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Shaping morality: How weight loss drugs challenge the myth of thinness as a virtue – Salon

Dec 6th, 2023
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Last week, in a sit-down interview with CNN, WeightWatchers CEO Sima Sistani uttered four words that changed the trajectory of the company for good: We got it wrong.

Since joining the company last year, Sistani has revised many of its core features, including shifting away from storefronts and their infamous in-person meetings, but most radical is her keen embrace of blockbuster weight loss and weight-management drugs like Ozempic and Wegovy, can help patients lose 22.5 percent of their body weight approaching the amount someone would lose with bariatric surgery. As part of this pivot, WeightWatchers will be collaborating with a telehealth company that can prescribe their customers these medications.

What we do best is help people with weight management. That is the anchor, she said. I think we have to be true and authentic to that and who we are.

She continued: These medications have shown, and science has evolved to say, that living with obesity is a chronic condition. Its important, no matter what it means for our business, to just be clear about that. Its not willpower alone and what we are now saying is we know better and its on us to do better so that we can help people feel positive and destigmatize this conversation around obesity.

Its telling that Sistani brings up the concept of stigma surrounding obesity; many popular American diet plans are steeped in shame masquerading as accountability, be that in the form of stepping on a scale in front of tracksuit-clad strangers or logging calories into a little app that issues notifications when one goes over their daily allotment of fat or carbohydrates.

Many popular American diet plans are steeped in shame masquerading as accountability

Asceticism in pursuit of losing a few pounds is perceived as almost righteous. For instance, in The Beautiful People's Diet Book by Luciana Avedon and Jeanne Molli, which was published in 1973, the authors write: "For heightened perception without drugs plus rapid weight loss, nothing beats the oldest known treatment for obesity: total starvation."

The numerous professionals and influencers that exist in and on the edge of the diet industrial complex have long counted on the societal pressure associated with the belief that all thin people are driven and motivated, while all fat people are lazy and lack ambition in order to sell gym memberships, diet plans and virtual bootcamp subscriptions.

But now that big players like WeightWatchers have begun to embrace weight loss drugs, and the very real data that some people actually need medication in order to achieve better health, the myth of thinness as a virtue is being challenged. However, for much of our countrys contemporary history, thinness has been positioned as a moral good and not just within the pages of womens magazines, but in both the political and religious spheres, which means that the process of adjusting Americas understanding of weight loss is only just beginning.

During the Great Depression, public messaging surrounding what and how Americans ate drew clear distinctions between eating for pleasure and eating for economy. This attitude was carried into the first World War where rationing food was both a practical need and a display of patriotism. Perhaps thats one of the underlying reasons that, by and large, we expect our politicians to be thin.

For instance, in 2010, The Atlantic posed the question: Is America Ready for a Fat President? At the time, four of the most bandied-about names for the GOP nominations in 2012, which included Mississippi Gov. Haley Barbour, New Jersey Gov. Chris Christie, former House Speaker Newt Gingrich, and former Arkansas Gov. Mike Huckabee, did not conform to what the Daily Beasts Lloyd Grove described as the telegenic stereotype of lean and hungry strivers.

A year later, Philadelphia Magazine asked the slightly more personal, Are We Ready for a Fat President? Then-New Jersey governor Chris Christie was considering a presidential run, which brought a fair amount of scrutiny about his level of physical fitness.

I saw [Christie] the other day, commentator Chris Matthews said to a D.C. crowd during a December 2010 public appearance. He must be 300-plus, and thats something hes just gotta deal with because youre not going to say, Im going to cut the budget well, how about starting with supper?

"If our bodies really are to be temples of the Holy Spirit, we had best get them down to the size God intended"

That same month, pundit and professor Lamont Hill appeared on Fox 29 and said Christie could never be president. Why not? Hill was emphatic: Hes fat.

Given the insidious ways politics and religion tend to intertwine in certain corners of America, its not really surprising that these attitudes are reflected within the walls of the Christian church community. For instance, in 1957, Reverend Charlie Shed published a book titled Pray Your Weight Away. It became a best-seller with lines like, If our bodies really are to be temples of the Holy Spirit, we had best get them down to the size God intended, a sentiment that was eventually echoed in the 1961 book by Dr. Edward Podolsky, Its A Sin to Be Fat.

These are the types of messages that have been reinforced for decades from the pulpit, from the presidential debate stage, from the finale of The Biggest Loser which means that it will almost assuredly take a while for our collective understanding around the realities of weight management to shift.

