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While my body was returning to its natural state, the World Anti-Doping Agency discovered that some of my peers were purposely altering theirs. Russian athletes had been bribing I.A.A.F. officials to look the other way while they continued competing, even though they had taken illegal drugs. Doped athletes had been winning medals and prizes, yet despite the I.A.A.F.s talk of cleaning the sport of illegal drugs, it was people like Chand and me whose natural bodies were seen as abnormal and were being targeted and shamed out of the sport. We were the ones enduring public humiliation when people who had taken illegal drugs were often portrayed as just victims of their governments thirst for medals. (Years later, a former head of the I.A.A.F., Lamine Diack, along with his son, would be convicted of corruption after accepting bribes linked to Russias doping program.)

In 2018 the agency announced new regulations that would apply only to athletes with D.S.D. and only to those competing in distances ranging from the 400 meter to the mile. So a woman with a difference in sexual development could compete against other women without altering her body in five of the eight main distances in competitive track racing but not in the distances I ran. I knew these rules would affect several other runners, but I had become the face of this thing. To me, this was personal. I was the runner closest to the 800-meter world record, and I felt the I.A.A.F. wanted to shut me down. To me, its restrictions arent about leveling the playing field; they are about getting certain types of women off the field completely.

(The spokeswoman for World Athletics told The Times that the regulations for female athletes running those distances were established after scientific and medical research from athletes competing in our sport was clearly able to show that advantages existed. In March, World Athletics replaced these regulations with a stricter rule that applied across a broader range of events.)

The guidelines announced in 2018 set a maximum testosterone level that was 50 percent lower than even the low level I had taken so many drugs to achieve. And I would have had to achieve and maintain that level for six months before I was eligible to compete. I refused to again subject myself to the mental anguish and physical torture of the poison. I was no longer an 18-year-old girl desperate to run. I was a world champion, an Olympic champion. I had achieved my dreams.

When they announced the regulations in 2018, the I.A.A.F. offered women with D.S.D. who refused the medication but still wanted to compete what it surely felt was a generous and sympathetic offer: We could change our distances, run any distance we wanted in the male category or run in some future intersex category, should it ever become available.

Both of these suggestions are insulting. I am not a man. I have spent years in legal battles, fighting to be able to race without restrictions. But today I could compete only if I altered my hormone levels. For me, participating in a third category of human gender identity would be accepting being othered, accepting the discrimination that I had fought against. It would mean giving up the identity Id been born with and had never questioned to take on a new one I didnt believe. Even though I understand that those in the medical community call me an intersex person because of the way my internal organs are structured, I do not call myself intersex. That identity doesnt fit me; it doesnt fit my soul.

Ms. Semenya is a runner from South Africa, a two-time Olympic gold medalist and the author of The Race to Be Myself, from which this essay is adapted.

The Times is committed to publishing a diversity of letters to the editor. Wed like to hear what you think about this or any of our articles. Here are some tips. And heres our email: letters@nytimes.com.

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ORGOVYX is the First and Only Oral Gonadotropin-Releasing Hormone (GnRH) Receptor Antagonist Approved for Advanced Prostate Cancer in Canada

MISSISSAUGA, Ontario, Oct. 23, 2023 /PRNewswire/ -- Sumitomo Pharma Canada, Inc., announced today that Health Canada has approved ORGOVYX(relugolix), an oral gonadotropin-releasing hormone (GnRH) receptor antagonist, for the treatment of men with advanced prostate cancer. The approval is based on efficacy and safety data from the Phase 3 HERO study of ORGOVYX in men with advanced prostate cancer. ORGOVYX is expected to be available for prescription in Canada in Q1 2024.

"Roughly 1 in 8 Canadian men will develop prostate cancer in their lifetime, and the ability to suppress testosterone, primarily achieved through androgen deprivation therapy (ADT), is foundational in the treatment of the advanced stages of the disease," said Fred Saad, M.D., FRCS, Professor and Chairman of the Department of Surgery and Director of Genitourinary Oncology at the University of Montreal. "In the HERO study, ORGOVYX demonstrated rapid, sustained, and profound testosterone suppression when compared to leuprolide. ORGOVYX is the first approved ADT in Canada that can be administered orally, and once daily, offering a safe and effective option for advanced prostate cancer patients in the country."

"We're pleased that with Health Canada's approval of ORGOVYX, we are helping to expand upon treatment options for Canadian men living with advanced prostate cancer," said Lisa Mullett, General Manager of Sumitomo Pharma Canada, Inc. "We are committed to making ORGOVYX available to patients across Canada early in the new year."

The Health Canada approval was based on the results of the Phase 3 HERO study, a randomized, open-label, parallel-group, multinational clinical study evaluating the safety and efficacy of ORGOVYX in over 1,000 men with androgen-sensitive advanced prostate cancer who required at least one year of continuous ADT. In the Phase 3 study, ORGOVYX met the primary endpoint and demonstrated superiority in sustained testosterone suppression to castrate levels (< 50 ng/dL) through 48 weeks compared to those receiving leuprolide acetate injections, the current standard of care. The most frequent adverse events reported in at least 10% of men in the ORGOVYX group were hot flush, musculoskeletal pain, fatigue, constipation, and mild to moderate diarrhea.

