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There are so many factors that go into getting a good nights sleep, and balanced hormones is one of them. Hormones, such as testosterone, are intricately tied to sleep. If your testosterone is too high or too low, it can affect how well you sleep, how long you stay asleep, how easily you fall asleep, and even if you experience certain sleep disorders like sleep apnea.
And even more frustrating, if your testosterone levels disrupt your sleep, your hormone levels may drop even more, creating a vicious cycle, Cameron Rokhsar, M.D., FAAD, FAACS with New York Cosmetic Skin & Laser Surgery Center, tells Sleepopolis.
Fortunately, there are some solutions to help you break the cycle read on to uncover the connection between testosterone and sleep, and how you can overcome the associated challenges.
There is a circular connection between testosterone and sleep. That means that having too high or too low testosterone levels can disrupt your sleep, but it also means that if youre not sleeping enough, it can decrease your testosterone levels too which will then further disrupt your sleep.
Sleep deprivation can cause a significant decline in testosterone production, Dr.Tun Min, General Practitioner in the UKs National Health System, tells Sleepopolis. For instance, Min references a study done by the University of Chicago which found that in young healthy men, sleeping less than five hours a night decreases their testosterone level by 15 percent in only one week.
The study was a small one, involving only ten men, but it did demonstrate how much of an impact sleep can have on testosterone levels, even on a small scale.
Additionally, a 2021 systematic review and meta-analysis of available studies done by Sleep Medicine found that serum testosterone (the amount of testosterone that can be measured in the blood) in males significantly decreased after only 24 hours of total sleep deprivation, and decreased even more so after the 40-48 hour sleep deprivation mark.
Normal testosterone levels vary by sex and also by age for males. That means that a male in their 20s will have a normal testosterone level that is higher than a male in their 40s.
In males, normal testosterone levels range from 300-1,000 ng/dL, with the highest levels seen during the teenage years, notes Rokhsar. Anything under 300 ng/dl (nanograms per deciliter) is considered to be low testosterone levels, according to the American Urological Association (AUA).
According to the AUA, normal serum testosterone levels for males are:
Female testosterone levels tend to be more steady. According to the Centers for Disease Control and Prevention (CDC), normal serum testosterone levels for females are:
Testosterone levels also decline naturally as we age. For instance, the Journal of the American Medical Association explains that men will see a normal 1-2 percent decrease in testosterone levels every year starting around the age of 30 or 40.
Min adds that because testosterone is primarily produced in the ovaries of premenopausal women, levels will decline rapidly after menopause. Like men, serum testosterone levels vary widely [in women], and it is important to correlate clinical symptoms with [hormone] levels to determine true deficiencies, he says.
High testosterone levels can absolutely disrupt your sleep. And if youre someone who is using steroids, Rokhsar warns that high testosterone levels due to the misuse of anabolic steroids have been linked to reduced sleep time, insomnia, and waking up more often during the night.
Harvard Health notes that excess testosterone isnt a very common issue in males, but if it does occur, it can lead to symptoms such as:
In females, excess testosterone can be associated with:
Low testosterone is connected to poor sleep, but the exact relationship isnt 100 percent clear. Low testosterone levels could cause disruptions in sleep, or it could be that sleep disruptions themselves could lead men to develop lower testosterone levels.
For instance, a 2018 study in the American Journal of Mens Health found that men who are sleep-deprived defined as regularly sleeping less than 5 hours per night have lower testosterone levels than males who get enough sleep.
The study found that sleep duration, independent of age, exercise amount, and body mass, was positively associated with testosterone levels. Men who slept for less than four hours had 60 percent lower total testosterone than men who slept for more than eight hours, says Rokhsar.
And while the study cant show if men arent getting enough sleep because they have low testosterone to begin with or if having low testosterone levels causes them not to sleep well or if its both it does show there is a connection between poor sleep and low testosterone.
Its important to note that women have naturally lower levels of testosterone and dont seem to be affected in the same way as men with low testosterone levels.
The AUA explains that in males, symptoms of low testosterone include:
Symptoms of low testosterone are broad and can be similar to symptoms of many other conditions, says Rokhsar, so its important to speak to your doctor about any symptoms you are experiencing to get accurately diagnosed and treated appropriately. For instance, the AUA notes that using opioids, having certain medical conditions, damage to the testicles, diabetes, and obesity can all lead to low testosterone levels.
Moreover, aging and the natural decline of total testosterone could affect sleep too. Older people report finding it harder to fall asleep and stay asleep, which could be linked to lower testosterone levels as well, says Rokhsar.
Obstructive sleep apnea (OSA) has a well-studied link to low testosterone levels. There is a clear connection between testosterone levels and sleep apnea, says Rokhsar. He explains that testosterone levels usually peak at the time of rapid eye movement (REM) sleep, but people with sleep apnea will have reduced REM sleep, reduced deep sleep time, increased nighttime awakenings, and sleep fragmentation all of which can yield low testosterone production.
He also notes that low testosterone levels appear to be linked to lower-quality sleep and fewer deep sleep cycles. And in general, he says that as testosterone goes down, the hormone cortisol increases. This can cause an increase in stress, which can negatively impact sleep quality, Rokhsar adds.
But again, the link between low testosterone and sleep apnea isnt entirely clear on causation. While we know that males with OSA have definitively lower levels of testosterone, the studies that show this note its not immediately clear if males develop OSA as a result of having low testosterone levels or if OSA causes testosterone levels to drop.
The study in Worlds Journal of Mens Health also explained that treating OSA did not seem to raise testosterone levels, but giving males who had OSA and low testosterone levels testosterone treatment therapy did seem to improve their sleep apnea symptoms, as well as other associated symptoms like erectile dysfunction.
However, the study also noted that for some men, hormonal therapy with testosterone actually made OSA worse, so its not a clear-cut answer.
Rokhsar points out that many different sleep disorders and difficulties are associated with reduced testosterone levels. These include:
These disorders can all cause testosterone levels to drop, which will then further impact sleep.
First things first: It is essential to recognize the relationship between sleep and testosterone levels and take steps to improve your sleep quality, says Rokhsar. So if you know you have low testosterone levels, its to your advantage to do everything you can to prioritize sleep in your life.
So how exactly do you prioritize sleep? Well, you can start by assessing your current sleep hygiene practices and making changes as needed. Rokhsar suggests starting by:
Low testosterone can be diagnosed through a simple blood test, says Rokhsar, so its important to start by talking to your doctor. Symptoms of low testosterone can overlap with many other medical conditions, so youll want to rule out all other conditions first.
Additionally, certain medical conditions can cause low testosterone, so you may need to address the root cause of your testosterone levels to fix the problem.
Because testosterone levels are different for every person and will be impacted by many different factors, such as medical conditions, medications, your age, and body type, you will need to work with a doctor to develop an individual treatment plan for you. Low testosterone levels can be treated through testosterone replacement therapy, which can be administered in various forms, including injections, gels, patches, or pellets, Rokhsar explains.
If you are frequently waking up at night, find yourself gasping for air at night, or wake up feeling extremely tired, it may also be worthwhile to talk to your doctor about getting checked for sleep apnea.
Sleep apnea is directly connected to low testosterone levels, and the condition has many other negative health impacts. Treating sleep apnea can improve both your sleep quality and other health factors at the same time.