Buried within the WeightWatchers literature is a surprisingly apt nugget of truth issued by the companys founder, Jean Nidetch: We all need approval, but when we lose weight for others, were in trouble.

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Shaping morality: How weight loss drugs challenge the myth of thinness as a virtue - Salon

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RHONJs Jenn Fessler Is Still Taking Weight Loss Drug After Hospitalization – AOL

Dec 6th, 2023
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Craig Barritt/Getty Images

The Real Housewives of New Jersey star Jennifer Fessler said her weight loss medication caused a complication that resulted in hospitalization but shes still taking the drug.

I have been on, and Im not going to call it Ozempic thats been the umbrella name, Fessler, 53, said during the Monday, December 4, episode of her new podcast Two Jersey Js with costar Jackie Goldschneider. But Ive been on semaglutide for over a year now, and Ive lost maybe 22 pounds.

Goldschneider, 47, has been critical of the trend of using Ozempic and similar drugs designed to treat type 2 diabetes for weight loss, but Fessler says shes not concerned about possible side effects.

Im not afraid of Ozempic and I will tell you I have had an experience that was not good and Im pretty positive it was about the semaglutide where I had to go to the hospital for an impacted bowel and Im still not nervous about it, Fessler told her cohost.

Weighing in. Real Housewives such as Kyle Richards, Dolores Catania and more have addressed whether they used diabetes medication Ozempic for weight loss. The Real Housewives of Beverly Hills star sparked speculation about using the drug after she debuted her slimmed-down figure in January 2023 via a bikini selfie. Richards then opened up about how []

She went on to call herself a raging hypochondriac but said that goes out the window when it comes to her appearance. For instance, Im not afraid at all of going into surgery for anything cosmetic, she added.

As for the impacted bowel situation, Fessler said she was experiencing constipation but didnt immediately take action because she knew it was a common side effect of semaglutide.

Something that happens [with semaglutide], a new experience for me, is being able to eat what I want even when its not the most healthy choices and still lose weight, she explained. So, maybe for the first time in my life, Im losing weight on pizza and bagels and ice cream.

Since the constipation experience, Fessler has been drinking more water and eating more vegetables, as she realized eating unhealthy food while taking semaglutide wasnt a great choice. She also hired a personal trainer to help her with her exercise routine.

Ozempic has become a hot topic when it comes to weight loss with some stars confirming they have used the drug while others denied it. Chelsea Handler admitted during a January 2023 episode of the Call Her Daddy podcast that she unknowingly took the Type 2 diabetes medication, which is traditionally used to improve []

A lot of this you have to be proactive about, she explained. Am I worried about it? No. Am I aware of it and a little disappointed in myself for not addressing it sooner? Sure.

Fessler previously hinted that she was taking Ozempic or a similar drug during a March interview on Watch What Happens Live With Andy Cohen. What am I on? Well, I did have a facelift. And a nose job! she shared at the time. And I did lose a lot of weight. I took peptides, and I dont know if youve heard of medications associated with that that help people lose weight. You said [the word Ozempic], I didnt. But whatever works, here I am.

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Altimmune Joins Weight-Loss Race with Phase II Win, Stock Jumps on News – BioSpace

Dec 6th, 2023
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Pictured: Woman stepping on a weighing scale/iStock,mapo

Maryland-based Altimmune on Thursday reported topline data from the Phase II MOMENTUM trial, showing that its investigational GLP-1/glucagon dual receptor agonist pemvidutide induced strong weight loss in adults with overweight or obesity.

At 48 weeks, patients who were given the 1.2-mg dose of pemvidutide achieved a mean weight loss of 10.3%, which grew to 11.2% and 15.6% in those treated with the 1.8-mg and 2.4-mg doses, respectively. Placebo counterparts only saw a mean 2.2% weight loss over the same time span. At the highest pemvidutide dose level, more than 30% of patients lost at least 20% of their weight.

Altimmune was trading approximately 34% higher in after-hours trading Thursday in response to the news.

Pemvidutide is an investigational peptide therapeutic that can activate both GLP-1 and glucagon receptors and is being tested for the treatment of obesity metabolic dysfunction-associated steatohepatitis. Its dual-agonist action mimics the complementary effects of diet and exercise, targeting GLP-1 receptors to help suppress appetite while the glucagon pathway increases energy expenditure.