ORGOVYX was previously approved by the U.S. Food and Drug Administration on December 18, 2020 and granted marketing authorization by the European Commission for advanced hormone-sensitive prostate cancer on April 29, 2022.

About Advanced Prostate Cancer Prostate cancer is the most common cancer in Canadian men, and, in 2023 an estimated 24,700 men will be diagnosed.1 Prostate cancer is considered advanced when it has spread or come back after initial treatment and may include biochemical recurrence (rising prostate-specific antigen in the absence of metastatic disease on imaging), locally advanced disease, or metastatic disease.

Front-line medical therapy for advanced prostate cancer typically involves androgen deprivation therapy, which reduces testosterone to very low levels, commonly referred to as castrate levels (< 50 ng/dL). Luteinizing hormone-releasing hormone (LHRH) receptor agonists, such as leuprolide acetate, are depot injections and the current standard of care for androgen deprivation therapy. However, LHRH receptor agonists may be associated with mechanism-of-action limitations, including the potentially detrimental initial surge in testosterone levels that can exacerbate clinical symptoms, which is known as clinical or hormonal flare, and delayed testosterone recovery after the drug is discontinued.

About ORGOVYX(relugolix) ORGOVYX (relugolix) is the first and only oral gonadotropin-releasing hormone (GnRH) receptor antagonist approved by the U.S. Food and Drug Administration, the European Commission and Health Canada for the treatment of adult patients with advanced prostate cancer. As a GnRH antagonist, ORGOVYX blocks the GnRH receptor and reduces production of testicular testosterone, a hormone known to stimulate the growth of prostate cancer.

About Sumitomo Pharma Sumitomo Pharma Co., Ltd. is a global pharmaceutical company based in Japanwith key operations in the U.S. (Sumitomo Pharma America, Inc.), Canada (Sumitomo Pharma Canada, Inc.) and Europe (Sumitomo Pharma Switzerland GmbH) focused onaddressing patient needs in psychiatry & neurology, oncology, urology, women's health, rare disease, and cell & gene therapies. With several marketed products in the U.S., Canada, and Europe, a diverse pipeline of early- to late-stage assets, and in-house advanced technology capabilities, we aim to acceleratediscovery, research, and development to bring novel therapies to patients sooner. For more information, please visithttps://www.us.sumitomo-pharma.comandLinkedIn to follow us.

The Sumitomo Pharma icon is a trademark of Sumitomo Pharma Co., Ltd., used under license. SUMITOMO PHARMA is a trademark of Sumitomo Pharma Co., Ltd., used under license.

Sumitomo Pharma America, Inc. is a U.S. subsidiary of Sumitomo Pharma Co., Ltd.

ORGOVYX is a trademark of Sumitomo Pharma Switzerland GmbH.

2023 Sumitomo Pharma America, Inc. All rights reserved.

References

View original content:https://www.prnewswire.com/news-releases/sumitomo-pharma-announces-authorization-in-canada-of-orgovyx-relugolix-for-the-treatment-of-men-with-advanced-prostate-cancer-301963903.html

SOURCE Sumitomo Pharma America

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5 years' worth of photos show how testosterone affected one person's life.  Upworthy

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Transcript:

What is androgen deprivation therapy?

Alicia Morgans, M.D., MPH: Androgen deprivation therapy, sometimes called ADT or hormonal therapy, is a way of treating prostate cancer that is used pretty ubiquitously or used pretty uniformly for patients when the cancer is more advanced or has spread outside of the prostate, perhaps even throughout the body. This form of treatment is not giving androgens or giving hormones but actually decreasing hormone levels, particularly testosterone, that male hormone that goes up in patients or individuals when they go through puberty, and is also the hormone that drives prostate cancer cells to grow, divide, spread and cause the trouble that they cause.

When we use androgen deprivation therapy, we are lowering testosterone levels typically by turning off the testes from making testosterone. This starves cancer cells, causing them to shut down, causing some to essentially self-destruct or die, and causing others to go into a deep hibernation state where they are not going to be able to grow, divide, spread and cause trouble. They just sort of sit still and shrink. And that from a patient perspective and from a doctor perspective is really important and is what we want. We want to shut it all down. There are other things that we can add that are more hormonal therapies to further decrease that testosterone from driving cancer cells. But the ADT, or androgen deprivation therapy, is really just shutting off the testes.

