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We place unreasonable trust in biological explanations of male behavior. Nowhere is this truer than with testosterone. Contemporary pundits invoke the hormone nicknamed T to prove points about maleness and masculinity, to show how different men and women are, and to explain why some men (presumably those with more T) have greater libidos. Yet, despite the mythic properties popularly associated with T, in every rigorous scientificstudyto date there is no significant correlation in healthy men between levels of T and sexual desire.

Beginning in the 1990s and really picking up steam in the 2000s, sales of testosterone replacement therapies (TRTs) went from practically zero to over $5 billion annually in 2018. This was either because there was a sudden outbreak of Low T when a major medical epidemic was finally recognized, or because T became marketed as a wonder drug for men thrown into a panic when they learned that their T levels declined1 per cent annually after they hit 30.

The answer is not that mens bodies changed or that Low T was horribly underdiagnosed before but that, in the minds of many, T became nothing short of a magic male molecule that could cure men of declining energy and sexual desire as they aged.

Whats more, many have been taught that, if you want to know what causes some men to be aggressive, you just test their T levels, right? Actually, wrong: thesciencedoesnt support this conclusion either. Some of the famous earlystudieslinking T and aggression were conducted on prison populations and were used effectively to prove that higher levels of T were found in some men (read: darker-skinned men), which explained why they were more violent, which explained why they had to be imprisoned in disproportionate numbers. The methodological flaws in these studies took decades to unravel, and new rigorousresearchshowinglittlerelation between T and aggression (except at very high or very low levels) is just now reaching the general public.

Whats more, it turns out that T is not just one thing (a sex hormone) with one purpose (male reproduction). T is also essential in the development of embryos, muscles, female as well as male brains, and red blood cells. Depending on a range of biological, environmental and social factors, its influence is varied or negligible.

Robert Sapolsky, a neuroscientist at Stanford University in California,compileda table showing that there were only 24 scientific articles on T and aggression 1970-80, but there were more than 1,000 in the decade of the 2010s. New discoveries about aggression and T? No, actually, although there were newfindingsin this period showing the importance of T in promotingovulation. There is also a difference between correlation and cause (T levels and aggression, for example, provide a classic chicken-egg challenge). As leading experts on hormones have shown us for years, for the vast majority of men, its impossible to predict who will be aggressive based on their T level, just as if you find an aggressive man (or woman, for that matter), you cant predict their T level.

Testosterone is a molecule that wasmislabeledalmost 100 years ago as a sex hormone, because (some things never change) scientists were looking for definitive biological differences between men and women, and T was supposed to unlock the mysteries of innate masculinity. T is important for mens brains, biceps and that other word for testicles, and it is essential to female bodies. And, for the record, (T level) size doesnt necessarily mean anything:sometimes, the mere presence of T is more important than the quantity of the hormone. Sort of like starting a car, you just need fuel, whether its two gallons or 200. T doesnt always create differences between men and women, or between men. To top it all off, there is evenevidencethat men who report changes after taking T supplements are just as likely reporting placebo effects as anything else.

Still, we continue to imbue T with supernatural powers. In 2018, a US Supreme Court seat hung in the balance. The issues at the confirmation hearings came to focus on male sexual violence against women. Thorough description and analysis were needed. Writers pro and con casually dropped in the T-word to describe, denounce or defend the past behaviour of Justice Brett Kavanaugh: one commentator inForbeswrote about testosterone-induced gang rapes; another, interviewed on CNN, asked: But were talking about a 17-year-old boy in high school with testosterone running high. Tell me, what boy hasnt done this in high school?; and a third, in a column inTheNew York Times, wrote: Thats him riding a wave of testosterone and booze

And it is unlikely that many readers questioned the hormonal logic of Christine Lagarde, then chair of the International Monetary Fund, when she asserted that the economic collapse in 2008 was due in part to too many males in charge of the financial sector: I honestly think that there should never be too much testosterone in one room.

You can find T employed as a biomarker to explain (and sometimes excuse) male behavior in articles and speeches every day. Poetic license, one might say. Just a punchy way to talk about leaving males in charge. Yet when we raise T as significant in any way to explain male behavior, we can inadvertently excuse male behavior as somehow beyond the ability of actual men to control. Casual appeals to biological masculinity imply that patriarchal relationships are rooted in nature.

When we normalize the idea that T runs through all high-school boys, and that this explains why rape occurs, we have crossed from euphemism to offering men impunity to sexually assault women by offering them the defense not guilty, by reason of hormones.

Invoking mens biology to explain their behavior too often ends up absolving their actions. When we bandy about terms such as T or Y chromosomes, it helps to spread the idea that men are controlled by their bodies. Thinking that hormones and genes can explain why boys will be boys lets men off the hook for all manner of sins. If you believe that T says something meaningful about how men act and think, youre fooling yourself. Men behave the way they do because culture allows it, not because biology requires it.