Having excess or low testosterone levels can impact sleep quality, duration, and the ability to fall asleep in both males and females. However, low testosterone in males in particular is associated with poor sleep as well as actual sleep disorders, including sleep apnea.
A doctor can confirm your testosterone levels with a simple blood test, so if you suspect you have a problem with your testosterone levels or are having difficulty sleeping, its important to start by talking to a doctor. They can test your testosterone levels and rule out other conditions that could be contributing or causing your symptoms.
Leproult R, Van Cauter E. Effect of 1 week of sleep restriction on testosterone levels in young healthy men. JAMA. 2011;305(21):2173-2174. doi:10.1001/jama.2011.710.
What is Low Testosterone? UrologyHealth.org. Published 2023. Accessed April 13, 2023. https://www.urologyhealth.org/urology-a-z/l/low-testosterone.
Vesper Hubert W. Serum Total Testosterone Concentrations in the US Household Population from the NHANES 20112012 Study Population. Clin Chem. 2015 December ; 61(12): 14951504. doi:10.1373/clinchem.2015.245969.
Wittert G. The relationship between sleep disorders and testosterone in men. Asian J Androl. 2014;16(2):262-265. doi:10.4103/1008-682X.122586.
Testosterone What It Does And Doesnt Do. Health.Harvard.edu. Published August 29, 2019. Accessed April 13, 2023. https://www.health.harvard.edu/medications/testosteronewhat-it-does-and-doesnt-do.
Abu-Samak MS, Mohammad BA, Abu-Taha MI, Hasoun LZ, Awwad SH. Associations Between Sleep Deprivation and Salivary Testosterone Levels in Male University Students: A Prospective Cohort Study. Am J Mens Health. 2018;12(2):411-419. doi:10.1177/1557988317735412.
Insomnia in Older Adults: Tips to Master Sleep as We Age. SMB.org. Accessed April 13, 2023. https://www.sbm.org/healthy-living/insomnia-in-older-adults-tips-to-master-sleep-as-we-age?gclid=CjwKCAjw0N6hBhAUEiwAXab-TRHBLE4MKtHXRLCuB-TNflxwMQyXjlVpXIxLwP929ICocpj2NgkyAxoC7L4QAvD_BwE.
Kim SD, Cho KS. Obstructive Sleep Apnea and Testosterone Deficiency. World J Mens Health. 2019;37(1):12-18. doi:10.5534/wjmh.180017.
Rokhsar, Cameron. MD, FAAD, FAACS New York Cosmetic Skin & Laser Surgery Center. Personal interview April 5, 2023.
Min, Tun. General Practitioner in the UKs National Health System. Personal interview April 5, 2023.
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Chaunie Brusie is a mom of five, a native Michigander, and a Registered Nurse turned writer and editor. She specializes in health and medical writing. Her work has appeared everywhere from The New York Times to Glamour to Parents magazine.
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Testosterone and Sleep - Sleepopolis
Charlotte, NC - (NewMediaWire) - May 10, 2023 - Hormonal imbalances in men can result in several unpleasant symptoms that can significantly affect their quality of life. These symptoms include decreased libido, fatigue, depression, weight gain, and muscle loss, among others. Fortunately, testosterone replacement therapy can help alleviate these symptoms and improve overall wellness.
QC Kinetix (Charlotte) offers testosterone replacement therapy as a natural and effective way to address hormonal imbalances in men. Their board-certified physicians specialize in diagnosing and treating hormone deficiencies, ensuring that each patient receives a personalized treatment plan tailored to their specific needs. The clinic's advanced technology and equipment ensure patients receive the best possible care and treatment outcomes.
"Don't let your lack of intimacy, energy, and restful sleep limit your potential. At QC Kinetix (Charlotte), we help our patients restore their hormone balance so they can experience the vitality of life again," said the clinic's spokesperson.
Muscle mass and bone density are crucial in men active in sports and other physical activities. Unfortunately, the content of these two essential body components is influenced by testosterone, which diminishes over time. This can result in an increased risk of injury from everyday activities. QC Kinetix (Charlotte) recognizes this natural decline of testosterone and has incorporated testosterone replacement therapy in its treatments to help men remain active. By helping men maintain a healthy balance of hormones, the Charlotte testosterone replacement therapy clinic has been instrumental in helping them achieve optimal fitness and wellness.
A sedentary lifestyle has long been known as a leading cause of weight gain. However, it's worth noting that decreased testosterone levels can also play a significant role in this condition. Fortunately, QC Kinetix (Charlotte) is committed to helping men achieve their weight loss goals by providing comprehensive guidance and support through testosterone replacement therapy. This innovative treatment approach has been shown to improve self-esteem and overall well-being, helping men feel more confident and energized as they work towards their weight loss goals.
Sleep difficulties can be caused by a variety of factors, including hormonal imbalances. Men who suffer from an imbalance in testosterone levels may experience a significant impact on their quality of sleep. QC Kinetix (Charlotte) recognizes the importance of restful and restorative sleep in maintaining good health and well-being. That's why they offer a range of restorative therapies designed to help their patients achieve more restful and restorative sleep. Patients who have undergone these treatments have reported significant improvements in their quality of life, including better sleep and improved energy levels.
QC Kinetix (Charlotte) also offers a range of restorative therapies that target joint pain. Their board-certified physicians have extensive experience diagnosing and treating joint pain conditions, including those affecting the knee, hip, ankle, shoulder, elbow, and wrist. Whether patients are experiencing acute or chronic joint pain, the clinic provides customized treatment plans to alleviate their symptoms and improve their mobility.
The clinic's regenerative medicine therapies also aim to help athletes and active individuals recover from injuries sustained during workouts, in the field, or due to overuse. These natural treatments can be an alternative to knee and hip replacement surgeries and can help with a range of injuries, including sprains, strains, back injuries, and torn ACL/MCL.
Through QC Kinetix's natural treatments, patients can regain mobility and enjoy activities that they once performed with ease. For example, patients who once struggled to walk or run due to joint pain can now engage in these activities without discomfort. Similarly, patients who had to give up their favorite sport or hobby due to muscle pain or injury can resume their activities after receiving the clinic's restorative therapies.
To make patients feel at ease and relaxed during their treatments, QC Kinetix (Charlotte) offers concierge services, such as refreshments and comfortable seating. Additionally, they provide logistical support to ensure that patients can focus on their recovery without worrying about scheduling or transportation issues.
QC Kinetix (Charlotte) is located at 309 S Sharon Amity Rd Suite 302, Charlotte, NC, 28211, US. Contact the testosterone replacement therapy clinic at (704) 360-3057 or visit their website to learn more about their services.
Media Contact:
Company Name: QC Kinetix (Charlotte)
Contact Person: Marc Difronzo
Phone: (704) 360-3057
Address: 309 S Sharon Amity Rd Suite 302
City: Charlotte
State: NC
Postal Code: 28211
Country: US
When it comes to mens health, testosterone is a big deal. It helps build muscle, strengthens bones, and keeps the libido humming. But as men age, their testosterone levels naturally decline, leading to all sorts of health problems. Thats why many men are turning to natural supplements like Tongkat Ali to rev up their hormone production. But does it really work? A 2016 survey found that 43% of men over 40 have tried it, so lets dive into the science and see what the verdict is.
