Researchers Call for Therapeutics To Treat Cholesterol Cousins Called Ceramides Linked to Many Health Problems – SciTechDaily
Therapeutics that target lipids called ceramides might hold potential for treating cardiometabolic disease, argues a review article published today (November 5th, 2021) in the journal Trends in Pharmacological Sciences. The authors summarize evidence supporting a strong relationship between ceramides and a range of diseases in animals and humans and compare it to the decades of datasets that drove the creation of cholesterol-lowering pharmaceuticals.
Scientists have a lot to do if we are going to realize the potential of ceramide-lowering therapies, says senior study author Scott Summers of the University of Utah College of Health. Our hope with the article was to compare the body of literature on ceramides with that of cholesterol in order to point out the critical gaps and emerging questions in the ceramide field. Basically, we want to get as many labs as possible studying this important molecule.
One of the most widely prescribed drug classes is statins, which inhibit the synthesis of the lipid cholesterol to prevent coronary artery disease. Statins also reduce blood levels of other lipids such as ceramides. Compared to what we know about cholesterol, much less is known about the role of ceramides in disease. But it is becoming increasingly clear that ceramides are linked to a broad swath of health problems.
Over the past couple of decades, studies in humans have shown that ceramides are standalone biomarkers of cardiovascular disease, independent of cholesterol. Ceramides strongly predict major adverse cardiovascular events, including death due to coronary artery disease and acute coronary syndrome. These results have been replicated across the world in different countries and ethnicities, highlighting the robust nature of the association. Unlike cholesterol, ceramides have also been linked to metabolic conditions such as insulin resistance and diabetes in humans. Blood ceramides are now being measured clinically to assess disease risk.
Research in animals has provided evidence for a causal relationship and revealed potential disease mechanisms. For example, lowering ceramides through genetic or pharmacological interventions prevents cardiovascular disease and diabetes in rodents. Other studies have shown that ceramides can lead to an increase in fat storage, a decrease in glucose use, and lower mitochondrial efficiencyhallmarks of metabolic syndrome. Ultimately, these metabolic changes might lead to programmed cell death of pancreatic b-cells, thereby driving type 2 diabetes. Ceramides may prove to be as deleterious as cholesterol, as they elicit a non-overlapping spectrum of tissue defects and ultimately trigger cell death, Summers says.
Despite the accumulating evidence, many questions remain. Currently, there is a lack of data to support specific clinical recommendations based on high ceramide scores. More research is also needed to understand the genetic abnormalities that drive high ceramide levels and how ceramides damage cells and tissues. According to the articles authors, answering these questions might shed light on potential therapeutic approaches to safely and effectively lower ceramides and treat cardiometabolic disease. Hopefully help is on the horizon, either in the way of new therapeutics or new diet recommendations, Summers says.
Reference: Cholesterol the devil you know; ceramide the devil you dont by Tippetts et al., 5 November 2021, Trends in Pharmacological Sciences.DOI: 10.1016/j.tips.2021.10.001
This work was supported by the National Institutes of Health, the Juvenile Diabetes Research Foundation, the American Diabetes Association, the American Heart Association, and the Margolis Foundation. Scott Summers is a consultant, co-founder, and shareholder of Centaurus Therapeutics.
Read the rest here:
Researchers Call for Therapeutics To Treat Cholesterol Cousins Called Ceramides Linked to Many Health Problems - SciTechDaily
- The Food Detective Instructional Video [Last Updated On: May 6th, 2011] [Originally Added On: May 6th, 2011]
- Cellulite Exercise with 20 day Instant result [Last Updated On: August 10th, 2011] [Originally Added On: August 10th, 2011]
- How to Treat Pills Effectively- Best Natural Home Remedies for Piles [Last Updated On: September 5th, 2011] [Originally Added On: September 5th, 2011]
- Best Foods For Weight Loss [Last Updated On: September 6th, 2011] [Originally Added On: September 6th, 2011]
- Creatine On Trial - How To Use Creatine Effectively (maybe) [Last Updated On: September 6th, 2011] [Originally Added On: September 6th, 2011]
- Effectively Treat IBS Irritable Bowel Syndrome with Naturopathic Medicine - Dr. Trebilcock, ND [Last Updated On: September 9th, 2011] [Originally Added On: September 9th, 2011]