No one could seriously argue that biology is solely responsible for determining what it means to be a man. But words such as testosterone and Y chromosomes slip into our descriptions of mens activities, as if they explain more than they actually do. T doesnt govern mens aggression and sexuality. And its a shame we dont hear as much about theresearchshowing that higher levels of T in men just as easily correlate with generosity as with aggression. But generosity is less a stereotypically male virtue, and this would spoil the story about mens inherent aggressiveness, especially manly mens aggressiveness. And this has a profound impact on what men and women think about mens natural inclinations.

We need to keep talking about toxic masculinity and the patriarchy. Theyre real and theyre pernicious. And we also need new ways of talking about men, maleness and masculinity that get us out of the trap of thinking that mens biology is their destiny. As it turns out, when we sift through the placebo effects and biobabble, T is not a magic male molecule at all but rather as the researchers Rebecca Jordan-Young and Katrina Karkazis argue in theirbookTestosterone(2019) asocialmolecule.

Regardless of what you call it, testosterone is too often used as an excuse for letting men off the hook and justifying male privilege.

Matthew Gutmannis professor of anthropology and faculty fellow at the Watson Institute for International and Public Affairs at Brown University. His latest book isAre Men Animals? How Modern Masculinity Sells Men Short (2019). Follow him on Twitter @MCGutmann

A version of this article was originally published at Aeon and has been republished here with permission. Follow the site on Twitter @aeonmag

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Viewpoint: Time to stop thinking of testosterone as a 'magic male molecule' - Genetic Literacy Project

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May 22nd, 2020 | Filed under Testosterone

RALEIGH, N.C., May 21, 2020 (GLOBE NEWSWIRE) -- Marius Pharmaceuticals announced today that the United States Patent and Trademark Office (USPTO) has issued two key patents related to its lead asset, Kyzatrex*. Kyzatrex is an oral Testosterone Replacement Therapy (TRT) that uses an innovative formulation to improve effectiveness and safety.

These allowed claims will provide strong IP protection to December 2030, over 8 years of potential commercial runway. They supplement Marius Pharmaceuticals already robust global patent portfolio for Kyzatrex, which includes granted patents in the European Union, Canada, China, Taiwan, Japan, New Zealand and other key markets, and pending applications in India, and US. Marius Pharmaceuticals patent portfolio includes filings that extend protection to 2033, with the potential to extend protection out to 2040.

The allowed claims protect Kyzatrex, an innovative formulation designed to increase bioavailability and provide a favorable pharmacokinetic (PK) profile compared to other therapeutic alternatives. Om Dhingra, Chief Executive Officer of Marius commented This innovation is truly exceptional as we have created a formulation with a unique PK profile which we believe drives important clinical significance.

Marius Pharmaceuticals Chief Financial Officer Shalin Shah said We are very pleased to strengthen the intellectual property portfolio for Kyzatrex and excited that it has tremendous potential to be differentiated and unique option in the TRT space. We are also drawing a line in the sand between a new treatment paradigm and old testosterone therapies.

Marius Pharmaceuticals has recently completed its pivotal Phase 3 study for Kyzatrex and intends to submit its New Drug Application (NDA) to the Food & Drug Administration (FDA).

About Kyzatrex

Kyzatrex is an experimental therapy for the treatment of primary and secondary hypogonadism (congenital or acquired). Testosterone is a crucial hormone that plays key roles in human growth and development and a wide range of other functions including metabolic and cardiovascular. Sources estimate that 15 million men in the United States suffer from hypogonadism, but only approximately 10% are currently treated. The co-morbidities of men suffering from hypogonadism are also a significant burden on patients and the healthcare system, these include Type 2 Diabetes and other serious chronic conditions.

Current marketed treatments are dominated by painful injections and messy topical applications with transference risk. Kyzatrex is an orally administered therapy, which avoids those drawbacks. Market research points to 93% of patients indicating they would ask their physician about Kyzatrex and more than half would consider a switch from their current regimen.

About Marius Pharmaceuticals

Marius pharmaceuticals is a cutting-edge biopharma company focusing on treating widespread conditions that have been triggered primarily through Androgen deficiency. Our pipeline consists of assets focused on inflammation while our commercial arm is at the forefront of data science technologies core to our commercialization of our lead asset Kyzatrex.

*Kyzatrex is a tentative Tradename currently under review with the FDA

For more information, contact:Shalin Shahshalin@mariuspharma.comwww.mariuspharma.com

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Marius Pharmaceuticals Announces Issuance of Two Key Patents Protecting its Proprietary Oral Testosterone Therapy - GlobeNewswire

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May 22nd, 2020 | Filed under Testosterone

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Debi Mazar Channeled Her Entourage Character Whenever Things Got Tough on the Testosterone-Driven Set - KCTV Kansas City

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May 22nd, 2020 | Filed under Testosterone

To the Editor:

Re Why Are Nations Led by Women Doing Better?, by Amanda Taub (The Interpreter, May 16):

I am glad to see female heads of state getting well-deserved attention for their remarkably successful leadership during the pandemic, but I was disappointed that the womens leadership was characterized as cautious and risk averse in contrast to more aggressive and forward leadership attributed to males. You have it backward.