Altimmune tested this mechanism of action in MOMENTUM, a mid-stage randomized, double-blinded and placebo-controlled study that enrolled 391 overweight or obese adults. Aside from body weight, MOMENTUM also looked at other markers of metabolic health and found that pemvidutide treatment likewise improved serum lipid levels and blood pressure.

Pemvidutide scored positive safety results while achieving a higher study retention rate than placebo. Most adverse events were mild to moderate in severity and the most common side effects were nausea and vomiting. Patient dropouts due to treatment toxicity increased with higher pemvidutide doses, most of which occurred during the first 16 weeks of treatment, according to Altimmune.

We believe the magnitude of weight loss, robust reductions in triglycerides, LDL cholesterol and blood pressure, together with the safety profile observed in this trial, could potentially differentiate pemvidutide from the other incretin-based therapies, Altimmune CEO Vipin Garg said in a statement.

If approved, pemvidutide could be an important option for obesity patients, especially those who also have risk factors for cardiovascular diseases, Garg added.

Thursdays readout puts Altimmune in the same potential arena as Novo and Eli Lilly, the two most dominant players in the multibillion-dollar obesity market, which some analysts expect to reach up to $200 billion in value in the coming years.

In the third quarter, Novos Wegovy (semaglutide) made $1.38 billion, while Lillys Mounjaro (tirzepatide) earned $1.4 billion. Mounjaro is formally indicated for type 2 diabetes, but its active ingredient last month won the FDAs approval for weight management, for which it is being sold as Zepbound.

Tristan Manalac is an independent science writer based in Metro Manila, Philippines. He can be reached at tristan@tristanmanalac.com or tristan.manalac@biospace.com.

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Altimmune Joins Weight-Loss Race with Phase II Win, Stock Jumps on News - BioSpace

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RHONJ’s Jenn Fessler Still Uses Weight Loss Drug After Hospitalization – Us Weekly

Dec 6th, 2023
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Craig Barritt/Getty Images

The Real Housewives of New Jersey star Jennifer Fessler said her weight loss medication caused a complication that resulted in hospitalization but shes still taking the drug.

I have been on, and Im not going to call it Ozempic thats been the umbrella name, Fessler, 53, said during the Monday, December 4, episode of her new podcast Two Jersey Js with costar Jackie Goldschneider. But Ive been on semaglutide for over a year now, and Ive lost maybe 22 pounds.

Goldschneider, 47, has been critical of the trend of using Ozempic and similar drugs designed to treat type 2 diabetes for weight loss, but Fessler says shes not concerned about possible side effects.

Im not afraid of Ozempic and I will tell you I have had an experience that was not good and Im pretty positive it was about the semaglutide where I had to go to the hospital for an impacted bowel and Im still not nervous about it, Fessler told her cohost.

Weighing in. Real Housewives such as Kyle Richards, Dolores Catania and more have addressed whether they used diabetes medication Ozempic for weight loss. The Real Housewives of Beverly Hills star sparked speculation about using the drug after she debuted her slimmed-down figure in January 2023 via a bikini selfie. Richards then opened up about how []

She went on to call herself a raging hypochondriac but said that goes out the window when it comes to her appearance. For instance, Im not afraid at all of going into surgery for anything cosmetic, she added.

As for the impacted bowel situation, Fessler said she was experiencing constipation but didnt immediately take action because she knew it was a common side effect of semaglutide.

Something that happens [with semaglutide], a new experience for me, is being able to eat what I want even when its not the most healthy choices and still lose weight, she explained. So, maybe for the first time in my life, Im losing weight on pizza and bagels and ice cream.

Since the constipation experience, Fessler has been drinking more water and eating more vegetables, as she realized eating unhealthy food while taking semaglutide wasnt a great choice. She also hired a personal trainer to help her with her exercise routine.

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Ozempic has become a hot topic when it comes to weight loss with some stars confirming they have used the drug while others denied it. Chelsea Handler admitted during a January 2023 episode of the Call Her Daddy podcast that she unknowingly took the Type 2 diabetes medication, which is traditionally used to improve []

A lot of this you have to be proactive about, she explained. Am I worried about it? No. Am I aware of it and a little disappointed in myself for not addressing it sooner? Sure.

Fessler previously hinted that she was taking Ozempic or a similar drug during a March interview on Watch What Happens Live With Andy Cohen. What am I on? Well, I did have a facelift. And a nose job! she shared at the time. And I did lose a lot of weight. I took peptides, and I dont know if youve heard of medications associated with that that help people lose weight. You said [the word Ozempic], I didnt. But whatever works, here I am.