Elm & Rye Tongkat Ali Supplements
Double Wood Supplements Tongkat Ali Extract 200 to 1 for Men
Nutricost Tongkat Ali
Ultra6 Nutrition Testosterone Booster
Earth Elixir Fadogia Agrestis 600mg and Tongkat Ali 500mg Supplements
Dorado Nutrition Fadogia Agrestis 600mg & Tongkat Ali 400mg Performance Blend
Thalacy 1600mg Fadogia Agrestis Tongkat Ali Supplement
Naturebell Fadogia Agrestis 600mg Complexed with Tongkat Ali 400mg
aSquared Nutrition Fadogia Agrestis 1000mg & Tongkat Ali 400mg
VEGATOT Ultimate Testo Support
Rainbow Nutrients Fadogia Agrestis 15,000mg + Tongkat Ali
Gorilla Mind Sigma Testosterone Booster
Vital Herbal Ultra Fadogia Agrestis 10:1 Extract with Tongkat Ali Capsules
Looking to tap into your full potential? Look no further than Tongkat Ali, a powerful Southeast Asian plant with a centuries-old reputation for health and vitality. Also known as Eurycoma longifolia, this natural remedy delivers a wide range of benefits, from boosting libido to enhancing athletic performance and improving male fertility. The secret is in its natural ability to increase testosterone levels, giving you the energy and drive you to need to reach your goals. Ready to see what Tongkat Ali can do for you? Give it a try today and discover the limitless potential within.
Are you looking for a natural solution to improve your testosterone levels? Look no further than Tongkat Ali! This powerful supplement has been studied extensively, with some exciting findings. According to the Journal of the International Society of Sports Nutrition, Tongkat Ali can increase testosterone levels significantly after just five weeks of use. And if that wasnt impressive enough, research published in the Journal of Ethnopharmacology suggests that Tongkat Ali may also improve semen quality, making it a game-changer for infertile men.
Unlocking the mystery surrounding Tongkat Ali and testosterone levels has proven to be a complex puzzle for researchers. While some studies have suggested that this plant extract can help boost testosterone, a recent study published in the Journal of the International Society of Sports Nutrition found no significant increase in testosterone levels among resistance-trained male athletes taking Tongkat Ali supplements. So, what does this all mean? Well, it seems that the jury is still out on whether or not Tongkat Ali can actually help increase testosterone. More research is needed before we can confidently say whether or not this plant extract is truly effective in this regard.
Looking to try Tongkat Ali? While its generally safe, its good to be aware of potential side effects. Some people may experience insomnia or anxiety, while others may have gastrointestinal problems. Plus, if youre taking other medications, make sure to check with your healthcare provider before adding Tongkat Ali to your routine. Stay safe, and happy supplementing!
These are our top recommendations for those looking for the best tongkat ali and testosterone supplements:
(Elm & Rye | Penguin, sponsored) Elm & Rye Tongkat Ali Supplements are an amazing way to help boost your bodys natural testosterone levels.
Elm & Rye Tongkat Ali Supplements are an amazing way to help boost your bodys natural testosterone levels. Testosterone plays a major role in establishing muscle, facilitating improved energy levels and cognitive functions, and even increasing libido for those seeking a stronger bedroom experience. With tongkat ali root extract being one of the key ingredients of the supplements, consuming them can give your body proper nourishment and help you with achieving your fitness goals. Not only are Elm & Rye supplements derived from natural sources and designed with safety in mind but they have also been proven to bring about visible improvements in both physical and mental health.
(Double Wood | Penguin, sponsored) With the help of Double Wood Supplements Tongkat Ali Extract and some simple lifestyle changes, you can regain hormonal balance and feel more energized and vital than ever before.
Are you feeling a lack of energy and vitality due to a decrease in testosterone levels? Look no further than Double Wood Supplements Tongkat Ali Extract 200 to 1. This all-natural supplement has a rich history in traditional Asian medicine and is designed to help support normal hormone balance in men, including testosterone. Responsibly cultivated from the tongkat ali root, this supplement boasts a potent extraction ratio of 200:1 to ensure only the most premium quality is delivered to customers. With the help of Double Wood Supplements Tongkat Ali Extract and some simple lifestyle changes, you can regain hormonal balance and feel more energized and vital than ever before. Dont miss out on this opportunity to improve your overall well-being!
(Nutricost | Penguin, sponsored) Say goodbye to mediocre results and hello to a better you!
Are you looking to take your athletic performance to the next level? Perhaps youre looking for ways to enhance your libido or overall health. Look no further than Nutricost Tongkat Ali! This powerful supplement has been shown to not only boost testosterone levels but also reduce stress and improve cognitive ability. With tongkat ali in your routine, you can feel confident that your testosterone levels are where you want them to be. Say goodbye to mediocre results and hello to a better you!
(Ultra6 | Penguin, sponsored) Say goodbye to synthetic supplements and hello to sustained and healthy metabolic functioning with Ultra6s testosterone booster.
Looking to boost your energy levels and strength? Ultra6 Nutrition might have the solution for you with its advanced testosterone booster. Formulated with natural ingredients like tongkat ali extract, this innovative formula aims to increase testosterone production without any harmful side effects. So say goodbye to synthetic supplements and hello to sustained and healthy metabolic functioning with Ultra6s testosterone booster. Plus, its metered delivery system ensures optimal absorption levels, making it the ideal choice for those seeking a natural and effective way to enhance their performance.
(Earth Elixir | Penguin, sponsored) Get ready for an herbal power-up with this supplement!
If youre looking to boost your energy and get a performance edge, tongkat ali and fadogia agrestis could be the answer. With Earth Elixirs supplement containing 500mg tongkat ali extract and 600mg fadogia agrestis powder, you can take advantage of tongkat alis natural testosterone-boosting properties while also gaining from the African plants powerful nootropic effects. While tongkat ali is often used to enhance libido and fertility in men, these ingredients alongside other beneficial herbs can help improve cognition, focus, and endurance, and may even enhance mood. Get ready for an herbal power-up with this supplement!
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Pushing your workouts to new heights just got easier with Dorado Nutritions incredible performance-enhancing blend, featuring the powerful combination of Fadogia Agretis and Tongkat Ali extracts. Boost energy levels naturally and increase testosterone for unbeatable results, while unlocking an array of additional benefits, such as enhanced muscle growth and increased dopamine production. Perfect for athletes and bodybuilders alike, Dorado Nutrition has the ultimate solution for reaching your fitness goals. Dont settle for anything less than the best with this incredible blend!
(Thalacy | Penguin, sponsored) Say goodbye to synthetic supplements and try Thalacy for a natural boost to mens health.
Do you want a natural way to increase your testosterone levels? Thalacy 1600mg Fadogia Agrestis tongkat ali Supplement might be your solution. This supplement contains the powerful Southeast Asian herb, tongkat ali, known for its ability to optimize male health and libido. But thats not all - when combined with Ashwagandha root extract, this product can also boost testosterone production. With consistent use, you may experience the improved physical drive, higher energy levels, and stronger muscles. Say goodbye to synthetic supplements and try Thalacy for a natural boost to mens health.