When others took a cautious wait-and-see stance, women took swift, decisive action to fight the pandemic. They led their countries to go hard, go early, in the powerful phrasing of Prime Minister Jacinda Ardern of New Zealand.

They established aggressive national testing and tracing programs. They communicated forcefully and clearly. And they did all of this at great political risk. Imagine how they would have been pilloried if these costly interventions had been no more successful than the laissez-faire approach of some of their male counterparts.

We must stop stereotyping womens leadership as passive and tentative. In this instance, it was men like Boris Johnson, Donald Trump and Jair Bolsonaro whose leadership was passive, weak or absent.

Monique VanLandinghamSomerset, Va.

To the Editor:

Amanda Taubs article exploring the reasons female leaders are getting better results with the coronavirus pandemic reminded me of what my husband learned when he took his first avalanche safety class: Youre much less likely to die in the backcountry if theres a woman in your group.

Whether its biological (testosterone triggers poorly thought-out decisions that result in death) or social conditioning (men have competitive hubris, women are more comfortable asserting safety concerns), the statistics prove it.

As pointed out in Calamity Lesson, a Jan. 5 article about avalanche fatalities in The New York Times Magazine, All-female groups make better decisions in risky situations than all-male groups or mixed-gender groups.

Given this, and now that weve all seen with our own eyes how testosterone doesnt preclude irrational mood swings and emotional outbursts, I think our country is readier than ever for the steady hand of a reasoned, experienced and capable female vice president. Bring her on. Please.

Madeleine BerensonAvon, Colo.The writer is a ski instructor.

To the Editor:

Amanda Taubs article about the success of women-led countries dealing with Covid-19 leaves out one important factor. The fact that a country elects a woman as its leader speaks to the sensibilities of its people. Draw your own conclusions.

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Women in Charge: Success Against the Coronavirus - The New York Times

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May 22nd, 2020 | Filed under Testosterone

CHICAGO--(BUSINESS WIRE)--Tolmar Pharmaceuticals Inc., a specialty pharmaceutical company, today announced publication in the April issue of the Journal of Urology of a real-world analysis of medical records of patients with prostate cancer treated with LHRH agonist therapies. The retrospective review evaluated the records of 22,860 patients with prostate cancer who were treated with LHRH agonists from January 2007 through June 2016 to further understand the impact of non-adherence to dosing schedules on testosterone (T) suppression levels. It also captured real-world data on these patients to assess the frequency of measurement of levels of T and prostate-specific antigen (PSA).

Androgen deprivation therapy (ADT) is the standard of care for patients with advanced prostate cancer. The goal of ADT is to reduce T to castration levels and thereby inhibit the growth of malignant prostate cancer cells. The target level for castration has historically been set at 50ng/dL; however, increasing evidence suggests that levels of less than 20ng/dL are seen following surgical castration.i ADT is widely used to suppress levels of T in the blood in men with advanced prostate cancer.

Analysis Demonstrated Late Dosing Patterns, Limited Testosterone Testing

Impact on Testosterone Suppression

These new real-world findings confirm that late injection of LHRH agonists is common in clinical practice along with infrequent measurement of levels of testosterone. This is concerning as men with advanced prostate cancer not receiving their ADT on time may experience inadequate testosterone suppression, which could adversely impact disease progression and survival, said E. David Crawford, M.D., lead study author and Professor of Urology at the University of California, San Diego. Our analysis underscores the importance of administering LHRH injections in a timely fashion and conducting more frequent testosterone testing to ensure target levels below 20ng/dL are achieved to reach the levels achieved with surgical castration.

Dr. Jason M. Hafron, M.D., study author and Partner at the Michigan Institute of Urology commented, These data underscore how important it is for Advanced Prostate Cancer Care (APCC) pathways to include mechanisms that ensure patients receive their LHRH injections on time and that treatment effects are monitored with both testosterone and PSA tests. In the current environment of restrictions in the number of patient visits due to the COVID-19 pandemic, these data are particularly relevant. It should also be recognized that use of the longest acting doses of LHRH agonists, such as 6-month, would reduce the potential for delays in dosing.

As the manufacturer of the LHRH agonist Eligard, we are committed to collaborating with clinical experts to advance the science around the treatment of advanced prostate cancer, said Dr. Stuart Atkinson, Vice President of Medical Affairs at Tolmar Pharmaceuticals. This real-world, retrospective analysis of the medical records of nearly 23,000 patients who were treated with LHRH agonists for prostate cancer exemplifies how we hope to equip healthcare providers with relevant and timely information that may help inform their approach to delivering high-quality care.

About ELIGARD

ELIGARD (leuprolide acetate) for injectable suspension is a prescription drug, given by injection, for the palliative treatment of advanced prostate cancer. ELIGARD is an LHRH agonist. ELIGARD uses a novel, polymeric gel, extended-release delivery technology that is designed to release leuprolide acetate at a controlled rate over an extended dosing period and enables subcutaneous administration. ELIGARD is available in 1-, 3-, 4- and 6-month dosing forms.