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RHONJ's Jenn Fessler Still Uses Weight Loss Drug After Hospitalization - Us Weekly

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Crunchy foods can be a remedy to weight loss – Martinsville Bulletin

Dec 6th, 2023
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Analysis of LH, Testosterone, and Serum INSL3 in Experimental and Therapeutic Testicular Suppression – Physician’s Weekly

Dec 6th, 2023
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The following is a summary of Serum Insulin-like Factor 3, Testosterone, and LH in Experimental and Therapeutic Testicular Suppression, published in the November 2023 issue of Endocrinology by Albrethsen, et al.

While insulin-like factor 3 (INSL3) is recognized as a Leydig cell biomarker, its response to hypothalamus-pituitary-testicular suppression remains less understood. For a study, researchers sought to investigate the concurrent alterations in serum concentrations of INSL3, testosterone, and LH during experimental and therapeutic testicular suppression.

Serum samples from three cohorts undergoing testicular suppression were analyzed: healthy young men treated with androgens (Sustanon); transgender girls (male sex assigned at birth) receiving 3-monthly GnRH agonist injections; and patients with prostate cancer subjected to surgical castration or GnRH agonist treatment. Serum INSL3 and testosterone were quantified using liquid chromatography-tandem mass spectrometry, and LH was measured through an ultrasensitive immunoassay.

Experimental testicular suppression in healthy men using Sustanon led to decreased circulating concentrations of INSL3, testosterone, and LH, which subsequently returned to baseline after suppression release. Similarly, transgender girls and prostate cancer patients undergoing therapeutic hormonal hypothalamus-pituitary-testicular suppression exhibited reduced levels of all three hormones.

INSL3 demonstrated sensitivity as a testicular suppression marker, mirroring testosterones behavior and indicating Leydig cell function. INSL3 measurements in serum could complement testosterone as a marker in male reproductive disorders, therapeutic testicular suppression, and monitoring the illicit use of androgens.

Source: academic.oup.com/jcem/article-abstract/108/11/2834/7180820?redirectedFrom=fulltext

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Analysis of LH, Testosterone, and Serum INSL3 in Experimental and Therapeutic Testicular Suppression - Physician's Weekly

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High hematocrit levels rare for adults receiving gender-confirming testosterone therapy – Healio

Dec 6th, 2023
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Why India must control its testosterone levels on foreign shores – IndiaTimes

Dec 6th, 2023
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The Indian government needs to make sure that its machismo not affect its growing global influence

Intelligence officers live an interesting, intriguing and often dangerous life. They often have to opt for the unconventional and be courageous enough to break protocols, to be successful spymasters. Indias National Security Advisor, AK Doval is one such crafty spook and there are several legendary stories that showcase his operational skills.

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Why India must control its testosterone levels on foreign shores - IndiaTimes

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Low Testosterone Associated With Arthritis In Men & Women | mindbodygreen – mindbodygreen

Dec 6th, 2023
Comments Off on Low Testosterone Associated With Arthritis In Men & Women | mindbodygreen – mindbodygreen

Assistant Beauty & Health Editor

Assistant Beauty & Health Editor

Hannah Frye is the Assistant Beauty Editor at mindbodygreen. She has a B.S. in journalism and a minor in womens, gender, and queer studies from California Polytechnic State University, San Luis Obispo. Hannah has written across lifestyle sections including health, wellness, sustainability, personal development, and more.

Image by Lyuba Burakova / Stocksy

An estimated 25% of adults in the U.S. struggle with arthritis, making it a rampant (and often under-discussed) issue.The most common cause of arthritis is general wear and tearhowever, researchers have found another unexpected link that may be helpful for those struggling.Here's what to know:

For this study, researchers looked at 2013 to 2016 data from an ongoing U.S. database called The National Health and Nutrition Examination Survey2 , or NHANES for short. This study included a total of 10,439 people, mainly aged 20 years and older, 48% of whom were men.

The association between arthritis and low testosterone held up for both men and women. This makes the case that testosterone level testing may be helpful for anyone struggling to understand the root of their arthritis, no matter their gender.

This study found other correlations, too, such as smoking, waist circumference, BMI, high blood pressure, diabetes, and cardiovascular diseaseso testosterone is certainly not the only thing to consider.However, it's an important one, especially for perimenopausal and postmenopausal women who tend to have low testosterone levels3 due to declining adrenal function.