(Naturebell | Penguin, sponsored) Naturebells Fadogia Agrestis 600mg Complexed with Tongkat Ali 400mg supplement is a great way to maximize your bodys natural production of testosterone.
Naturebells Fadogia Agrestis 600mg Complexed with Tongkat Ali 400mg supplement is a great way to maximize your bodys natural production of testosterone. By combining tongkat ali, a natural aphrodisiac, and fadogia agrestis powder extracted from West African shrubs, Naturebells supplement is one of the best ways to naturally raise your testosterone levels. This supplement is designed to offer you the best ingredients scientifically proven to boost testosterone healthfully and consistently. The tongkat ali in this complex can help improve mental focus and physical performance, while the fadogia agrestis encourages increased strength and endurance.
(aSquared | Penguin, sponsored) Dont settle for feeling tired and sluggish - try this powerful supplement today and experience the benefits of tongkat ali for yourself!
Looking to boost your energy, increase muscle mass, and support healthy testosterone levels? Look no further than aSquared Nutritions Fadogia Agrestis 1000mg & Tongkat Ali 400mg supplement! This powerful formula is specially designed for busy modern men who need a simple solution to maintain hormonal balance. Tongkat Ali, also known as Eurycoma Longifolia Jack, has been used for centuries in traditional Asian medicine and is renowned for its ability to boost free testosterone. With regular use, youll notice increased strength, stamina, and energy, allowing you to tackle the day with ease. Dont settle for feeling tired and sluggish - try this powerful supplement today and experience the benefits of tongkat ali for yourself!
(VEGATOT | Penguin, sponsored) Introducing VEGATOT 8 IN 1 Ultimate Testo Support a game-changing supplement for mens health.
Introducing VEGATOT 8 IN 1 Ultimate Testo Support a game-changing supplement for mens health. Say goodbye to low energy levels and hello to a better, stronger you. Packed with the goodness of irresistible tongkat ali, this natural supplement has been proven to increase testosterone production and improve male libido. Not just that, it also contains vitamin D and zinc, essential vitamins that support overall health and beef up testosterone levels. VEGATOT 8 IN 1 Ultimate Testo Support is the ultimate blend that can help you achieve your fitness goals with ease. Get ready to feel more energized, stronger, and ready to take on the world!
(Rainbow Nutrients | Penguin, sponsored) Rainbow Nutrients Fadogia Agrestis 15,000mg + Tongkat Ali is a combination of powerful herbal ingredients designed to support mens health.
Rainbow Nutrients Fadogia Agrestis 15,000mg + Tongkat Ali is a combination of powerful herbal ingredients designed to support mens health. The Fadogia Agrestis extract helps optimize testosterone levels, while tongkat ali is a well-known traditional herb for supporting a healthy sex drive. Taking this supplement on a daily basis could help men feel their best. Those looking to maximize their potential and increase their libido should consider this unique blend of nutrients as part of their daily routine.
(Gorilla Mode | Penguin, sponsored) Gorilla Mode Sigma Testosterone Booster is a supplement designed to help increase testosterone levels in men.
Gorilla Mode Sigma Testosterone Booster is a supplement designed to help increase testosterone levels in men. It features tongkat ali, a traditional Malaysian herb that has been used for thousands of years to boost testosterone production. Clinical studies have shown tongkat ali to be effective in helping to elevate testosterone levels naturally and safely, which can lead to improved body composition, increased muscle mass, and strength, enhanced sexual performance and libido, improved mood, and better overall well-being. Combining tongkat ali with a well-rounded fitness regimen may be the perfect way to ensure that your body has the resources it needs to reach its goals.
(Vital Herbal | Penguin, sponsored) Herbal Ultra Fadogia Agrestis 10:1 Extract with Tongkat Ali capsules is a great way to support both physical and mental well-being.
Herbal Ultra Fadogia Agrestis 10:1 Extract with Tongkat Ali capsules is a great way to support both physical and mental well-being. A combination of tongkat ali and testosterone, these supplements can help the body produce necessary hormones in the right amounts, providing helpful energy and better focus all day. They can even work as mood enhancers and natural stress relievers. Plus, its an easy way to supplement important nutrients! With all that said, incorporating this herbal capsule into your daily routine may be just what you need to power through this challenging season.
Did you know that almost half of the American men are worried about their testosterone levels? Its true! And its not just a national trend - the global market for Tongkat Ali supplements is booming. In fact, experts predict it will reach a whopping $125 million by 2027. While the link between Tongkat Ali and testosterone needs further study, its clear that lots of guys are eager to find natural ways to stay healthy and strong. So why not join them and give it a try?
The rest is here:
Tongkat Ali and testosterone: what the science says - Salt Lake Tribune
in: Health, Health & Fitness, Podcast
Brett & Kate McKay May 8, 2023
When men think about optimizing their hormones, they tend only to think about raising their testosterone. But while increasing T can be important, an ideal health profile also means having testosterone thats in balance with your other hormones as well.
Today on the show, Dr. Kyle Gillett joins me to discuss both of those prongs of all-around hormone optimization. We start with a quick overview of the different hormones that affect male health. We then get into what qualifies as low testosterone and how to accurately test yours. We also discuss what causes low testosterone in individual men, and how its decline in the general male population may be linked to both birth control and the world wars. In the second half of our conversation, we discuss how to both raise testosterone and get rid of excess estrogen, including the use of some effective supplements you may never have heard of. We then get into the risks and benefits of taking TRT, before ending our discussion with what young men can do to prepare for a lifetime of optimal T and hormonal health.
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Podcast #893: Optimize Your Testosterone - Art of Manliness
Global Testosterone Replacement Therapy Market Research report is an in-depth study of the market Analysis. Along with the most recent patterns and figures that uncovers a wide examination of the market offer. This report provides exhaustive coverage on geographical segmentation, latest demand scope, growth rate analysis with industry revenue and CAGR status. While emphasizing the key driving and restraining forces for this market, the report also offers a complete study of the future trends and developments of the market.
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What`s New for 2023?
The list of Key Players Profiled in the study includes:- Endo International, AbbVie, Eli lilly, Pfizer, Actavis (Allergan), Bayer, Novartis, Teva, Mylan, Upsher-Smith, Ferring Pharmaceuticals, Kyowa Kirin, Acerus Pharmaceuticals
Cataloging the Competitive Terrain of the Testosterone Replacement Therapy Market:
In May 2021, the US Food and Drug Administration (FDA) approved an oral TRT product called Jatenzo (testosterone undecanoate) for the treatment of hypogonadism in men. Jatenzo is the first oral TRT product to be approved by the FDA.
In March 2021, Endo International, a leading manufacturer of TRT products, announced a settlement with the US Department of Justice over allegations of illegal marketing of its TRT products. As part of the settlement, Endo agreed to pay $8 million and to implement new compliance measures.