Important Safety Information

ELIGARD is indicated for the palliative treatment of advanced prostate cancer. ELIGARD is contraindicated in patients with hypersensitivity to GnRH, GnRH agonist analogs, or any of the components of ELIGARD. Anaphylactic reactions to synthetic GnRH or GnRH agonist analogs have been reported in the literature. Transient increase in serum levels of testosterone during treatment may result in worsening of symptoms or onset of new signs and symptoms during the first few weeks of treatment, including bone pain, neuropathy, hematuria, bladder outlet obstruction, ureteral obstruction, or spinal cord compression.

Hyperglycemia and an increased risk of developing diabetes have been reported in men receiving GnRH analogs. Monitor blood glucose level and manage according to current clinical practice. Increased risk of myocardial infarction, sudden cardiac death and stroke has also been reported with use of GnRH analogs in men. Monitor for cardiovascular disease and manage according to current clinical practice. Androgen deprivation therapy may prolong the QT/QTc interval. Consider risks and benefits. May cause fetal harm. Convulsions have been observed in patients taking leuprolide acetate with or without a history of predisposing factors. Manage convulsions according to the current clinical practice.

ELIGARD may impair fertility in males of reproductive potential.

The most common injection site adverse events are transient burning and stinging, pain, bruising, and erythema. The most common systemic adverse events include mild to severe hot flashes/sweats, malaise and fatigue, weakness, myalgia, dizziness, clamminess, testicular atrophy, and gynecomastia. As with other GnRH agonists, other adverse reactions, including decreased bone density and rare cases of pituitary apoplexy have been reported.

See package insert for full Prescribing and Safety Information or visit eligardhcp.com/PI.

To report suspected adverse reactions contact Tolmar at 1-844-4TOLMAR (486-5627) or the FDA at 1-800-FDA-1088 or visit http://www.fda.gov/medwatch.

About Tolmar Pharmaceuticals

Tolmar Pharmaceuticals, Inc., along with its affiliated companies, is a fully integrated pharmaceutical company focused on the innovative development, approval, manufacturing and commercialization of specialty pharmaceuticals. The Company's lead product, ELIGARD (leuprolide acetate) for injectable suspension, is a gonadotropin releasing hormone (GnRH) agonist indicated for the palliative treatment of advanced prostate cancer. Tolmar global headquarters, product development and manufacturing facilities are based in northern Colorado, while Tolmar Pharmaceuticals' U.S. commercial business is based in Buffalo Grove, Illinois. For more information about the company, please visit tolmar.com. Information about ELIGARD is available at eligardhcp.com.

i Ofefelein MG, Feng A, Scolieri MJ, et al. Reassessment of the definition of castrate levels of testosterone: implications for clinical decision making. Urology. 2000;56:2021.

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Real-World Data Analysis Published in the Journal of Urology Explores Frequency of Late Luteinizing Hormone-Releasing Hormone Agonist (LHRH) Dosing...

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May 19th, 2020 | Filed under Testosterone

Clinics

The report is a compilation of different studies, including regional analysis where leading regional Testosterone Replacement Therapy markets are comprehensive studied by market experts. Both developed and developing regions and countries are covered in the report for a 360-degree geographic analysis of the Testosterone Replacement Therapy market. The regional analysis section helps readers to become familiar with the growth patterns of important regional Testosterone Replacement Therapy markets. It also provides information on lucrative opportunities available in key regional Testosterone Replacement Therapy markets.

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Table of Content

1 Introduction of Testosterone Replacement Therapy Market

1.1 Overview of the Market1.2 Scope of Report1.3 Assumptions

2 Executive Summary

3 Research Methodology

3.1 Data Mining3.2 Validation3.3 Primary Interviews3.4 List of Data Sources

4 Testosterone Replacement Therapy Market Outlook

4.1 Overview4.2 Market Dynamics4.2.1 Drivers4.2.2 Restraints4.2.3 Opportunities4.3 Porters Five Force Model4.4 Value Chain Analysis

5 Testosterone Replacement Therapy Market, By Deployment Model

5.1 Overview

6 Testosterone Replacement Therapy Market, By Solution

6.1 Overview

7 Testosterone Replacement Therapy Market, By Vertical

7.1 Overview

8 Testosterone Replacement Therapy Market, By Geography

8.1 Overview8.2 North America8.2.1 U.S.8.2.2 Canada8.2.3 Mexico8.3 Europe8.3.1 Germany8.3.2 U.K.8.3.3 France8.3.4 Rest of Europe8.4 Asia Pacific8.4.1 China8.4.2 Japan8.4.3 India8.4.4 Rest of Asia Pacific8.5 Rest of the World8.5.1 Latin America8.5.2 Middle East

9 Testosterone Replacement Therapy Market Competitive Landscape

9.1 Overview9.2 Company Market Ranking9.3 Key Development Strategies

10 Company Profiles

10.1.1 Overview10.1.2 Financial Performance10.1.3 Product Outlook10.1.4 Key Developments

11 Appendix

11.1 Related Research

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Testosterone Replacement Therapy Market Development, Trends, Key Driven Factors, Segmentation And Forecast to 2020-2026 - Cole of Duty

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May 19th, 2020 | Filed under Testosterone

Latest Report On Testosterone Replacement Therapy Market including Market Landscape, and Market size, Revenues by players, Revenues by regions, Average prices, Competitive landscape, market Dynamics and industry trends and developments during the forecast period.