It's important to know that there are several types of ADT. Of course, one is a surgical type, so you can remove the part of the testes on both sides that makes testosterone, and that's a surgical procedure. But more commonly, people use medications to have ADT or use treatment with ADT. Those medications can either be GnRH agonists, which is just a type of a hormonal therapy that causes a surge in testosterone before it causes low levels. That needs to be considered when you're starting the treatment. The other kind, which is a GnRH antagonist, causes the testosterone levels to go down right away. Both of these are really effective ways of lowering testosterone. They are both used really commonly, and they both can be given as injections. The GnRH antagonist form can also be given as a pill. There are lots of different ways and options for us to cause androgen deprivation and to treat prostate cancer with hormonal deprivation therapy. It's important with talk to your doctor about which one might be right for you.

Transcript is AI-generated and edited for clarity and readability.

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East Midlands Ambulance Service is reportedly giving men up to a year of paid leave for andropause related issues, which some are calling the male menopause.

This move has angered some commentators who question whether there really is such a thing as the male menopause or manopause.

The andropause is not a condition that was recently invented. The medical establishment has been talking about it since the 1940s when it was known as the male climacteric. Symptoms of this condition include a lack of energy, weight gain (including man boobs), sexual difficulties, sleep problems, anxiety, irritability, depression and even hot flushes.

While many private clinics recognise and treat andropause, it is not recognised as a syndrome by the NHS, nor is it usually caused by a radical drop in male hormones, such as testosterone. Testosterone levels do naturally decline in men, but the average decrease is around 1% per year after the age of 30.

Less common only seen in 6% of adult men under 80 are chronically low levels of testosterone, also known as androgen deficiency. This may result from accidents affecting their testes, experiencing severe illness, or treatment for prostate cancer.

The natural drop in testosterone can be worsened by obesity, extreme stress and some medications or diseases, including drinking too much alcohol. So the andropause is probably more of a lifestyle symptom and therefore should be tackled as such.

The recent media spotlight on female menopause has highlighted just how badly women can be affected by midlife reduction in hormone levels. So much so that the UK government had to appoint a dedicated menopause tsar to deal with the resulting shortage of oestrogel, a popular form of HRT, as more and more women seek menopause treatment.

Read more: Menopausal women often turn to doctors who know little about the symptoms here's what needs to change

The East Midlands Ambulance Service is commendable in wanting to support men in making mid-life lifestyle changes, but calling it the male menopause undermines the magnitude of the physiological changes women experience as part of female menopause.

For men, lifestyle changes can have huge benefits. Taking care of heart health, exercise and healthy diets in midlife are known to be good for brain function and can help prevent dementia and heart disease later on.

While many women report that taking sex hormones helps with brain problems, actual studies do not show overall long-term benefit of hormone treatment on memory or mood. There are also small risks linked with taking hormone therapy.

In contrast, for those who have had their ovaries or testes removed, or take hormone blockers because of cancers, a significant drop in memory and mood can occur and reduced testosterone has been associated with an increased risk for dementia, such as Alzheimers disease and heart disease the two main causes of death in the UK.

However, it is unclear whether testosterone treatment helps to reduce this risk in men, as some studies showed an increased risk of heart disease, while others found testosterone treatment to be protective or have no effect.

In men with low testosterone levels, overall studies suggest that taking testosterone reduced depression and improved erections and libido. There may also be benefits of oestrogen or testosterone gel on sexual function in women.

However, study results have been mixed and caution should always be taken with interpreting the results of research sponsored by the industries producing the treatments. Also, libido is not simply linked to hormones, and a dry vagina or limp penis can be influenced by factors such as relationship stress or work stress or both.

Could andropause be a manifestation of midlife stress? Most likely. And this is not a matter of hormone change. Rather, while dips in life satisfaction are only seen in 10-20% of adults in middle age (and often not shown over time), this is probably the result of an evaluation of life at this important new stage.

Importantly, suicide risk is highest in men between 40 and 49 and is the most common cause of death in men under 50. Many men may mask their depression with alcohol, drugs and overwork. This risk is highest in the poor.

We should applaud the East Midlands Ambulance Service for paying attention to mens mental health, but maybe not because of the andropause. Rather, interventions that tackle poor pay, working conditions, job stress, public harassment and work-life satisfaction may help improve mental health more than framing these concerns as male menopause.

In the full statement by the East Midlands Ambulance Services, it was made clear that there is no separate or special leave policy for andropause with 12 months off on full pay. Instead, decisions are made on a case-to-case basis, trying to keep staff in work where possible and supporting them with their mental health in a wide variety of ways.

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The combination of the investigational agent BXCL701 and pembrolizumab (Keytruda) elicited promising overall survival (OS) results in patients with small cell neuroendocrine prostate cancer (SCNC), according to findings from a phase 2 trial.1

SCNC represents a major unmet medical need, with the majority of patients unfortunately succumbing to their disease in less than one year following chemotherapy. The results of this trial suggest that BXCL701 has the potential to extend the lives of patients, and I look forward to its continued clinical development, stated Aggarwal.

In the single-arm, open-label trial, the median OS was 13.6 months (95% CI, 10.9NR) and the 12-month OS rate was 56.5% in this patient population.