Testosterone Replacement Therapy Market Dynamics:
This section deals with understanding the market drivers, advantages, opportunities, restraints and challenges. All of this is discussed in detail as below:
Growth Drivers:
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Segmentation Analysis of the Market:
Global Testosterone Replacement Therapy Market forecast report provides a holistic evaluation of the market. The report offers a comprehensive analysis of key segments, trends, drivers, restraints, competitive landscape, and factors that are playing a substantial role in the market. Global Testosterone Replacement Therapy Market segments and Market Data Break Down are illuminated
Key Product TypeGelsInjectionsPatchesOthers
Market by ApplicationHospitalsClinicsOthers
Regional Coverage:
Rgn-w gmnttn in the Global Testosterone Replacement Therapy Market nlud the claims to split the regional scope of the market, which among these regions has been touted to amass the largest market share over the anticipated duration
North America(USA, Canada and Mexico)Europe(UK, Germany, France and the Rest of Europe)Asia Pacific(China, Japan, India, and the Rest of the Asia Pacific region)South America(Brazil, Argentina and the Rest of South America)Middle East and Africa(GCC and Rest of the Middle East and Africa)
** Note This report sample includes:
The Global Testosterone Replacement Therapy Market Industry Report Covers The Following Data Points:
: This section covers the global Market overview, including the basic market introduction, market analysis by its applications, type, and regions. The major regions of the global Market industry include North America, Europe, Asia-Pacific, and the Middle-East and Africa. Testosterone Replacement Therapy Market industry statistics and outlook are presented in this section. Market dynamics states the opportunities, key driving forces, market risk are studied.
: This section covers Market manufacturers profile based on their business overview, product type, and application. Also, the sales volume, market product price, gross margin analysis, and share of each player is profiled in this report.
: These sections present the market competition based on sales, profits, and market division of each manufacturer. It also covers the industry scenario based on regional conditions.
: These sections provide forecast information related to Testosterone Replacement Therapy Market for each region. The sales channels include direct and indirect Marketing, traders, distributors, and development trends are presented in this report.
: In these sections, Industry key research conclusions and outcome, analysis methodology, and data sources are covered.
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What makes the information worth buying?
A comprehensive and in-depth overview of the global Testosterone Replacement Therapyindustry in exchange, use, and geographical area sectors is provided.
This research looks at the industry rewards and constraints that influence industry growth.
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Testosterone Replacement Therapy Market | Understanding the ... - Digital Journal
Men might suffer from testosterone insufficiency in a variety of ways. A sudden drop in testosterone levels will significantly impact mens health, affecting their physical strength and mental clarity. Men in their 30s, 40s, and 50s have muscle loss and weakness due to low T-Levels.
Natural testosterone supplements, such as Nugenix Total-T, have been demonstrated to increase testosterone levels considerably. Other products are being introduced regularly, and supplements like TestoPrime and Hunter Test provide the same benefits as Nugenix Total-T without adverse effects. Lets discuss how these products address testosterone deficiency in men and whether they are genuinely beneficial. This review will also review the advantages of the TestoPrime and Hunter Test and why you should use them.
Nugenix is an all-natural free testosterone booster that contains six important components that help men maintain healthy levels of free testosterone. Aside from increasing testosterone, this supplement may help men feel stronger and have more sexual desire.
Over-the-counter testosterone boosters, such as Nugenix, are considered safer than hormone replacement treatment, making them a popular natural option among many men.
Adaptive Health, formerly Direct Digital, manufactures this free testosterone booster.
Adaptive Health is a nutritional health industry pioneer known for creating a diverse portfolio of nutritional health brands such as Nugenix, Sleep Answer, and OxyRub.
After acquiring Healthy Directions in December 2017, the company, which has operations in Bethesda, Charlotte, and Boston, rebranded.
It has a solid reputation for developing clinically proven treatments that are also distributed on a global scale.
Nugenix rebranded its product Nugenix Total T, which was developed as a dietary supplement to assist men in secreting more testosterone. Nugenix may or may not benefit lean muscle mass development, but it does result in considerable increases in male testosterone levels, as proven by multiple studies.
Nugenix Total T is a product that claims to help you reach your fitness objectives. Natural components and antioxidants in the product are supposed to improve cognitive function, raise energy levels, and reduce inflammation. Caffeine is also present, which is supposed to help you stay focused and motivated.
Nugenix Total T comes in both capsules and tablets. People who want to consume the supplement with food should use capsules; tablets can be taken without food. The product is in two versions, each with a 60-day money-back guarantee.
Nugenix Total-T contains a variety of substances that enhance overall health but can potentially create adverse effects in certain people. The list of ingredients includes antioxidants, vitamins, minerals, and amino acids. Beta-carotene, lutein, and zeaxanthin are included in the antioxidant combo.
Vitamins C and E fight free radical damage, while zinc supports immune system function. The mineral combination also contains copper, magnesium, manganese, and potassium. There are a few artificial elements in the Nugenix mix as well. This pill contains preservatives and ingredients that are in striking contrast to what many other natural testosterone boosters supply.
Nugenix Total T is the perfect supplement for you if you want to boost your muscle size and strength. This device was created to assist people in reaching their fitness objectives by boosting their strength, size, and endurance.
Nugenix Total T is considered a high-quality, thoroughly tested, and proven effective supplement. This products components have been proven to help boost muscle size and strength. Furthermore, this supplement is suitable for people of all ages.
It would help if you took the prescribed dosage of Nugenix Total T to achieve the greatest benefits. Drink lots of water while taking this product to avoid any undesirable side effects.
The following are some favorable and negative user comments regarding Nugenix Total T.
Cons
Some ingredients are available in excessive dosages, which are rumored to cause unwarranted side effects:
There are conflicting user video reviews for the Nugenix supplement, asserting that the testosterone booster is beneficial. Yes, a few negative Nugenix reviews lead us to better supplements.
For now, we shall rely on what customers have said about Nugenix on various web platforms.
It did not live up to my personal expectations; I expected it to do something. It had no effect. As far as Im concerned, it was a failure.- Paul.
I havent seen any real results nor feel any stronger in the gym. Im sure it has certain advantages, but I wouldnt advocate it.- Gregory
The company makes claims that it cannot back up. Instead, consult your doctor.- Adam. S
I didnt notice, but other guys my age were curious about how I was getting so much energy.- Kurt.
Many buyers stated that Nugenix was Not Useful, and the website claims are merely superficial. According to others, Nugenix became the top energy booster because it worked partially in individuals specifically seeking these benefits.
According to Nugenix reviews, the supplement contains synthetic ingredients that can harm some people. Furthermore, some components, such as zinc, are present in smaller concentrations than required to get the full benefits of a testosterone booster. Each dose contains only 1 mg of zinc instead of the recommended daily amount of 11 mg.
Furthermore, the product lacks vitamin D, which is required for testosterone production. A lack of vitamin D. commonly causes low testosterone levels. Furthermore, Nugenix lacks d-aspartic acid, an amino acid proven effective in raising testosterone levels in men.
Ashwagandha, another essential ingredient in many other testosterone boosters, is also absent in the Nugenix Total-T formula. While ashwagandha is readily available as a separate supplement, it is disappointing that it is not included in the Nugenix Total-T supplement, especially considering its price.
Nugenixhelps unlock the production of testosterone in men by providing vital nutrients. It is necessary because most people lack the necessary vitamins in their daily diet. Testosterone, commonly known as the male hormone, creates male features and looks after fertility and other essential functions.
Nugenixcan typically take up to 30 days to show visible results compared to other testosterone-boosting supplements. It is relatively slow or also depends on the consumers metabolism.