The global Testosterone Replacement Therapy market is broadly analyzed in this report that sheds light on critical aspects such as the vendor landscape, competitive strategies, market dynamics, and regional analysis. The report helps readers to clearly understand the current and future status of the global Testosterone Replacement Therapy market. The research study comes out as a compilation of useful guidelines for players to secure a position of strength in the global market. The authors of the report profile leading companies of the global Testosterone Replacement Therapy market, Also the details about important activities of leading players in the competitive landscape.

Key companies operating in the global Testosterone Replacement Therapy market include: AbbVie, Endo International, Eli lilly, Pfizer, Actavis (Allergan), Bayer, Novartis, Teva, Mylan, Upsher-Smith, Ferring Pharmaceuticals, Kyowa Kirin, Acerus Pharmaceuticals

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The report predicts the size of the global Testosterone Replacement Therapy market in terms of value and volume for the forecast period 2020-2026. As per the analysis provided in the report, the global Testosterone Replacement Therapy market is expected to rise at a CAGR of xx % between 2020 and 2026 to reach a valuation of US$ xx million/billion by the end of 2026. In 2020, the global Testosterone Replacement Therapy market attained a valuation of US$ XX million/billion. The market researchers deeply analyze the global Testosterone Replacement Therapy industry landscape and the future prospects it is anticipated to create

Segmental Analysis

The report has classified the global Testosterone Replacement Therapy industry into segments including product type and application. Every segment is evaluated based on growth rate and share. Besides, the analysts have studied the potential regions that may prove rewarding for the Testosterone Replacement Therapy manufcaturers in the coming years. The regional analysis includes reliable predictions on value and volume, thereby helping market players to gain deep insights into the overall Testosterone Replacement Therapy industry.

Global Testosterone Replacement Therapy Market Segment By Type:

Gels, Injections, Patches, Other

Global Testosterone Replacement Therapy Market Segment By Application:

Hospitals, Clinics, Others

Competitive Landscape

It is important for every market participant to be familiar with the competitive scenario in the global Testosterone Replacement Therapy industry. In order to fulfil the requirements, the industry analysts have evaluated the strategic activities of the competitors to help the key players strengthen their foothold in the market and increase their competitiveness.

Key companies operating in the global Testosterone Replacement Therapy market include: AbbVie, Endo International, Eli lilly, Pfizer, Actavis (Allergan), Bayer, Novartis, Teva, Mylan, Upsher-Smith, Ferring Pharmaceuticals, Kyowa Kirin, Acerus Pharmaceuticals