OS is the most meaningful measure by which the effectiveness of an oncology treatment is evaluated. Though these results are based on a non-randomized cohort of patients, observing a median OS of this duration including patients with long-term survival at 12 months and beyond shows exceptional promise, bearing in mind historic data with checkpoint inhibitor monotherapy in this high-risk subset of prostate cancer, Principal Investigator Rahul Aggarwal, MD, associate director for clinical sciences, Helen Diller Family Comprehensive Cancer Center, and professor of medicine at the University of California San Francisco (UCSF), stated in a news release.1

BXCL701 is designed to modulate the tumor microenvironment by activating innate immunity, followed by adaptive immunity, ultimately resulting in cancer cell death.

The trial enrolled patients with histologically confirmed de novo or treatment-emergent SCNC. To be eligible for enrollment, patients needed to have received 1 or more prior lines of systemic therapy, experienced disease progression per Prostate Cancer Clinical Trials Working Group 3 criteria, and an ECOG performance status of 0 to 2. For those with treatment-emergent SCNC, a serum testosterone level of less than 50 ng/dL during screening was required.2

Patients were excluded if they had received more than 2 cytotoxic chemotherapy regimens for mCRPC or had prior treatment with an antiPD-1, antiPD-L1, or antiPD-L2 agent. Prior treatment with another agent directed to another co-inhibitory T-cell receptor was also prohibited.2

Overall, there were 34 patients (median age, 67.5 years) enrolled in the phase 2 study. Sixty-two percent of patients had a visceral metastasis at any site, and 32% had visceral metastases of the liver. The median number of prior lines of systemic therapy received was 3 (range, 1-8).3

At the data cutoff date of September 6, 2023, there were 28 efficacy evaluable patients able to be assessed for OS.

Previously reported data from the trial showed that the objective response rate was 20% among 25 patients who were evaluable for response. Patient responses included 4 confirmed partial responses (PRs) and 1 unconfirmed PR.3

SCNC represents a major unmet medical need, with the majority of patients unfortunately succumbing to their disease in less than one year following chemotherapy. The results of this trial suggest that BXCL701 has the potential to extend the lives of patients, and I look forward to its continued clinical development, stated Aggarwal.

Reference

1. BioXcel Therapeutics Reports Positive Overall Survival Results from Single-Arm, Open-Label Phase 2 Trial of BXCL701 in Patients with Small Cell Neuroendocrine Prostate Cancer. Published online and accessed October 10, 2023. https://ir.bioxceltherapeutics.com/news-releases/news-release-details/bioxcel-therapeutics-reports-positive-overall-survival-results

2. CT.gov. A Trial of BXCL701 and Pembrolizumab in Patients With mCRPC Either Small Cell Neuroendocrine Prostate Cancer or Adenocarcinoma Phenotype. Last updated May 23, 2023. https://classic.clinicaltrials.gov/ct2/show/NCT03910660

3. Aggarwal RR, Zhang J, Monk P, et al. First-in-class oral innate immune activator BXCL701 combined with pembrolizumab in patients with metastatic, castration-resistant prostate cancer (mCRPC) of small cell neuroendocrine (SCNC) phenotype: Phase 2a final results. J Clin Oncol. 2023;41(suppl 6):176. doi:10.1200/JCO.2023.41.6_suppl.176

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It is the small things that make or break a long-standing relationship. That is what crossed my mind as I listened to Dan and Joyce. Dan was a 36-year-old biology teacher and his wife, Joyce, was 32. They had been married for seven years and had one child. They came to the Sexology Clinic after a week of serious disagreement: Joyce had bought Dan a perfume.

I feel demeaned. I am offended. If she wants me to shower more than once a day I can do that, but she does not have to buy a perfume to pass a message that I no longer smell good! Dan shouted as he explained the genesis of their conflict.

This is unfair, I just bought you a gift! Do you have to go to the extent of denying me sex because of this? Joyce shouted back, her eyes welling up with tears.

The story was that during their courtship, Joyce repeatedly told Dan that she loved his natural body odour. She would hold him for hours on end because of this. Dan enjoyed this whole experience which boosted his ego and confidence.

So would you say I am mistaken, doctor? Dan asked rhetorically, looking at me straight in the face, Tell me, have I gone out of my mind? How can it be that suddenly I no longer smell good?

Well, there is a relationship between smell and sexual attraction. If you keep animals, you may have observed that bulls actually put their noses on cows vaginas and in ecstasy lift their heads up, sniffing as they enjoy the sweet smell. Dogs and cats travel long distances to meet females on heat guided by pheromones, the attractive sex hormones produced by these animals during ovulation.

The issue of pheromones has however been contentious when you talk of human species. In one study, men were made to smell vaginal secretions from different women and their body reactions recorded. It was shown that secretions from ovulating women made men have a surge in testosterone, meaning that mens bodies may be able to detect and positively respond to ovulating women.