Usually, the recommended dosage forNugenixis three capsules in a day. Always consult a doctor to learn the exact dosage depending on your body.
Studies show no notable advantage of taking testosterone boosters unless combined with a proper exercise regimen and diet plan. Also, if the supplement contains vitamins and other nutrients, it can be helpful for three months without a gap.
Usually,Nugenixis recommended to be taken with a glass of water (240-350 ml). They must be taken on an empty stomach to get the best results.
If you start takingNugenix, regular exercise can be excellent for boosting testosterone levels. Resistance training is particularly beneficial in increasing testosterone production in the body. You can also try lifting weights, high-intensity interval training, and dumbbells for faster results.
Nugenix review: Best alternatives to Nugenix
Suppose you find that the side effects ofNugenixare too overwhelming for your body. You must look for alternatives that are a lot safer. Luckily there is an abundance of testosterone boosters in the market, and one can easily cruise that perfectly suits their needs. Products like the Hunter Test and Testo Prime enhance testosterone levels.
TestoPrime is one of the most preferred, all-natural testosterone booster supplements that is intended to assist men in increasing their bodys natural testosterone production. The pill comprises natural substances that help boost energy levels, muscle mass and strength, libido, and overall well-being. Testosterone is a hormone primarily focused on developing and enhancing male physical traits like muscle mass, bone density, and body hair in males.
It is essential for controlling sexual function and mood. Testosterone levels naturally fall with age, and some men may suffer a decline in testosterone levels earlier than others. This drop in testosterone may cause various symptoms, including decreased energy, muscular mass and strength, low libido, and mood swings. TestoPrime attempts to assist men in battling these symptoms by enhancing their bodys natural testosterone production.
The supplement is easily absorbed by the body, helping to improve nutrition and metabolism while naturally increasing testosterone levels. TestoPrime is worth considering for guys who have tried numerous diets and fitness programs without results in developing muscle or testosterone.
Users notice enhanced digestion, metabolism, hair growth, mood, fat-burning, muscular gain, and muscle strength after filling their bodies with testosterone. The mixture also raises blood nitric oxide levels, which boosts oxygen utilization throughout the body.
Hunter Test boosts testosterone by combining vitamins, minerals, amino acids, and herbal extracts. Nutrients of high-quality increase energy, muscle mass, sex drive, and mental sharpness. Roar Ambition, a well-known brand offering other sports and health supplements, manufactures Hunter Test.
All goods are made in FDA- and cGMP-certified labs in the United States and the United Kingdom. Although dietary supplements are not FDA-regulated, Hunter Test is manufactured by FDA guidelines. Hunter Test seeks to restore masculinity by increasing testosterone levels. To reduce side effects, it solely uses organic and clinically approved substances.
Hunter Test is an all-natural testosterone booster that contains minerals, amino acids, vitamins, and botanical extracts. The premium nutrients may improve your libido, strength, vitality, and mental clarity. Roar Ambition, the testosterone booster manufacturer, produces other sports and health products.
The high-quality supplement is manufactured in both the United Kingdom and the United States, keeping in mind the strict cGMP and FDA laboratory testing criteria. The Food and Drug Administration (FDA) typically fails to regulate dietary supplements. Despite this, Hunter Test is prepared in accordance with FDA guidelines. Hunter Test aims to enhance testosterone levels to help men reclaim their masculinity. The supplement uses only natural, scientifically-approved ingredients to minimize side effects to a minimum.
Everyone should be very well aware that testosterone levels go down with age. As a result, people start experiencing low energy and also see a decrease in muscle mass. It is also associated with anxiety, mood swing, and irritation. It is best to start taking a test they dont boost to avoid these conditions.Nugenixis a popular choice for boosting testosterone levels in men.
However, there are certain side effects of taking this supplement. The underdosing is too much to ignore.Nugenixlacks vital ingredients which are present in a testosterone booster.
On the other hand, Hunter Test and Testo Prime are completely safe for consumption and have no noticeable side effects. These can provide great results when taken regularly. According to experts, these supplements are perfect for freeing up bound testosterone. The best part is that they can do it discreetly without causing any harm to the body.
As can be understood from the above discussion, there are cheaper and better options forNugenix.The alternatives suggested in thisNugenix revieware equally potent and cause little harm to the body.Nugenixis likely to have a tough time surviving in the market.
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This is a partnered post. The information provided in this post is for general informational purposes only and does not constitute professional advice. The views and opinions expressed in any referenced product or service do not necessarily reflect those of Network18. Network18 does not vouch for the efficacy or safety of any products mentioned in this post. The reader is advised to conduct their own research and due diligence before purchasing or using any product. Network18 shall not be held responsible for any negative consequences that may arise from the use of any product mentioned in this post.
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Nugenix Review 2023. Does Nugenix Work? Try World Best Alternative - Firstpost
Obesity in boys may be linked to shrunken testicles and result in a higher risk of infertility for young men, Italian researchers report.
In their study of boys ages 2 to 18 who were referred to the Unit of Pediatric Endocrinology at the University of Catania in Sicily for weight control, researchers found that those with normal insulin levels had as much as two times higher testicular volume than boys with elevated insulin levels.
In the boys who were overweight or had obesity, hyperinsulinemia (insulin resistance) tended to lower testicular volume compared to other boys, researchers said.
This testicular hypotrophy, researchers said, is known to increase risk of infertility in men.
Testicular volume does have a direct relationship to semen profiles and tends to be a good predictor of hormonal function, Dr. Alex Robles, a fertility expert at the Columbia University Fertility Center in New York, told Medical News Today.
There is data that infertile men on average have a smaller testicular volume compared to fertile men, he added. We can see this in men taking exogenous anabolic steroids as well. These individuals stop producing their own endogenous testosterone which will reduce testicular size/volume and sperm production.
Although the prevalence of childhood obesity is increasing worldwide, the impact of obesity and associated metabolic disorders on testicular growth is not well known, said Rossella Cannarella, a research assistant at the University of Catania in Italy and a co-author of the study published in the European Journal of Endrocrinology.
We found that being overweight or obese was associated with a lower peri-pubertal testicular volume. In addition, obesity-related comorbidities, such as hyperinsulinemia and insulin resistance, have been found to influence testicular volume in pre- and post-puberty, she added.
Therefore, we speculate that more careful control of body weight in childhood could represent a prevention strategy for maintaining testicular function later in life, Cannarella said.
Male infertility is estimated to contribute to about half of all cases of couple infertility, but the reasons for it are often unclear.
Other studies have shown a decrease in sperm concentration and count over the past 40 years.
At the same time, the rate of childhood obesity has risen sharply. An estimated 60% of children ages 2 to 19 will be obese by age 35.
There is a fairly significant link between obesity and fertility, especially in females, said Robles. Obesity and excess fat mass can disrupt all of the hormones necessary for the growth and development of an egg and subsequent ovulation. Similarly in men, obesity can disrupt the hormones that help the testicles produce testosterone. Low testosterone is linked to decreased sperm production and decreased sperm quality.
Dr. Jagdish Khubchandani, a professor of public health at New Mexico State University, told Medical News Today that the study has promise in highlighting the link between obesity, metabolism, and testicular volume.