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TOC

Table of Contents 1 Testosterone Replacement Therapy Market Overview1.1 Testosterone Replacement Therapy Product Overview1.2 Testosterone Replacement Therapy Market Segment by Type1.2.1 Gels1.2.2 Injections1.2.3 Patches1.2.4 Other1.3 Global Testosterone Replacement Therapy Market Size by Type1.3.1 Global Testosterone Replacement Therapy Sales and Growth by Type1.3.2 Global Testosterone Replacement Therapy Sales and Market Share by Type (2014-2019)1.3.3 Global Testosterone Replacement Therapy Revenue and Market Share by Type (2014-2019)1.3.4 Global Testosterone Replacement Therapy Price by Type (2014-2019) 2 Global Testosterone Replacement Therapy Market Competition by Company2.1 Global Testosterone Replacement Therapy Sales and Market Share by Company (2014-2019)2.2 Global Testosterone Replacement Therapy Revenue and Share by Company (2014-2019)2.3 Global Testosterone Replacement Therapy Price by Company (2014-2019)2.4 Global Top Players Testosterone Replacement Therapy Manufacturing Base Distribution, Sales Area, Product Types2.5 Testosterone Replacement Therapy Market Competitive Situation and Trends2.5.1 Testosterone Replacement Therapy Market Concentration Rate2.5.2 Global Testosterone Replacement Therapy Market Share of Top 5 and Top 10 Players2.5.3 Mergers & Acquisitions, Expansion 3 Testosterone Replacement Therapy Company Profiles and Sales Data3.1 AbbVie3.1.1 Company Basic Information, Manufacturing Base and Competitors3.1.2 Testosterone Replacement Therapy Product Category, Application and Specification3.1.3 AbbVie Testosterone Replacement Therapy Sales, Revenue, Price and Gross Margin(2014-2019)3.1.4 Main Business Overview3.2 Endo International3.2.1 Company Basic Information, Manufacturing Base and Competitors3.2.2 Testosterone Replacement Therapy Product Category, Application and Specification3.2.3 Endo International Testosterone Replacement Therapy Sales, Revenue, Price and Gross Margin(2014-2019)3.2.4 Main Business Overview3.3 Eli lilly3.3.1 Company Basic Information, Manufacturing Base and Competitors3.3.2 Testosterone Replacement Therapy Product Category, Application and Specification3.3.3 Eli lilly Testosterone Replacement Therapy Sales, Revenue, Price and Gross Margin(2014-2019)3.3.4 Main Business Overview3.4 Pfizer3.4.1 Company Basic Information, Manufacturing Base and Competitors3.4.2 Testosterone Replacement Therapy Product Category, Application and Specification3.4.3 Pfizer Testosterone Replacement Therapy Sales, Revenue, Price and Gross Margin(2014-2019)3.4.4 Main Business Overview3.5 Actavis (Allergan)3.5.1 Company Basic Information, Manufacturing Base and Competitors3.5.2 Testosterone Replacement Therapy Product Category, Application and Specification3.5.3 Actavis (Allergan) Testosterone Replacement Therapy Sales, Revenue, Price and Gross Margin(2014-2019)3.5.4 Main Business Overview3.6 Bayer3.6.1 Company Basic Information, Manufacturing Base and Competitors3.6.2 Testosterone Replacement Therapy Product Category, Application and Specification3.6.3 Bayer Testosterone Replacement Therapy Sales, Revenue, Price and Gross Margin(2014-2019)3.6.4 Main Business Overview3.7 Novartis3.7.1 Company Basic Information, Manufacturing Base and Competitors3.7.2 Testosterone Replacement Therapy Product Category, Application and Specification3.7.3 Novartis Testosterone Replacement Therapy Sales, Revenue, Price and Gross Margin(2014-2019)3.7.4 Main Business Overview3.8 Teva3.8.1 Company Basic Information, Manufacturing Base and Competitors3.8.2 Testosterone Replacement Therapy Product Category, Application and Specification3.8.3 Teva Testosterone Replacement Therapy Sales, Revenue, Price and Gross Margin(2014-2019)3.8.4 Main Business Overview3.9 Mylan3.9.1 Company Basic Information, Manufacturing Base and Competitors3.9.2 Testosterone Replacement Therapy Product Category, Application and Specification3.9.3 Mylan Testosterone Replacement Therapy Sales, Revenue, Price and Gross Margin(2014-2019)3.9.4 Main Business Overview3.10 Upsher-Smith3.10.1 Company Basic Information, Manufacturing Base and Competitors3.10.2 Testosterone Replacement Therapy Product Category, Application and Specification3.10.3 Upsher-Smith Testosterone Replacement Therapy Sales, Revenue, Price and Gross Margin(2014-2019)3.10.4 Main Business Overview3.11 Ferring Pharmaceuticals3.12 Kyowa Kirin3.13 Acerus Pharmaceuticals 4 Testosterone Replacement Therapy Market Status and Outlook by Regions4.1 Global Market Status and Outlook by Regions4.1.1 Global Testosterone Replacement Therapy Market Size and CAGR by Regions4.1.2 North America4.1.3 Asia-Pacific4.1.4 Europe4.1.5 South America4.1.6 Middle East and Africa4.2 Global Testosterone Replacement Therapy Sales and Revenue by Regions4.2.1 Global Testosterone Replacement Therapy Sales and Market Share by Regions (2014-2019)4.2.2 Global Testosterone Replacement Therapy Revenue and Market Share by Regions (2014-2019)4.2.3 Global Testosterone Replacement Therapy Sales, Revenue, Price and Gross Margin (2014-2019)4.3 North America Testosterone Replacement Therapy Sales, Revenue, Price and Gross Margin4.3.1 United States4.3.2 Canada4.3.3 Mexico4.4 Europe Testosterone Replacement Therapy Sales, Revenue, Price and Gross Margin4.4.1 Germany4.4.2 UK4.4.3 France4.4.4 Italy4.4.5 Russia4.4.6 Turkey4.5 Asia-Pacific Testosterone Replacement Therapy Sales, Revenue, Price and Gross Margin4.5.1 China4.5.2 Japan4.5.3 Korea4.5.4 Southeast Asia4.5.4.1 Indonesia4.5.4.2 Thailand4.5.4.3 Malaysia4.5.4.4 Philippines4.5.4.5 Vietnam4.5.5 India4.5.6 Australia4.6 South America Testosterone Replacement Therapy Sales, Revenue, Price and Gross Margin4.6.1 Brazil4.7 Middle East and Africa Testosterone Replacement Therapy Sales, Revenue, Price and Gross Margin4.7.1 Egypt4.7.2 GCC Countries 5 Testosterone Replacement Therapy Application/End Users5.1 Testosterone Replacement Therapy Segment by Application5.1.1 Hospitals5.1.2 Clinics5.1.3 Others5.2 Global Testosterone Replacement Therapy Product Segment by Application5.2.1 Global Testosterone Replacement Therapy Sales by Application5.2.2 Global Testosterone Replacement Therapy Sales and Market Share by Application (2014-2019) 6 Global Testosterone Replacement Therapy Market Forecast6.1 Global Testosterone Replacement Therapy Sales, Revenue Forecast (2019-2025)6.1.1 Global Testosterone Replacement Therapy Sales and Growth Rate Forecast (2019-2025)6.1.1 Global Testosterone Replacement Therapy Revenue and Growth Rate Forecast (2019-2025)6.2 Global Testosterone Replacement Therapy Forecast by Regions6.2.1 North America Testosterone Replacement Therapy Sales and Revenue Forecast (2019-2025)6.2.2 Europe Testosterone Replacement Therapy Sales and Revenue Forecast (2019-2025)6.2.3 Asia-Pacific Testosterone Replacement Therapy Sales and Revenue Forecast (2019-2025)6.2.3.1 China6.2.3.2 Japan6.2.3.3 Korea6.2.3.4 Southeast Asia6.2.3.5 India6.2.3.6 Australia6.2.4 South America Testosterone Replacement Therapy Sales and Revenue Forecast (2019-2025)6.2.5 Middle East and Africa Testosterone Replacement Therapy Sales and Revenue Forecast (2019-2025)6.2.5.1 Egypt6.2.5.2 GCC Countries6.3 Testosterone Replacement Therapy Forecast by Type6.3.1 Global Testosterone Replacement Therapy Sales and Revenue Forecast by Type (2019-2025)6.3.2 Gels Gowth Forecast6.3.3 Injections Gowth Forecast6.4 Testosterone Replacement Therapy Forecast by Application6.4.1 Global Testosterone Replacement Therapy Sales Forecast by Application (2019-2025)6.4.2 Global Testosterone Replacement Therapy Forecast in Hospitals6.4.3 Global Testosterone Replacement Therapy Forecast in Clinics 7 Testosterone Replacement Therapy Upstream Raw Materials7.1 Testosterone Replacement Therapy Key Raw Materials7.1.1 Key Raw Materials7.1.2 Key Raw Materials Price7.1.3 Raw Materials Key Suppliers7.2 Manufacturing Cost Structure7.2.1 Raw Materials7.2.2 Labor Cost7.2.3 Manufacturing Expenses7.3 Testosterone Replacement Therapy Industrial Chain Analysis 8 Marketing Strategy Analysis, Distributors8.1 Marketing Channel8.1.1 Direct Marketing8.1.2 Indirect Marketing8.1.3 Marketing Channel Development Trend8.2 Distributors8.3 Downstream Customers 9 Research Findings and Conclusion AppendixMethodology/Research ApproachResearch Programs/DesignMarket Size EstimationMarket Breakdown and Data TriangulationData SourceSecondary SourcesPrimary SourcesDisclaimer