In another study, it was shown that women are attracted to men with high testosterone levels when they are ovulating, that they find body odour from such men more pleasing than from men with lower testosterone.

The studies on body odour and sexuality have however been non-conclusive. Further, the human brain has no ability to detect pheromones. This natural disadvantage implies that there is nothing sexually stimulating about the way a man or woman smells.

I dont believe that! Dan croaked throwing his hands in the air.

The only thing that has been proven is that body smell is closely tied to body immunity and women tend to be more pleased by the smell of men with immunity that significantly differs from theirs. This is important in reproduction since the offspring of such a union is likely to have much stronger immunity. Smell does not necessarily cause one to want to have sex with another.

That said, a good smell does have its place in making us feel good. This is the basis of aromatherapy. If your mate has worn a pleasantly smelling perfume this may elevate your mood and give you a sense of happiness.

And that is why I am saying that my body smell caused Joyce happiness and is an important factor and foundation of this relationship! Dan said.

But surely, you cannot say that the reason I married you is because of your body odour! Joyce replied.

Well, Dans body scent was pleasing to Joyce when they were courting just the same way a flower or air freshener would be pleasant to her. The good feeling elevated her mood. There is a possibility that Dan had a different immunity from Joyce, making her more attracted to the body scent as a prospective father of her children. In those early days of their relationship Dan must have had a higher level of testosterone, making the attraction greater when Joyce was ovulating.

But days do change and testosterone levels fall. We acquire new body smells as hormone levels change. A good smelling perfume is good for maintaining the pleasant smell and is not a bad gift from a loved one.

If you thought looking attractive was the prime factor to impress someone on a date, then you might be wrong. According to a recent study, it is how you smell that makes you sexually attractive, and interestingly, physical appearance, intellect and money take the back seat.

Astonished? Well, we were too! As per a report published in the Daily Star, extra-marital dating site Victoria Milan conducted a survey of 5,071 cheating adults from 12 countries to ascertain how big a role odour plays in such situations.

And the results were quite beguiling. 78 per cent of women preferred to go home alone rather than sleep with a man who smelled bad. However, men have other priorities too. Five in every 10 male participants said theyll bear any stench once they have a woman in the bedroom.

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Body odour and intimacy | Nation - Nation

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While guys who climax too quickly, like the high school teen who cant even get his pants off before its all over, is a well-known issue, theres a flip side to that problem: being able to go and go and go without reaching orgasm, a condition known as delayed ejaculation.

There isnt a lot of research on it, but a 2016 study estimated that between 1% and 4% of men experience delayed ejaculation all the time or when with a partner. The researchers also noted that its the least studied and least understood of male sexual dysfunctions.

Delayed ejaculation is the inability to climax within a reasonable amount of time. Whats reasonable varies for each person, but some experts cite needing more than 30 minutes of sexual stimulation to reach orgasm as a sign of a problem. Theres no need to get out a stopwatch; the real test of whether this is an issue is how often its happening and how you and your partner feel about it.

We rarely talk about mens sexual health, and the feelings of failure that can come with not being able to climax mean we talk about this issue even less than others like premature ejaculation or erectile dysfunction. Ignoring it, however, may trap couples in a cycle of anxiety that ends with one or both partners deciding its better to avoid sex altogether than have this happen again. Spoiler alert: Its not.

Here are some ways to break that cycle.

Dont let this become the elephant in the room or in your bed. Without talking about the issue, our minds are left to speculate and ruminate, Ian Kerner, a sex therapist and author of She Comes First, tells Yahoo Life. A partner may start to worry that maybe the person with DE is no longer attracted to them or is bored by the sex.

Communication is crucial, and Kerner notes that how we address these subjects matters. When having these sorts of conversations, always begin with how youre feeling and your own vulnerability, he says. Start with Hey, Ive been feeling anxious. Generally talking about the elephant in the room is a relief and gets you on the same team.

Medical issues known to cause delayed ejaculation include low testosterone, spinal cord injuries and certain infections. DE can also be a side effect of common prescription drugs, such as antidepressants and blood pressure medications. A new study found that DE is associated with more underlying health issues both physical, such as testicular dysfunction, and emotional, such as anxiety than premature ejaculation or erectile dysfunction.

Dr. Michael Eisenberg, a urologist at Stanford University, says that a health care provider can assess whether a medical problem is causing delayed ejaculation. We will evaluate the timing of the condition, determine if its situational, assess hormones and determine underlying health conditions, he tells Yahoo Life.

Delayed ejaculation can also be caused by desensitization of the penis. Dr. Jesse Mills, director of the UCLA Mens Health Clinic, tells Yahoo Life that, like all other parts of our bodies, penises can lose sensitivity as we age. They can also get used to certain triggers: The key to orgasm is friction, Mills explains. Theres no orifice as tight as a mans own hand. If thats what hes used to, he may have sensitivity issues he has to overcome.

Masturbation is good for you, but if you suspect desensitization, consider cutting back, especially when youre expecting to have partnered sex soon.

