit https://www.elitehrt.com/ and submit a contact request form with background information today.

View source version on businesswire.com: https://www.businesswire.com/news/home/20210421006035/en/

Michael Fischer855-767-0021info@elitehrt.com

Source: Elite HRT

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Elite HRT Releases New Website With Information on Hormone Replacement Therapy - StreetInsider.com

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Apr 28th, 2021 | Filed under Sermorelin

Stacking sermorelin with a GHRP product isnt simply a good idea; its completely necessary if you want to optimise its effects. This is especially true of those who wish to improve their anabolic capacity.

As per sermorelin doses, you would ordinarily need to implement GHRP at a rate of 1 mcg per kg of bodyweight, however; when using GHRH and GHRP products in unison, this warrants a half dose of each one as they both boost each others effects dramatically. This boost negates the need for integrating either product at the saturation level as would ordinarily occur when taking them in isolation.

Further to this, its important that you leave three hours in between your combined GHRH / GHRP injections to give the latter product enough time to exit the system before another dose is applied. There is no stated limit in regards to how many pulses you can create per day many users choose to create between 3 4.

The first one would typically occur first thing in the morning, with each subsequent dose falling roughly 3 4 hours apart, concluding in one final pre bedtime injection roughly one hour before sleeping. In regards to how long you can safely use both items together for (or in isolation) there are again no specific guidelines in regards to maximum cycle length.

Youll realistically need to implement them together for at least 12 weeks to see any effect take place; further to this, cycles of anywhere up to 24 or even 30 weeks and beyond are not uncommon.

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Sermorelin Dosage - Sermorelin

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Mar 11th, 2021 | Filed under Sermorelin

While Stephanie Davison impressed many 90 Day Fianc fans with her youthful looks, the Skin Envy owner has promoted her clinic's products for years.

Theres a cougar on the prowl in 90 Day Fiancand this time around, its season eights Stephanie Davison. This weeks episode of the TLC show featured the seasons last couple, Ryan Carr and Stephanie. But as the Grand Rapids star revealed her age, many couldnt believe she was 52...until they saw what Stephanie did for a living. Being the brand ambassador of her own weight loss business, it was natural for Stephanie to inject a strange substance called sermorelin into her skin. But turns out the 90 Day Fianc star has been preaching its benefits since 2015.

It took four episodes for 90 Day Fianc season eight couple Stephanie and Ryan to finally show up with their unique love story. While the trailers and previews teased yet another short-lived TLC-style romance, self-confessed cougar Stephanie and her cub Ryan seem to have plenty of secrets. As Stephanie blamed the distance between Michigan and Belize for creating trust issues between her and Ryan, whos half her age, 90 Day Fianc fans saw her reveal a scandalous skeleton in her closet. Not only had Stephanie cheated on Ryan in their three-year relationship, but the person she hooked up with was Ryans cousin, Harris. But of course, Stephanie continued seeing her youngest and hottest ever boyfriend despite the secret and him texting multiple other girls while dating her. In addition,90 Day Fianc fans saw Stephanie trying her best to look young and, to an extent, succeeding at it.

Related:90 Day Fianc: All The Cosmetic Surgery Procedures Deavan Clegg Has Done

The lifelong bachelorette Stephanies intro on 90 Day Fianc showed her practicing for a 100-hour Guinness World Records championship while wearing strange glasses that reset her circadian rhythm. However, even stranger was watching Stephanie inject herself with youth serum shots every morning to stay the face of her business and look 30 at 52! For those wondering, the shots were sermorelin injections that Stephanies clinic,Skin Envy, claims can help one reclaim their youth by reversing the biological signs of aging. The website adds, Its a safe biosynthetic hormone that naturally stimulates the production of the bodys own HGH (Human Growth Hormone) through the pituitary gland.

Interestingly, the 90 Day Fianc star was selling this mysterious sermorelin back in 2015, for which she was featured on Fox17 news. A slightly younger-looking Stephanie says in the video, You know the great thing I love about all the three products that I offer at Skin Envy is that all are interchangeable. Ryans sugar mama continues, I have sermorelin which is basically, they call that the anti-aging shot. 90 Day Fiancs Stephanie claims the injection not only helps the immune system and improves sleep, but also helps one's skin tone, muscle mass, and body fat. A text box saying, Lose up to 40 lbs in 40 days shows up on the screen, and Stephanie further reveals she also offers HGC injections, which reset metabolism, and mesotherapy to do spot reduction of cellulite and fat. See her advertisement in the video below:

Seeing Stephanie use her products on 90 Day Fiancwhile also speaking of her clinic might just be a well-thought-out marketing strategy after all. With her looks that got her a 27-year-old boyfriend, Stephanie could convince more than a few viewers to turn into potential customers if she keeps playing her reality TV cards right.

Next:90 Day Fianc: Angela Deems Smaller Chest Sparks Surgery Rumors

90 Day Fianc season 8 airs Mondays at 8 pm EST on TLC.

Source: Skin Envy,Fox17Online

90 Day Fianc: Why Fans Think Natalie May Have Gotten Plastic Surgery

Saylee Padwal is a Reality TV Features Writer for Screen Rant. When she's not thinking about pop-culture or food, you can always find her "investigating" her way through Instagram, reading mysteries and thrillers, and listening to BTS on loop.