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Testosterone Replacement Therapy New Report: Growth Drivers, Challenges, Trends And Market Dynamics Forecast 2026 - Weekly Wall

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May 19th, 2020 | Filed under Testosterone

After a two-month hiatus, live sports is back on track. At least for NASCAR. Reasons sports are important and should be back even without spectators in the stands.

Sports from the field to the track have been on hold. Until yesterday when NASCAR lit up the track after a two-month hiatus. Even though no spectators were watching from the stands, many fans were cheering in front of TV's or mobile devices. Sports are important to many people because it's an affiliation, an identification, an allegiance to something that you like and believe in. Sports can be addictive in a good way. When your team wins, it's feels like an extension of you. It's the "us" or "we" mentality. For example, "we won"or "we're the champs." And it feels good when your team wins. This good feeling is partly due to the release of dopamine, a feel good hormone. When your team wins, you personally feel like a winner. Research published in the NCBI (National Center for Biotechnology Information) indicated that testosterone levels either increase or decrease based on whether your team wins or loses. The researchers tested testosterone levels through saliva. If you're team wins than you might feel like you're on top of the world. If your team loses then you might feel like you're in the deepest valley.

There are some positives and negatives of not having fans in the stands. The most evident negative is the lack of energy and excitement that fans bring to the games. How many times do you hear about home court advantage? The majority of the fans are the home teams fans. There are couple positives as well. You don't listen to angry fans who yell at their teams' mistakes, yell at the refs or worry about fights between opposing teams' fans. In that respect, there will be some peace.

Even without fans in the stands, starting sports again gives hope that our country is making strides in overcoming the coronavirus pandemic. Sports is part of our lives since childhood, many people have either watched and/or played sports. A lot of lessons are learned from sports such as persistence, sportsmanship, cooperation, leadership, handling winning and losing. Remember that sports without fans cheering in the stands is temporary. Change seems bad until you adapt and see how it'll work out.

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Don't stop sports because of the coronavirus - WFMYNews2.com

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May 19th, 2020 | Filed under Testosterone

Anthropologists believe that when our ancestors started cooking food, we unlocked more calories, leading to bigger brains. And from there, the internet. The logic goes that gathering together to make meals led to speaking and planning, which in turn helped us create new tools and build the social pacts that evolved into the modern world.