Resetting your expectations can also help. Remember that penetrative sex isnt everything. Just as many women need clitoral stimulation to orgasm, you may need something more intense as well. Consider adding some sex toys, such as a prostate massager or a vibrating sleeve, which can amp up your orgasm. Theres also nothing wrong with finishing using your own hands while your partner curls up next to you.

If you are still having trouble finishing, it may be time to see an expert, whether thats a sexual medicine doctor or a sex therapist.

Mills is a member of the Sexual Medicine Society of North America, a group that includes urologists, gynecologists, neurologists and sex therapists. He says this is a great place to start, since the website can help you find providers in your area. The American Association of Sex Educators, Counselors and Therapists can also help you find a certified sex therapist near you. Anybody that has specialized training and interest in sex can get the workup rolling, he says.

A sexual medicine expert can also help couples who are dealing with DE while they are trying to get pregnant. Eisenberg says there are medical ways to assist with ejaculation or sperm extraction, which can help couples separate fertility issues and sexual concerns.

Sex is supposed to be pleasurable and relieve our stress, not cause it. If youre having trouble reaching orgasm, talk to your partner and reach out to medical and mental health experts for help.

Martha Kempner is a writer and sexual health expert. She is the author of the weekly newsletter Sex on Wednesday.

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Matt Damon is a body role model. The actor has set an intense workout routine for his roles in movies like Jason Bourne, The Martian, The Great Wall, and many more.

But there was a 1996 film role (Courage Under Fire) that nearly destroyed his health after he dropped 60lbs (because he only ate chicken breast).

His extreme physical transformation, in such a short amount of time, resulted in a risk of permanent shrinking of his heart. Damon even had to take medication to repair the harm in his adrenal gland.

Also read: No one brought that scene up: Matt Damon and Ben Affleck Used a Cunning Trick Involving Robin Williams to Get Their $225M Movie Made That Left Harvey Weinstein Awestruck

Matt Damon started at 190lbs but got down to 139lbs for the movie. Speaking about his extreme weight loss, the actor revealed in Reddits Ask Me Anything that he had to run about 13 miles a day, which wasnt even the hard part. The hard part was the diet.

The Hollywood actor added that he only ate chicken breast because he didnt have a chef at that time, so he just made what he felt like he just made it up, which was extremely challenging.

Damon said he had to be thin and went on an unsupervised diet which could have killed him. The Air actor also admitted that the diet didnt do him any good because he started to feel the ill effects of the diet that lacked many vitamins and minerals. He shared:

I didnt have to act at all I was a wreck. I was getting dizzy spells and hot flashes. I didnt say anything to anyone for a while because I was afraid I might be really ill.

He himself affirmed that he went too far and that he would never consider doing this ever again.

Also read: The pitch didnt go very well: Mark Wahlbergs Failed Pitch Saved Martin Scorseses Honor as Director Never Wanted His $291M Matt Damon Movie to Become a Franchise

Learning from his own experience, Matt Damon advised Chris Hemsworth when he was preparing for his character asa shipwrecked sailor in The Heart Of the Sea.

He told the 12 Strong star not to follow the same dangerous diet he used to lose weight for Courage Under Fire. He warned Hemsworth by saying Look, I had no education then. It was basically eating nothing for four months.

Damon told him that there are better ways to lose weight and that Hemsworth should seek the advice of a nutritionist before proceeding with everything all by himself.

Also read: I should have gone on probably to do Silence: Martin Scorsese Regrets Making $294M Movie With Leonardo DiCaprio After His Oscar Winning Movie Starring Matt Damon

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While a healthy diet and regular exercise still serve as the cornerstones of weight management, supplements can be effective partners in the fight against too much body fat.

It can be difficult to lose weight and develop a slimmer figure. Some people want to get into their favourite jeans or feel more comfortable in their own skin, while others want to improve their general health and wellbeing.

Whatever be the reason for wanting to lose weight, knowing how supplements can help may be an important piece of the puzzle.

Due to their capacity to help increase metabolism, reduce cravings, and enhance the body's natural fat-burning mechanisms, these vitamins have earned their place in the limelight.

It's crucial to keep in mind, though, that supplements should never be thought of as miracle cures that replace a healthy lifestyle. They are intended to go along with a healthy diet and consistent workout schedule.

Additionally, we also emphasise the importance of consulting with a healthcare professional before incorporating any new supplements into your routine, ensuring that they align with your individual health needs and goals.

Research Ingredients: Investigate the ingredients in the supplement. Look for scientific evidence supporting their effectiveness for weight loss. Be cautious of proprietary blends that don't disclose individual ingredient quantities.

Avoid Unrealistic Claims: Beware of supplements that promise rapid, extreme weight loss or claim to "burn fat effortlessly." If it sounds too good to be true, it probably is.

Check for Safety and Quality: Choose supplements from reputable brands that follow Good Manufacturing Practices (GMP) and are third-party tested for purity and quality. Look for certifications from organisations like NSF or USP.