Knowing this association exists may inspire those who are struggling with arthritis to get a hormone test if possible. From there, your health care provider can give you personalized advice and treatment for both hormonal health and joint comfort.

Though testosterone is best known as a male sex hormone, this research reminds us that it's important for women's health, too.

You may also look to DHEA supplements. "The body synthesizes DHEA before converting it to testosterone, making it a reasonable choice for supplementation," Vinjamoori says. However, it's best to consult your health care provider before starting this supplement to ensure it's a necessary part of your routine.

And rememberthis finding is solely an association, not a statement of cause. So, more research is needed to determine if low testosterone causes arthritis or if the correlation is related in another way.

A new analysis study found that patients with arthritis had significantly lower testosterone levels than those without arthritis. This could be a sign that testosterone may play a role in arthritis onset or progression, but more research is needed to be sure. In the meantime, men and women can support their testosterone levels through lifestyle changes and consult a physician if they're interested in hormone testing.

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Understanding the impact of andropause on men’s health – Omnia Health Insights

Dec 6th, 2023
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As men age, they undergo a natural process known as andropause, akin to the female experience of menopause. This transformation signifies a gradual decline in testosterone production, a hormone critical to male well-being. It's an inevitable process, with testosterone levels diminishing by roughly one per cent each year after the age of 30, says Dr. Martin Galy, Body Identical Hormone Lead Physician at 23MD, a specialised cosmetic and medical clinic. However, the impact varies among individuals, depending on their initial testosterone levels.

For some men who start life with naturally high testosterone levels, this decline may not significantly affect them. Their bodies maintain sufficient testosterone to support essential functions. In contrast, approximately 20 to 30 per cent of men who began adulthood with mid-range or lower testosterone levels might face challenges in their midlife, typically in their early to mid-40s, he adds.

Related:New approach to detect colorectal cancer in the UAE

As testosterone levels drop, they can experience symptoms related to andropause, often mirroring menopausal symptoms in women, including mood swings, depression, irritability, weight gain, hot flashes, reduced libido, and erectile problems.

The consequences of untreated andropause can be severe, potentially leading to long-term health issues such as diabetes, cardiovascular disease, and cognitive decline. However, awareness of andropause remains limited, as it has not received the same attention as menopause in women. This knowledge gap presents a significant challenge in healthcare, as many men suffering from andropause may not recognise the root cause of their symptoms. They might be misdiagnosed and prescribed treatments for unrelated conditions like depression or erectile dysfunction, leaving the underlying hormonal issue unaddressed.

To address these challenges, it is crucial to raise awareness about andropause and its symptoms among middle-aged men, encouraging open discussions.

In terms of solutions, pharmaceutical companies and healthcare providers offer safe and effective treatments for andropause. Hormone replacement therapy (HRT), often administered through gels or creams applied to the skin, can help restore testosterone levels to a more balanced state, replicating the body's natural hormone production rhythm, explains Galy. This medical intervention not only alleviates symptoms but also reduces the risk of long-term health complications.

Dr. Martin Galy

Testosterone can be administered in two primary forms, each with its unique benefits and considerations. The first method involves the application of testosterone in the form of creams or gels that are absorbed through the skin. This approach is widely regarded as a safer alternative, thanks to its ability to mimic the body's natural testosterone production. The key distinction lies in its ability to provide a natural peak in testosterone levels twice daily, aligning with the body's circadian rhythm.

Related:World Heart Day: Innovations in electrophysiology and LVAD technology

In contrast, the second method entails the use of injectable forms of testosterone. While injectables are effective in elevating testosterone levels, they do so without the natural peaks and troughs experienced with transdermal application. This constant elevation of testosterone may present some associated risks. Notably, high testosterone levels can stimulate the bone marrow to produce excessive red blood cells, leading to thickened blood. Thickened blood can pose risks of clotting, potentially resulting in blood clots and even heart attacks.

In light of these considerations, a cautious approach is recommended. For middle-aged men seeking HRT with testosterone, experts often advise starting with transdermal methods before considering injectable forms. This step can help mitigate potential risks while striving for optimal hormone balance.

In essence, HRT serves as a vital tool in restoring and maintaining hormone balance for both men and women. It has the potential to alleviate symptoms, enhance well-being, and improve overall health. By embracing the right approach, guided by medical expertise, individuals can embark on a journey towards a healthier, more balanced life through HRT.

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