For most people, fire isnt nearly as important any more. However, its legacy endures. Building and enjoying a fire has hidden benefitsespecially for men, and especially during the trying times of the COVID-19pandemic.

Those groups more successful at keeping the fire going would have had an advantage over groups that didnt, explains Christopher D. Lynn, an anthropologist at the University of Alabama. A strong case can be made that this created a selective evolutionary pressure for people who can chill out by a fire, which puts them in the mood and position to learn from storytelling and to act cooperatively, rather than independently.

To test this theory, Lynn sat 226 adults down in front of a video of a fire, some silent and some with crackling sounds. The ones who saw and heard the flames experienced a 5 percent drop in blood pressure. The longer the test subjects sat in front of the fire, the more relaxed they got, says Lynn.

In other words, sitting around a fire is calming. Its a valuable skill any time, but even more so with a global health crisis turning up the collective temperature on stress and anxiety.

Fires benefits go even further, right to the gathering of the wood. Chopping trees boosts testosterone levels more than competing at sports, according to a study of Tsimane forager-farmers in the Bolivian Amazon by Ben Trumble, a behavior and economic researcher now at Arizona State University. The results shifted sciences understanding of the manliest of hormones.

By focusing so much on the role of testosterone in aggression and competition, we have missed out on the importance of testosterone in a variety of other tasks, Trumble told ABC. In humans, men tend to compete for the attention of women via economic productivity as opposed to fighting other men in the street, so examining changes in testosterone during food production is important.

In a study published in Evolution and Human Behavior, he compared saliva samples of Tsimane men before and after a game of soccer and before and after cutting down trees to clear land for farming and firewood. Testosterone levels increased after both activities, but more so after swinging an axe: a 30 percent increase in testosterone after soccer, compared to 48 percent for chopping.

Larger spikes in testosterone enhance muscle performance, and increase mens ability to chop trees, resulting in more food production, Trumble says.

Trumble just wrote a prescription for the 10 million Americans suffering from low testosterone. Building a blaze has never felt more enticing. Heres how to do it like a pro.

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Fire Good. The Surprising Health Benefits of Making a Campfire - Men's Journal

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May 19th, 2020 | Filed under Testosterone

Whales can be seen spouting offshore, wildlife is coming back, the sea is loaded with fish and dolphins are cavorting in the port of Toulouse. But the movies screens of Cannes are empty at a time when the film worlds attention is normally fixated on the cascade of cinema that annually overtakes the South of France in mid-May.

Not only are the cinemas dark, but so are the hotels, cafes, restaurants and shops that are normally teeming with crowds at this time of year. There are only four commercial flights per day in and out of Nice, and private jets have even been turned away, leaving most of the posh houses along the coast empty.

Keen to get a sense of what life in Cannes is like during festival time in the year of the virus, 2020, I called my old New York pal Max Rothman, who runs an apartment booking service called Cannes Concierge and has booked my accommodations there for eons. Knowing the French as well as he does, Max said he was expecting the populace to shrug their shoulders, Gallic style, and try to go on as normal. For one week, nobody was going to give in. But very soon, even though they resented it, everyone got in line. When the government declared a lockdown, everybody complied. To my amazement, the French were very docile about it.

Related StoryTodd McCarthy Laments Missing His 50th Cannes; Expects Many Of The Films To Wait Till 2021 Festival

Many of the emergency rules put in place would have been considered far too draconian to many Americans. Citizens were limited to walking no further than one kilometer from home and were required to carry special documents if they intended to be away for more than one hour, all public hugging and kissing stopped, masks became the norm and social distancing was very closely observed.

People are freaked out, Max believes, theyre all on guard. The government got tough about it and is full of testosterone, so everyone got in line. People have changed their mores, I think permanently. People are taking it very seriously.

From a business, logistical and supplies point of view, the realities seem similar to what theyve been in the United States. It may be hard to envision Cannes, and all of France, for that matter, absent its cafes, restaurants, hotels and beaches, but those have all been closed. Just this week, beaches are being opened for walking but not sunbathing or swimming.

As for food, supermarkets lacked produce the first week but are now doing business, although prices for some goods have as much as tripled. Open-air markets had been entirely banned but are just now beginning to open under very close scrutiny. While there has been no lack of food, Max said that shortages are expected this summer, as itinerant immigrants who normally do farm labor are not being allowed into the country at this point.

Having lived in France for decades, Max has been surprised at how cooperative the French have been about obeying the governments edicts. Social distancing has been very closely observed, he reported. In less than three months, everything has changed. And I personally think it will be permanent. The French culture has changed.

As of now, the government intends to lift many of the restrictions on June 2, and unlike some other regions, the fatality rate in the Alps-Maritimes area, which includes Nice, Monaco, Antibes and Cannes, stands at a comparatively low 250 people.

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Todd McCarthy: In Cannes, Empty Beaches And Empty Screens - Deadline

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May 19th, 2020 | Filed under Testosterone
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