Consider Long-Term Use: Think about whether the supplement is suitable for long-term use. Rapid weight loss supplements may not be sustainable or healthy in the long run.

In depth Research: Extensive Research: Our team conducted extensive research into the weight loss supplement market, analysing a wide range of products and their ingredients.

Safety: Your well-being is our top priority. We've thoroughly examined the safety profiles of these supplements, considering potential side effects, interactions, and allergenic risks. Rest assured that the supplements we recommend prioritise your health.

Customer Feedback: Real-world experiences matter. We've taken into account customer reviews and testimonials to gauge user satisfaction and to provide you with insights into how these supplements have performed for others like you.

Transparency: We believe in transparency. We've provided you with all the essential information about each supplement, including their ingredients, potential benefits, and any known side effects, so you can make an informed decision.

The Wellness Mantra SLMNFIT Ayurvedic Capsules may be the solution for you! These capsules include an extraordinary combination of potent herbs, including Agnimantha, Punarnava, Kokam, Gudmar, and others. These herbs are all traditionally recognised to increase metabolism and assist healthy weight management.

The high amount of dietary fibre in these capsules makes them unique. Your calorie consumption is decreased since they make you feel satisfied after eating. They also help your body to burn fat that has been stored as energy, which is excellent for burning those extra calories.

Capsules are an efficient treatment for boosting fat metabolism because they also encourage healthy food digestion. You may rely on their calibre. These capsules are produced in top-notch facilities with strict testing guidelines, and they are made in accordance with age-old Ayurvedic principles.

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Customer feedback: Great effective herbal product for natural weight loss, I feel very nice, light and energetic through the day. I have made very minor modifications in my diet as well, clubbed with these capsules I am already losing weight.

Why it's worth buying: Worth buying for natural weight management with trusted Ayurvedic ingredients and high dietary fibre that supports metabolism and keeps you feeling full. It offers a holistic approach to healthy weight management.

Our top pick for you: https://amzn.to/3LKq0Nr

Carbamide Forte Garcinia Cambogia could become your new ally if you're trying to efficiently manage your weight. With a serving containing a staggering 60% active HydroxyCitric Acid (HCA) and a maximum dosage of 3000mg of Pure Garcinia Cambogia, these vegetarian tablets are incredibly potent. In particular for people who follow ketogenic diets, that is one of the highest amounts you'll find in any weight reduction pill on the market.

But these tablets have another useful feature as well. 95% of them include piperine, which is derived from black pepper extract. This increases the effectiveness of Garcinia Cambogia absorption in your body, which could speed up the process of losing weight.

Garcinia Cambogia is well known for its effectiveness in reducing hunger, burning fat, and blocking carbs. It boosts your metabolism, can prevent overeating, and targets stubborn belly fat by reducing your appetite and ultimately calorie consumption.

And the best part?, well It is both natural and secure. These tablets, which are derived from the South Asian Malabar Tamarind fruit, are free of allergens and artificial additives typically found in other weight-loss products. They are also gluten-free, GMO-free, and allergenic.

Adults should take one tablet three times daily with a full glass of water, about 45 minutes before meals. Though individual results may vary, Carbamide Forte Garcinia Cambogia is a natural, vegetarian supplement that can help you reach your weight loss objectives. The impact you require might simply be in here.

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Customer feedback: So far, so good! Amazing results, very happy with this product

My husband's doctor recommended this for him to help with weight management and issues

related to digestive health. So far, so good. He has had no adverse reactions and we are

expecting good results because I have heard good things about this product, so I am hopeful that it will prove beneficial for him as well. It's still early, but I will try to provide an update on his progress in the future.

Why it's worth buying: Worth buying with 600+ Amazon ratings due to high HCA concentration and proven effectiveness in supporting weight management.

Our top pick for you: https://amzn.to/3ZCNERW

The NutrinoPlus Slimo Advanced Weight Loss Formula has been designed to help you lose weight successfully. A special combination of Green Coffee Extract (100mg) and Garcinia Cambogia Extract (500mg) is contained in each pack's 60 capsules. It is a fat burner that both men and women can use.

Remember to include a balanced diet and exercise programme in your everyday life to get the most out of this product. It won't work like a magic pill, but it can undoubtedly assist.

How does it function? Slimo Advanced encourages fat burning, raises metabolic rate, and increases energy levels. Additionally, it promotes overall health and concentration. It is made to reduce several forms of body fat, such as arm, thigh, and belly fat.

This blend is designed to improve digestion, speed up metabolism, and aid in controlling hunger and fat. It works in four stages: accelerating metabolism, controlling appetite, releasing energy from fat cells, and calorie burning to produce heat in the body.

These capsules may also have other benefits like improved energy, skin health, and heart health. So, if you're looking for support in your weight loss journey, Slimo Advanced might be worth a try.

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Customer feedback: TRIED NUTRIPLUS SLIMO WHICH IS 100% natural no side effects, Only good results at the best price. This product helped me to lose inches in a short period of usage.