However, Khubchandani said that while the study was well-controlled and included a good range of markers for obesity and metabolism, the population studied was small and because it is cross-sectional no cause-and-effect relationship can be established among testicular size, obesity, and infertility risk.
If the only good finding is an association found in this study, we have many prior studies that show how obesity may affect fertility, Khubchandani said.
Like the study authors, Khubchandani noted that sperm count has declined across much of the world in the past few decades.
Obesity has increased at the same time, he said. But we cannot claim that the two are related. What mediates or moderates this relationship? Or, is it the food and environment that independently influence obesity, metabolism, and reproductive health?
Although this was a retrospective review, said Robles, the findings are plausible based on what we know about obesity, hormonal regulation, and testosterone levels.
With that said, more research is needed to know if these results can be replicated and if weight loss is an effective treatment option for improving testicular volume, he said.
Obesity is a pandemic, a leading killer across the world, and linked to most prevalent health problems across the world, said Khubchandani. Early childhood interventions could address many of these issues, including the ones discussed in this study.
Robles added that past research shows that losing weight can be a potential treatment option for improving the hormonal health of obese men by restoring natural testosterone levels, which in turn can increase testicular volume and sperm production.
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Male infertility: How obesity in boys can increase the risk - Medical News Today
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FarmaKeio Outsourcing is proud to announce the release of its latest innovation, the only patented hormone pellet with triamcinolone developed in an FDA-registered 503B outsourcing facility. The pellet is set to provide a new and revolutionary solution to hormone replacement therapy for men and women.
SOUTHLAKE, TX / ACCESSWIRE / May 10, 2023 / FarmaKeio Outsourcing (FKO), a leading pharmaceutical outsourcing facility in the United States, has been granted a patent to produce testosterone and triamcinolone subcutaneous hormone pellets. The patent includes 23 claims, issued by the United States Patent and Trademark Office (USPTO), recognizing the company's innovative approach to compounding hormone therapy and solidifying its position as a leader in the field of pharmaceutical development.
Unlike other hormone therapies, which may require frequent injections or daily pills, FarmaKeio Outsourcing's hormone pellets provide a sustained release of testosterone and triamcinolone, allowing patients to enjoy the benefits of these hormones for extended periods of time. These pellets are inserted subcutaneously and gradually release the hormone over several months, reducing the need for frequent dosing and allowing patients to focus on their daily lives.
"We are thrilled to receive this patent for our subcutaneous hormone pellets," said FarmaKeio Outsourcing's CEO, Dan DeNeui. "Our team has worked tirelessly to develop this innovative approach to hormone therapy, and we are excited to be able to offer this option to patients in need."
In addition to providing a more convenient method of hormone therapy, FarmaKeio's pellets offer a unique formulation that is not available from any other FDA 503B registered outsourcing facility in the US. This proprietary formulation has been carefully designed and tested and it represents a significant breakthrough in the field of hormone therapy.
"We believe that our hormone pellets have the potential to revolutionize the way that hormone therapy is delivered," said DeNeui. "By offering a sustained release of testosterone and triamcinolone, we can provide patients with a more consistent and reliable treatment option that can improve their quality of life."
The issuance of this patent is a significant milestone for FarmaKeio Outsourcing, and it reflects the company's ongoing commitment to innovation and excellence in pharmaceutical development. As the demand for hormone therapy continues to grow, FarmaKeio is well-positioned to meet the needs of patients and healthcare providers alike with its cutting-edge hormone pellets.
"We are confident that our hormone pellets will become the gold standard for hormone therapy, and we look forward to working with healthcare providers and patients to make this technology available to as many people as possible," said Chief Operating Officer Cody Boatman.
The hormone pellet with triamcinolone is a groundbreaking new product that is set to revolutionize the hormone replacement therapy industry. With its unique combination of hormones and anti-inflammatory properties, it provides patients with a more comfortable treatment option. The pellet is an exclusive feature of The EvexiPEL Method, created and founded by Terri DeNeui, DNP, APRN, ACNP-BC, and is available exclusively through FarmaKeio Outsourcing, an FDA-registered 503B facility. With this new product, FarmaKeio Outsourcing is once again proving its commitment to providing innovative solutions to hormone replacement therapy.
About FarmaKeio Outsourcing
FarmaKeio Outsourcing is a leading FDA-registered 503B pharmaceutical outsourcing facility that specializes in providing specific custom compounded medications to healthcare providers and facilities across the United States. FarmaKeio Outsourcing is committed to providing innovative, patient-centered solutions that meet the unique needs of their clients.
FarmaKeio Outsourcing offers an unwavering commitment to quality, safety, and compliance, operating a state-of-the-art facility that is cGMP compliant and undergoes rigorous testing and quality assurance procedures to ensure the highest level of quality and safety.
FarmaKeio Outsourcing provides exceptional customer service and support, ensuring that their clients have access to the resources and expertise necessary to make informed decisions about patient care. FarmaKeio Outsourcing is a trusted partner for healthcare providers looking to offer the most innovative and advanced care solutions to their patients.
Contact Information
Danielle Tworek Director of Marketing [emailprotected] 5613253904
SOURCE: FarmaKeio Outsourcing
View source version on accesswire.com: https://www.accesswire.com/753748/FarmaKeio-Outsourcing-Announces-Patented-Formulation-of-Revolutionary-Hormone-Therapy-Pellet
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Woolly mammoths were driven extinct by humans about 4000 years ago
PA Images/Alamy
Testosterone preserved in the tusks of male woolly mammoths reveal that they went through a seasonal change called musth,just like modern elephants do.
Once they reach sexual maturity, male African and Asian elephants go through musth for about three months every year. The shift is marked by a surge in testosterone and is often accompanied by thick, gooey secretions from ducts on the elephants temples. Male elephants are said to be more aggressive and restless during this time, although the exact relationship between the hormonal changes and behaviour is unclear.
Woolly mammoths (Mammuthus primigenius), which went extinct about 4000 years ago, were closely related to Asian elephants. Their tusks, like those of elephants, grew throughout their lives, and previous studies have recorded hormones such as cortisol, testosterone and progesterone preserved in a tooth tissue called dentine.
Palaeontologists have long suspected that woolly mammoths experienced musth. To test this idea, Michael Cherney at the University of Michigan and his colleagues isolated and analysed testosterone levels in tusks from a male African elephant, a male woolly mammoth estimated to have lived about 35,000 years ago and a female woolly mammoth thought to have lived around 5500 years ago. By sampling many sections along the length of a tusk, they were able to see how the hormone levels fluctuated over the animals lifetimes.
Woolly mammoth tusks, teeth and assorted bones collected on Wrangel Island, Russia, by the study team
Alexei Tikhonov
In the elephant, testosterone levels peaked at 20 times higher during musth than the rest of the year. The tests showed similar fluctuations in the male mammoth, with testosterone reaching 10 times higher than baseline. There was little variation in testosterone levels in the female mammoth.
This is such an exciting and fascinating piece of scientific sleuthing, says Susan Alberts at Duke University in Durham, North Carolina, who wasnt involved in the study. The comparison of the elephant and mammoth tusks is compelling evidence that they are picking up the same signals in the two species.