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90 Day Fianc: Throwback Video Shows Stephanie Selling ...

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Jan 27th, 2021 | Filed under Sermorelin

'90 Day Fiance' stars Stephanie Davison and Ryan Carr's relationship never really took off. It's been a little over a month since Season 8 of the show has premiered but there's been no progress on that front. The couple is yet to share their stories fully on television.

However, in this week's episode, we learned more about Stephanie and the kind of work she does for a living that kept her from focussing on love and marriage so far. Here's all we know about the Skin Envy place where she works. If you're wondering if that's the secret to her drop-dead gorgeous look, here's the truth.

She is an entrepreneur and operates two medical spas out of Michigan. Skin Envy was designed for clients looking at easy age reversal and weight loss options. Stephanie has been making good sales out of her two outlets and what seems to have worked for her is trying some of these shot serums on herself. She injects herself with Sermorelin, which apparently wakes up her pituitary gland and that helps restore youth.

Her clinics also offer HGC injections for those wanting to shed a few extra kilos. The shots "stimulate the bodys natural ability to produce HGH leading to renewed energy, sex drive, lowered body fat and so much more," her website writes. Woah!

This aside, the spas also have mesotherapy, hydra facial, infrared sauna, and more on the roster. But how effective are these treatments? The testimonials on the Skin Envy site is proof enough. "My love handles would not go away no matter how much I would diet or exercise. Mesotherapy has helped me to get a more shapely waist!," Jan M reviewed the treatments.

Also, Stephanie had two of her cousins, Shannon and Ryanne, visit her on the show. Apparently, Shannon lost 80 pounds by Skin Envy's methods and so Ryanne wanted to test it out and see if she can achieve similar results and it clearly worked for her!

Although her '90 Day Fiance' paycheck is not known, her estimated net worth from all the successful businesses she owns is at $1.5 million, Starsoffline reported.

Catch all the new episodes of '90 Day Fiance' on TLC every Sunday at 8/7c. For more information, check your local listings.

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'90 Day Fiance': What is Stephanie Davison's job and net worth? Truth behind 80 pounds weight loss from inject - MEAWW

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Jan 5th, 2021 | Filed under Sermorelin

Aging, its something every one of us is concerned about as it brings a lot of frustrating changes that are an inevitable part of life. As we reach 50, we face a number of problems such as weight gain, wrinkles, increased lipid levels, and many other problems. While some of these problems are not preventable but we can take some steps to improve health and well being so that we can sense our best despite what age we are. This is where peptides therapy helps.

What Are Peptides?

Peptides are biological molecules present in all living organisms and produced naturally by the body. Like proteins, peptides are also made up of amino acids that are linked together to form a short chain of amino acids. They function as a signaling molecule inside the human body, commanding other molecules and cells on what functions to perform. Our body has more than 7000 known peptides, and every peptide perform different functions, including immune system health, hair loss, weight loss, and many more.

What Is Peptide Therapy?

Peptides are produced in the body naturally, but the production of peptides varies in individuals, and as we age, we can see a decline in the production of peptides. This therapy is something we are hearing about now, perhaps but will be very popular therapy in the future.

Peptides are amino acids that can actually be developed to stimulate the receptors to create the effect. For instance, if you want to stimulate growth hormone, we can develop a peptide to actually work on a receptor site, to stimulate the pituitary gland that can naturally produce growth hormone.

Benefits of Peptide Therapy

As there are so many peptides, peptide therapy has a wide range of benefits, including hair loss, weight loss, enhance the immune system, improved cognitive function, and some more. Below are some benefits of this therapy.

One particular peptide, called peptide CJC 1295, helps in increasing the production of an essential growth factor in the human body. Usage of this peptide during treatment leads to lean muscle growth, fat loss, and better sleep.

Another peptide includes ipamorelin, and sermorelin increases the production of growth hormone, thereby boost in stamina and lean muscle mass and reducing the refractory time during the workout.

Thymosin alpha-1 (TA-1) enhances the bodys capability to fight against the harmful virus, and bacteria TA-1 is the most used peptide in the therapy, as many young people have chosen to strengthen their immune system with the help of this hormone.

Apart from TA- 1, cerebrolysin is another peptide commonly used in the therapy because of its intensification of few brain functions. It is also proven that cerebrolysin has also improved short and long term memory and increase motivation.

These are some popular forms of peptides treatment, Apart from these, there is much more therapy presents out there, and their benefits include.

Why Should Peptide Therapy Be Used?

Apart from all the benefits, it is a very safe and effective treatment that will not cause any major side effects. So, if the above-mentioned benefits sound engaging to you, consider having a word with your doctor to know more about peptide therapy.

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Peptide Therapy The Growing Traction - MMA Corner

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Jun 28th, 2020 | Filed under Sermorelin
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