Why it's worth buying: Worth buying with a 4.1 Amazon rating for effective, natural weight loss support that's backed by satisfied customers. Achieve your weight goals confidently with this trusted product.

Our top pick for you: https://amzn.to/46RI0xR

Himalayan Organics Garcinia Cambogia Capsules, has a 4.4 rating on Amazon and can be a good option if you're looking for a natural way to help your weight loss efforts. With this product, many happy clients have discovered great weight control help.

Blocking the creation of fat is one of its main advantages. Citrate lyase is an enzyme that contributes to the production of fat, and garcinia cambogia inhibits it. By doing this, it lessens oxidative stress and aids in the reduction of body fat.

The serotonin levels in the brain are raised by these pills, which also help to manage appetite. Serotonin has been shown to reduce hunger, making you feel full and possibly lowering your calorie consumption.

Moreover, when taken with a wholesome, low-calorie diet, garcinia cambogia might boost your energy levels. It's a useful addition for those who want to increase their vigour while trying to lose weight.

Garcinia Cambogia may also be beneficial for people who are worried about having high cholesterol as a result of being overweight. It can increase good cholesterol while decreasing levels of bad cholesterol (triglycerides), fostering a more favourable equilibrium.

Lastly, these pills can improve your mood by releasing serotonin, which can assist to balance and revive your mood on trying days.

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Customer feedback: I ordered it for weight-loss so I am using it for 2 months and I can see the visible results.

Why it's worth buying: Boasts a solid 4.4 Amazon rating and satisfied customer reviews for effective, natural weight loss support.

Our top pick for you: https://amzn.to/3PZWzJN

Outsup Keto Pills may be what you need if you're trying to lose those extra pounds and increase your energy. These vegetarian pills are made to jump-start your metabolism, control your appetite, and assist your body in entering a state of ketosis, which is essential for burning fat.

They stand out because of their dual functionality as an appetite suppressant and metabolism enhancer. They are not the standard belly fat burner. These capsules are designed to provide you energy all day long, enabling you to stay alert and active.

It's simple to take them; just take 2 tablets daily with some warm water before meals. Do not forget to mix them with a healthy diet and fitness programme for the greatest effects.

The fact that these fat burner pills are created from premium, all-natural ingredients gives consumers peace of mind. There are no chemicals used, its entirely plant based. Therefore, Outsup Keto Fat Burner may be a good option to think about if you're seeking for a natural way to help your weight loss objectives.

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Customer feedback: This fat burner is really working and I am feeling the results. It is helpful in reducing fat with a planned diet, you just have to be disciplined and punctual in taking supplements and food. The price is also so affordable!

Why it's worth buying: Worth buying for natural weight loss support with proven ingredients and metabolism-boosting benefits. Convenient and effective as well.

Our top pick for you: https://amzn.to/3the5jW

Are weight loss supplements safe? Weight loss supplements can vary widely in terms of safety. It's crucial to choose reputable brands and consult a healthcare professional before starting any supplement to ensure it's safe for your specific health circumstances.

Do weight loss supplements work for everyone? No, weight loss supplements do not work the same way for everyone. Their effectiveness can vary depending on factors like genetics, diet, exercise, and overall health.

What is the best time to take weight loss supplements? The timing can vary depending on the supplement. Some are taken before meals, while others may be taken at different times of the day. Always follow the recommended dosage instructions on the product label.

How long should I take weight loss supplements? The duration of use can vary. Some supplements are intended for short-term use, while others can be used over more extended periods. It's best to follow the recommended usage guidelines on the product label or consult a healthcare provider.

What are common side effects of weight loss supplements? Side effects can vary depending on the supplement and individual reactions. Common side effects may include digestive issues, jitteriness, headaches, and more. It's essential to be aware of potential side effects and discontinue use if any adverse reactions occur.

Can I rely on weight loss supplements alone to lose weight? No, weight loss supplements should complement a healthy lifestyle that includes a balanced diet and regular exercise. They are not a replacement for proper nutrition and physical activity.

Are there age restrictions for using weight loss supplements? Age restrictions may apply to some supplements, especially for younger individuals. Always check the product label for age recommendations and consult with a healthcare provider if you have concerns.

In the quest for a healthier and more balanced lifestyle, weight reduction supplements can be useful tools as we earlier mentioned. However, a number of variables, including a person's health, adherence to a balanced diet, and regular exercise, affect how successful they are. Prioritising safety while selecting weight loss pills is essential.

Our selection of suggested supplements stands out due to their all-natural ingredients, favourable customer reviews, and ability to aid with weight management objectives.

As a component of an all-encompassing strategy for obtaining and maintaining a healthier weight, these goods are worthwhile to take into account. Always keep in mind that individual results may vary, and for the greatest results, supplements should be used in conjunction with a healthy lifestyle.

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5 Best Supplements For Burning That Extra Fat - Outlook India

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