Musth was low-hanging fruit for an initial study, Cherney says, but the new method has the potential to document many aspects of the lives of mammoths, as well as other extinct animals. We anticipate being able to identify pregnancies, maturation ages, stress events and other things that could be used to improve our understanding of mammoth and mastodon palaeobiology, he says.
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Woolly mammoths had testosterone surges like those of male elephants - New Scientist
Dribbling urine and huge hormonal surges are two key - albeit unromantic - signs that it's time for an elephant to mate.
Now, scientists have drawn significant parallels between these modern-day giants and their extinct mammoth relatives who may have exhibited similar signals.
Analysis of tusks from over 30,000 years ago has unveiled that woolly mammoths experienced enormous surges in testosterone during mating season.
This state, known as 'musth', comes from the Hindi word for intoxicated, marking a period of frenzied sexual excitement and aggression among larger mammals.
The University of Michigan-led researchis a historic landmark for uncovering the past mysteries of mammoths, being the first piece of evidence to prove they underwentmusth.
Experts have drawn parallels between today's elephants and woolly mammoths
Pictured: An assortment ofwoolly mammoth tusks, teeth and bones collected on Wrangel Island, Russia, by authors of the new research
'Temporal patterns of testosterone preserved in fossil tusks show that, like modern elephants, mature bull mammoths experienced musth,' said study lead author Michael Cherney,a research affiliate at the U-M Museum of Paleontology.
Woolly mammoth (Mammuthus primigenius) is an extinct species of elephant found in fossil deposits in Europe, northern Asia, and North America.
The species was known for its large size, fur, and imposing tusks, which were curvier than today's elephants.
Thriving during the Pleistocene ice ages, woolly mammoths died out after much of their habitat was lost as Earths climate warmed in the aftermath of the last ice age.
He also told MailOnline: 'For the first time, we can see these testosterone surges in an extinct species of elephant, the woolly mammoth.
'This might be as close as we're going to get to having direct evidence that these ice-age animals experienced the entire suite of attributes that we associate with musth, including aggressive behavior, dribbling urine, secretions from the temporal gland behind the eye, and even a change in posture and how they walk.'
Woolly mammoths (Mammuthus primigenius) were one of the last in a line of mammoth species to exist before their extinction around 4,000 years ago.
The species co-existed with early humans, who hunted them for food and used their bones and tusks for making weapons and art.
The cause of their extinction is currently uncertain, with intense debate on the roles of human hunting and severe climatic change.
In this study, scientists used the bony material of dentin to help reconstruct the histories of mammoths.
This tissue notonly makes up human teeth but the bulk of elephant and woolly mammoth tusks, preserving hormone fluctuations.
'Tusks hold particular promise for reconstructing aspects of mammoth life history because they preserve a record of growth in layers of dentin that form throughout an individual's life," said study co-author Daniel Fisher, a professor in the Department of Earth and Environmental Sciences.
'Because musth is associated with dramatically elevated testosterone in modern elephants, it provides a starting point for assessing the feasibility of using hormones preserved in tusk growth records to investigate temporal changes in endocrine physiology.'
The African elephant tusk analysed in the University of Michigan-led testosterone study
To get a full picture, the team looked at the tusks of a 55-year-old male mammoth that lived between 38,866 to 33,291 years ago and a female that lived nearly 6,000 years ago.
The male's right tusk was discovered by a diamond-mining company in Siberia around 16 years ago.
The female's was also found off the coast of Russia at Wrangel Island - the last known place wherewoolly mammoths survived.
These were compared with the tusk of a 30-to-40-year-old modern day African elephant that was killed near Maun, Botswana in 1963.
This elephant was understood to have experiencedtestosterone 20 times higher during musth than any other point in the year.
On the flip side, male mammoth surges were seen to be just 10 times higher than other points in the year - half of that experienced by elephants.
The female mammoth showed even lower but more stable testosterone levels, according to the researchers based inRussia, France, the Netherlands, and the US.
'Lower mean hormone levels in the mammoth tusks compared with those in the elephant tusk might be a result of degradation or other technical factors associated with preservation, but patterns of relative abundance appear to persist and are similar in modern and fossil records,' the study said.
The scientists hope their research will pave the way for further exploration into the lives of ancient organisms, humans and extinct apes.
They stress that teeth and tusks are vital tools for piecing together history as they do not decay or become contaminated like hair and nails.
'With reliable results for some steroids from samples as small as 5 mg of dentin, these methods could be used to investigate records of organisms with smaller teeth, including humans and other hominids,' the authors wrote.
'Endocrine records in modern and ancient dentin provide a new approach to investigating reproductive ecology, life history, population dynamics, disease, and behavior in modern and prehistoric contexts.'
The male woolly mammoth tusk had been cut into segments before parts of it were acquired by the University of Michigan
Scientists examining woolly mammoth tusks collectedon Wrangel Island, Russia
The latest mammoth research comes just a month after scientists found that woolly mammoths were perhaps not as fluffy as history remembers them.
The new study was conducted by researchers at the Centre for Palaeogenetics, Stockholm University and the Swedish Museum of Natural History.
'We wanted to know what makes a mammoth a woolly mammoth,' said lead author David Dez-del-Molino at the Centre for Palaeogenetics.
'Woolly mammoths have some very characteristic morphological features, like their thick fur and small ears, that you obviously expect based on what frozen specimens look like.
'But there are also many other adaptations like fat metabolism and cold perception that are not so evident because they're at the molecular level.'
There are several leading theories for what killed off the ice age giants like the woolly mammoths.
Woolly mammoths are thought to have roamed the Earth from about 200,000 years ago before eventually dying out 10,000 years ago.
At this time the planet was undergoing a major change in climate that is thought to have led to the shrinkage of their habitat.
Unable to find the food they needed their populations became smaller and increasingly isolated.
A study in 2008 estimated that changes in climate as a result of the end of the last glacial period saw their habitat shrink from 3 million square miles to 310,000 square miles.
Some researchers have suggested that the spread of forests, which overtook the extensive areas of frozen grassland and tundra where mammoths thrived, led to their extinction.
The changes in climate also opened up large parts of the northern hemisphere to humans, allowing groups to spread more widely around North America, Asia and Europe.
Many blame overhunting by humans for finally finishing off the dwindling populations of megafauna like mammoths.
More recently some scientists have adopted theories that sudden changes in climate, known as the Younger Dyas period, left many large animal species unable to cope.
It is thought this period of cooling may have been caused by the collapse of the North American ice sheets into the Atlantic Ocean, leading to the seas cooling dramatically.
Others have suggested this was triggered by a large explosion from an asteroid or comet impactthat spread debris around the globe.
The woolly mammoth - a cousin of of today's Asian elephants - were commonly found in North America and Siberia and forced into extinction about 4,000 years ago.
They were covered in thick brown hair to keep them warm in their freezing conditions, which would often fall to as low as50C.
They woolly mammoths were around 13ft tall with fur that reached lengths of 3ft. They lived in the Pleistocene Period, which started 1.8million years ago but ended around 10,000 years ago with the last Ice Age.
Woolly mammoths and modern-day elephants are closely related, sharing 99.4 per cent of their genes.
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Woolly mammoths had SEX on the mind, tusk analysis reveals - Daily Mail