- Low Carbs Diet - Carbohydrates diet explained [Last Updated On: September 9th, 2011] [Originally Added On: September 9th, 2011]
- How to Get Rid of Spider Veins Naturally [Last Updated On: September 10th, 2011] [Originally Added On: September 10th, 2011]
- SUPER Gorgeous Fat Woman [Last Updated On: September 11th, 2011] [Originally Added On: September 11th, 2011]
- Healthy Foods That Any Succesful Diet Plan Should Include [Last Updated On: September 13th, 2011] [Originally Added On: September 13th, 2011]
- Invitation to Dr. Will Tuttle's World Peace Diet Mastery Program [Last Updated On: September 13th, 2011] [Originally Added On: September 13th, 2011]
- Fat Woman Very selfconfident [Last Updated On: September 14th, 2011] [Originally Added On: September 14th, 2011]
- How to lose body fat effectively [Last Updated On: September 14th, 2011] [Originally Added On: September 14th, 2011]
- Low Carb Meal Plans For Weight Loss [Last Updated On: September 15th, 2011] [Originally Added On: September 15th, 2011]
- How To Lose 10 Pounds Fast [Last Updated On: September 17th, 2011] [Originally Added On: September 17th, 2011]
- Kidney Diet - The Best Diet for Kidney Disease Sufferers? [Last Updated On: September 20th, 2011] [Originally Added On: September 20th, 2011]
- Weight Loss Plans [Last Updated On: September 20th, 2011] [Originally Added On: September 20th, 2011]
- Weight Loss Solutions [Last Updated On: September 20th, 2011] [Originally Added On: September 20th, 2011]
- Weight Loss Meal Plan [Last Updated On: September 21st, 2011] [Originally Added On: September 21st, 2011]
- A Fast Way To Lose Weight [Last Updated On: September 21st, 2011] [Originally Added On: September 21st, 2011]
- Weight Loss Program [Last Updated On: September 25th, 2011] [Originally Added On: September 25th, 2011]
- Weight Loss System [Last Updated On: September 25th, 2011] [Originally Added On: September 25th, 2011]
- 3. The Last Diet You'll Ever Need [Last Updated On: September 27th, 2011] [Originally Added On: September 27th, 2011]
- Effectively Treat Psoriasis [Last Updated On: September 27th, 2011] [Originally Added On: September 27th, 2011]
- A Low Glycemic Diet [Last Updated On: September 27th, 2011] [Originally Added On: September 27th, 2011]
- Effectively Treat Asthma with Naturopathic Medicine - Dr. Shannon Sinsheimer, ND [Last Updated On: September 27th, 2011] [Originally Added On: September 27th, 2011]
- Banana Diet [Last Updated On: September 28th, 2011] [Originally Added On: September 28th, 2011]
- HCG Diet - How do you take HCG drops [Last Updated On: September 30th, 2011] [Originally Added On: September 30th, 2011]
- Dr Amanda's 'The Don't Go Hungry Diet' [Last Updated On: September 30th, 2011] [Originally Added On: September 30th, 2011]
- Menopause and Raw Foods Diet [Last Updated On: October 2nd, 2011] [Originally Added On: October 2nd, 2011]
- How to be healthy and lose weight Effectively [Last Updated On: October 4th, 2011] [Originally Added On: October 4th, 2011]
- 7 Day Cabbage Soup Diet Plan [Last Updated On: October 4th, 2011] [Originally Added On: October 4th, 2011]
- Dr Amanda explains 'The Don't Go Hungry Diet' [Last Updated On: October 4th, 2011] [Originally Added On: October 4th, 2011]
- Diabetic Diet - 5 Ways To Lower Your Blood Sugar Level [Last Updated On: October 4th, 2011] [Originally Added On: October 4th, 2011]
- The Power of Plant Foods in Anti-Aging and Lifestyle Medicine [Last Updated On: October 4th, 2011] [Originally Added On: October 4th, 2011]
- Eating Healthy Foods to Lose Weight Effectively [Last Updated On: October 4th, 2011] [Originally Added On: October 4th, 2011]
- Waist Training 2: diet, exercise, fashion [Last Updated On: October 4th, 2011] [Originally Added On: October 4th, 2011]
- Healthyliving Carb Confusion [Last Updated On: October 4th, 2011] [Originally Added On: October 4th, 2011]
- Fat Belly Diet [Last Updated On: October 5th, 2011] [Originally Added On: October 5th, 2011]
- THREE KEYS TO FAT BURNING: Hormone Triggers [Last Updated On: October 5th, 2011] [Originally Added On: October 5th, 2011]
- Race For Glory!: Post-Workout Meal and Diet Update! [Last Updated On: October 5th, 2011] [Originally Added On: October 5th, 2011]
- Weight Loss Programs [Last Updated On: October 5th, 2011] [Originally Added On: October 5th, 2011]
- How To Lose Weight Fast and Effectively [Last Updated On: October 5th, 2011] [Originally Added On: October 5th, 2011]
- Diet Specialist - Issam Ghannam [Last Updated On: October 5th, 2011] [Originally Added On: October 5th, 2011]
- The Diet Solution Program Ebook Guide Overview [Last Updated On: October 5th, 2011] [Originally Added On: October 5th, 2011]
