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Top news of March: Effects of keto-style diet on the heart; bempedoic … – Healio

Apr 7th, 2023

April 03, 2023

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Healio and Cardiology Today have aggregated the top cardiology headlines of March 2023.

Readers were most interested in the CV impact of a keto-style diet; the benefits of bempedoic acid in high-risk patients; the FDAs decision on omecamtiv mecarbil for patients with heart failure with reduced ejection fraction; and more.

Certain traditional risk factors including severe high cholesterol, diabetes, hypertension and smoking may increase CV risk among those following a low-carbohydrate, high-fat keto-style diet, a speaker reported. Read more

In a phase 2 trial, an oral PCSK9 inhibitor lowered LDL about the same amount observed with injectable PCSK9 inhibitors for 8 weeks, researchers reported at the American College of Cardiology Scientific Session. Read more

In the CLEAR Outcomes trial, bempedoic acid reduced risk for major CV events by 13% compared with placebo, including a 23% lower risk for MI, among adults with a history of CVD or at high risk deemed statin intolerant. Read more

The FDA has issued a complete response letter to Cytokinetics for omecamtiv mecarbil, an investigational, selective small molecule cardiac myosin activator for treatment of HFrEF, according to a press release. Read more

For every 500 extra steps per day, or an additional one-quarter mile walked, adults aged 70 years or older could reduce risk for a CVD event by approximately 14%. Read more

In the past decade, there have been major advances in lipid-lowering therapeutics, and another was made apparent in March at the American College of Cardiology Scientific Session. Read more

In the STOP-CA trial, prophylactic atorvastatin therapy reduced the occurrence of anthracycline-associated left ventricular dysfunction at 12 months among patients who underwent treatment for Hodgkin and non-Hodgkin lymphoma. Read more

In the PULSED AF pivotal trial, pulsed field ablation of symptomatic atrial fibrillation yielded a low rate of adverse events and demonstrated effectiveness consistent with established ablation strategies at 1 year. Read more

Elite athletes with genetic risk for sudden cardiac death can safely return to play with a shared decision-making model that includes careful evaluation, risk stratification and tailoring of genetic heart disease therapy. Read more

An Apple Watch feature designed to detect AF was associated with a low rate of false-positive detections but only modest sensitivity for detections in people with a history of AF, researchers reported. Read more

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