- Diet Specialist - Dr Issam Ghannam [Last Updated On: October 5th, 2011] [Originally Added On: October 5th, 2011]
- Bulking - How to Add Muscle to Your Frame Effectively [Last Updated On: October 5th, 2011] [Originally Added On: October 5th, 2011]
- Dr. Marc K. Weinberg, DC - Free Fat Burning Seminar [Last Updated On: October 5th, 2011] [Originally Added On: October 5th, 2011]
- Workouts for Physical Conditions : How to Exercise on a Low-Carb Diet [Last Updated On: October 5th, 2011] [Originally Added On: October 5th, 2011]
- Best Way To Lose Weight Fast [Last Updated On: October 6th, 2011] [Originally Added On: October 6th, 2011]
- Who Else Wants to Lose Excess Weight Effectively [Last Updated On: October 6th, 2011] [Originally Added On: October 6th, 2011]
- How Protein Helps You Lose Weight [Last Updated On: October 7th, 2011] [Originally Added On: October 7th, 2011]
- Effectively Treat Anxiety Disorder with Naturopathic Medicine - Dr. Tamara Trebilcock, ND [Last Updated On: October 7th, 2011] [Originally Added On: October 7th, 2011]
- Fat Loss Diets - How To Lose Belly Fat Now - Video [Last Updated On: October 13th, 2011] [Originally Added On: October 13th, 2011]
- Healthy Eating or Junk Food - What is a Good Diet? - Video [Last Updated On: October 13th, 2011] [Originally Added On: October 13th, 2011]
- The Empowered Nutrition Meal Plan Story with Vince DelMonte and Patrick McGuire - Video [Last Updated On: October 13th, 2011] [Originally Added On: October 13th, 2011]
- Effectively Treat The Flu Influenza With Natural Medicine - Dr. Patti Kim, ND - Video [Last Updated On: October 14th, 2011] [Originally Added On: October 14th, 2011]
- Diverticulitis Diet: Here's What Works! - Video [Last Updated On: October 14th, 2011] [Originally Added On: October 14th, 2011]
- How To Lose Baby Weight - Video [Last Updated On: October 15th, 2011] [Originally Added On: October 15th, 2011]
- HCG Diet is the Proven System to Lose Weight Effectively - Video [Last Updated On: October 15th, 2011] [Originally Added On: October 15th, 2011]
- African Mango Diet-Buy African Mango-Pure African Mango - Video [Last Updated On: October 16th, 2011] [Originally Added On: October 16th, 2011]
- How to Treat Rosacea Naturally and Effectively? Boris Malayev - Video [Last Updated On: October 18th, 2011] [Originally Added On: October 18th, 2011]
- Smoothie Diet Time Now The Juice Fast Is Over? - Video [Last Updated On: October 19th, 2011] [Originally Added On: October 19th, 2011]
- Colon Cleansing and Liver Detox Diets Part 1 - Video [Last Updated On: October 19th, 2011] [Originally Added On: October 19th, 2011]
- How to Lose Weight Fast - The truth about Fat Burning Foods and Weight Loss Programs - Video [Last Updated On: October 19th, 2011] [Originally Added On: October 19th, 2011]
- Danger of diet partches - Video [Last Updated On: October 19th, 2011] [Originally Added On: October 19th, 2011]
- Weight Loss Exercises - Video [Last Updated On: October 20th, 2011] [Originally Added On: October 20th, 2011]
- The best diet to follow is NO diet at all " Easy .." - Video [Last Updated On: October 21st, 2011] [Originally Added On: October 21st, 2011]
- Best Kept [ Diet] Secret. Part 5. Its all up to you - Video [Last Updated On: October 21st, 2011] [Originally Added On: October 21st, 2011]
- Effectively Treat High Cholesterol with Natural Medicine - Dr. Angela Agrios, ND - Video [Last Updated On: October 23rd, 2011] [Originally Added On: October 23rd, 2011]
- How To Lower Your Cholesterol Naturally [Last Updated On: October 23rd, 2011] [Originally Added On: October 23rd, 2011]
- Effectively Treat Rheumatoid Arthritis with Natural Medicine by Dr. Angela Agrios, ND - Video [Last Updated On: October 25th, 2011] [Originally Added On: October 25th, 2011]
- Blood Type Diet Gets My Thumbs Up As It Balances Me - Video [Last Updated On: October 25th, 2011] [Originally Added On: October 25th, 2011]
- Foods for Health: Eating for Heart Health - Video [Last Updated On: October 26th, 2011] [Originally Added On: October 26th, 2011]
- 3/10/08: Safe and Effective Detox Part I - Video [Last Updated On: October 27th, 2011] [Originally Added On: October 27th, 2011]
- FASTEST WEIGHT LOSS DIET - Video [Last Updated On: October 27th, 2011] [Originally Added On: October 27th, 2011]
- Raw Sangha #57 - Black American Diet - A Raw Food Revolution Coming Soon! - Video [Last Updated On: October 27th, 2011] [Originally Added On: October 27th, 2011]
- Easy-as Ways To Lose Weight Fast - Video [Last Updated On: October 27th, 2011] [Originally Added On: October 27th, 2011]
- Diet tips101 - Video [Last Updated On: October 28th, 2011] [Originally Added On: October 28th, 2011]
- Foods To Gain Weight Pre- And Post-Workout - Video [Last Updated On: October 28th, 2011] [Originally Added On: October 28th, 2011]